| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L N Yatham, P F Liddle, I S Shiah, G Scarrow, R W Lam, M J Adam, A P Zis, T J Rut. Brain serotonin2 receptors in major depression: a positron emission tomography study. Archives of general psychiatry. vol 57. issue 9. 2000-09-21. PMID:10986548. |
postmortem and brain imaging studies that measured brain serotinin(2) (5-ht(2)) receptors in major depression reported an increase, decrease, and no change compared with controls. |
2000-09-21 |
2023-08-12 |
Not clear |
| S G Kornstein, A F Schatzberg, M E Thase, K A Yonkers, J P McCullough, G I Keitner, A J Gelenberg, S M Davis, W M Harrison, M B Kelle. Gender differences in treatment response to sertraline versus imipramine in chronic depression. The American journal of psychiatry. vol 157. issue 9. 2000-09-20. PMID:10964861. |
the authors examined gender differences in treatment response to sertraline, a selective serotonin reuptake inhibitor (ssri), and to imipramine, a tricyclic antidepressant, in chronic depression. |
2000-09-20 |
2023-08-12 |
Not clear |
| L Franke, H J Schewe, B Müller, V Campman, W Kitzrow, R Uebelhack, A Berghöfer, B Müller-Oerlinghause. Serotonergic platelet variables in unmedicated patients suffering from major depression and healthy subjects: relationship between 5HT content and 5HT uptake. Life sciences. vol 67. issue 3. 2000-09-19. PMID:10983874. |
serotonergic platelet variables in unmedicated patients suffering from major depression and healthy subjects: relationship between 5ht content and 5ht uptake. |
2000-09-19 |
2023-08-12 |
human |
| J R Oliveira, D R Carvalho, D Pontual, R M Gallindo, E B Sougey, V Gentil, B Lafer, L G Maia, M A Morais, S Matioli, H Vallada, R A Moreno, A Nishimura, P A Otto, M R Passos-Bueno, M Zat. Analysis of the serotonin transporter polymorphism (5-HTTLPR) in Brazilian patients affected by dysthymia, major depression and bipolar disorder. Molecular psychiatry. vol 5. issue 4. 2000-09-14. PMID:10889543. |
analysis of the serotonin transporter polymorphism (5-httlpr) in brazilian patients affected by dysthymia, major depression and bipolar disorder. |
2000-09-14 |
2023-08-12 |
Not clear |
| P A Newhouse, K R Krishnan, P M Doraiswamy, E M Richter, E D Batzar, C M Clar. A double-blind comparison of sertraline and fluoxetine in depressed elderly outpatients. The Journal of clinical psychiatry. vol 61. issue 8. 2000-09-14. PMID:10982198. |
there has been a paucity of well-designed studies comparing selective serotonin reuptake inhibitor (ssri) medications in the treatment of depression in the elderly. |
2000-09-14 |
2023-08-12 |
Not clear |
| A Honi. [Depression following a heart infarct and increased risk of death]. Nederlands tijdschrift voor geneeskunde. vol 144. issue 27. 2000-09-08. PMID:10918909. |
early detection of post-infarction depression and treatment with a selective serotonin reuptake inhibitor (ssri) is advised. |
2000-09-08 |
2023-08-12 |
Not clear |
| I Massat, D Souery, O Lipp, S Blairy, G Papadimitriou, D Dikeos, M Ackenheil, S Fuchshuber, C Hilger, R Kaneva, V Milanova, G Verheyen, P Raeymaekers, L Staner, L Oruc, M Jakovljevic, A Serretti, F Macciardi, C Van Broeckhoven, J Mendlewic. A European multicenter association study of HTR2A receptor polymorphism in bipolar affective disorder. American journal of medical genetics. vol 96. issue 2. 2000-09-06. PMID:10893484. |
the available data on the role of 5-ht in a variety of behaviors support the hypothesis that a dysfunction in brain serotoninergic system activity contributes to vulnerability to major depression. |
2000-09-06 |
2023-08-12 |
Not clear |
| M Alda, P D Hrdin. Distribution of platelet 5-HT(2A) receptor densities in suicidal and non-suicidal depressives and control subjects. Psychiatry research. vol 94. issue 3. 2000-08-30. PMID:10889293. |
the frequency distribution of platelet 5-ht(2a) receptor densities (measured as [3h]lsd b(max)) was analysed in 60 patients with major depression and 40 matched control subjects to determine whether the observed receptor densities come from a single distribution or whether there are more distributions that are represented differently in control subjects and in diagnostic subgroups of non-suicidal and suicidal patients. |
2000-08-30 |
2023-08-12 |
human |
| T I Cremers, P de Boer, Y Liao, F J Bosker, J A den Boer, B H Westerink, H V Wikströ. Augmentation with a 5-HT(1A), but not a 5-HT(1B) receptor antagonist critically depends on the dose of citalopram. European journal of pharmacology. vol 397. issue 1. 2000-08-29. PMID:10844100. |
the latter may have consequences for selective serotonin reuptake inhibitor augmentation strategies with 5-ht(1a) receptor antagonists in the therapy of depression and anxiety disorders. |
2000-08-29 |
2023-08-12 |
rat |
| R Brenner, V Azbel, S Madhusoodanan, M Pawlowsk. Comparison of an extract of hypericum (LI 160) and sertraline in the treatment of depression: a double-blind, randomized pilot study. Clinical therapeutics. vol 22. issue 4. 2000-08-24. PMID:10823363. |
hypericum (st. john's wort) has been shown to be as efficacious and well tolerated as standard antidepressants in the treatment of depression but has not been compared with selective serotonin reuptake inhibitors (ssris). |
2000-08-24 |
2023-08-12 |
Not clear |
| K Rasmussen, D O Calligaro, J F Czachura, L J Dreshfield-Ahmad, D C Evans, S K Hemrick-Luecke, M J Kallman, W T Kendrick, J D Leander, D L Nelson, C D Overshiner, D B Wainscott, M C Wolff, D T Wong, T A Branchek, J M Zgombick, Y C X. The novel 5-Hydroxytryptamine(1A) antagonist LY426965: effects on nicotine withdrawal and interactions with fluoxetine. The Journal of pharmacology and experimental therapeutics. vol 294. issue 2. 2000-08-24. PMID:10900249. |
these preclinical results indicate that ly426965 is a selective, full 5-ht(1a) antagonist that may have clinical use as pharmacotherapy for smoking cessation and depression and related disorders. |
2000-08-24 |
2023-08-12 |
human |
| J J Mann, Y Y Huang, M D Underwood, S A Kassir, S Oppenheim, T M Kelly, A J Dwork, V Arang. A serotonin transporter gene promoter polymorphism (5-HTTLPR) and prefrontal cortical binding in major depression and suicide. Archives of general psychiatry. vol 57. issue 8. 2000-08-22. PMID:10920459. |
a serotonin transporter gene promoter polymorphism (5-httlpr) and prefrontal cortical binding in major depression and suicide. |
2000-08-22 |
2023-08-12 |
Not clear |
| J J Mann, Y Y Huang, M D Underwood, S A Kassir, S Oppenheim, T M Kelly, A J Dwork, V Arang. A serotonin transporter gene promoter polymorphism (5-HTTLPR) and prefrontal cortical binding in major depression and suicide. Archives of general psychiatry. vol 57. issue 8. 2000-08-22. PMID:10920459. |
major depression and suicide are associated with fewer serotonin transporter (5-htt) sites. |
2000-08-22 |
2023-08-12 |
Not clear |
| D Mischoulon, A A Nierenberg, L Kizilbash, J F Rosenbaum, M Fav. Strategies for managing depression refractory to selective serotonin reuptake inhibitor treatment: a survey of clinicians. Canadian journal of psychiatry. Revue canadienne de psychiatrie. vol 45. issue 5. 2000-08-16. PMID:10900529. |
strategies for managing depression refractory to selective serotonin reuptake inhibitor treatment: a survey of clinicians. |
2000-08-16 |
2023-08-12 |
Not clear |
| J P Anthony, T J Sexton, J F Neumaie. Antidepressant-induced regulation of 5-HT(1b) mRNA in rat dorsal raphe nucleus reverses rapidly after drug discontinuation. Journal of neuroscience research. vol 61. issue 1. 2000-08-14. PMID:10861803. |
serotonin release from dorsal raphe projections in the forebrain is regulated by terminal 5-ht(1b) autoreceptors; dysregulation of these receptors may be involved in the pathophysiology of clinical depression. |
2000-08-14 |
2023-08-12 |
rat |
| E Mundo, M Walker, H Tims, F Macciardi, J L Kenned. Lack of linkage disequilibrium between serotonin transporter protein gene (SLC6A4) and bipolar disorder. American journal of medical genetics. vol 96. issue 3. 2000-08-10. PMID:10898918. |
the serotonin transporter (5htt) gene appears to be of particular interest as 5htt is the selective site of action of selective serotonin reuptake inhibitors (ssris) that successfully treat bipolar depression (bp). |
2000-08-10 |
2023-08-12 |
Not clear |
| K J Holm, B Jarvis, R H Foste. Mirtazapine. A pharmacoeconomic review of its use in depression. PharmacoEconomics. vol 17. issue 5. 2000-08-10. PMID:10977391. |
there is evidence for a faster onset of action with mirtazapine than with the selective serotonin (5-hydroxytryptamine; 5-ht) re-uptake inhibitors (ssris) on the basis of mean depression rating scale scores. |
2000-08-10 |
2023-08-12 |
Not clear |
| B Shapira, M E Newman, Y Gelfin, B Lere. Blunted temperature and cortisol responses to ipsapirone in major depression: lack of enhancement by electroconvulsive therapy. Psychoneuroendocrinology. vol 25. issue 5. 2000-08-03. PMID:10818278. |
depression has been shown in some studies to be associated with a reduction in hypothalamic 5-ht(1a) receptor function, as indicated by reduced hormone and/or hypothermic responses to 5-ht(1a) agonists such as ipsapirone. |
2000-08-03 |
2023-08-12 |
human |
| B Shapira, M E Newman, Y Gelfin, B Lere. Blunted temperature and cortisol responses to ipsapirone in major depression: lack of enhancement by electroconvulsive therapy. Psychoneuroendocrinology. vol 25. issue 5. 2000-08-03. PMID:10818278. |
we conclude that hypothalamic 5-ht(1a) receptor function is reduced in depression. |
2000-08-03 |
2023-08-12 |
human |
| T D Epperly, K E Moor. Health issues in men: Part II. Common psychosocial disorders. American family physician. vol 62. issue 1. 2000-08-03. PMID:10905783. |
selective serotonin reuptake inhibitors have become first-line therapy for depression. |
2000-08-03 |
2023-08-12 |
Not clear |