| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P J Cowe. Psychopharmacology of 5-HT(1A) receptors. Nuclear medicine and biology. vol 27. issue 5. 2000-11-03. PMID:10962247. |
use of this technique has demonstrated that unmedicated patients with major depression have decreased sensitivity of both pre- and postsynaptic 5-ht(1a) receptors. |
2000-11-03 |
2023-08-12 |
Not clear |
| W C Drevets, E Frank, J C Price, D J Kupfer, P J Greer, C Mathi. Serotonin type-1A receptor imaging in depression. Nuclear medicine and biology. vol 27. issue 5. 2000-11-03. PMID:10962258. |
serotonin type-1a receptor imaging in depression. |
2000-11-03 |
2023-08-12 |
human |
| E A Rabiner, R N Gunn, M R Wilkins, P A Sargent, E Mocaer, E Sedman, P J Cowen, P M Grasb. Drug action at the 5-HT(1A) receptor in vivo: autoreceptor and postsynaptic receptor occupancy examined with PET and [carbonyl-(11)C]WAY-100635. Nuclear medicine and biology. vol 27. issue 5. 2000-11-03. PMID:10962259. |
serotonin(1a) (5-ht(1a)) receptors have been implicated in the pathophysiology and treatment of anxiety and depression and are a target for novel drug development. |
2000-11-03 |
2023-08-12 |
human |
| B Andrée, C Halldin, S O Thorberg, J Sandell, L Fard. Use of PET and the radioligand [carbonyl-(11)C]WAY-100635 in psychotropic drug development. Nuclear medicine and biology. vol 27. issue 5. 2000-11-03. PMID:10962260. |
this drug has been suggested in combination with selective serotonin reuptake inhibitors for the treatment of depression and was given to healthy males in the second study. |
2000-11-03 |
2023-08-12 |
human |
| B Andrée, C Halldin, S O Thorberg, J Sandell, L Fard. Use of PET and the radioligand [carbonyl-(11)C]WAY-100635 in psychotropic drug development. Nuclear medicine and biology. vol 27. issue 5. 2000-11-03. PMID:10962260. |
this observation suggests that pindolol may have a role for the suggested potentiation of selective serotonin reuptake inhibitor treatment of depression. |
2000-11-03 |
2023-08-12 |
human |
| B Andrée, C Halldin, S O Thorberg, J Sandell, L Fard. Use of PET and the radioligand [carbonyl-(11)C]WAY-100635 in psychotropic drug development. Nuclear medicine and biology. vol 27. issue 5. 2000-11-03. PMID:10962260. |
the third study was on robalzotan (nad-299), a recently developed 5-ht(1a) receptor antagonist and putative drug with implications for the treatment of depression. |
2000-11-03 |
2023-08-12 |
human |
| N Ghaziuddin, C A King, K B Welch, J Zaccagnini, E Weidmer-Mikhail, A M Mellow, M Ghaziuddin, J F Grede. Serotonin dysregulation in adolescents with major depression: hormone response to meta-chlorophenylpiperazine (mCPP) infusion. Psychiatry research. vol 95. issue 3. 2000-10-31. PMID:10974357. |
serotonin dysregulation in adolescents with major depression: hormone response to meta-chlorophenylpiperazine (mcpp) infusion. |
2000-10-31 |
2023-08-12 |
human |
| N Ghaziuddin, C A King, K B Welch, J Zaccagnini, E Weidmer-Mikhail, A M Mellow, M Ghaziuddin, J F Grede. Serotonin dysregulation in adolescents with major depression: hormone response to meta-chlorophenylpiperazine (mCPP) infusion. Psychiatry research. vol 95. issue 3. 2000-10-31. PMID:10974357. |
this study examined central serotonin disturbance, as reflected by neuroendocrine hormones, among adolescents with major depression. |
2000-10-31 |
2023-08-12 |
human |
| A Condat, M C Mouren-Simeon. [Selective serotonin reuptake inhibitors and depression in the child and adolescent]. L'Encephale. vol 26. issue 3. 2000-10-19. PMID:10951906. |
[selective serotonin reuptake inhibitors and depression in the child and adolescent]. |
2000-10-19 |
2023-08-12 |
Not clear |
| A Condat, M C Mouren-Simeon. [Selective serotonin reuptake inhibitors and depression in the child and adolescent]. L'Encephale. vol 26. issue 3. 2000-10-19. PMID:10951906. |
the potential interest of selective serotonin reuptake inhibitors (ssri) for child and adolescent depression treatment is now well recognized. |
2000-10-19 |
2023-08-12 |
Not clear |
| A J Claxton, Z Li, J McKendric. Selective serotonin reuptake inhibitor treatment in the UK: risk of relapse or recurrence of depression. The British journal of psychiatry : the journal of mental science. vol 177. 2000-10-19. PMID:11026957. |
selective serotonin reuptake inhibitor treatment in the uk: risk of relapse or recurrence of depression. |
2000-10-19 |
2023-08-12 |
Not clear |
| C Murr, B Widner, B Sperner-Unterweger, M Ledochowski, C Schubert, D Fuch. Immune reaction links disease progression in cancer patients with depression. Medical hypotheses. vol 55. issue 2. 2000-10-13. PMID:10904430. |
because tryptophan is precursor for the biosynthesis of the neurotransmitter serotonin (= 5-hydroxytryptamine, 5ht), low tryptophan concentrations will lead to decreased availability of serotonin which finally increases the susceptibility for the development of mood disturbances and depression in the patients. |
2000-10-13 |
2023-08-12 |
Not clear |
| P Ramchandani, B Murray, K Hawton, A Hous. Deliberate self poisoning with antidepressant drugs: a comparison of the relative hospital costs of cases of overdose of tricyclics with those of selective-serotonin re-uptake inhibitors. Journal of affective disorders. vol 60. issue 2. 2000-10-12. PMID:10967368. |
debate continues over the relative merits of tricyclics and selective serotonin re-uptake inhibitors (ssris) as first line antidepressant treatment for depression. |
2000-10-12 |
2023-08-12 |
Not clear |
| W Zhang, K W Perry, D T Wong, B D Potts, J Bao, G D Tollefson, F P Bymaste. Synergistic effects of olanzapine and other antipsychotic agents in combination with fluoxetine on norepinephrine and dopamine release in rat prefrontal cortex. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 23. issue 3. 2000-10-11. PMID:10942849. |
to understand the mechanism of the clinical efficacy of olanzapine and fluoxetine combination therapy for treatment-resistant depression (trd), we studied the effects of olanzapine and other antipsychotics in combination with the selective serotonin uptake inhibitors fluoxetine or sertraline on neurotransmitter release in rat prefrontal cortex (pfc) using microdialysis. |
2000-10-11 |
2023-08-12 |
rat |
| N Herrman. Use of SSRIs in the elderly: obvious benefits but unappreciated risks. The Canadian journal of clinical pharmacology = Journal canadien de pharmacologie clinique. vol 7. issue 2. 2000-10-11. PMID:10958704. |
selective serotonin reuptake inhibitors (ssris) are frequently recommended as a first-line treatment for depression in elderly patients. |
2000-10-11 |
2023-08-12 |
Not clear |
| H J Möller, H Grunz. Have some guidelines for the treatment of acute bipolar depression gone too far in the restriction of antidepressants? European archives of psychiatry and clinical neuroscience. vol 250. issue 2. 2000-10-10. PMID:10853919. |
furthermore, the fact that apparently the selective serotonin re-uptake inhibitors and possibly some other modern antidepressants have only a low risk of inducing a switch to mania should stimulate a rewriting of the guidelines on drug treatment in acute bipolar depression in a less restrictive way concerning the use of antidepressants. |
2000-10-10 |
2023-08-12 |
Not clear |
| R V Parsey, L S Kegeles, D R Hwang, N Simpson, A Abi-Dargham, O Mawlawi, M Slifstein, R L Van Heertum, J J Mann, M Laruell. In vivo quantification of brain serotonin transporters in humans using [11C]McN 5652. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 41. issue 9. 2000-10-05. PMID:10994724. |
abnormal brain regional densities of serotonin (5-hydroxytryptamine [5-ht]) transporters have been reported in postmortem studies in several neuropsychiatric conditions, such as major depression and schizophrenia. |
2000-10-05 |
2023-08-12 |
human |
| A M Hussain, A K Mitr. Effect of aging on tryptophan hydroxylase in rat brain: implications on serotonin level. Drug metabolism and disposition: the biological fate of chemicals. vol 28. issue 9. 2000-10-04. PMID:10950846. |
such alterations in trph activity may reduce the level of serotonin in brain, which may be linked to late-life depression and other brain disorders, such as alzheimer and parkinson diseases. |
2000-10-04 |
2023-08-12 |
rat |
| S J Wilson, C Bell, N J Coupland, D J Nut. Sleep changes during long-term treatment of depression with fluvoxamine--a home-based study. Psychopharmacology. vol 149. issue 4. 2000-10-03. PMID:10867963. |
the effects of antidepressants on sleep in depression have been extensively investigated, although to date there have been relatively few studies of newer drug classes such as specific serotonin reuptake inhibitors (ssris). |
2000-10-03 |
2023-08-12 |
Not clear |
| Y Barak, R Kimhi, R Weizma. Is selectivity for serotonin uptake associated with a reduced emergence of manic episodes in depressed patients? International clinical psychopharmacology. vol 15. issue 1. 2000-09-25. PMID:10836288. |
to determine whether selectivity for serotonin reuptake plays a role in antidepressant-associated mania (aam), we evaluated the frequency of treatment-emergent mania in patients with unipolar depression who received either citalopram, a highly selective serotonin uptake inhibitor, or the adrenergic tetracyclic antidepressants (ttcas) maproriline and mianserin, or placebo. |
2000-09-25 |
2023-08-12 |
Not clear |