| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C Moret, M Brile. The possible role of 5-HT(1B/D) receptors in psychiatric disorders and their potential as a target for therapy. European journal of pharmacology. vol 404. issue 1-2. 2001-02-22. PMID:10980257. |
with the help of some animal models of depression and anxiety and with some data from clinical studies it has been hypothesised that 5-ht(1b) receptors may be supersensitive in depression, anxiety and obsessive compulsive disorder. |
2001-02-22 |
2023-08-12 |
Not clear |
| L Yee, S H Wong, V A Skrinsk. Chiral high-performance liquid chromatographic analysis of fluoxetine and norfluoxetine in rabbit plasma, urine, and vitreous humor using an acetylated beta-cyclodextrin column. Journal of analytical toxicology. vol 24. issue 7. 2001-02-22. PMID:11043675. |
fluoxetine (prozac) is a potent selective serotonin reuptake inhibitor used for the treatment of major depression. |
2001-02-22 |
2023-08-12 |
rabbit |
| A Harkin, R Nally, J P Kelly, B E Leonar. Effects of reboxetine and sertraline treatments alone and in combination on the binding properties of cortical NMDA and beta1-adrenergic receptors in an animal model of depression. Journal of neural transmission (Vienna, Austria : 1996). vol 107. issue 10. 2001-02-22. PMID:11129111. |
in the present investigation we examined the effects of the noradrenaline reuptake inhibitor, reboxetine, the serotonin reuptake inhibitor, sertraline, alone and in combination on the binding properties of cortical nmda receptors and cortical beta1-adrenoceptors following 14 days of treatment in the olfactory bulbectomized rat model of depression. |
2001-02-22 |
2023-08-12 |
rat |
| J H Meyer, S Kapur, B Eisfeld, G M Brown, S Houle, J DaSilva, A A Wilson, S Rafi-Tari, H S Mayberg, S H Kenned. The effect of paroxetine on 5-HT(2A) receptors in depression: an [(18)F]setoperone PET imaging study. The American journal of psychiatry. vol 158. issue 1. 2001-02-22. PMID:11136637. |
the effect of paroxetine on 5-ht(2a) receptors in depression: an [(18)f]setoperone pet imaging study. |
2001-02-22 |
2023-08-12 |
Not clear |
| A R Peirson, J W Heucher. Correlations for serotonin levels and measures of mood in a nonclinical sample. Psychological reports. vol 87. issue 3 Pt 1. 2001-02-22. PMID:11191371. |
the importance of serotonin (5-ht) in the treatment of major depression is evident but the nature of this involvement is unclear. |
2001-02-22 |
2023-08-12 |
Not clear |
| S A Montgomery, R Judg. Treatment of depression with associated anxiety: comparisons of tricyclic antidepressants and selective serotonin reuptake inhibitors. Acta psychiatrica Scandinavica. Supplementum. vol 403. 2001-02-15. PMID:11019930. |
treatment of depression with associated anxiety: comparisons of tricyclic antidepressants and selective serotonin reuptake inhibitors. |
2001-02-15 |
2023-08-12 |
Not clear |
| W H Crow. Economic outcomes associated with tricyclic antidepressant and selective serotonin reuptake inhibitor treatments for depression. Acta psychiatrica Scandinavica. Supplementum. vol 403. 2001-02-15. PMID:11019937. |
economic outcomes associated with tricyclic antidepressant and selective serotonin reuptake inhibitor treatments for depression. |
2001-02-15 |
2023-08-12 |
Not clear |
| W H Crow. Economic outcomes associated with tricyclic antidepressant and selective serotonin reuptake inhibitor treatments for depression. Acta psychiatrica Scandinavica. Supplementum. vol 403. 2001-02-15. PMID:11019937. |
to compare the economic outcomes associated with the tricyclic antidepressants (tcas) and the selective serotonin reuptake inhibitors (ssris) in the treatment of depression. |
2001-02-15 |
2023-08-12 |
Not clear |
| W Stewart, D J Maxwel. Morphological evidence for selective modulation by serotonin of a subpopulation of dorsal horn cells which possess the neurokinin-1 receptor. The European journal of neuroscience. vol 12. issue 12. 2001-02-15. PMID:11122373. |
serotonin selectively depresses transmission of nociceptive information through the spinal dorsal horn but the mechanisms of this depression are poorly understood. |
2001-02-15 |
2023-08-12 |
Not clear |
| F C Colpaert, L A Bruins Slot, W Koek, D S Dupui. Memory of an operant response and of depressed mood retained in activation states of 5-HT(1A) receptors: evidence from rodent models. Behavioural brain research. vol 117. issue 1-2. 2001-02-08. PMID:11099756. |
three series of studies were conducted to specify the role of 5-ht(1a) receptors in memory; using selective ligands that differentially activate 5-ht(1a) receptors, it was determined whether a change in the activation state of these receptors can lead to deficient retrieval, and whether a so-produced deficit can occur in an animal model of depression. |
2001-02-08 |
2023-08-12 |
rat |
| H Bird, M Broggin. Paroxetine versus amitriptyline for treatment of depression associated with rheumatoid arthritis: a randomized, double blind, parallel group study. The Journal of rheumatology. vol 27. issue 12. 2001-02-08. PMID:11128665. |
to compare the efficacy and tolerability of paroxetine (a selective serotonin reuptake inhibitor) with that of amitriptyline (a tricyclic antidepressant) in the treatment of depression in 191 patients with rheumatoid arthritis (ra). |
2001-02-08 |
2023-08-12 |
Not clear |
| E Gur, E Dremencov, B Lerer, M E Newma. Functional effects of corticosterone on 5-HT(1A) and 5-HT(1B) receptor activity in rat brain: in vivo microdialysis studies. European journal of pharmacology. vol 411. issue 1-2. 2001-02-08. PMID:11137865. |
the decrease in presynaptic 5-ht(1b) receptor activity after chronic administration of antidepressant drugs complements the increases in 5-ht(1b) receptor number observed in animal models of depression. |
2001-02-08 |
2023-08-12 |
rat |
| R J Steingar. The neuroscience of depression in adolescence. Journal of affective disorders. vol 61 Suppl 1. 2001-02-08. PMID:11155964. |
endocrine studies have indicated that, as in adult depression, a dysregulation of the serotonin (5-ht) axis is involved in childhood depression. |
2001-02-08 |
2023-08-12 |
Not clear |
| E B Weller, R A Welle. Treatment options in the management of adolescent depression. Journal of affective disorders. vol 61 Suppl 1. 2001-02-08. PMID:11155965. |
treatment for depression in children and adolescents often requires pharmacotherapy with tricyclic antidepressants (tcas) or selective serotonin reuptake inhibitors (ssris), followed by psychotherapy. |
2001-02-08 |
2023-08-12 |
Not clear |
| M Collin, M L Håkansson-Ovesjö, I Misane, S O Ogren, B Meiste. Decreased 5-HT transporter mRNA in neurons of the dorsal raphe nucleus and behavioral depression in the obese leptin-deficient ob/ob mouse. Brain research. Molecular brain research. vol 81. issue 1-2. 2001-02-01. PMID:11000478. |
decreased 5-ht transporter mrna in neurons of the dorsal raphe nucleus and behavioral depression in the obese leptin-deficient ob/ob mouse. |
2001-02-01 |
2023-08-12 |
mouse |
| M Dahlström, A Ahonen, H Ebeling, P Torniainen, J Heikkilä, I Moilane. Elevated hypothalamic/midbrain serotonin (monoamine) transporter availability in depressive drug-naive children and adolescents. Molecular psychiatry. vol 5. issue 5. 2001-02-01. PMID:11032385. |
cumulative data suggest depression in adulthood being connected to reduced availability of brain serotonin while the role of dopamine remains less specific. |
2001-02-01 |
2023-08-12 |
Not clear |
| M Dahlström, A Ahonen, H Ebeling, P Torniainen, J Heikkilä, I Moilane. Elevated hypothalamic/midbrain serotonin (monoamine) transporter availability in depressive drug-naive children and adolescents. Molecular psychiatry. vol 5. issue 5. 2001-02-01. PMID:11032385. |
to test the serotonin hypothesis and the dopamine hypothesis regarding depression in children and adolescents, the series was divided into groups with depression present (31) and no depression present (10). |
2001-02-01 |
2023-08-12 |
Not clear |
| S K Srivastava, C Nat. The differential effects of calcium channel blockers in the behavioural despair test in mice. Pharmacological research. vol 42. issue 4. 2001-01-25. PMID:10987986. |
various studies have shown that calcium channel blockers (ccb) affect the release of central neurotransmitters including noradrenaline (na) and 5-hydroxytryptamine (5-ht), which are involved in depression. |
2001-01-25 |
2023-08-12 |
mouse |
| M R Salaza. Alpha lipoic acid: a novel treatment for depression. Medical hypotheses. vol 55. issue 6. 2001-01-25. PMID:11090300. |
in accordance with the serotonin theory of depression, it may be possible to treat depression by increasing insulin activity. |
2001-01-25 |
2023-08-12 |
Not clear |
| D Nut. Treatment of depression and concomitant anxiety. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 10 Suppl 4. 2001-01-25. PMID:11114488. |
selective serotonin re-uptake inhibitors (ssris) are a newer class of antidepressants that are as effective as tcas in treating depression and are well tolerated in the long term and have demonstrated efficacy in the treatment of anxiety. |
2001-01-25 |
2023-08-12 |
Not clear |