| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S Horschitz, R Hummerich, P Schlos. Down-regulation of the rat serotonin transporter upon exposure to a selective serotonin reuptake inhibitor. Neuroreport. vol 12. issue 10. 2001-09-06. PMID:11447330. |
sert represents the target of various antidepressants which inhibit 5-ht transport and are widely used for the pharmacotherapy of depression. |
2001-09-06 |
2023-08-12 |
rat |
| J R Slaughter, K A Slaughter, D Nichols, S E Holmes, M P Marten. Prevalence, clinical manifestations, etiology, and treatment of depression in Parkinson's disease. The Journal of neuropsychiatry and clinical neurosciences. vol 13. issue 2. 2001-09-06. PMID:11449025. |
pd depression is effectively treated with a variety of antidepressants, most commonly at present the selective serotonin reuptake inhibitors. |
2001-09-06 |
2023-08-12 |
Not clear |
| S M Garraway, S Hochma. Serotonin increases the incidence of primary afferent-evoked long-term depression in rat deep dorsal horn neurons. Journal of neurophysiology. vol 85. issue 5. 2001-08-30. PMID:11353003. |
in most cells (80%), 5-ht caused a depression of the naïve synaptic response. |
2001-08-30 |
2023-08-12 |
rat |
| A M Kumar, J R Berger, C Eisdorfer, J B Fernandez, K Goodkin, M Kuma. Cerebrospinal fluid 5-hydroxytryptamine and 5-hydroxyindoleacetic acid in HIV-1 infection. Neuropsychobiology. vol 44. issue 1. 2001-08-30. PMID:11408787. |
in the hiv-1 + group, although csf 5-ht level was significantly negatively correlated with serostatus, there was no correlation between either csf 5-ht or 5-hiaa levels and cd4 cell number or any behavioral measures evaluated in this study, including beck's depression inventory and state/trait anxiety scores. |
2001-08-30 |
2023-08-12 |
human |
| A M Kumar, J R Berger, C Eisdorfer, J B Fernandez, K Goodkin, M Kuma. Cerebrospinal fluid 5-hydroxytryptamine and 5-hydroxyindoleacetic acid in HIV-1 infection. Neuropsychobiology. vol 44. issue 1. 2001-08-30. PMID:11408787. |
these data suggest that hiv-1 infection affects the cns 5-ht status with no significant association with measures of depression and anxiety, at least in the early stage of infection. |
2001-08-30 |
2023-08-12 |
human |
| C Schmahl, M Bohu. [Symptom-focussed drug therapy in borderline personality disorder]. Fortschritte der Neurologie-Psychiatrie. vol 69. issue 7. 2001-08-30. PMID:11488246. |
comorbid depression should be treated with selective serotonin reuptake inhibitors. |
2001-08-30 |
2023-08-12 |
Not clear |
| K J Ressler, C B Nemerof. Role of serotonergic and noradrenergic systems in the pathophysiology of depression and anxiety disorders. Depression and anxiety. vol 12 Suppl 1. 2001-08-23. PMID:11098410. |
there is abundant evidence for abnormalities of the norepinephrine (ne) and serotonin (5ht) neurotransmitter systems in depression and anxiety disorders. |
2001-08-23 |
2023-08-12 |
Not clear |
| R K Mahendru, S Mahendr. Selection of antidepressant drugs in general practice. Journal of the Indian Medical Association. vol 99. issue 1. 2001-08-23. PMID:11480958. |
selective serotonin reuptake inhibitors are well tolerated and are considered by many to be the agents of choice in primary care treatment of depression because of their favourable adverse effect profile. |
2001-08-23 |
2023-08-12 |
Not clear |
| O Spreux-Varoquaux, J C Alvarez, I Berlin, G Batista, P G Despierre, A Gilton, D Cremnite. Differential abnormalities in plasma 5-HIAA and platelet serotonin concentrations in violent suicide attempters: relationships with impulsivity and depression. Life sciences. vol 69. issue 6. 2001-08-09. PMID:11476186. |
differential abnormalities in plasma 5-hiaa and platelet serotonin concentrations in violent suicide attempters: relationships with impulsivity and depression. |
2001-08-09 |
2023-08-12 |
Not clear |
| O Spreux-Varoquaux, J C Alvarez, I Berlin, G Batista, P G Despierre, A Gilton, D Cremnite. Differential abnormalities in plasma 5-HIAA and platelet serotonin concentrations in violent suicide attempters: relationships with impulsivity and depression. Life sciences. vol 69. issue 6. 2001-08-09. PMID:11476186. |
plasma 5-hiaa concentration was inversely associated with the degree of impulsivity and platelet 5-ht with the intensity of depression. |
2001-08-09 |
2023-08-12 |
Not clear |
| F Duval, M C Mokrani, H Correa, P Bailey, M Valdebenito, J Monreal, M A Crocq, J P Mache. Lack of effect of HPA axis hyperactivity on hormonal responses to d-fenfluramine in major depressed patients: implications for pathogenesis of suicidal behaviour. Psychoneuroendocrinology. vol 26. issue 5. 2001-08-02. PMID:11337135. |
however, in depression the relationship between altered cortisol levels and brain 5-ht function remains to be clarified. |
2001-08-02 |
2023-08-12 |
human |
| S M Dursun, J R Blackburn, S P Kutche. An exploratory approach to the serotonergic hypothesis of depression: bridging the synaptic gap. Medical hypotheses. vol 56. issue 2. 2001-08-02. PMID:11425295. |
in this exploratory review, we attempt to integrate pre and post synaptic theories of the biochemical basis of depression--in particular with regard to 5-ht. |
2001-08-02 |
2023-08-12 |
Not clear |
| B G Appelberg, E K Syvälahti, T E Koskinen, O P Mehtonen, T T Muhonen, H H Naukkarine. Patients with severe depression may benefit from buspirone augmentation of selective serotonin reuptake inhibitors: results from a placebo-controlled, randomized, double-blind, placebo wash-in study. The Journal of clinical psychiatry. vol 62. issue 6. 2001-08-02. PMID:11465522. |
patients with severe depression may benefit from buspirone augmentation of selective serotonin reuptake inhibitors: results from a placebo-controlled, randomized, double-blind, placebo wash-in study. |
2001-08-02 |
2023-08-12 |
Not clear |
| B G Appelberg, E K Syvälahti, T E Koskinen, O P Mehtonen, T T Muhonen, H H Naukkarine. Patients with severe depression may benefit from buspirone augmentation of selective serotonin reuptake inhibitors: results from a placebo-controlled, randomized, double-blind, placebo wash-in study. The Journal of clinical psychiatry. vol 62. issue 6. 2001-08-02. PMID:11465522. |
although case reports and open studies have reported augmentation with buspirone to be beneficial in the treatment of depression refractory to treatment with a selective serotonin reuptake inhibitor (ssri), a recently published randomized, placebo-controlled, double-blind study failed to show superiority of buspirone over placebo in this respect. |
2001-08-02 |
2023-08-12 |
Not clear |
| R Mössner, A Henneberg, A Schmitt, Y V Syagailo, M Grässle, T Hennig, R Simantov, M Gerlach, P Riederer, K P Lesc. Allelic variation of serotonin transporter expression is associated with depression in Parkinson's disease. Molecular psychiatry. vol 6. issue 3. 2001-07-26. PMID:11326308. |
allelic variation of serotonin transporter expression is associated with depression in parkinson's disease. |
2001-07-26 |
2023-08-12 |
Not clear |
| W A Wallace, M Balsitis, B J Harriso. Male breast neoplasia in association with selective serotonin re-uptake inhibitor therapy: a report of three cases. European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology. vol 27. issue 4. 2001-07-26. PMID:11417992. |
we report three cases of men with malignant and pre-malignant breast disease who had all been prescribed selective serotonin re-uptake inhibitors (ssris) for depression. |
2001-07-26 |
2023-08-12 |
Not clear |
| P Blie. Pharmacology of rapid-onset antidepressant treatment strategies. The Journal of clinical psychiatry. vol 62 Suppl 15. 2001-07-26. PMID:11444761. |
the neuronal circuitry of the 5-ht and norepinephrine (ne) systems and their connections to forebrain areas believed to be involved in depression has been dissected. |
2001-07-26 |
2023-08-12 |
Not clear |
| J L Rausch, H M Hobby, N Shendarkar, M E Johnson, J L. Fluvoxamine treatment of mixed anxiety and depression: evidence for serotonergically mediated anxiolysis. Journal of clinical psychopharmacology. vol 21. issue 2. 2001-07-19. PMID:11270909. |
this study examined the relationship between the change in the 5-htt's apparent affinity for 5-ht and the anxiolytic response in a group of 18 fluvoxamine-treated patients meeting structured clinical interview for dsm-iv criteria for both generalized anxiety disorder and major depression. |
2001-07-19 |
2023-08-12 |
human |
| J L Rausch, H M Hobby, N Shendarkar, M E Johnson, J L. Fluvoxamine treatment of mixed anxiety and depression: evidence for serotonergically mediated anxiolysis. Journal of clinical psychopharmacology. vol 21. issue 2. 2001-07-19. PMID:11270909. |
these results suggest that the therapeutic effect of ssri treatment can be linked to the magnitude and time-course of 5-ht transport inhibition effected with fluvoxamine, a drug that seems to have an antianxiety effect of the same magnitude as its effect on depression. |
2001-07-19 |
2023-08-12 |
human |
| S M Garraway, S Hochma. Pharmacological characterization of serotonin receptor subtypes modulating primary afferent input to deep dorsal horn neurons in the neonatal rat. British journal of pharmacology. vol 132. issue 8. 2001-07-19. PMID:11309251. |
a pharmacological analysis of the depression evoked by 5-ht suggested an action partly mediated by 5-ht(1a) receptor activation, since antagonism of the 5-ht(1a) receptor with nan-190 or way-100635 partly reversed 5-ht-evoked depression. |
2001-07-19 |
2023-08-12 |
rat |