| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J R Cornelius, O G Bukstein, B Birmaher, I M Salloum, K Lynch, N K Pollock, S Gershon, D Clar. Fluoxetine in adolescents with major depression and an alcohol use disorder: an open-label trial. Addictive behaviors. vol 26. issue 5. 2002-02-06. PMID:11676382. |
recently, a first placebo-controlled study of an selective serotonin reuptake inhibitor (ssri) medication was conducted among a sample of adolescents with major depression by emslie et al. |
2002-02-06 |
2023-08-12 |
Not clear |
| G Li Volsi, F Licata, G Fretto, M D Mauro, F Santangel. Influence of serotonin on the glutamate-induced excitations of secondary vestibular neurons in the rat. Experimental neurology. vol 172. issue 2. 2002-02-06. PMID:11716569. |
ejection of 5-ht modified neuronal responsiveness to glutamate in 86% of the studied units, the effect being a depression of the excitatory responses in two-thirds of cases and an enhancement in the remaining third. |
2002-02-06 |
2023-08-12 |
rat |
| A Kozlov, J H Kotaleski, E Aurell, S Grillner, A Lansne. Modeling of substance P and 5-HT induced synaptic plasticity in the lamprey spinal CPG: consequences for network pattern generation. Journal of computational neuroscience. vol 11. issue 2. 2002-02-01. PMID:11717534. |
substance p can induce a faster and larger depression of inhibitory connections but potentiation of excitatory inputs, whereas 5-ht induces facilitation of both inhibitory and excitatory inputs. |
2002-02-01 |
2023-08-12 |
Not clear |
| A Kozlov, J H Kotaleski, E Aurell, S Grillner, A Lansne. Modeling of substance P and 5-HT induced synaptic plasticity in the lamprey spinal CPG: consequences for network pattern generation. Journal of computational neuroscience. vol 11. issue 2. 2002-02-01. PMID:11717534. |
the aim of the present study has been to implement the activity dependent synaptic depression and facilitation induced by substance p and 5-ht into two alternative models of the lamprey spinal locomotor network, one relying on reciprocal inhibition for bursting and one in which each hemicord is capable of oscillations. |
2002-02-01 |
2023-08-12 |
Not clear |
| A Kozlov, J H Kotaleski, E Aurell, S Grillner, A Lansne. Modeling of substance P and 5-HT induced synaptic plasticity in the lamprey spinal CPG: consequences for network pattern generation. Journal of computational neuroscience. vol 11. issue 2. 2002-02-01. PMID:11717534. |
in the network model relying on reciprocal inhibition, the observed effects substance p and 5-ht have on network behavior (i.e., a frequency increase and decrease respectively) can to a substantial part be explained by their effects on the total extent and time dynamics of synaptic depression and facilitation. |
2002-02-01 |
2023-08-12 |
Not clear |
| V Arango, M D Underwood, M Boldrini, H Tamir, S A Kassir, S Hsiung, J J Chen, J J Man. Serotonin 1A receptors, serotonin transporter binding and serotonin transporter mRNA expression in the brainstem of depressed suicide victims. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 25. issue 6. 2002-01-28. PMID:11750182. |
less total 5-ht(1a) and sert binding is consistent with results of in vivo studies in depression. |
2002-01-28 |
2023-08-12 |
Not clear |
| S E Møller, F Larsen, A Z Khant, P E Rola. Lack of effect of citalopram on the steady-state pharmacokinetics of carbamazepine in healthy male subjects. Journal of clinical psychopharmacology. vol 21. issue 5. 2002-01-24. PMID:11593075. |
carbamazepine, a drug used in the treatment of seizure disorders, and citalopram, a highly selective serotonin reuptake inhibitor used for the treatment of depression and other psychiatric disorders, are both metabolized predominantly by the cytochrome p4503a4 isozyme. |
2002-01-24 |
2023-08-12 |
human |
| J S Olver, G D Burrows, T R Norma. Third-generation antidepressants: do they offer advantages over the SSRIs? CNS drugs. vol 15. issue 12. 2002-01-15. PMID:11735614. |
claims have been made for these agents in terms of improved efficacy, faster speed of onset of effect and greater safety in the treatment of depression compared with previous medications, such as the selective serotonin reuptake inhibitors (ssris). |
2002-01-15 |
2023-08-12 |
Not clear |
| H Tsukada, T Kakiuchi, S Nishiyama, H Ohba, N Harad. Effects of aging on 5-HT(1A) receptors and their functional response to 5-HT(1a) agonist in the living brain: PET study with [carbonyl-(11)C]WAY-100635 in conscious monkeys. Synapse (New York, N.Y.). vol 42. issue 4. 2002-01-10. PMID:11746722. |
in addition, these observations suggested that the age-related impairment of 5-ht(1a) receptor responses to 8-oh-dpat might be related to the reduced efficacy of antidepressant therapy in elderly patients with depression. |
2002-01-10 |
2023-08-12 |
monkey |
| P L Hensley, H G Nurnber. Formulary restriction of selective serotonin reuptake inhibitors for depression: potential pitfalls. PharmacoEconomics. vol 19. issue 10. 2002-01-03. PMID:11735668. |
formulary restriction of selective serotonin reuptake inhibitors for depression: potential pitfalls. |
2002-01-03 |
2023-08-12 |
Not clear |
| L Du, G Faludi, M Palkovits, D Bakish, P D Hrdin. Serotonergic genes and suicidality. Crisis. vol 22. issue 2. 2001-12-21. PMID:11727894. |
studies have shown that the number of brain and platelet serotonin transporter binding sites are reduced in patients with depression and in suicide victims, and that the density of 5-ht2a receptors is increased in brain regions of depressed in suicide victims and in platelets of depressed suicidal patients. |
2001-12-21 |
2023-08-12 |
Not clear |
| U Halbreich, L S Kah. Role of estrogen in the aetiology and treatment of mood disorders. CNS drugs. vol 15. issue 10. 2001-12-19. PMID:11602005. |
it is still unclear whether estrogen is efficacious as an adjunct to selective serotonin reuptake inhibitors or as one of the paradigms to manage treatment-resistance depression in menopausal women, but such efficacy is plausible. |
2001-12-19 |
2023-08-12 |
Not clear |
| J H Meyer, A A Wilson, N Ginovart, V Goulding, D Hussey, K Hood, S Houl. Occupancy of serotonin transporters by paroxetine and citalopram during treatment of depression: a [(11)C]DASB PET imaging study. The American journal of psychiatry. vol 158. issue 11. 2001-12-13. PMID:11691690. |
occupancy of serotonin transporters by paroxetine and citalopram during treatment of depression: a [(11)c]dasb pet imaging study. |
2001-12-13 |
2023-08-12 |
Not clear |
| J H Meyer, A A Wilson, N Ginovart, V Goulding, D Hussey, K Hood, S Houl. Occupancy of serotonin transporters by paroxetine and citalopram during treatment of depression: a [(11)C]DASB PET imaging study. The American journal of psychiatry. vol 158. issue 11. 2001-12-13. PMID:11691690. |
selective serotonin reuptake inhibitors are commonly used to treat major depression; however, the percentage of serotonin (5-ht) transporter (5-htt) sites occupied during clinical dosing is unknown. |
2001-12-13 |
2023-08-12 |
Not clear |
| L Frank, D A Revicki, S V Sorensen, Y C Shi. The economics of selective serotonin reuptake inhibitors in depression: a critical review. CNS drugs. vol 15. issue 1. 2001-12-11. PMID:11465013. |
the economics of selective serotonin reuptake inhibitors in depression: a critical review. |
2001-12-11 |
2023-08-12 |
Not clear |
| L Frank, D A Revicki, S V Sorensen, Y C Shi. The economics of selective serotonin reuptake inhibitors in depression: a critical review. CNS drugs. vol 15. issue 1. 2001-12-11. PMID:11465013. |
the prevalence of depression and the high costs associated with its treatment have increased interest in pharmacoeconomic evaluations of drug treatment, particularly in the 1990s as the use of selective serotonin (5-hydroxytryptamine; 5-ht) reuptake inhibitors (ssris) expanded substantially. |
2001-12-11 |
2023-08-12 |
Not clear |
| H K Strüder, H Weicke. Physiology and pathophysiology of the serotonergic system and its implications on mental and physical performance. Part II. International journal of sports medicine. vol 22. issue 7. 2001-12-11. PMID:11590475. |
impairment of neuromodulation and neuronal network in the brain with transient dysfunctions or permanent substantial deficits at manifestation of various types of depression results from prevalent impairment of 5-ht neurotransmission and its central interaction with other neurotransmitter systems. |
2001-12-11 |
2023-08-12 |
Not clear |
| Z Xu, F J Seidler, S F Ali, W Slikker, T A Slotki. Fetal and adolescent nicotine administration: effects on CNS serotonergic systems. Brain research. vol 914. issue 1-2. 2001-12-07. PMID:11578609. |
long-term changes in 5ht innervation and/or synaptic activity may play a role in the subsequent development of depression in the offspring of women who smoke during pregnancy or in adolescent smokers. |
2001-12-07 |
2023-08-12 |
rat |
| A McFarlane, M V Kamath, E L Fallen, V Malcolm, F Cherian, G Norma. Effect of sertraline on the recovery rate of cardiac autonomic function in depressed patients after acute myocardial infarction. American heart journal. vol 142. issue 4. 2001-12-07. PMID:11579351. |
the aim of this clinical physiologic study was to determine whether sertraline, a selective serotonin reuptake inhibitor, facilitates the rate of recovery of cardiac autonomic function after an acute myocardial infarction (mi) in patients with depression. |
2001-12-07 |
2023-08-12 |
Not clear |
| D A Axelson, B Birmahe. Relation between anxiety and depressive disorders in childhood and adolescence. Depression and anxiety. vol 14. issue 2. 2001-12-05. PMID:11668659. |
selective serotonin reuptake inhibitors and cognitive-behavioral therapy have been shown in randomized controlled trials to be efficacious for both pediatric depression and anxiety disorders. |
2001-12-05 |
2023-08-12 |
Not clear |