| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Daniel S Pine, Judith A Cohe. Trauma in children and adolescents: risk and treatment of psychiatric sequelae. Biological psychiatry. vol 51. issue 7. 2002-05-28. PMID:11950454. |
in terms of psychopharmacological treatments, data from randomized controlled trials in traumatized children have not been generated, but recent studies in other groups of children exhibiting symptoms of anxiety or depression suggest the utility of selective serotonin reuptake inhibitors. |
2002-05-28 |
2023-08-12 |
Not clear |
| David C Steffens, Ingrid Svenson, Douglas A Marchuk, Robert M Levy, Judith C Hays, Elizabeth P Flint, K Ranga Rama Krishnan, Ilene C Siegle. Allelic differences in the serotonin transporter-linked polymorphic region in geriatric depression. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry. vol 10. issue 2. 2002-05-23. PMID:11925279. |
allelic differences in the serotonin transporter-linked polymorphic region in geriatric depression. |
2002-05-23 |
2023-08-12 |
human |
| R E Wilcox, J E Ragan, R S Pearlman, M Y Brusniak, R M Eglen, D W Bonhaus, T E Tenner, J D Mille. High-affinity interactions of ligands at recombinant guinea pig 5HT7 receptors. Journal of computer-aided molecular design. vol 15. issue 10. 2002-05-20. PMID:11918075. |
the serotonin 5ht7 receptor has been implicated in numerous physiological and pathological processes from circadian rhythms to depression and schizophrenia. |
2002-05-20 |
2023-08-12 |
Not clear |
| Lijun Feng, Edward K Novak, Lisa M Hartnell, Juan S Bonifacino, Lucy M Collinson, Richard T Swan. The Hermansky-Pudlak syndrome 1 (HPS1) and HPS2 genes independently contribute to the production and function of platelet dense granules, melanosomes, and lysosomes. Blood. vol 99. issue 5. 2002-05-16. PMID:11861280. |
lysosomal and platelet dense granule abnormalities, including hyposecretion of lysosomal enzymes from kidneys and depression of serotonin concentrations of platelet dense granules were likewise more severe in double than single mutants. |
2002-05-16 |
2023-08-12 |
mouse |
| Cornelius Gross, Xiaoxi Zhuang, Kimberly Stark, Sylvie Ramboz, Ronald Oosting, Lynn Kirby, Luca Santarelli, Sheryl Beck, René He. Serotonin1A receptor acts during development to establish normal anxiety-like behaviour in the adult. Nature. vol 416. issue 6879. 2002-05-14. PMID:11919622. |
serotonin is implicated in mood regulation, and drugs acting via the serotonergic system are effective in treating anxiety and depression. |
2002-05-14 |
2023-08-12 |
mouse |
| Patrizia Blardi, Arianna De Lalla, Alessandro Leo, Alberto Auteri, Sonia Iapichino, Angela Di Muro, Alice Dell'Erba, Paolo Castrogiovann. Serotonin and fluoxetine levels in plasma and platelets after fluoxetine treatment in depressive patients. Journal of clinical psychopharmacology. vol 22. issue 2. 2002-05-13. PMID:11910257. |
depression is a mood disorder characterized by complex alterations of neurotransmitters such as serotonin, norepinephrine, and dopamine. |
2002-05-13 |
2023-08-12 |
Not clear |
| Patrizia Blardi, Arianna De Lalla, Alessandro Leo, Alberto Auteri, Sonia Iapichino, Angela Di Muro, Alice Dell'Erba, Paolo Castrogiovann. Serotonin and fluoxetine levels in plasma and platelets after fluoxetine treatment in depressive patients. Journal of clinical psychopharmacology. vol 22. issue 2. 2002-05-13. PMID:11910257. |
peripheral parameters of serotoninergic transmission, such as the 5-hydroxytryptamine content of plasma and platelets, have been used to identify biochemical alterations related to depression. |
2002-05-13 |
2023-08-12 |
Not clear |
| Zeruesenay Desta, Nadia Soukhova, David A Flockhar. In vitro inhibition of pimozide N-dealkylation by selective serotonin reuptake inhibitors and azithromycin. Journal of clinical psychopharmacology. vol 22. issue 2. 2002-05-13. PMID:11910261. |
pimozide is often coprescribed with serotonin reuptake inhibitor (ssri) antidepressants to treat depression in patients with tourette's syndrome. |
2002-05-13 |
2023-08-12 |
human |
| M Bianchi, C Moser, C Lazzarini, E Vecchiato, F Cresp. Forced swimming test and fluoxetine treatment: in vivo evidence that peripheral 5-HT in rat platelet-rich plasma mirrors cerebral extracellular 5-HT levels, whilst 5-HT in isolated platelets mirrors neuronal 5-HT changes. Experimental brain research. vol 143. issue 2. 2002-05-10. PMID:11880895. |
in particular, the present data support the idea that peripheral 5-ht platelet levels can reflect the state of the central 5-ht system in conditions of depression. |
2002-05-10 |
2023-08-12 |
rat |
| Dianne Kirby, Susan Harrigan, David Ame. Hyponatraemia in elderly psychiatric patients treated with Selective Serotonin Reuptake Inhibitors and venlafaxine: a retrospective controlled study in an inpatient unit. International journal of geriatric psychiatry. vol 17. issue 3. 2002-04-30. PMID:11921151. |
to determine the prevalence of hyponatraemia associated with selective serotonin reuptake inhibitor (ssri) and venlafaxine use in elderly patients compared to that in elderly patients not prescribed these drugs, while controlling for age, sex, depression status and illnesses or prescribed medications also associated with hyponatraemia. |
2002-04-30 |
2023-08-12 |
Not clear |
| David J Goldstein, Craig Mallinckrodt, Yili Lu, Mark A Demitrac. Duloxetine in the treatment of major depressive disorder: a double-blind clinical trial. The Journal of clinical psychiatry. vol 63. issue 3. 2002-04-24. PMID:11926722. |
duloxetine hydrochloride, a dual reuptake inhibitor of serotonin and norepinephrine, was evaluated for therapeutic efficacy and safety/tolerability in the treatment of major depression. |
2002-04-24 |
2023-08-12 |
Not clear |
| Gerard Sanacora, Graeme F Mason, Douglas L Rothman, John H Krysta. Increased occipital cortex GABA concentrations in depressed patients after therapy with selective serotonin reuptake inhibitors. The American journal of psychiatry. vol 159. issue 4. 2002-04-18. PMID:11925309. |
the goal of this study was to determine whether these occipital cortex gaba concentrations are altered after administration of selective serotonin reuptake inhibitors (ssris) in the treatment of depression. |
2002-04-18 |
2023-08-12 |
human |
| Zhongzhou Shen, Sui Wang, Ray Bakhtia. Enantiomeric separation and quantification of fluoxetine (Prozac) in human plasma by liquid chromatography/tandem mass spectrometry using liquid-liquid extraction in 96-well plate format. Rapid communications in mass spectrometry : RCM. vol 16. issue 5. 2002-04-15. PMID:11857715. |
fluoxetine (prozac) is currently one of the widely prescribed selective serotonin reuptake inhibitors (ssris) for the treatment of depression. |
2002-04-15 |
2023-08-12 |
human |
| Seong Who Kim, So Yeon Park, Onyou Hwan. Up-regulation of tryptophan hydroxylase expression and serotonin synthesis by sertraline. Molecular pharmacology. vol 61. issue 4. 2002-04-11. PMID:11901216. |
the neurotransmitter serotonin is involved in a variety of brain functions, and abnormal changes in serotonin neurotransmission are associated with an array of psychiatric disorders, including depression. |
2002-04-11 |
2023-08-12 |
rat |
| Tatsuki Yoshino, Koichi Nisijima, Satoshi Katoh, Kunio Yui, Mitsutaka Nakamur. Tandospirone potentiates the fluoxetine-induced increases in extracellular dopamine via 5-HT(1A) receptors in the rat medial frontal cortex. Neurochemistry international. vol 40. issue 4. 2002-04-05. PMID:11792466. |
these results indicate that tandospirone potentiates the fluoxetine-induced increase in dopamine release via 5-ht(1a) receptors in the rat medial frontal cortex, and suggest that tandospirone may have therapeutic potential for the treatment of depression. |
2002-04-05 |
2023-08-12 |
rat |
| W J Riedel, T Klaassen, E Griez, A Honig, P P C A Menheere, H M van Praa. Dissociable hormonal, cognitive and mood responses to neuroendocrine challenge: evidence for receptor-specific serotonergic dysregulation in depressed mood. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 26. issue 3. 2002-04-02. PMID:11850150. |
the results support the evidence for both hypothalamic and possibly hippocampal 5-ht(1a) receptor desensitisation and non-hypothalamic, 5-ht(2c) receptor sensitisation, probably fronto-cortical, in patients with major depression and dysthymia. |
2002-04-02 |
2023-08-12 |
Not clear |
| Oliver Tucha, Steffen Aschenbrenner, Peter Eichhammer, Albert Putzhammer, Heino Sartor, Helmfried E Klein, Klaus W Lang. The impact of tricyclic antidepressants and selective serotonin re-uptake inhibitors on handwriting movements of patients with depression. Psychopharmacology. vol 159. issue 2. 2002-04-02. PMID:11862351. |
the impact of tricyclic antidepressants and selective serotonin re-uptake inhibitors on handwriting movements of patients with depression. |
2002-04-02 |
2023-08-12 |
Not clear |
| Barbara L Shay, Shawn Hochma. Serotonin alters multi-segmental convergence patterns in spinal cord deep dorsal horn and intermediate laminae neurons in an in vitro young rat preparation. Pain. vol 95. issue 1-2. 2002-04-01. PMID:11790462. |
bicuculline and strychnine did not affect the 5-ht induced short-latency synaptic depression. |
2002-04-01 |
2023-08-12 |
rat |
| M Yamamot. Depression in Parkinson's disease: its prevalence, diagnosis, and neurochemical background. Journal of neurology. vol 248 Suppl 3. 2002-03-27. PMID:11697689. |
however, there is no high quality evidence to indicate the effectiveness of selective serotonin reuptake inhibitors for depression in pd. |
2002-03-27 |
2023-08-12 |
human |
| Donald Addington, Jean Addington, Scott Patten, Gary Remington, Javad Moamai, Alain Labelle, Linda Beauclai. Double-blind, placebo-controlled comparison of the efficacy of sertraline as treatment for a major depressive episode in patients with remitted schizophrenia. Journal of clinical psychopharmacology. vol 22. issue 1. 2002-03-25. PMID:11799338. |
the effectiveness of selective serotonin reuptake inhibitors for depression in remitted schizophrenia has not been clearly demonstrated. |
2002-03-25 |
2023-08-12 |
human |