| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J P Lépine, J Goger, C Blashko, C Probst, M F Moles, J Kosolowski, B Scharfetter, R M Lan. A double-blind study of the efficacy and safety of sertraline and clomipramine in outpatients with severe major depression. International clinical psychopharmacology. vol 15. issue 5. 2001-01-18. PMID:10993128. |
this study compared the efficacy and safety of the selective serotonin reuptake inhibitor sertraline with that of the tricyclic antidepressant clomipramine in patients with severe depression, as defined by a baseline 17-item hamilton depression rating scale (ham-d) of at least 25. |
2001-01-18 |
2023-08-12 |
Not clear |
| L N Venditti, A Arcelus, H Birnbaum, P Greenberg, C E Barr, C Rowland, T Williamso. The impact of antidepressant use on social functioning: reboxetine versus fluoxetine. International clinical psychopharmacology. vol 15. issue 5. 2001-01-18. PMID:10993130. |
this study evaluated the differential effects of two antidepressants on social functioning outcomes for patients with major depression comparing reboxetine, a non-tricyclic, selective noradrenaline reuptake inhibitor and fluoxetine, a commonly prescribed selective serotonin reuptake inhibitor. |
2001-01-18 |
2023-08-12 |
human |
| C A Marsden, S C Stanfor. CNS drugs III: psychotherapeutics. Expert opinion on investigational drugs. vol 9. issue 8. 2001-01-18. PMID:11203476. |
the main areas covered were how serotonergic ligands could he used with greater effect in depression and schizophrenia, the therapeutic value of serotonin noradrenaline uptake inhibitors (snris) and the potential clinical value of new amine re-uptake inhibitors. |
2001-01-18 |
2023-08-12 |
Not clear |
| P Moore, H P Landolt, E Seifritz, C Clark, T Bhatti, J Kelsoe, M Rapaport, J C Gilli. Clinical and physiological consequences of rapid tryptophan depletion. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 23. issue 6. 2001-01-04. PMID:11063917. |
its current popularity was stimulated by reports that rtd reversed the antidepressant effects of selective serotonin reuptake inhibitors (ssris) and monoamine oxidase inhibitors (maois) in remitted patients with a history of depression but not in patients treated with antidepressants which promote catecholaminergic rather than serotonergic neurotransmission (such as tricyclic antidepressants or buproprion). |
2001-01-04 |
2023-08-12 |
Not clear |
| J Semb. [Clinical significance of selective serotonin reuptake inhibitor (SSRI) in the treatment of depression]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 116. issue 2. 2000-12-13. PMID:10976459. |
[clinical significance of selective serotonin reuptake inhibitor (ssri) in the treatment of depression]. |
2000-12-13 |
2023-08-12 |
Not clear |
| J Semb. [Clinical significance of selective serotonin reuptake inhibitor (SSRI) in the treatment of depression]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 116. issue 2. 2000-12-13. PMID:10976459. |
since ssri primary acts on the serotonergic system, wide use of this drug has questioned the postulated dichotomy of the biological hypothesis of depression, the so-called serotonin depression or norepinephrine depression. |
2000-12-13 |
2023-08-12 |
Not clear |
| R Ceravolo, A Nuti, A Piccinni, G Dell'Agnello, G Bellini, G Gambaccini, L Dell'Osso, L Murri, U Bonuccell. Paroxetine in Parkinson's disease: effects on motor and depressive symptoms. Neurology. vol 55. issue 8. 2000-12-07. PMID:11071504. |
selective serotonin reuptake inhibitors have been used in the treatment of depression in patients with pd. |
2000-12-07 |
2023-08-12 |
Not clear |
| J J López-Ibor, C Alamo, F López-Muñoz, E Cuenca, G Rubio, F J Oter. Evolution of the management of depression in Spain from the psychiatrist's perspective. A comparative analysis: 1997 vs 1982. European psychiatry : the journal of the Association of European Psychiatrists. vol 15. issue 6. 2000-12-01. PMID:11004731. |
a comparative analysis of the therapeutic resources used was not possible, for prior to 1982 the only drugs available to physicians were the classical tricyclic agents and some mao inhibitors; the selective serotonin reuptake inhibitors (ssris) - possibly the greatest advance in the treatment of depression in these 15 years - had not yet been introduced. |
2000-12-01 |
2023-08-12 |
Not clear |
| B G Pollock, R E Ferrell, B H Mulsant, S Mazumdar, M Miller, R A Sweet, S Davis, M A Kirshner, P R Houck, J A Stack, C F Reynolds, D J Kupfe. Allelic variation in the serotonin transporter promoter affects onset of paroxetine treatment response in late-life depression. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 23. issue 5. 2000-11-21. PMID:11027924. |
allelic variation in the serotonin transporter promoter affects onset of paroxetine treatment response in late-life depression. |
2000-11-21 |
2023-08-12 |
human |
| B G Pollock, R E Ferrell, B H Mulsant, S Mazumdar, M Miller, R A Sweet, S Davis, M A Kirshner, P R Houck, J A Stack, C F Reynolds, D J Kupfe. Allelic variation in the serotonin transporter promoter affects onset of paroxetine treatment response in late-life depression. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 23. issue 5. 2000-11-21. PMID:11027924. |
the relationship of the serotonin transporter gene promoter region polymorphism (5-httlpr) to antidepressant response was examined in 95 elderly patients receiving a protocolized treatment for depression with paroxetine or nortriptyline. |
2000-11-21 |
2023-08-12 |
human |
| T L Skaer, D A Sclar, L M Robison, R S Gali. The need for an iterative process for assessing economic outcomes associated with SSRIs. PharmacoEconomics. vol 18. issue 3. 2000-11-21. PMID:11147388. |
pharmacotherapeutic advances in the treatment of depression have included the development of the selective serotonin reuptake inhibitors (ssris), thereby providing alternatives to tricyclic antidepressants. |
2000-11-21 |
2023-08-12 |
Not clear |
| S Hjorth, H J Bengtsson, A Kullberg, D Carlzon, H Peilot, S B Auerbac. Serotonin autoreceptor function and antidepressant drug action. Journal of psychopharmacology (Oxford, England). vol 14. issue 2. 2000-11-16. PMID:10890313. |
if a further increase in extracellular 5-ht is crucial to the remission of depression in patients responding only partially to prolonged administration of antidepressants, then sustained adjunctive treatment with autoreceptor-blocking drugs may consequently prove useful in the long term. |
2000-11-16 |
2023-08-12 |
rat |
| S J Dencke. The need for new and better antidepressants: reboxetine a new option. Acta psychiatrica Scandinavica. Supplementum. vol 402. 2000-11-16. PMID:10901153. |
the selective serotonin reuptake inhibitors (ssris) have obtained global attention but have not demonstrated superior efficacy in major depression compared with older tricyclic antidepressants. |
2000-11-16 |
2023-08-12 |
Not clear |
| E Eriksso. Antidepressant drugs: does it matter if they inhibit the reuptake of noradrenaline or serotonin? Acta psychiatrica Scandinavica. Supplementum. vol 402. 2000-11-16. PMID:10901154. |
the current popularity of the selective serotonin reuptake inhibitors (ssris) for the treatment of depression should not conceal the fact that noradrenergic neurones also seem to influence depressed mood. |
2000-11-16 |
2023-08-12 |
Not clear |
| W T Blow. The neurobiology of antidepressants. The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses. vol 32. issue 3. 2000-11-16. PMID:10907206. |
likely mechanisms include correction of the diminished sensitivity and numbers of specific serotonin and noradrenaline receptors found in depression. |
2000-11-16 |
2023-08-12 |
Not clear |
| J R Davidso. Social anxiety disorder under scrutiny. Depression and anxiety. vol 11. issue 3. 2000-11-15. PMID:10875049. |
the international consensus group on depression and anxiety recently recommended that a selective serotonin reuptake inhibitor (ssri) should be considered as first-line pharmacotherapy. |
2000-11-15 |
2023-08-12 |
Not clear |
| A Zahorodna, K Tokarski, M Bija. [Electrophysiologic tests for testing the effects of antidepressant drugs and corticosterone on reactivity of serotonin receptors in the hippocampus]. Postepy higieny i medycyny doswiadczalnej. vol 54. issue 3. 2000-11-13. PMID:10941273. |
disturbances in the serotonin (5-ht) system and the limbic-hypothalamo-pituitary-adrenal axis (lhpa) have been implicated in the pathophysiology of depression. |
2000-11-13 |
2023-08-12 |
Not clear |
| R D Levitan, J H Shen, R Jindal, H S Driver, S H Kennedy, C M Shapir. Preliminary randomized double-blind placebo-controlled trial of tryptophan combined with fluoxetine to treat major depressive disorder: antidepressant and hypnotic effects. Journal of psychiatry & neuroscience : JPN. vol 25. issue 4. 2000-11-07. PMID:11022398. |
because the initial phase of treatment of depression with a selective serotonin reuptake inhibitor is often complicated by a delayed onset of action of the antidepressant or severe insomnia or both, we investigated whether tryptophan, an amino acid with both antidepressant-augmenting and hypnotic effects, would benefit patients with depression at the beginning of treatment with fluoxetine. |
2000-11-07 |
2023-08-12 |
Not clear |
| L G Almeida-Montes, V Valles-Sanchez, J Moreno-Aguilar, R A Chavez-Balderas, J A García-Marín, J F Cortés Sotres, G Hheinze-Marti. Relation of serum cholesterol, lipid, serotonin and tryptophan levels to severity of depression and to suicide attempts. Journal of psychiatry & neuroscience : JPN. vol 25. issue 4. 2000-11-07. PMID:11022402. |
relation of serum cholesterol, lipid, serotonin and tryptophan levels to severity of depression and to suicide attempts. |
2000-11-07 |
2023-08-12 |
Not clear |
| L G Almeida-Montes, V Valles-Sanchez, J Moreno-Aguilar, R A Chavez-Balderas, J A García-Marín, J F Cortés Sotres, G Hheinze-Marti. Relation of serum cholesterol, lipid, serotonin and tryptophan levels to severity of depression and to suicide attempts. Journal of psychiatry & neuroscience : JPN. vol 25. issue 4. 2000-11-07. PMID:11022402. |
to determine if there is a relation to low serum cholesterol, lipoprotein, serotonin or tryptophan levels in patients with depression who have recently attempted suicide. |
2000-11-07 |
2023-08-12 |
Not clear |