| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| John F Grede. Physical symptoms of depression: unmet needs. The Journal of clinical psychiatry. vol 64 Suppl 7. 2003-07-01. PMID:12755646. |
thus, it is reasonable to hypothesize that antidepressants that incorporate both serotonin and norepinephrine reuptake inhibition might be a more efficacious treatment approach for patients with physical symptoms of depression. |
2003-07-01 |
2023-08-12 |
Not clear |
| Gil Zalsman, Amos Frisch, Alan Apter, Abraham Weizma. Genetics of suicidal behavior: candidate association genetic approach. The Israel journal of psychiatry and related sciences. vol 39. issue 4. 2003-07-01. PMID:12756857. |
we found a possible association of tryptophane hydroxylase gene polymorphism with depression and serotonin transporter promoter gene to violence traits by family-based methods. |
2003-07-01 |
2023-08-12 |
Not clear |
| Yang Dong Teng, Marian Bingaman, Angelo M Taveira-DaSilva, Peter P Pace, Richard A Gillis, Jean R Wrathal. Serotonin 1A receptor agonists reverse respiratory abnormalities in spinal cord-injured rats. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 10. 2003-06-25. PMID:12764106. |
in seeking ways to improve respiration after sci, we tested drugs that stimulate serotonin 1a (5-ht1a) receptors, based on our previous findings that these agents can counteract respiratory depression produced by morphine overdose. |
2003-06-25 |
2023-08-12 |
rat |
| Adamantios Serafeim, Michelle J Holder, Gillian Grafton, Anita Chamba, Mark T Drayson, Quang T Luong, Christopher M Bunce, Christopher D Gregory, Nicholas M Barnes, John Gordo. Selective serotonin reuptake inhibitors directly signal for apoptosis in biopsy-like Burkitt lymphoma cells. Blood. vol 101. issue 8. 2003-06-18. PMID:12515726. |
selective serotonin reuptake inhibitors (ssris) are the treatment of choice for clinical depression and a range of anxiety-related disorders. |
2003-06-18 |
2023-08-12 |
Not clear |
| Christelle Monaca, Benjamin Boutrel, René Hen, Michel Hamon, Joëlle Adrie. 5-HT 1A/1B receptor-mediated effects of the selective serotonin reuptake inhibitor, citalopram, on sleep: studies in 5-HT 1A and 5-HT 1B knockout mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 28. issue 5. 2003-06-11. PMID:12637954. |
selective serotonin reuptake inhibitors (ssris) are extensively used for the treatment of depression. |
2003-06-11 |
2023-08-12 |
mouse |
| Nicolas Bouvier, T Trenque, H Millar. [Development of antidepressant drugs. Experience and prospects]. Presse medicale (Paris, France : 1983). vol 32. issue 11. 2003-06-03. PMID:12733393. |
the first routes of research: the first antidepressants were developed after the discovery of the existence during depression of a perturbation in the synaptic transmission of the principle monoamines: noradrenalin, serotonin and dopamine. |
2003-06-03 |
2023-08-12 |
Not clear |
| Claudio N Soares, Jennifer R Poitras, Jennifer Prout. Effect of reproductive hormones and selective estrogen receptor modulators on mood during menopause. Drugs & aging. vol 20. issue 2. 2003-05-29. PMID:12534310. |
there are preliminary, though promising, data on the use of estradiol (particularly transdermal estradiol) to alleviate depression during perimenopause, use of a combination of estrogens and selective serotonin reuptake inhibitors for depression during the postmenopausal period, and the use of testosterone to improve psychological well-being and increase libido among women with induced menopause. |
2003-05-29 |
2023-08-12 |
Not clear |
| Bernhard Widner, Andreas Laich, Barbara Sperner-Unterweger, Maximilian Ledochowski, Dietmar Fuch. Neopterin production, tryptophan degradation, and mental depression--what is the link? Brain, behavior, and immunity. vol 16. issue 5. 2003-05-28. PMID:12401473. |
disturbed metabolism of tryptophan affects biosynthesis of neurotransmitter 5-hydroxytryptamine (serotonin), and it appears to be associated with an increased susceptibility for depression. |
2003-05-28 |
2023-08-12 |
human |
| Udo Bonne. Moclobemide: therapeutic use and clinical studies. CNS drug reviews. vol 9. issue 1. 2003-05-28. PMID:12595913. |
nearly all meta-analyses and most comparative studies indicated that in the acute management of depression this drug is more efficacious than placebo and as efficacious as tricyclic (or some heterocyclic) antidepressants or selective serotonin reuptake inhibitors (ssris). |
2003-05-28 |
2023-08-12 |
Not clear |
| Steve MacGillivray, Bruce Arroll, Simon Hatcher, Simon Ogston, Ian Reid, Frank Sullivan, Brian Williams, Iain Crombi. Efficacy and tolerability of selective serotonin reuptake inhibitors compared with tricyclic antidepressants in depression treated in primary care: systematic review and meta-analysis. BMJ (Clinical research ed.). vol 326. issue 7397. 2003-05-27. PMID:12742924. |
efficacy and tolerability of selective serotonin reuptake inhibitors compared with tricyclic antidepressants in depression treated in primary care: systematic review and meta-analysis. |
2003-05-27 |
2023-08-12 |
Not clear |
| Steve MacGillivray, Bruce Arroll, Simon Hatcher, Simon Ogston, Ian Reid, Frank Sullivan, Brian Williams, Iain Crombi. Efficacy and tolerability of selective serotonin reuptake inhibitors compared with tricyclic antidepressants in depression treated in primary care: systematic review and meta-analysis. BMJ (Clinical research ed.). vol 326. issue 7397. 2003-05-27. PMID:12742924. |
to compare the efficacy and tolerability of tricyclic antidepressants with selective serotonin reuptake inhibitors in depression in primary care. |
2003-05-27 |
2023-08-12 |
Not clear |
| Phil Skolnick, Piotr Popik, Aaron Janowsky, Bernard Beer, Arnold S Lipp. Antidepressant-like actions of DOV 21,947: a "triple" reuptake inhibitor. European journal of pharmacology. vol 461. issue 2-3. 2003-05-23. PMID:12586204. |
the ability of dov 21,947 to inhibit the reuptake of three biogenic amines closely linked to the etiology of depression may result in a therapeutic profile different from antidepressants that inhibit the reuptake of serotonin and/or norepinephrine. |
2003-05-23 |
2023-08-12 |
human |
| Alvaro Lista Varel. [Serotonin and antidepressant treatments: new issues about the therapeutic mechanism of action]. Vertex (Buenos Aires, Argentina). vol 14. issue 51. 2003-05-23. PMID:12690406. |
the main mechanism of action of biological therapeutic approaches in the treatment of depression involve the serotonin neurotransmission. |
2003-05-23 |
2023-08-12 |
Not clear |
| Alvaro Lista Varel. [Serotonin and antidepressant treatments: new issues about the therapeutic mechanism of action]. Vertex (Buenos Aires, Argentina). vol 14. issue 51. 2003-05-23. PMID:12690406. |
recent data even strong the rol of serotonin in depression and in the therapeutic response. |
2003-05-23 |
2023-08-12 |
Not clear |
| Neal D Rya. Medication treatment for depression in children and adolescents. CNS spectrums. vol 8. issue 4. 2003-05-22. PMID:12679743. |
to date, there have been a number of randomized, controlled trials of both tricyclic antidepressants (tcas) and selective serotonin reuptake inhibitors (ssris) in the acute treatment of depression in youths. |
2003-05-22 |
2023-08-12 |
Not clear |
| Eric J Lenze, Benoit H Mulsant, M Katherine Shear, Patricia Houck, Charles F Reynolds II. Anxiety symptoms in elderly patients with depression: what is the best approach to treatment? Drugs & aging. vol 19. issue 10. 2003-05-20. PMID:12390052. |
while antidepressants such as selective serotonin reuptake inhibitors and tricyclic agents are efficacious for late-life depression, there is no evidence that either class is superior, in terms of efficacy or tolerability, in the treatment of anxious depression. |
2003-05-20 |
2023-08-12 |
Not clear |
| Motoko Honda, Takashi Nishida, Hideki On. Tricyclic analogs cyclobenzaprine, amitriptyline and cyproheptadine inhibit the spinal reflex transmission through 5-HT(2) receptors. European journal of pharmacology. vol 458. issue 1-2. 2003-05-16. PMID:12498911. |
5-ht depletion significantly prevented the depression of the spinal reflex potentials induced by these drugs. |
2003-05-16 |
2023-08-12 |
rat |
| Arata Watanabe, Yoshihiro Tohyama, Khanh Q Nguyen, Shu Hasegawa, Guy Debonnel, Mirko Diksi. Regional brain serotonin synthesis is increased in the olfactory bulbectomy rat model of depression: an autoradiographic study. Journal of neurochemistry. vol 85. issue 2. 2003-05-14. PMID:12675923. |
regional brain serotonin synthesis is increased in the olfactory bulbectomy rat model of depression: an autoradiographic study. |
2003-05-14 |
2023-08-12 |
human |
| Arata Watanabe, Yoshihiro Tohyama, Khanh Q Nguyen, Shu Hasegawa, Guy Debonnel, Mirko Diksi. Regional brain serotonin synthesis is increased in the olfactory bulbectomy rat model of depression: an autoradiographic study. Journal of neurochemistry. vol 85. issue 2. 2003-05-14. PMID:12675923. |
this imbalance in 5-ht synthesis and the subsequent elevation of tissue 5-ht may be responsible for the creation of non-physiological circuitry which may, in part, be reflected in the symptoms resembling human depression. |
2003-05-14 |
2023-08-12 |
human |
| Xingqun Ni, Joseph M Trakalo, Emanuela Mundo, Lisa Lee, Sagar Parikh, James L Kenned. Family-based association study of the serotonin-2A receptor gene (5-HT2A) and bipolar disorder. Neuromolecular medicine. vol 2. issue 3. 2003-05-09. PMID:12622403. |
the serotonin 2a receptor gene (5-ht2a) is of great interest for research in neuropsychiatric disorders based on the observation that various neuroleptic agents and antidepressants bind with relatively high affinity at 5-ht2a receptors, and the fact that the receptor density in platelets tends to increase in depression. |
2003-05-09 |
2023-08-12 |
Not clear |