| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mike Brile. New hope in the treatment of painful symptoms in depression. Current opinion in investigational drugs (London, England : 2000). vol 4. issue 1. 2003-10-10. PMID:12625027. |
recent, principally open, trials with members of the new selective serotonin and norepinephrine reuptake inhibitor class of antidepressants such as venlafaxine, milnacipran and duloxetine (eli lilly & co/shionogi & co ltd), suggest that these compounds may be effective in relieving pain both associated with, and independent of depression. |
2003-10-10 |
2023-08-12 |
Not clear |
| Massimiliano Bianchi, Christian Heidbreder, Francesco Cresp. Cytoskeletal changes in the hippocampus following restraint stress: role of serotonin and microtubules. Synapse (New York, N.Y.). vol 49. issue 3. 2003-10-07. PMID:12774303. |
the aetiology of depression is associated with depletion in central levels of serotonin (5-ht). |
2003-10-07 |
2023-08-12 |
rat |
| S E Gartside, M M Leitch, A H Youn. Altered glucocorticoid rhythm attenuates the ability of a chronic SSRI to elevate forebrain 5-HT: implications for the treatment of depression. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 28. issue 9. 2003-10-06. PMID:12784107. |
altered glucocorticoid rhythm attenuates the ability of a chronic ssri to elevate forebrain 5-ht: implications for the treatment of depression. |
2003-10-06 |
2023-08-12 |
rat |
| Florence Leber. [Serotonin reuptake inhibitors in depression of Alzheimer's disease and other dementias]. Presse medicale (Paris, France : 1983). vol 32. issue 25. 2003-10-06. PMID:13677882. |
[serotonin reuptake inhibitors in depression of alzheimer's disease and other dementias]. |
2003-10-06 |
2023-08-12 |
Not clear |
| Steven P Roos. Treatment of depression in patients with heart disease. Biological psychiatry. vol 54. issue 3. 2003-09-26. PMID:12893102. |
though the data are limited and are primarily from open or comparator trials, the tricyclic antidepressants (tcas), selective serotonin reuptake inhibitors (ssris), and specific psychotherapies appear to be effective for treatment of depression in patients with ischemic heart disease (ihd), and response rates are comparable to those reported in depressed patients without heart disease; however, there has been only one placebo-controlled trial to date, and therefore it is premature to come to definitive conclusions regarding the efficacy of antidepressant therapies in this patient population. |
2003-09-26 |
2023-08-12 |
Not clear |
| George M Simpson, Adel El Sheshai, Ahmed Rady, Steven J Kingsbury, Mohamed Faye. Sertraline as monotherapy in the treatment of psychotic and nonpsychotic depression. The Journal of clinical psychiatry. vol 64. issue 8. 2003-09-25. PMID:12927014. |
previous studies suggest that selective serotonin reuptake inhibitors (ssris) are effective when used alone in the treatment of unipolar depression with psychotic features. |
2003-09-25 |
2023-08-12 |
Not clear |
| V Fabre, M Hamo. [Mechanisms of action of antidepressants: new data from Escitalopram]. L'Encephale. vol 29. issue 3 Pt 1. 2003-09-17. PMID:12876551. |
a first improvement in the treatment of depression was achieved in 1970-80 with the development of selective serotonin reuptake inhibitors (ssri) because these drugs, which are as potent antidepressants as the tricyclics, are devoid of most of the secondary effects of the latter drugs (orthostatic hypotension, weight gain, dry mouth, etc, mainly caused by their capacity to block alpha1-adrenergic, h1 histaminergic and muscarinic receptors). |
2003-09-17 |
2023-08-12 |
human |
| Ying Qu, Lisa Chang, Justin Klaff, Ruth Seemann, Stanley I Rapopor. Imaging brain phospholipase A2-mediated signal transduction in response to acute fluoxetine administration in unanesthetized rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 28. issue 7. 2003-09-02. PMID:12784122. |
fluoxetine, a selective serotonin (5-hydroxytryptamine, 5-ht) reuptake inhibitor, is used widely to treat depression and related disorders. |
2003-09-02 |
2023-08-12 |
rat |
| Nela Pivac, Dorotea Mück-Seler, Mirko Diksi. Effects of desipramine on regional serotonin synthesis in the rat brain: acute and chronic autoradiographic studies. Neurochemistry international. vol 43. issue 7. 2003-08-26. PMID:12892648. |
various studies have implicated the involvement of noradrenaline (na) and/or serotonin (5-hydroxytryptamine (5-ht)) in the pathogenesis and treatment of depression. |
2003-08-26 |
2023-08-12 |
rat |
| Bengt Andrée, Ann Hedman, Seth-Olav Thorberg, Dag Nilsson, Christer Halldin, Lars Fard. Positron emission tomographic analysis of dose-dependent NAD-299 binding to 5-hydroxytryptamine-1A receptors in the human brain. Psychopharmacology. vol 167. issue 1. 2003-08-22. PMID:12632244. |
the serotonin 5-ht(1a) receptor has been ascribed a putative role in the pathophysiology and drug treatment of depression. |
2003-08-22 |
2023-08-12 |
human |
| Zhonghui Guan, Joung-Hun Kim, Stavros Lomvardas, Kerri Holick, Shiqin Xu, Eric R Kandel, James H Schwart. p38 MAP kinase mediates both short-term and long-term synaptic depression in aplysia. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 19. 2003-08-22. PMID:12917365. |
we conclude that p38 kinase, which itself is bidirectionally regulated by fmrfa and 5-ht, acts as a modulator of synaptic plasticity by positively regulating depression and serving as an inhibitory constraint for facilitation. |
2003-08-22 |
2023-08-12 |
aplysia |
| Rivka Ofir, Snait Tamir, Soliman Khatib, Jacob Vay. Inhibition of serotonin re-uptake by licorice constituents. Journal of molecular neuroscience : MN. vol 20. issue 2. 2003-08-18. PMID:12794307. |
blocking or reducing serotonin re-uptake at the synapse alleviates depression. |
2003-08-18 |
2023-08-12 |
human |
| Rivka Ofir, Snait Tamir, Soliman Khatib, Jacob Vay. Inhibition of serotonin re-uptake by licorice constituents. Journal of molecular neuroscience : MN. vol 20. issue 2. 2003-08-18. PMID:12794307. |
in conclusion, this study showed that several isoflavans are unique phytoestrogens, which like estradiol, affects the serotonergic system and inhibits serotonin re-uptake and, thus, potentially may be beneficial for mild to moderate depression in pre- and postmenopausal women. |
2003-08-18 |
2023-08-12 |
human |
| Ewa Tatarczyńska, Aleksandra Kłodzińska, Ewa Chojnacka-Wójci. Effects of combined administration of 5-HT1A and/or 5-HT1B receptor antagonists and paroxetine or fluoxetine in the forced swimming test in rats. Polish journal of pharmacology. vol 54. issue 6. 2003-08-15. PMID:12866716. |
clinical data suggest that coadministration of pindolol, a 5-ht1a/5-ht1b/beta-adrenoceptor antagonist, and selective serotonin reuptake inhibitors (ssris) may shorten the time of onset of a clinical action and may increase beneficial effects of the therapy of drug-resistant depression. |
2003-08-15 |
2023-08-12 |
rat |
| Lucimey Lima, Mary Urbin. Serotonin transporter modulation in blood lymphocytes from patients with major depression. Cellular and molecular neurobiology. vol 22. issue 5-6. 2003-08-13. PMID:12585696. |
serotonin transporter modulation in blood lymphocytes from patients with major depression. |
2003-08-13 |
2023-08-12 |
human |
| Lucimey Lima, Mary Urbin. Serotonin transporter modulation in blood lymphocytes from patients with major depression. Cellular and molecular neurobiology. vol 22. issue 5-6. 2003-08-13. PMID:12585696. |
lymphocytes serotonin transporter number was significantly reduced, while the affinity was unchanged, in patients with major depression disorder as compare to controls. |
2003-08-13 |
2023-08-12 |
human |
| Lucimey Lima, Mary Urbin. Serotonin transporter modulation in blood lymphocytes from patients with major depression. Cellular and molecular neurobiology. vol 22. issue 5-6. 2003-08-13. PMID:12585696. |
in addition, there was a partial recovery in lymphocytes serotonin (5ht) transporter number in the period posterior to the antidepressants administration, accompanied with clinical and depression rating scales improvement. |
2003-08-13 |
2023-08-12 |
human |
| Arash Nakhost, Gry Houeland, Vincent F Castellucci, Wayne S Sossi. Differential regulation of transmitter release by alternatively spliced forms of synaptotagmin I. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 15. 2003-08-13. PMID:12867508. |
overexpression of syt ivq, but not of syt i, in aplysia neurons blocked the ability of serotonin to reverse synaptic depression. |
2003-08-13 |
2023-08-12 |
aplysia |
| Arash Nakhost, Gry Houeland, Vincent F Castellucci, Wayne S Sossi. Differential regulation of transmitter release by alternatively spliced forms of synaptotagmin I. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 15. 2003-08-13. PMID:12867508. |
this effect is upstream of pkc activation, because neither syt ivq nor syt i blocked the effects of phorbol esters on reversing synaptic depression or the effects of serotonin on facilitating nondepressed synapses. |
2003-08-13 |
2023-08-12 |
aplysia |
| M Urbina, S Pineda, L Piñango, I Carreira, L Lim. [3H]Paroxetine binding to human peripheral lymphocyte membranes of patients with major depression before and after treatment with fluoxetine. International journal of immunopharmacology. vol 21. issue 10. 2003-08-06. PMID:12609459. |
serotonin has been involved in major depression and is also related to central and peripheral mechanisms of neuroimmunomodulation. |
2003-08-06 |
2023-08-12 |
human |