| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| David L Dunner, David J Goldstein, Craig Mallinckrodt, Yili Lu, Michael J Detk. Duloxetine in treatment of anxiety symptoms associated with depression. Depression and anxiety. vol 18. issue 2. 2004-02-12. PMID:12964171. |
duloxetine, a potent and balanced dual serotonin and norepinephrine reuptake inhibitor, is effective in the treatmentof depression. |
2004-02-12 |
2023-08-12 |
Not clear |
| Marieke Wichers, Michael Mae. The psychoneuroimmuno-pathophysiology of cytokine-induced depression in humans. The international journal of neuropsychopharmacology. vol 5. issue 4. 2004-02-11. PMID:12466036. |
changes in serotonin (5-ht) receptors and in levels of 5-ht and its precursor tryptophan in depressed people support a role for 5-ht in the development of depression. |
2004-02-11 |
2023-08-12 |
Not clear |
| Marieke Wichers, Michael Mae. The psychoneuroimmuno-pathophysiology of cytokine-induced depression in humans. The international journal of neuropsychopharmacology. vol 5. issue 4. 2004-02-11. PMID:12466036. |
altogether, administration of cytokines may induce alterations in the brain resembling those found in depressed patients, which leads to the hypothesis that cytokines induce depression by their influence on the 5-ht, noradrenergic and hpa system. |
2004-02-11 |
2023-08-12 |
Not clear |
| Justin W C Leung, Hong Xu. GABAergic functions and depression: from classical therapies to herbal medicine. Current drug targets. CNS and neurological disorders. vol 2. issue 6. 2004-01-30. PMID:14683464. |
classical medications employed to treat depression comprise mostly tricyclic antidepressants (tcas), specific serotonin reuptake inhibitors (ssris) and monoamine oxidase inhibitors (maois), in accord with the recognized involvement of serotonergic and adrenergic systems in depression. |
2004-01-30 |
2023-08-12 |
Not clear |
| Paolo Castrogiovanni, Patrizia Blardi, Arianna De Lalla, Alice Dell'Erba, Alberto Auter. Can serotonin and fluoxetine levels in plasma and platelets predict clinical response in depression? Psychopharmacology bulletin. vol 37. issue 2. 2004-01-28. PMID:14566218. |
can serotonin and fluoxetine levels in plasma and platelets predict clinical response in depression? |
2004-01-28 |
2023-08-12 |
Not clear |
| E Paolucci, N Berretta, A Tozzi, G Bernardi, N B Mercur. Depression of mGluR-mediated IPSCs by 5-HT in dopamine neurons of the rat substantia nigra pars compacta. The European journal of neuroscience. vol 18. issue 10. 2004-01-26. PMID:14656323. |
depression of mglur-mediated ipscs by 5-ht in dopamine neurons of the rat substantia nigra pars compacta. |
2004-01-26 |
2023-08-12 |
rat |
| E Paolucci, N Berretta, A Tozzi, G Bernardi, N B Mercur. Depression of mGluR-mediated IPSCs by 5-HT in dopamine neurons of the rat substantia nigra pars compacta. The European journal of neuroscience. vol 18. issue 10. 2004-01-26. PMID:14656323. |
in the present report we examined the role of 5-ht in the modulation of the metabotropic glutamate receptor-mediated inhibitory postsynaptic current (mglur-ipsc) in midbrain dopamine neurons, and we found a reversible depression of this synaptic response at concentrations of 5-ht ranging from 100 nm to 30 microm (ec50 1.06 microm). |
2004-01-26 |
2023-08-12 |
rat |
| E Paolucci, N Berretta, A Tozzi, G Bernardi, N B Mercur. Depression of mGluR-mediated IPSCs by 5-HT in dopamine neurons of the rat substantia nigra pars compacta. The European journal of neuroscience. vol 18. issue 10. 2004-01-26. PMID:14656323. |
no significant depression of the mglur-ipsc by 5-ht was observed in the presence of the 5-ht2 antagonist cinanserin or the 5-ht4 receptor antagonist rs 23597-190, whereas the 5-ht2c antagonist rs 102221 was ineffective. |
2004-01-26 |
2023-08-12 |
rat |
| Craig A Stockmeie. Involvement of serotonin in depression: evidence from postmortem and imaging studies of serotonin receptors and the serotonin transporter. Journal of psychiatric research. vol 37. issue 5. 2004-01-22. PMID:12849929. |
involvement of serotonin in depression: evidence from postmortem and imaging studies of serotonin receptors and the serotonin transporter. |
2004-01-22 |
2023-08-12 |
human |
| Craig A Stockmeie. Involvement of serotonin in depression: evidence from postmortem and imaging studies of serotonin receptors and the serotonin transporter. Journal of psychiatric research. vol 37. issue 5. 2004-01-22. PMID:12849929. |
definitive conclusions on the role of serotonin receptors and transporter in suicide and depression have been elusive in studies of postmortem brain tissue. |
2004-01-22 |
2023-08-12 |
human |
| Violetta Klimek, Gary Roberson, Craig A Stockmeier, Gregory A Ordwa. Serotonin transporter and MAO-B levels in monoamine nuclei of the human brainstem are normal in major depression. Journal of psychiatric research. vol 37. issue 5. 2004-01-22. PMID:12849931. |
serotonin transporter and mao-b levels in monoamine nuclei of the human brainstem are normal in major depression. |
2004-01-22 |
2023-08-12 |
human |
| Violetta Klimek, Gary Roberson, Craig A Stockmeier, Gregory A Ordwa. Serotonin transporter and MAO-B levels in monoamine nuclei of the human brainstem are normal in major depression. Journal of psychiatric research. vol 37. issue 5. 2004-01-22. PMID:12849931. |
the specific binding of [(3)h]paroxetine to serotonin transporter (sert) and of [(3)h]lazabemide to monoamine oxidase (mao-b) were measured autoradiographically in tissue sections cut transversely at multiple levels along the rostro-caudal extent of the lc, as well as in the caudal portion of the dorsal raphe nucleus, from psychiatrically normal subjects and age-matched subjects with major depression. |
2004-01-22 |
2023-08-12 |
human |
| Yoshifumi Kagamiishi, Tsuneyuki Yamamoto, Shigenori Watanab. Hippocampal serotonergic system is involved in anxiety-like behavior induced by corticotropin-releasing factor. Brain research. vol 991. issue 1-2. 2004-01-22. PMID:14575894. |
taken with the evidence for hypersecretion of crf in patients with depression and anxiety-related disorders, our findings lead to the intriguing hypothesis that interaction between crf and 5-ht, especially in the ventral hippocampus, plays a role in the etiology of affective and anxiety disorders. |
2004-01-22 |
2023-08-12 |
rat |
| William A Wol. SLV-308. Solvay. Current opinion in investigational drugs (London, England : 2000). vol 4. issue 7. 2004-01-22. PMID:14619412. |
solvay is developing slv-308 (sme-308), a partial dopamine d2 agonist and noradrenergic agonist with serotonin 5-ht1a agonist properties, for the potential oral treatment of parkinson's disease (pd), panic and depression. |
2004-01-22 |
2023-08-12 |
Not clear |
| Maurizio Fav. The role of the serotonergic and noradrenergic neurotransmitter systems in the treatment of psychological and physical symptoms of depression. The Journal of clinical psychiatry. vol 64 Suppl 13. 2004-01-20. PMID:14552653. |
although the pathophysiology of depression is still unknown, there is significant evidence for abnormalities of the norepinephrine (ne) and serotonin (5-ht) neurotransmitter systems in depressive disorders. |
2004-01-20 |
2023-08-12 |
Not clear |
| Katharine P Baile. Physical symptoms comorbid with depression and the new antidepressant duloxetine. Journal of psychosocial nursing and mental health services. vol 41. issue 12. 2004-01-16. PMID:14682027. |
a growing body of evidence suggests that serotonin and norepinephrine may share neurochemical mechanisms that tie depression and physical symptoms together. |
2004-01-16 |
2023-08-12 |
Not clear |
| Hubert H Fernandez, Chuang-Kuo Wu, Brian R Ot. Pharmacotherapy of dementia with Lewy bodies. Expert opinion on pharmacotherapy. vol 4. issue 11. 2004-01-14. PMID:14596656. |
anxiety and depression are best treated with selective serotonin re-uptake inhibitors, whereas rem sleep behaviour disorder may be treated with low dose clonazepam. |
2004-01-14 |
2023-08-12 |
Not clear |
| J-P Olié, F Baylé, S Kaspe. [A meta-analysis of randomized controlled trials of tianeptine versus SSRI in the short-term treatment of depression]. L'Encephale. vol 29. issue 4 Pt 1. 2004-01-14. PMID:14615702. |
a meta-analysis was performed to compare the efficacy of tianeptine and selective serotonin reuptake inhi-bitors (ssri) in the short-term treatment of depression. |
2004-01-14 |
2023-08-12 |
human |
| Tsuyoshi Miyaoka, Rei Yasukawa, Takumi Mihara, Yoshiko Shimizu, Ken Tsubouchi, Takahiro Maeda, Shoichi Mizuno, Jun Uegaki, Takuji Inagaki, Jun Horiguchi, Hisayuki Tachiban. Successful electroconvulsive therapy in major depression with fluvoxamine-induced bruxism. The journal of ECT. vol 19. issue 3. 2004-01-06. PMID:12972988. |
a 61-year-old patient with major depression and selective serotonin reuptake inhibitor-induced bruxism was successfully treated with a course of bilateral electroconvulsive therapy. |
2004-01-06 |
2023-08-12 |
Not clear |
| Stephen M Stahl, Ivan Gergel, Dayong L. Escitalopram in the treatment of panic disorder: a randomized, double-blind, placebo-controlled trial. The Journal of clinical psychiatry. vol 64. issue 11. 2004-01-06. PMID:14658946. |
escitalopram, the therapeutically active isomer of the racemic selective serotonin reuptake inhibitor antidepressant citalopram, has shown significant anxiolytic effects in placebo-controlled clinical trials of social anxiety disorder, generalized anxiety disorder, and anxiety symptoms associated with major depression. |
2004-01-06 |
2023-08-12 |
Not clear |