| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rajiv Mallick, Jieling Chen, A Richard Entsuah, Alan F Schatzber. Depression-free days as a summary measure of the temporal pattern of response and remission in the treatment of major depression: a comparison of venlafaxine, selective serotonin reuptake inhibitors, and placebo. The Journal of clinical psychiatry. vol 64. issue 3. 2003-05-09. PMID:12716275. |
depression-free days as a summary measure of the temporal pattern of response and remission in the treatment of major depression: a comparison of venlafaxine, selective serotonin reuptake inhibitors, and placebo. |
2003-05-09 |
2023-08-12 |
Not clear |
| Richard J Porter, Roger T Mulder, Peter R Joyc. Baseline prolactin and L-tryptophan availability predict response to antidepressant treatment in major depression. Psychopharmacology. vol 165. issue 3. 2003-05-07. PMID:12439628. |
depression may be associated with a hypofunction of central serotonin (5ht) systems. |
2003-05-07 |
2023-08-12 |
Not clear |
| Baojian Yu, Jie Liu, David H Overstreet, Joel P Gallaghe. Serotonin produces an enhanced outward current recorded at rat dorsal lateral septal neurons from the Flinders Sensitive Line of rats, a genetically-selected animal model of depression. Neuroscience letters. vol 339. issue 3. 2003-05-05. PMID:12633896. |
serotonin produces an enhanced outward current recorded at rat dorsal lateral septal neurons from the flinders sensitive line of rats, a genetically-selected animal model of depression. |
2003-05-05 |
2023-08-12 |
rat |
| Baojian Yu, Jie Liu, David H Overstreet, Joel P Gallaghe. Serotonin produces an enhanced outward current recorded at rat dorsal lateral septal neurons from the Flinders Sensitive Line of rats, a genetically-selected animal model of depression. Neuroscience letters. vol 339. issue 3. 2003-05-05. PMID:12633896. |
abnormalities in serotonin (5-ht), serotonin receptors, and serotonergic neurons have been reported in studies of brains from patients diagnosed clinically with depression. |
2003-05-05 |
2023-08-12 |
rat |
| Baojian Yu, Jie Liu, David H Overstreet, Joel P Gallaghe. Serotonin produces an enhanced outward current recorded at rat dorsal lateral septal neurons from the Flinders Sensitive Line of rats, a genetically-selected animal model of depression. Neuroscience letters. vol 339. issue 3. 2003-05-05. PMID:12633896. |
our results suggest that within a particular population of dlsn neurons from rats exhibiting a known phenotype of depression a post-synaptic 5-ht(1a) receptor is functionally hyper-responsive compared to controls. |
2003-05-05 |
2023-08-12 |
rat |
| Cristiano Mendes-da-Silva, Sandra Lopes de Souza, Jairza Maria Barreto-Medeiros, Sebastião Rogério de Freitas-Silva, Daniela Eugênia Costa Antunes, Allan Delano Urbano Cunha, Valdenilson Ribeiro Ribas, Maria Flávia Simões de França, Maria Inês Nogueira, Raul Manhães-de-Castr. Neonatal treatment with fluoxetine reduces depressive behavior induced by forced swim in adult rats. Arquivos de neuro-psiquiatria. vol 60. issue 4. 2003-05-01. PMID:12563382. |
serotonin plays a role at the pathophysiology of depression in humans and in experimental models. |
2003-05-01 |
2023-08-12 |
rat |
| B Arias, M J Arranz, C Gasto, R Catalan, L Pintor, B Gutierrez, R W Kerwin, L Fanana. Analysis of structural polymorphisms and C-1018G promoter variant of the 5-HT(1A) receptor gene as putative risk factors in major depression. Molecular psychiatry. vol 7. issue 9. 2003-04-30. PMID:12399944. |
analysis of structural polymorphisms and c-1018g promoter variant of the 5-ht(1a) receptor gene as putative risk factors in major depression. |
2003-04-30 |
2023-08-12 |
Not clear |
| Gwenn S Smith, Elisse Kramer, Carol R Hermann, Sara Goldberg, Yilong Ma, Vijay Dhawan, Anna Barnes, Thomas Chaly, Abdel Belakhleff, Fouzia Laghrissi-Thode, Blaine Greenwald, David Eidelberg, Bruce G Polloc. Acute and chronic effects of citalopram on cerebral glucose metabolism in geriatric depression. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry. vol 10. issue 6. 2003-04-30. PMID:12427580. |
in the present study, the authors evaluated the cerebral metabolic effects of acute and continued administration of the selective serotonin reuptake inhibitor citalopram in patients with geriatric depression as a potential marker of serotonin dysfunction. |
2003-04-30 |
2023-08-12 |
Not clear |
| R L Rudolp. Achieving remission from depression with venlafaxine and venlafaxine extended release: a literature review of comparative studies with selective serotonin reuptake inhibitors. Acta psychiatrica Scandinavica. Supplementum. issue 415. 2003-04-29. PMID:12492770. |
achieving remission from depression with venlafaxine and venlafaxine extended release: a literature review of comparative studies with selective serotonin reuptake inhibitors. |
2003-04-29 |
2023-08-12 |
Not clear |
| Masayuki Koshizaki, Mikito Kawamata, Steven G Shimada, Yoji Saito, J G Collin. 5-HT3 receptors partially mediate halothane depression of spinal dorsal horn sensory neurons. Anesthesia and analgesia. vol 96. issue 4. 2003-04-24. PMID:12651653. |
serotonin subtype 3 (5-ht(3)) receptors belong to the same ligand-activated ion-channel family as gamma-aminobutyric acid type a- and strychnine-sensitive glycine receptors, so we examined the possible involvement of 5-ht receptor systems in halothane depression of spinal sensory neurons. |
2003-04-24 |
2023-08-12 |
rat |
| Masayuki Koshizaki, Mikito Kawamata, Steven G Shimada, Yoji Saito, J G Collin. 5-HT3 receptors partially mediate halothane depression of spinal dorsal horn sensory neurons. Anesthesia and analgesia. vol 96. issue 4. 2003-04-24. PMID:12651653. |
in the presence of halothane, methysergide, a nonselective 5-ht antagonist, and tropisetron, a selective 5-ht(3) antagonist, significantly reversed the halothane-induced reduction in receptive field size but did not alter halothane depression of brush-induced activity. |
2003-04-24 |
2023-08-12 |
rat |
| Masayuki Koshizaki, Mikito Kawamata, Steven G Shimada, Yoji Saito, J G Collin. 5-HT3 receptors partially mediate halothane depression of spinal dorsal horn sensory neurons. Anesthesia and analgesia. vol 96. issue 4. 2003-04-24. PMID:12651653. |
methiothepin, a 5-ht(1) antagonist, and ketanserin, a 5-ht(2) antagonist, did not reverse halothane depression. |
2003-04-24 |
2023-08-12 |
rat |
| Gerard J Marek, Linda L Carpenter, Christopher J McDougle, Lawrence H Pric. Synergistic action of 5-HT2A antagonists and selective serotonin reuptake inhibitors in neuropsychiatric disorders. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 28. issue 2. 2003-04-21. PMID:12589395. |
recently, the addition of drugs with prominent 5-ht(2) receptor antagonist properties (risperidone, olanzapine, mirtazapine, and mianserin) to selective serotonin reuptake inhibitors (ssris) has been shown to enhance therapeutic responses in patients with major depression and treatment-refractory obsessive-compulsive disorder (ocd). |
2003-04-21 |
2023-08-12 |
Not clear |
| Richard T Robinson, Brandon C Drafts, Janet L Fishe. Fluoxetine increases GABA(A) receptor activity through a novel modulatory site. The Journal of pharmacology and experimental therapeutics. vol 304. issue 3. 2003-04-21. PMID:12604672. |
fluoxetine is a selective serotonin reuptake inhibitor used widely in the treatment of depression. |
2003-04-21 |
2023-08-12 |
Not clear |
| E M Cassidy, E Tomkins, T Dinan, O Hardiman, V O'Kean. Central 5-HT receptor hypersensitivity in migraine without aura. Cephalalgia : an international journal of headache. vol 23. issue 1. 2003-04-17. PMID:12534577. |
this is of relevance given the role of the 5-ht1a receptor in controlling raphe 5-ht tone and in the possible association between migraine and anxiety and depression. |
2003-04-17 |
2023-08-12 |
human |
| E Hernández, S Lastra, M Urbina, I Carreira, L Lim. Serotonin, 5-hydroxyindoleacetic acid and serotonin transporter in blood peripheral lymphocytes of patients with generalized anxiety disorder. International immunopharmacology. vol 2. issue 7. 2003-04-15. PMID:12188031. |
previous results indicate that serotonin transporter is reduced in these cells in major depression disorder; however, in generalized anxiety disorder, the number of transporters was not modified, although the functional efficiency of serotonin transporter might be altered. |
2003-04-15 |
2023-08-12 |
human |
| Zubin Bhagwagar, Sepehr Hafizi, P J Cowe. Cortisol modulation of 5-HT-mediated growth hormone release in recovered depressed patients. Journal of affective disorders. vol 72. issue 3. 2003-04-15. PMID:12450642. |
recent formulations of the pathophysiology of major depression suggest that stress-induced cortisol secretion may lower brain serotonin (5-ht) function, thereby precipitating depressive symptomatology. |
2003-04-15 |
2023-08-12 |
human |
| Zubin Bhagwagar, Sepehr Hafizi, P J Cowe. Cortisol modulation of 5-HT-mediated growth hormone release in recovered depressed patients. Journal of affective disorders. vol 72. issue 3. 2003-04-15. PMID:12450642. |
this implies that people who develop depression after stressful life events may be particularly vulnerable to the effect of cortisol on brain 5-ht activity. |
2003-04-15 |
2023-08-12 |
human |
| A Rasmussen, J Christensen, P M Clemmensen, N J Dalsgaard, H Dam, I Hindberg, M Lunde, P Plenge, E Melleru. Platelet serotonin transporter in stroke patients. Acta neurologica Scandinavica. vol 107. issue 2. 2003-04-15. PMID:12580867. |
post-stroke depression can be treated with serotonin transport inhibitors suggesting a role for the serotonin system in these patients. |
2003-04-15 |
2023-08-12 |
human |
| Jari A Larm, Pei-Juan Shen, Andrew L Gundlac. Differential galanin receptor-1 and galanin expression by 5-HT neurons in dorsal raphé nucleus of rat and mouse: evidence for species-dependent modulation of serotonin transmission. The European journal of neuroscience. vol 17. issue 3. 2003-04-10. PMID:12581166. |
however, these studies also identify important species differences in the relationship between midbrain galanin and 5-ht systems, which should prompt further investigations in relation to comparative human neurochemistry and which have implications for studies of animal models of relevant neurological conditions such as stress, anxiety and depression. |
2003-04-10 |
2023-08-12 |
mouse |