| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T Yoshitake, S Yoshitake, M Yamaguchi, S O Ogren, J Keh. Activation of 5-HT(1A) autoreceptors enhances the inhibitory effect of galanin on hippocampal 5-HT release in vivo. Neuropharmacology. vol 44. issue 2. 2003-04-02. PMID:12623219. |
thus, the enhanced galanin receptor-mediated inhibition of 5-ht neurotransmission may contribute to the pathophysiology of depression or to the reduced and delayed efficacy of antidepressant therapies. |
2003-04-02 |
2023-08-12 |
rat |
| Gin S Malhi, Philip B Mitchell, Shahzad Sali. Bipolar depression: management options. CNS drugs. vol 17. issue 1. 2003-03-31. PMID:12467490. |
the selective serotonin reuptake inhibitors (ssris), bupropion, tricyclic antidepressants and monoamine oxidase inhibitors are all effective antidepressants in the management of bipolar depression. |
2003-03-31 |
2023-08-12 |
Not clear |
| Jerónimo Sáiz-Ruiz, Angela Ibáñez, Marina Díaz-Marsá, Francisco Arias, Jesús Padín, Manuel Martín-Carrasco, José Manuel Montes, Laura Ferrando, José Luis Carrasco, Eloy Martín-Ballesteros, Lluis Jordá, Lorenzo Chamorr. Efficacy of venlafaxine in major depression resistant to selective serotonin reuptake inhibitors. Progress in neuro-psychopharmacology & biological psychiatry. vol 26. issue 6. 2003-03-26. PMID:12452535. |
efficacy of venlafaxine in major depression resistant to selective serotonin reuptake inhibitors. |
2003-03-26 |
2023-08-12 |
Not clear |
| b' Nela Pivac, Dorotea M\\xc3\\xbcck-Seler, Marina Sagud, Miro Jakovljevi\\xc4\\x8. Platelet serotonergic markers in posttraumatic stress disorder. Progress in neuro-psychopharmacology & biological psychiatry. vol 26. issue 6. 2003-03-26. PMID:12452545.' |
these findings suggest that platelet 5-ht concentration and platelet mao activity are not altered in three drug-free groups--war veterans who did or did not develop ptsd, or in prisoners of war with ptsd--and that these platelet serotonergic markers are not associated with symptoms of ptsd or comorbid depression. |
2003-03-26 |
2023-08-12 |
human |
| Susan J Murch, Praveen K Saxen. Mammalian neurohormones: potential significance in reproductive physiology of St. John's wort (Hypericum perforatum L.)? Die Naturwissenschaften. vol 89. issue 12. 2003-03-25. PMID:12536277. |
melatonin and serotonin are indoleamine neurohormones that function as photoperiod signals in many species and have recently been found in st. john's wort, a medicinal plant used in the treatment of depression. |
2003-03-25 |
2023-08-12 |
Not clear |
| Richard Entsuah, Michelle Shaffer, Jun Zhan. A critical examination of the sensitivity of unidimensional subscales derived from the Hamilton Depression Rating Scale to antidepressant drug effects. Journal of psychiatric research. vol 36. issue 6. 2003-03-21. PMID:12393314. |
symptoms of depression were assessed using the ham-d among intent-to-treat patients (2045) randomly assigned to receive venlafaxine (immediate release, n = 474; extended release, n = 377), one of several selective serotonin reuptake inhibitors (ssris) (n = 748), or placebo (n = 446) for up to 8 weeks. |
2003-03-21 |
2023-08-12 |
Not clear |
| Michael H Skinner, Han-Yi Kuan, Alan Pan, Korbtham Sathirakul, Mary Pat Knadler, Celedon R Gonzales, Kwee Poo Yeo, Shobha Reddy, Maggie Lim, Mosun Ayan-Oshodi, Stephen D Wis. Duloxetine is both an inhibitor and a substrate of cytochrome P4502D6 in healthy volunteers. Clinical pharmacology and therapeutics. vol 73. issue 3. 2003-03-20. PMID:12621382. |
duloxetine, a potent dual reuptake inhibitor of serotonin and norepinephrine currently undergoing clinical investigation for treatment of depression and stress urinary incontinence, has the potential to act as both a substrate and an inhibitor of cytochrome p4502d6 (cyp2d6). |
2003-03-20 |
2023-08-12 |
human |
| Sami Anttila, Esa Leinone. Duloxetine Eli Lilly. Current opinion in investigational drugs (London, England : 2000). vol 3. issue 8. 2003-03-18. PMID:12211418. |
duloxetine is a serotonin (5-ht) and norepinephrine (ne) uptake inhibitor in pre-registration for depression. |
2003-03-18 |
2023-08-12 |
Not clear |
| Esther Gómez-Gil, Cristóbal Gastó, Maribel Díaz-Ricart, Marta Carretero, Manel Salamero, Rosa Catalán, Ginés Escola. Platelet 5-HT2A-receptor-mediated induction of aggregation is not altered in major depression. Human psychopharmacology. vol 17. issue 8. 2003-03-17. PMID:12457378. |
studies of the 5-ht(2a) receptor subtype in major depression have focused on the density of these receptors in neuronal cells and platelets, showing an up-regulation secondary to a deficit in serotonergic activity in major depression. |
2003-03-17 |
2023-08-12 |
Not clear |
| Susana Aznar, Zhaoxia Qian, Reshma Shah, Birgitte Rahbek, Gitte M Knudse. The 5-HT1A serotonin receptor is located on calbindin- and parvalbumin-containing neurons in the rat brain. Brain research. vol 959. issue 1. 2003-03-17. PMID:12480158. |
the 5-ht(1a) receptor is a well-characterized serotonin receptor playing a role in many central nervous functions and known to be involved in depression and other mental disorders. |
2003-03-17 |
2023-08-12 |
rat |
| Melville M Leitch, Colin D Ingram, Allan H Young, Richard McQuade, Sarah E Gartsid. Flattening the corticosterone rhythm attenuates 5-HT1A autoreceptor function in the rat: relevance for depression. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 28. issue 1. 2003-03-17. PMID:12496947. |
recent data suggest that an important factor in the aetiology of depression may be a deficit in the function and expression of 5-ht(1a) receptors, which has been reported in depressed patients. |
2003-03-17 |
2023-08-12 |
rat |
| Melville M Leitch, Colin D Ingram, Allan H Young, Richard McQuade, Sarah E Gartsid. Flattening the corticosterone rhythm attenuates 5-HT1A autoreceptor function in the rat: relevance for depression. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 28. issue 1. 2003-03-17. PMID:12496947. |
the data suggest that the glucocorticoid abnormalities associated with depression may impact on the functioning of 5-ht(1a) receptors in the brain. |
2003-03-17 |
2023-08-12 |
rat |
| C J Harmer, Z Bhagwagar, D I Perrett, B A Völlm, P J Cowen, G M Goodwi. Acute SSRI administration affects the processing of social cues in healthy volunteers. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 28. issue 1. 2003-03-17. PMID:12496951. |
enhancement of serotonin neurotransmission plays an important role in the antidepressant response to agents presently available to treat depression. |
2003-03-17 |
2023-08-12 |
human |
| William J Burk. Escitalopram. Expert opinion on investigational drugs. vol 11. issue 10. 2003-03-12. PMID:12387707. |
escitalopram oxalate (s-citalopram, lexapro), a selective serotonin re-uptake inhibitor antidepressant which is the s-enantiomer of citalopram, is in clinical development worldwide for the treatment of depression and anxiety disorders. |
2003-03-12 |
2023-08-12 |
human |
| Astrid C E Linthorst, Rosana G Peñalva, Cornelia Flachskamm, Florian Holsboer, Johannes M H M Reu. Forced swim stress activates rat hippocampal serotonergic neurotransmission involving a corticotropin-releasing hormone receptor-dependent mechanism. The European journal of neuroscience. vol 16. issue 12. 2003-03-12. PMID:12492439. |
aberrant serotonin function is implicated in the aetiology of major depression and anxiety disorders. |
2003-03-12 |
2023-08-12 |
rat |
| Andrew A Nierenberg, George I Papakostas, Timothy Petersen, Karen E Kelly, Brian M Iacoviello, John J Worthington, Joyce Tedlow, Jonathan E Alpert, Maurizio Fav. Nortriptyline for treatment-resistant depression. The Journal of clinical psychiatry. vol 64. issue 1. 2003-03-05. PMID:12590621. |
up to 30% of patients with major depression fail to respond to an antidepressant trial, with most taking a selective serotonin reuptake inhibitor (ssri) as initial treatment. |
2003-03-05 |
2023-08-12 |
Not clear |
| Shigeyuki Chaki, Shiho Hirota, Takeo Funakoshi, Yoshiko Suzuki, Sayoko Suetake, Taketoshi Okubo, Takaaki Ishii, Atsuro Nakazato, Shigeru Okuyam. Anxiolytic-like and antidepressant-like activities of MCL0129 (1-[(S)-2-(4-fluorophenyl)-2-(4-isopropylpiperadin-1-yl)ethyl]-4-[4-(2-methoxynaphthalen-1-yl)butyl]piperazine), a novel and potent nonpeptide antagonist of the melanocortin-4 receptor. The Journal of pharmacology and experimental therapeutics. vol 304. issue 2. 2003-03-03. PMID:12538838. |
mcl0129 at 1 microm had no apparent affinity for other receptors, transporters, and ion channels related to anxiety and depression except for a moderate affinity for the sigma(1) receptor, serotonin transporter, and alpha(1)-adrenoceptor, which means that mcl0129 is selective for the mc4 receptor. |
2003-03-03 |
2023-08-12 |
mouse |
| J González-Maeso, R Rodríguez-Puertas, J J Meana, J A García-Sevilla, J Guimó. Neurotransmitter receptor-mediated activation of G-proteins in brains of suicide victims with mood disorders: selective supersensitivity of alpha(2A)-adrenoceptors. Molecular psychiatry. vol 7. issue 7. 2003-02-25. PMID:12192620. |
concentration-response curves of the [(35)s]gtpgammas binding stimulation by selective agonists of alpha(2)-adrenoceptors, 5-ht(1a) serotonin, mu-opioid, gaba(b), and cholinergic muscarinic receptors were performed in frontal cortical membranes from 28 suicide victims with major depression or bipolar disorder and 28 subjects who were matched for gender, age and postmortem delay. |
2003-02-25 |
2023-08-12 |
human |
| P H Silverstone, R Entsuah, D Hacket. Two items on the Hamilton Depression rating scale are effective predictors of remission: comparison of selective serotonin reuptake inhibitors with the combined serotonin/norepinephrine reuptake inhibitor, venlafaxine. International clinical psychopharmacology. vol 17. issue 6. 2003-02-25. PMID:12409680. |
two items on the hamilton depression rating scale are effective predictors of remission: comparison of selective serotonin reuptake inhibitors with the combined serotonin/norepinephrine reuptake inhibitor, venlafaxine. |
2003-02-25 |
2023-08-12 |
human |
| P H Silverstone, R Entsuah, D Hacket. Two items on the Hamilton Depression rating scale are effective predictors of remission: comparison of selective serotonin reuptake inhibitors with the combined serotonin/norepinephrine reuptake inhibitor, venlafaxine. International clinical psychopharmacology. vol 17. issue 6. 2003-02-25. PMID:12409680. |
the purpose of the present study was to determine if the responses on two items of the ham-d scale, depressed mood (item 1) and psychic anxiety (item 10), were predictive of remission of depression in placebo-controlled studies following treatment with venlafaxine or selective serotonin reuptake inhibitors (ssris). |
2003-02-25 |
2023-08-12 |
human |