| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jing Fang, Qi Chen. Etiological mechanisms of post-stroke depression: a review. Neurological research. vol 31. issue 9. 2010-02-02. PMID:19891854. |
for gene polymorphism, there was significant association between serotonin transporter gene-linked promoter region short variant genotype and post-stroke major depression. |
2010-02-02 |
2023-08-12 |
Not clear |
| Nereida González-Berrío. Sertraline-induced panic attack. Boletin de la Asociacion Medica de Puerto Rico. vol 101. issue 1. 2010-01-29. PMID:19954091. |
selective serotonin reuptake inhibitors are the treatment of choice for depression and anxiety disorders due to its tolerability, safety and side effects profile. |
2010-01-29 |
2023-08-12 |
Not clear |
| Michelle E Culang, Joel R Sneed, John G Keilp, Bret R Rutherford, Gregory H Pelton, D P Devanand, Steven P Roos. Change in cognitive functioning following acute antidepressant treatment in late-life depression. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry. vol 17. issue 10. 2010-01-28. PMID:19916207. |
selective serotonin reuptake inhibitors (ssris) are the most commonly prescribed medications for geriatric depression. |
2010-01-28 |
2023-08-12 |
Not clear |
| S J Bull, P Huezo-Diaz, E B Binder, J F Cubells, G Ranjith, C Maddock, C Miyazaki, N Alexander, M Hotopf, A J Cleare, S Norris, E Cassidy, K J Aitchison, A H Miller, C M Pariant. Functional polymorphisms in the interleukin-6 and serotonin transporter genes, and depression and fatigue induced by interferon-alpha and ribavirin treatment. Molecular psychiatry. vol 14. issue 12. 2010-01-27. PMID:18458677. |
functional polymorphisms in the interleukin-6 and serotonin transporter genes, and depression and fatigue induced by interferon-alpha and ribavirin treatment. |
2010-01-27 |
2023-08-12 |
Not clear |
| Julie A Brennan, Radka Graf, Steven M Grauer, Rachel L Navarra, Claudine M Pulicicchio, Zoë A Hughes, Qian Lin, Caitlin Wantuch, Sharon Rosenzweig-Lipson, Farhana Pruthi, Margaret Lai, Deborah Smith, Wouter Goutier, Martina van de Neut, Albert J Robichaud, David Rotella, Rolf W Feenstra, Chris Kruse, Pierre Broqua, Chad E Beyer, Andrew C McCreary, Mark H Pausch, Karen L Marqui. WS-50030 [7-{4-[3-(1H-inden-3-yl)propyl]piperazin-1-yl}-1,3-benzoxazol-2(3H)-one]: a novel dopamine D2 receptor partial agonist/serotonin reuptake inhibitor with preclinical antipsychotic-like and antidepressant-like activity. The Journal of pharmacology and experimental therapeutics. vol 332. issue 1. 2010-01-26. PMID:19828876. |
despite possessing serotonin reuptake inhibitory activity in addition to d(2) receptor partial agonism, ws-50030 displays activity in preclinical models predictive of antipsychotic- and antidepressant efficacy similar to aripiprazole, suggesting potential efficacy of ws-50030 versus positive and negative symptoms of schizophrenia, comorbid mood symptoms, bipolar disorder, major depressive disorder, and treatment-resistant depression. |
2010-01-26 |
2023-08-12 |
mouse |
| Kirsty Bannister, Lucy A Bee, Anthony H Dickenso. Preclinical and early clinical investigations related to monoaminergic pain modulation. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. vol 6. issue 4. 2010-01-25. PMID:19789074. |
the links between pain and the comorbidities of sleep problems, anxiety, and depression may be due to the dual roles of noradrenaline and of 5-ht in these functions and also in pain. |
2010-01-25 |
2023-08-12 |
Not clear |
| Shao-hua Wang, Zhi-jun Zhang, Yi-jing Guo, Gao-jun Teng, Bao-an Che. Decreased expression of serotonin 1A receptor in the dentate gyrus in association with chronic mild stress: a rat model of post-stroke depression. Psychiatry research. vol 170. issue 2-3. 2010-01-21. PMID:19896211. |
decreased expression of serotonin 1a receptor in the dentate gyrus in association with chronic mild stress: a rat model of post-stroke depression. |
2010-01-21 |
2023-08-12 |
rat |
| Shao-hua Wang, Zhi-jun Zhang, Yi-jing Guo, Gao-jun Teng, Bao-an Che. Decreased expression of serotonin 1A receptor in the dentate gyrus in association with chronic mild stress: a rat model of post-stroke depression. Psychiatry research. vol 170. issue 2-3. 2010-01-21. PMID:19896211. |
alterations of serotonin (5-ht) neurotransmission are implicated in post-stroke depression (psd). |
2010-01-21 |
2023-08-12 |
rat |
| Shao-hua Wang, Zhi-jun Zhang, Yi-jing Guo, Gao-jun Teng, Bao-an Che. Decreased expression of serotonin 1A receptor in the dentate gyrus in association with chronic mild stress: a rat model of post-stroke depression. Psychiatry research. vol 170. issue 2-3. 2010-01-21. PMID:19896211. |
serotonin 1a (5-ht(1a)) receptor-based abnormalities have been the focus of intensive study in depression. |
2010-01-21 |
2023-08-12 |
rat |
| Shao-hua Wang, Zhi-jun Zhang, Yi-jing Guo, Gao-jun Teng, Bao-an Che. Decreased expression of serotonin 1A receptor in the dentate gyrus in association with chronic mild stress: a rat model of post-stroke depression. Psychiatry research. vol 170. issue 2-3. 2010-01-21. PMID:19896211. |
psd animals displaying a behavioral index of depression (anhedonia) have significantly decreased protein expression of 5-ht(1a) receptors and mrna level relative to ischemic stroke animals at each timepoint, respectively, and all these were reversed by citalopram. |
2010-01-21 |
2023-08-12 |
rat |
| Shan Wang, Kerang Zhang, Yong Xu, Ning Sun, Yan Shen, Qi X. An association study of the serotonin transporter and receptor genes with the suicidal ideation of major depression in a Chinese Han population. Psychiatry research. vol 170. issue 2-3. 2010-01-21. PMID:19897250. |
an association study of the serotonin transporter and receptor genes with the suicidal ideation of major depression in a chinese han population. |
2010-01-21 |
2023-08-12 |
Not clear |
| Fabiano R Agostinho, Giselli Scaini, Gabriela K Ferreira, Isabela C Jeremias, Gislaine Z Réus, Gislaine T Rezin, Adalberto A Castro, Alexandra I Zugno, João Quevedo, Emilio L Strec. Effects of olanzapine, fluoxetine and olanzapine/fluoxetine on creatine kinase activity in rat brain. Brain research bulletin. vol 80. issue 6. 2010-01-20. PMID:19748553. |
recently, a fixed combination of the atypical antipsychotic olanzapine and the serotonin selective reuptake inhibitor (ssri) fluoxetine has been approved in the us for the treatment of bipolar i depression. |
2010-01-20 |
2023-08-12 |
human |
| C Rob Markus, Christine Fir. Differential effects of tri-allelic 5-HTTLPR polymorphisms in healthy subjects on mood and stress performance after tryptophan challenge. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 34. issue 13. 2010-01-19. PMID:19675533. |
earlier data suggest that a polymorphism at the serotonin (5-ht) transporter gene (5-httlpr) may affect depression particularly in the face of stress due to interactions between 5-ht vulnerability and stress exposure. |
2010-01-19 |
2023-08-12 |
human |
| C Rob Markus, Christine Fir. Differential effects of tri-allelic 5-HTTLPR polymorphisms in healthy subjects on mood and stress performance after tryptophan challenge. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 34. issue 13. 2010-01-19. PMID:19675533. |
this apparent genetic 5-ht vulnerability may become a meaningful risk factor for depression when brain 5-ht falls below functional need in the face of real severe stressful life events. |
2010-01-19 |
2023-08-12 |
human |
| Lan Wang, Zu-cong Mo, Yan Wang, Yu-lin J. [Association of 5-hydroxytryptamine transporter gene polymorphism with asthma and comorbid depression]. Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics. vol 26. issue 5. 2010-01-15. PMID:19806585. |
[association of 5-hydroxytryptamine transporter gene polymorphism with asthma and comorbid depression]. |
2010-01-15 |
2023-08-12 |
Not clear |
| Lan Wang, Zu-cong Mo, Yan Wang, Yu-lin J. [Association of 5-hydroxytryptamine transporter gene polymorphism with asthma and comorbid depression]. Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics. vol 26. issue 5. 2010-01-15. PMID:19806585. |
to explore the molecular genetic mechanism of complicating depression in asthma by detecting two gene polymorphisms of 5-hydroxytryptamine transporter (5-httlpr/stin2) gene. |
2010-01-15 |
2023-08-12 |
Not clear |
| Thomas R Insel, Philip S Wan. The STAR*D trial: revealing the need for better treatments. Psychiatric services (Washington, D.C.). vol 60. issue 11. 2010-01-15. PMID:19880463. |
the results provided insight into nonresponse to initial treatment with selective serotonin reuptake inhibitors and alternatives for second- and third-line treatment options and suggested opportunities for personalized approaches to depression care. |
2010-01-15 |
2023-08-12 |
Not clear |
| C Moret, M Isaac, M Brile. Problems associated with long-term treatment with selective serotonin reuptake inhibitors. Journal of psychopharmacology (Oxford, England). vol 23. issue 8. 2010-01-12. PMID:18635702. |
although the selective serotonin reuptake inhibitors (ssris), which are now widely used as a first-line treatment for depression and many other psychiatric conditions, are generally well tolerated, they are not devoid of side effects. |
2010-01-12 |
2023-08-12 |
Not clear |
| Zeng-You Ye, Yun-Gang Lu, Hao Sun, Xin-Ping Cheng, Tian-Le Xu, Jiang-Ning Zho. Fluoxetine inhibition of glycine receptor activity in rat hippocampal neurons. Brain research. vol 1239. 2010-01-12. PMID:18786514. |
fluoxetine is a selective serotonin reuptake inhibitor widely used for treating depression. |
2010-01-12 |
2023-08-12 |
rat |
| Joanna Dabrowska, Przemyslaw Nowak, Ryszard Bru. Reactivity of 5-HT1A receptor in adult rats after neonatal noradrenergic neurons' lesion--implications for antidepressant-like action. Brain research. vol 1239. 2010-01-12. PMID:18789911. |
5-ht1a autoreceptor is involved in the regulation of 5-ht release as well as the pathogenesis of depression. |
2010-01-12 |
2023-08-12 |
rat |