| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dhanisha J Jhaveri, Eirinn W Mackay, Adam S Hamlin, Swananda V Marathe, L Sanjay Nandam, Vidita A Vaidya, Perry F Bartlet. Norepinephrine directly activates adult hippocampal precursors via beta3-adrenergic receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 7. 2010-03-19. PMID:20164362. |
among the neurotransmitters that are widely implicated in regulating this process are serotonin and norepinephrine, levels of which are modulated by stress, depression and clinical antidepressants. |
2010-03-19 |
2023-08-12 |
mouse |
| Miho Nakano, Kenichi Osada, Atsushi Misonoo, Keisuke Fujiwara, Miho Takahashi, Yuriko Ogawa, Toshiaki Haga, Shigeto Kanai, Daisuke Tanaka, Yasuo Sasuga, Takuyoh Yanagida, Mikio Asakura, Noboru Yamaguch. Fluvoxamine and sigma-1 receptor agonists dehydroepiandrosterone (DHEA)-sulfate induces the Ser473-phosphorylation of Akt-1 in PC12 cells. Life sciences. vol 86. issue 9-10. 2010-03-18. PMID:19995565. |
the expression of brain-derived neurotrophic factor (bdnf) may be a downstream target of a variety of antidepressant treatments, and selective serotonin reuptake inhibitors (ssris) are used clinically for the treatment of depression. |
2010-03-18 |
2023-08-12 |
Not clear |
| Frederick Reimherr, Jay Amsterdam, David Dunner, Lenard Adler, Shuyu Zhang, David Williams, Barrie Marchant, David Michelson, Andrew Nierenberg, Alan Schatzberg, Peter Feldma. Genetic polymorphisms in the treatment of depression: speculations from an augmentation study using atomoxetine. Psychiatry research. vol 175. issue 1-2. 2010-03-16. PMID:19969374. |
treatment-resistant depression may be related to polymorphisms in the promoter region of the serotonin transporter gene (5-httlpr) or dysregulation of noradrenergic systems. |
2010-03-16 |
2023-08-12 |
Not clear |
| J-D Guo, D G Rainni. Presynaptic 5-HT(1B) receptor-mediated serotonergic inhibition of glutamate transmission in the bed nucleus of the stria terminalis. Neuroscience. vol 165. issue 4. 2010-03-12. PMID:19963045. |
this study illustrates a new pathway by which the activity of bnst neurons can be indirectly modulated by 5-ht, and suggests a potential new target for the development of novel treatments for depression and anxiety disorders. |
2010-03-12 |
2023-08-12 |
rat |
| Shao-Hua Wang, Zhi-Jun Zhang, Yi-Jing Guo, Yu-Xiu Sui, Yi Su. Notch1 signaling related hippocampal neurogenesis in adult poststroke depression rats: a valid index for an efficient combined citalopram and WAY100635 pharmacotherapy. Behavioural pharmacology. vol 21. issue 1. 2010-03-12. PMID:20038834. |
this indicated that augmentation of citalopram by cotreatment with a selective 5-hydroxytryptamine 1a antagonist would be an efficacious strategy for poststroke depression. |
2010-03-12 |
2023-08-12 |
rat |
| S Threlfell, S A Greenfield, S J Crag. 5-HT(1B) receptor regulation of serotonin (5-HT) release by endogenous 5-HT in the substantia nigra. Neuroscience. vol 165. issue 1. 2010-03-11. PMID:19819310. |
evoked 5-ht release exhibited short-term depression after an initial stimulus that recovered by 10 s. antagonists for 5-ht(1b) receptors, isamoltane (1 microm) or sb 224-289 (1 microm), did not modify release during a stimulus train, but rather, they modestly relieved depression of subsequent release evoked after a short delay (< or =2 s). |
2010-03-11 |
2023-08-12 |
rat |
| Tomislav Kovacević, Ivan Skelin, Mirko Diksi. Chronic fluoxetine treatment has a larger effect on the density of a serotonin transporter in the Flinders Sensitive Line (FSL) rat model of depression than in normal rats. Synapse (New York, N.Y.). vol 64. issue 3. 2010-03-02. PMID:19924693. |
chronic fluoxetine treatment has a larger effect on the density of a serotonin transporter in the flinders sensitive line (fsl) rat model of depression than in normal rats. |
2010-03-02 |
2023-08-12 |
rat |
| Tomislav Kovacević, Ivan Skelin, Mirko Diksi. Chronic fluoxetine treatment has a larger effect on the density of a serotonin transporter in the Flinders Sensitive Line (FSL) rat model of depression than in normal rats. Synapse (New York, N.Y.). vol 64. issue 3. 2010-03-02. PMID:19924693. |
the 5-hydroxytryptamine system is thought to play a crucial role in the pathophysiology of depression and represents the target for selective 5-ht reuptake inhibitors (ssris). |
2010-03-02 |
2023-08-12 |
rat |
| R Uher, P McGuffi. The moderation by the serotonin transporter gene of environmental adversity in the etiology of depression: 2009 update. Molecular psychiatry. vol 15. issue 1. 2010-03-02. PMID:20029411. |
the moderation by the serotonin transporter gene of environmental adversity in the etiology of depression: 2009 update. |
2010-03-02 |
2023-08-12 |
human |
| R Uher, P McGuffi. The moderation by the serotonin transporter gene of environmental adversity in the etiology of depression: 2009 update. Molecular psychiatry. vol 15. issue 1. 2010-03-02. PMID:20029411. |
an updated review of 34 human observational studies indicates that the length polymorphism of the serotonin transporter gene moderates the effect of environmental adversity in the development of depression. |
2010-03-02 |
2023-08-12 |
human |
| Kenneth Bee. Cost effectiveness of botulinum toxins for the treatment of depression: preliminary observations. Journal of drugs in dermatology : JDD. vol 9. issue 1. 2010-03-02. PMID:20120422. |
the standard of care for the treatment of depression involves pharmacologic therapy with selective serotonin reuptake inhibitors (ssris). |
2010-03-02 |
2023-08-12 |
Not clear |
| Seithikurippu R Pandi-Perumal, Ilya Trakht, Venkataramanujan Srinivasan, D Warren Spence, Burkhard Poeggeler, Ruediger Hardeland, Daniel P Cardinal. The effect of melatonergic and non-melatonergic antidepressants on sleep: weighing the alternatives. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry. vol 10. issue 4 Pt 2. 2010-03-01. PMID:18609422. |
the present review discusses the effects of antidepressants on sleep and evaluates the use of the recently developed melatonin agonist-selective serotonin antagonists on sleep and depression. |
2010-03-01 |
2023-08-12 |
Not clear |
| Lee A Dawson, Jeannette M Watso. Vilazodone: a 5-HT1A receptor agonist/serotonin transporter inhibitor for the treatment of affective disorders. CNS neuroscience & therapeutics. vol 15. issue 2. 2010-03-01. PMID:19499624. |
vilazodone (emd 68843; 5-{4-[4-(5-cyano-3-indolyl)-butyl]-1-piperazinyl}-benzofuran-2-carboxamide hydrochloride) is a combined serotonin specific reuptake inhibitor (ssri) and 5-ht1a receptor partial agonist currently under clinical evaluation for the treatment of major depression. |
2010-03-01 |
2023-08-12 |
rat |
| Roy Ann Sherrod, Angela Collins, Stephanie Wynn, Monika Grag. Dissecting dementia, depression, and drug effects in older adults. Journal of psychosocial nursing and mental health services. vol 48. issue 1. 2010-02-26. PMID:20102132. |
medications used to manage dementia and depression include selective serotonin reuptake inhibitors. |
2010-02-26 |
2023-08-12 |
Not clear |
| Hernán Silva, Patricia Iturra, Aldo Solari, Juana Villarroel, Sonia Jerez, Marco Jiménez, Felipe Galleguillos, Maria Leonor Bustamant. Fluoxetine response in impulsive-aggressive behavior and serotonin transporter polymorphism in personality disorder. Psychiatric genetics. vol 20. issue 1. 2010-02-24. PMID:20010449. |
a deletion/insertion polymorphism within the 5-ht transporter promoter gene (5-httlpr) is thought to be associated with disturbed impulse control, anxiety, and depression. |
2010-02-24 |
2023-08-12 |
Not clear |
| H P Chudasama, P A Bhat. Evaluation of anti-obesity activity of duloxetine in comparison with sibutramine along with its anti-depressant activity: an experimental study in obese rats. Canadian journal of physiology and pharmacology. vol 87. issue 11. 2010-02-18. PMID:19935897. |
5-ht and noradrenaline are important neurotransmitters that control increase in body mass and are involved in the pathophysiology of obesity and depression. |
2010-02-18 |
2023-08-12 |
rat |
| Christian Windischberger, Rupert Lanzenberger, Alexander Holik, Christoph Spindelegger, Patrycja Stein, Ulrike Moser, Florian Gerstl, Martin Fink, Ewald Moser, Siegfried Kaspe. Area-specific modulation of neural activation comparing escitalopram and citalopram revealed by pharmaco-fMRI: a randomized cross-over study. NeuroImage. vol 49. issue 2. 2010-02-12. PMID:19833214. |
area-specific and stimulation-dependent changes of human brain activation by selective serotonin reuptake inhibitors (ssri) are an important issue for improved understanding of treatment mechanisms, given the frequent prescription of these drugs in depression and anxiety disorders. |
2010-02-12 |
2023-08-12 |
human |
| S Heinisch, L G Kirb. Fractalkine/CX3CL1 enhances GABA synaptic activity at serotonin neurons in the rat dorsal raphe nucleus. Neuroscience. vol 164. issue 3. 2010-02-08. PMID:19748551. |
serotonin (5-hydroxytryptamine; 5-ht) has an important role in mood regulation, and its dysfunction in the central nervous system (cns) is associated with depression. |
2010-02-08 |
2023-08-12 |
rat |
| S Heinisch, L G Kirb. Fractalkine/CX3CL1 enhances GABA synaptic activity at serotonin neurons in the rat dorsal raphe nucleus. Neuroscience. vol 164. issue 3. 2010-02-08. PMID:19748551. |
therapies targeting cx3cl1 may treat serotonin related mood disorders, including depression experienced by patients with compromised immune systems. |
2010-02-08 |
2023-08-12 |
rat |
| Sara Bozzini, Patrick Gambelli, Chiara Boiocchi, Sandra Schirinzi, Rossana Falcone, Paola Buzzi, Cesare Storti, Colomba Falcon. Coronary artery disease and depression: possible role of brain-derived neurotrophic factor and serotonin transporter gene polymorphisms. International journal of molecular medicine. vol 24. issue 6. 2010-02-04. PMID:19885623. |
coronary artery disease and depression: possible role of brain-derived neurotrophic factor and serotonin transporter gene polymorphisms. |
2010-02-04 |
2023-08-12 |
human |