| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yiyun Huang, Wendol A William. Enhanced selective serotonin re-uptake inhibitors as antidepressants: 2004 - 2006. Expert opinion on therapeutic patents. vol 17. issue 8. 2010-06-09. PMID:20144065. |
encouraged by the success of venlafaxine and duloxetine, several companies have pursued dual-acting serotonin and noradrenaline re-uptake inhibitors as drug candidates for depression treatment. |
2010-06-09 |
2023-08-12 |
Not clear |
| Yiyun Huang, Wendol A William. Enhanced selective serotonin re-uptake inhibitors as antidepressants: 2004 - 2006. Expert opinion on therapeutic patents. vol 17. issue 8. 2010-06-09. PMID:20144065. |
despite mixed results from clinical trials with several nk(1) antagonists, effective therapeutic agents for depression may still emerge from compounds with combined serotonin reuptake inhibitor/nk(1) antagonist properties. |
2010-06-09 |
2023-08-12 |
Not clear |
| Raffaella Molteni, Annamaria Cattaneo, Francesca Calabrese, Flavia Macchi, Jocelien D A Olivier, Giorgio Racagni, Bart A Ellenbroek, Massimo Gennarelli, Marco A Riv. Reduced function of the serotonin transporter is associated with decreased expression of BDNF in rodents as well as in humans. Neurobiology of disease. vol 37. issue 3. 2010-06-08. PMID:20034565. |
in order to identify the molecular mechanisms that may contribute to the enhanced susceptibility to depression under serotonin transporter (sert) dysfunction, we analyzed the expression of brain-derived neurotrophic factor (bdnf), a key player in neuronal plasticity, which is implicated in the etiology and treatment of depression. |
2010-06-08 |
2023-08-12 |
human |
| Lisbeth Marner, Nic Gillings, Karine Madsen, David Erritzoe, William F C Baaré, Claus Svarer, Steen G Hasselbalch, Gitte M Knudse. Brain imaging of serotonin 4 receptors in humans with [11C]SB207145-PET. NeuroImage. vol 50. issue 3. 2010-06-08. PMID:20096787. |
pharmacological stimulation of the serotonin 4 (5-ht(4)) receptor has shown promise for treatment of alzheimer's disease and major depression. |
2010-06-08 |
2023-08-12 |
human |
| Erika E Forbes, Thomas M Olino, Neal D Ryan, Boris Birmaher, David Axelson, Donna L Moyles, Ronald E Dah. Reward-related brain function as a predictor of treatment response in adolescents with major depressive disorder. Cognitive, affective & behavioral neuroscience. vol 10. issue 1. 2010-06-07. PMID:20233959. |
adolescents with depression underwent a functional mri scan during a monetary reward task, participated in an 8-week open trial of cognitive behavioral therapy (cbt) or cbt plus selective serotonin reuptake inhibitor, and completed reports of anxiety and depressive symptoms before, during, and after treatment. |
2010-06-07 |
2023-08-12 |
Not clear |
| Shao-hua Wang, Zhi-jun Zhang, Yi-jing Guo, Yu-xiu Sui, Yi Su. Involvement of serotonin neurotransmission in hippocampal neurogenesis and behavioral responses in a rat model of post-stroke depression. Pharmacology, biochemistry, and behavior. vol 95. issue 1. 2010-06-01. PMID:20045434. |
involvement of serotonin neurotransmission in hippocampal neurogenesis and behavioral responses in a rat model of post-stroke depression. |
2010-06-01 |
2023-08-12 |
rat |
| Shao-hua Wang, Zhi-jun Zhang, Yi-jing Guo, Yu-xiu Sui, Yi Su. Involvement of serotonin neurotransmission in hippocampal neurogenesis and behavioral responses in a rat model of post-stroke depression. Pharmacology, biochemistry, and behavior. vol 95. issue 1. 2010-06-01. PMID:20045434. |
ischemia-stimulated dentate gyrus (dg) neurogenesis is hypothesized to be an etiological factor of post-stroke depression (psd) and a potential target of selective serotonin (5-hydroxytryptamine; 5-ht) reuptake inhibitors (ssris) in psd. |
2010-06-01 |
2023-08-12 |
rat |
| Hongmei Zhang, Wei Wang, Zhenzhou Jiang, Jing Shang, Luyong Zhan. Differential involvement of 5-HT(1A) and 5-HT(1B/1D) receptors in human interferon-alpha-induced immobility in the mouse forced swimming test. Arzneimittel-Forschung. vol 60. issue 3. 2010-05-26. PMID:20422941. |
all results suggest that (1) compared to the 5-ht(1b) receptor, the 5-ht(1a) receptor signal plays the dominant role in improving the anti-immobility effect of fluoxetine in the ifn-alpha-induced depression; (2) combination of the 5-ht(1a) antagonist with subactive fluoxetine can be helpful in ifn-alpha-induced depression treatment. |
2010-05-26 |
2023-08-12 |
mouse |
| Cecilie L Licht, Lisbeth Kirkegaard, Maha Zueger, Sabine Chourbaji, Peter Gass, Susana Aznar, Gitte M Knudse. Changes in 5-HT4 receptor and 5-HT transporter binding in olfactory bulbectomized and glucocorticoid receptor heterozygous mice. Neurochemistry international. vol 56. issue 4. 2010-05-25. PMID:20060867. |
the 5-ht(4) receptor is a new potential target for antidepressant treatment and may be implicated in the pathogenesis of depression. |
2010-05-25 |
2023-08-12 |
mouse |
| Gor Sarkisyan, Amanda J Roberts, Peter B Hedlun. The 5-HT(7) receptor as a mediator and modulator of antidepressant-like behavior. Behavioural brain research. vol 209. issue 1. 2010-05-25. PMID:20097233. |
the 5-ht(7) receptor has been suggested as a target for treating depression since inactivation or blockade of the receptor has an antidepressant-like behavioral effect. |
2010-05-25 |
2023-08-12 |
mouse |
| Gor Sarkisyan, Amanda J Roberts, Peter B Hedlun. The 5-HT(7) receptor as a mediator and modulator of antidepressant-like behavior. Behavioural brain research. vol 209. issue 1. 2010-05-25. PMID:20097233. |
the data furthermore support the hypothesis that the 5-ht(7) receptor might be a suitable target for treating depression. |
2010-05-25 |
2023-08-12 |
mouse |
| Nabeel Nabulsi, Yiyun Huang, David Weinzimmer, Jim Ropchan, James J Frost, Timothy McCarthy, Richard E Carson, Yu-Shin Din. High-resolution imaging of brain 5-HT 1B receptors in the rhesus monkey using [11C]P943. Nuclear medicine and biology. vol 37. issue 2. 2010-05-20. PMID:20152720. |
the serotonin 5-ht(1b) receptors regulate the release of serotonin and are involved in various disease states, including depression and schizophrenia. |
2010-05-20 |
2023-08-12 |
monkey |
| Avshalom Caspi, Ahmad R Hariri, Andrew Holmes, Rudolf Uher, Terrie E Moffit. Genetic sensitivity to the environment: the case of the serotonin transporter gene and its implications for studying complex diseases and traits. The American journal of psychiatry. vol 167. issue 5. 2010-05-17. PMID:20231323. |
the authors evaluate four lines of evidence about the 5-htt stress-sensitivity hypothesis: 1) observational studies about the serotonin transporter linked polymorphic region (5-httlpr), stress sensitivity, and depression in humans; 2) experimental neuroscience studies about the 5-httlpr and biological phenotypes relevant to the human stress response; 3) studies of 5-htt variation and stress sensitivity in nonhuman primates; and 4) studies of stress sensitivity and genetically engineered 5-htt mutations in rodents. |
2010-05-17 |
2023-08-12 |
human |
| F Desplenter, G Laekeman, K Demyttenaere, S Simoen. Medication information for Flemish inpatients with major depression: evaluation and construct validity of the Consumer Information Rating Form. Journal of clinical pharmacy and therapeutics. vol 34. issue 6. 2010-05-11. PMID:20175797. |
the objective of this study is to evaluate a patient pamphlet on selective serotonin reuptake inhibitors (ssris) by calculating flesch-douma readability scores and by applying the consumer information rating form (cirf) to flemish inpatients with major depression taking ssris. |
2010-05-11 |
2023-08-12 |
Not clear |
| Julie G Hensler, Miriam A Vogt, Peter Gas. Regulation of cortical and hippocampal 5-HT(1A) receptor function by corticosterone in GR+/- mice. Psychoneuroendocrinology. vol 35. issue 3. 2010-05-07. PMID:19766402. |
our objective in the present study was to examine 5-ht(1a) receptor function in prefrontal cortex and hippocampus of gr+/- mice, which appear to be an appropriate murine model of depression. |
2010-05-07 |
2023-08-12 |
mouse |
| Ana C Magalhaes, Kevin D Holmes, Lianne B Dale, Laetitia Comps-Agrar, Dennis Lee, Prem N Yadav, Linsay Drysdale, Michael O Poulter, Bryan L Roth, Jean-Philippe Pin, Hymie Anisman, Stephen S G Ferguso. CRF receptor 1 regulates anxiety behavior via sensitization of 5-HT2 receptor signaling. Nature neuroscience. vol 13. issue 5. 2010-05-07. PMID:20383137. |
stress and anxiety disorders are risk factors for depression and these behaviors are modulated by corticotrophin-releasing factor receptor 1 (crfr1) and serotonin receptor (5-ht(2)r). |
2010-05-07 |
2023-08-12 |
mouse |
| Karen K Miller, Roy H Perlis, George I Papakostas, David Mischoulon, Dan V Losifescu, Danielle J Brick, Maurizio Fav. Low-dose transdermal testosterone augmentation therapy improves depression severity in women. CNS spectrums. vol 14. issue 12. 2010-05-06. PMID:20394176. |
testosterone administration has been shown to be an effective augmentation therapy in depressed hypogonadal men with selective serotonin reuptake inhibitor-resistant depression. |
2010-05-06 |
2023-08-12 |
Not clear |
| Lena C Quilty, Kathryn M Godfrey, Sidney H Kennedy, R Michael Bagb. Harm avoidance as a mediator of treatment response to antidepressant treatment of patients with major depression. Psychotherapy and psychosomatics. vol 79. issue 2. 2010-05-05. PMID:20090398. |
the temperament harm avoidance (ha) has consistently demonstrated an association with major depressive disorder (mdd), serotonin functioning and reduction in depression symptoms in response to antidepressant medications targeting the serotonin system. |
2010-05-05 |
2023-08-12 |
Not clear |
| Eva L van Donkelaar, Arjan Blokland, Cindy K J Lieben, Gunter Kenis, Linda Ferrington, Paul A T Kelly, Harry W M Steinbusch, Jos Prickaert. Acute tryptophan depletion in C57BL/6 mice does not induce central serotonin reduction or affective behavioural changes. Neurochemistry international. vol 56. issue 1. 2010-05-04. PMID:19716853. |
we aimed to establish the rat model of acute tryptophan depletion in the mouse for potential application as serotonin challenge tool in genetic mouse models of depression. |
2010-05-04 |
2023-08-12 |
mouse |
| Volkan Sahiner, S Ozlem Erden Ak. [Serotonin syndrome associated with linezolid use: a case report]. Turk psikiyatri dergisi = Turkish journal of psychiatry. vol 20. issue 4. 2010-04-28. PMID:20013432. |
the growing use of ssris for depression and the introduction of pharmacological agents newly developed for the treatment of various medical disorders increases the risk of drug-drug interactions and toxic states like serotonin syndrome. |
2010-04-28 |
2023-08-12 |
Not clear |