| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Seppo Kähkönen, Nils Holmber. [Treatment of obsessive-compulsive disorder in an adult]. Duodecim; laaketieteellinen aikakauskirja. vol 126. issue 11. 2010-09-21. PMID:20681354. |
first-line drug therapy utilizes serotonin reuptake inhibitors at dosages that are usually higher and yield slower responses than those used in the treatment of major depression. |
2010-09-21 |
2023-08-12 |
Not clear |
| Arne Schäfer, Michael Scheurlen, Jochen Seufert, Christian Keicher, Benedikt Weissbrich, Peter Rieger, Michael R Krau. Platelet serotonin (5-HT) levels in interferon-treated patients with hepatitis C and its possible association with interferon-induced depression. Journal of hepatology. vol 52. issue 1. 2010-09-16. PMID:19897271. |
platelet serotonin (5-ht) levels in interferon-treated patients with hepatitis c and its possible association with interferon-induced depression. |
2010-09-16 |
2023-08-12 |
Not clear |
| Arne Schäfer, Michael Scheurlen, Jochen Seufert, Christian Keicher, Benedikt Weissbrich, Peter Rieger, Michael R Krau. Platelet serotonin (5-HT) levels in interferon-treated patients with hepatitis C and its possible association with interferon-induced depression. Journal of hepatology. vol 52. issue 1. 2010-09-16. PMID:19897271. |
interferon-associated depression is a frequent side effect of antiviral therapy for chronic hepatitis c. the aim of the present study was to investigate the correlation between platelet serotonin (5-hydroxytryptamine, 5-ht) concentrations and ifn-induced depression. |
2010-09-16 |
2023-08-12 |
Not clear |
| Emily M Stocking, Michael A Letavic, Pascal Bonaventure, Nicholas I Carruther. Exploration of structure-activity relationships for dual serotonin transporter reuptake inhibitors-histamine H3 receptor antagonists. Current topics in medicinal chemistry. vol 10. issue 5. 2010-09-16. PMID:20166942. |
depression is a major health issue, which is routinely treated with selective serotonin reuptake inhibitors. |
2010-09-16 |
2023-08-12 |
Not clear |
| Peng Zhang, George Cyriac, Theresa Kopajtic, Yongfang Zhao, Jonathan A Javitch, Jonathan L Katz, Amy Hauck Newma. Structure-activity relationships for a novel series of citalopram (1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile) analogues at monoamine transporters. Journal of medicinal chemistry. vol 53. issue 16. 2010-09-16. PMID:20672825. |
(+/-)-citalopram (1, 1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile), and its eutomer, escitalopram (s-(+)-1) are selective serotonin reuptake inhibitors (ssris) that are used clinically to treat anxiety and depression. |
2010-09-16 |
2023-08-12 |
Not clear |
| D Weintraub, S Mavandadi, E Mamikonyan, A D Siderowf, J E Duda, H I Hurtig, A Colcher, S S Horn, S Nazem, T R Ten Have, M B Ster. Atomoxetine for depression and other neuropsychiatric symptoms in Parkinson disease. Neurology. vol 75. issue 5. 2010-09-13. PMID:20679638. |
depression and antidepressant use, especially selective serotonin reuptake inhibitors (ssris), are common in parkinson disease (pd). |
2010-09-13 |
2023-08-12 |
Not clear |
| Judit Lazar. Serotonin transporter gene and negative life change events are associated with depressive phenotype. Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology. vol 12. issue 2. 2010-09-09. PMID:20606244. |
haplotype analyses of the serotonin transporter gene suggested that the majority of the s allele carriers for 5-httlpr with multiple threatening life events expressed high depression score, however, a subgroup with much lower depression score was also identified. |
2010-09-09 |
2023-08-12 |
Not clear |
| Franklin J Berke. Managing the adverse effects of radiation therapy. American family physician. vol 82. issue 4. 2010-09-09. PMID:20704169. |
selective serotonin reuptake inhibitors have been shown to significantly improve symptoms of depression in patients undergoing chemotherapy, although they have little effect on cancer-related fatigue. |
2010-09-09 |
2023-08-12 |
Not clear |
| Susana Aznar, Anders B Klein, Martin A Santini, Gitte M Knudsen, Fritz Henn, Peter Gass, Barbara Vollmay. Aging and depression vulnerability interaction results in decreased serotonin innervation associated with reduced BDNF levels in hippocampus of rats bred for learned helplessness. Synapse (New York, N.Y.). vol 64. issue 7. 2010-09-08. PMID:20222154. |
aging and depression vulnerability interaction results in decreased serotonin innervation associated with reduced bdnf levels in hippocampus of rats bred for learned helplessness. |
2010-09-08 |
2023-08-12 |
rat |
| Susana Aznar, Anders B Klein, Martin A Santini, Gitte M Knudsen, Fritz Henn, Peter Gass, Barbara Vollmay. Aging and depression vulnerability interaction results in decreased serotonin innervation associated with reduced BDNF levels in hippocampus of rats bred for learned helplessness. Synapse (New York, N.Y.). vol 64. issue 7. 2010-09-08. PMID:20222154. |
both reduced hippocampal serotonin neurotransmission and brain-derived neurotrophic factor (bdnf) levels have been associated with increased depression vulnerability and are also regulated during aging. |
2010-09-08 |
2023-08-12 |
rat |
| Natalia Jaworska, Andrea Thompson, Dhrasti Shah, Derek Fisher, Vadim Ilivitsky, Verner Knot. Electrocortical effects of acute tryptophan depletion on emotive facial processing in depression-prone individuals. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 20. issue 7. 2010-09-08. PMID:20395115. |
this study assessed the effects of acute tryptophan depletion (atd), which transiently lowers cns 5-ht, on electrocortical responses to facial expression processing in individuals with a family history of depression (fh+). |
2010-09-08 |
2023-08-12 |
Not clear |
| Joanna S Fowler, Jean Logan, Albert J Azzaro, Robert M Fielding, Wei Zhu, Amy K Poshusta, Daniel Burch, Barry Brand, James Free, Mahnaz Asgharnejad, Gene-Jack Wang, Frank Telang, Barbara Hubbard, Millard Jayne, Payton King, Pauline Carter, Scott Carter, Youwen Xu, Colleen Shea, Lisa Muench, David Alexoff, Elena Shumay, Michael Schueller, Donald Warner, Karen Apelskog-Torre. Reversible inhibitors of monoamine oxidase-A (RIMAs): robust, reversible inhibition of human brain MAO-A by CX157. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 35. issue 3. 2010-09-07. PMID:19890267. |
reversible inhibitors of monoamine oxidase-a (rima) inhibit the breakdown of three major neurotransmitters, serotonin, norepinephrine and dopamine, offering a multi-neurotransmitter strategy for the treatment of depression. |
2010-09-07 |
2023-08-12 |
human |
| Yasuhiro Katoh, Shinya Uchida, Masayoshi Kawai, Noriyoshi Takei, Norio Mori, Junichi Kawakami, Yoshiyuki Kagawa, Shizuo Yamada, Noriyuki Namiki, Hisakuni Hashimot. Effects of cigarette smoking and cytochrome P450 2D6 genotype on fluvoxamine concentration in plasma of Japanese patients. Biological & pharmaceutical bulletin. vol 33. issue 2. 2010-09-03. PMID:20118554. |
fluvoxamine is a selective serotonin reuptake inhibitor widely used in the treatment of depression and other psychiatric diseases. |
2010-09-03 |
2023-08-12 |
Not clear |
| V R Sela, I Hattanda, C M Albrecht, C B De Almeida, S Obici, D A Cortez, E A Aud. Effect of xanthone from Kielmeyera coriacea stems on serotonergic neurons of the median raphe nucleus. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 17. issue 3-4. 2010-08-30. PMID:19674881. |
these results suggest that xanthone acts as an antagonist at 5-ht1a autoreceptors in mrn and increases serotonin (5-ht) availability in projection regions, proving to be a prototype drug that may be useful in mood isorders such as depression, or indeed be a beneficial adjunctive treatment improving the efficacy and/or accelerating the effects of antidepressant drugs in patients with major depression. |
2010-08-30 |
2023-08-12 |
rat |
| Koji Otsuki, Shusaku Uchida, Yusuke Wakabayashi, Toshio Matsubara, Teruyuki Hobara, Hiromasa Funato, Yoshifumi Watanab. Aberrant REST-mediated transcriptional regulation in major depressive disorder. Journal of psychiatric research. vol 44. issue 6. 2010-08-26. PMID:19846118. |
rest has many target genes, including corticotropin releasing hormone (crh), brain-derived neurotrophic factor, serotonin 1a receptor, which are suggested to be involved in the pathophysiology of depression and the action of antidepressants. |
2010-08-26 |
2023-08-12 |
Not clear |
| Yi Li, Bo Xiao, Wenjing Qiu, Le Yang, Bo Hu, Xiaolin Tian, Huan Yan. Altered expression of CD4(+)CD25(+) regulatory T cells and its 5-HT(1a) receptor in patients with major depression disorder. Journal of affective disorders. vol 124. issue 1-2. 2010-08-23. PMID:19900711. |
altered expression of cd4(+)cd25(+) regulatory t cells and its 5-ht(1a) receptor in patients with major depression disorder. |
2010-08-23 |
2023-08-12 |
Not clear |
| Cinzia Finocchi, Veronica Villani, Gerardo Casucc. Therapeutic strategies in migraine patients with mood and anxiety disorders: clinical evidence. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 31 Suppl 1. 2010-08-17. PMID:20464594. |
when a specific treatment for the comorbid psychiatric disorder is needed, the selective serotonin reuptake inhibitors or the serotonin norepinephrine reuptake inhibitors are the drugs of choice both in depression and anxiety, and the cognitive behavioural therapy has good evidence of efficacy in anxiety disorders. |
2010-08-17 |
2023-08-12 |
Not clear |
| John R Cutcliffe, Richard Lakema. Challenging normative orthodoxies in depression: Huxley's Utopia or Dante's Inferno? Archives of psychiatric nursing. vol 24. issue 2. 2010-08-09. PMID:20303451. |
at the same time, it should be acknowledged that the last two decades have seen the widespread acceptance of depression as a chemical imbalance and a massive corresponding increase in the prescription of antidepressants, most notably of selective serotonin reuptake inhibitors (ssris). |
2010-08-09 |
2023-08-12 |
human |
| Shaila Misri, Kristin Kendrick, Tim F Oberlander, Sandhaya Norris, Lianne Tomfohr, Hongbin Zhang, Ruth E Gruna. Antenatal depression and anxiety affect postpartum parenting stress: a longitudinal, prospective study. Canadian journal of psychiatry. Revue canadienne de psychiatrie. vol 55. issue 4. 2010-08-05. PMID:20416145. |
we studied the effect of antenatal depression and anxiety and treatment with selective serotonin reuptake inhibitors and selective norepinephrine reuptake inhibitors (antidepressants [ads]) on postpartum parenting stress. |
2010-08-05 |
2023-08-12 |
Not clear |
| Ulla Knorr, Lars Vedel Kessin. The effect of selective serotonin reuptake inhibitors in healthy subjects. A systematic review. Nordic journal of psychiatry. vol 64. issue 3. 2010-08-03. PMID:20088752. |
selective serotonin reuptake inhibitors (ssris) show antidepressant properties in many patients with a diagnosis of depression. |
2010-08-03 |
2023-08-12 |
human |