| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Amar N Maurya, Shripad B Deshpand. Involvement of 5-hydroxytryptaminergic transmission for the Mesobuthus tamulus venom-induced depression of spinal reflexes in neonatal rat in vitro. Neuroscience letters. vol 482. issue 1. 2010-12-13. PMID:20603188. |
5-hydroxytryptamine (5-ht) is another excitatory transmitter in the spinal cord therefore, the present study was undertaken to examine the involvement of 5-ht in the venom-induced depression of reflexes. |
2010-12-13 |
2023-08-12 |
rat |
| Amar N Maurya, Shripad B Deshpand. Involvement of 5-hydroxytryptaminergic transmission for the Mesobuthus tamulus venom-induced depression of spinal reflexes in neonatal rat in vitro. Neuroscience letters. vol 482. issue 1. 2010-12-13. PMID:20603188. |
on the other hand, ketanserin (10 microm; 5-ht(2a/2c) receptor antagonist) or ondansetron (0.1 microm; 5-ht(3) receptor antagonist) blocked the venom-induced depression of msr and psr during entire exposure time (30 min). |
2010-12-13 |
2023-08-12 |
rat |
| Amar N Maurya, Shripad B Deshpand. Involvement of 5-hydroxytryptaminergic transmission for the Mesobuthus tamulus venom-induced depression of spinal reflexes in neonatal rat in vitro. Neuroscience letters. vol 482. issue 1. 2010-12-13. PMID:20603188. |
the results indicate that venom-induced depression of spinal reflexes is mediated via 5-htergic transmission involving 5-ht(1a/1b), 5-ht(2a/2c) and 5-ht(3) receptors. |
2010-12-13 |
2023-08-12 |
rat |
| Ronan Depoortère, Agnès L Auclair, Laurent Bardin, Francis C Colpaert, Bernard Vacher, Adrian Newman-Tancred. F15599, a preferential post-synaptic 5-HT1A receptor agonist: activity in models of cognition in comparison with reference 5-HT1A receptor agonists. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 20. issue 9. 2010-12-08. PMID:20488670. |
this suggests that preferential activation of post-synaptic 5-ht(1a) receptors could prove useful in pathologies characterized by cognitive/memory deficiencies, such as schizophrenia and depression. |
2010-12-08 |
2023-08-12 |
rat |
| Christian Albu. Psychological and social factors in coronary heart disease. Annals of medicine. vol 42. issue 7. 2010-12-07. PMID:20839918. |
in case of clinically significant symptoms of depression and anxiety, patients should be referred for psychotherapy, and/or medication according to established standards (especially selective serotonin reuptake inhibitors (ssris)) should be prescribed. |
2010-12-07 |
2023-08-12 |
Not clear |
| Jan A Mennigen, Wudu E Lado, Jake M Zamora, Paula Duarte-Guterman, Valérie S Langlois, Chris D Metcalfe, John P Chang, Thomas W Moon, Vance L Trudea. Waterborne fluoxetine disrupts the reproductive axis in sexually mature male goldfish, Carassius auratus. Aquatic toxicology (Amsterdam, Netherlands). vol 100. issue 4. 2010-12-07. PMID:20864192. |
fluoxetine (flx) is a pharmaceutical acting as a selective serotonin reuptake inhibitor and is used to treat depression in humans. |
2010-12-07 |
2023-08-12 |
Not clear |
| Noam S Katz, Bruno P Guiard, Mostafa El Mansari, Pierre Blie. Effects of acute and sustained administration of the catecholamine reuptake inhibitor nomifensine on the firing activity of monoaminergic neurons. Journal of psychopharmacology (Oxford, England). vol 24. issue 8. 2010-12-02. PMID:19939862. |
nomifensine likely treated depression by acting on dopamine, norepinephrine and 5-ht neurons, highlighting the importance of the functional connectivity between these three monoaminergic systems. |
2010-12-02 |
2023-08-12 |
rat |
| Nunzio Pomara, John J Sidti. Brain neurotoxic amyloid-beta peptides: their potential role in the pathophysiology of depression and as molecular therapeutic targets. British journal of pharmacology. vol 161. issue 4. 2010-12-02. PMID:21105218. |
the monoamine hypothesis ascribes an important role to the under activity of brain monoamines such as 5-ht, noradrenaline and dopamine to the pathophysiology of depression. |
2010-12-02 |
2023-08-12 |
Not clear |
| Lakshmi N Yatham, Peter F Liddle, Raymond W Lam, Athanasios P Zis, A Jon Stoessl, Vesna Sossi, Michael J Adam, Thomas J Rut. Effect of electroconvulsive therapy on brain 5-HT(2) receptors in major depression. The British journal of psychiatry : the journal of mental science. vol 196. issue 6. 2010-12-01. PMID:20513859. |
effect of electroconvulsive therapy on brain 5-ht(2) receptors in major depression. |
2010-12-01 |
2023-08-12 |
Not clear |
| Lakshmi N Yatham, Peter F Liddle, Raymond W Lam, Athanasios P Zis, A Jon Stoessl, Vesna Sossi, Michael J Adam, Thomas J Rut. Effect of electroconvulsive therapy on brain 5-HT(2) receptors in major depression. The British journal of psychiatry : the journal of mental science. vol 196. issue 6. 2010-12-01. PMID:20513859. |
positron emission tomography (pet) studies in individuals with depression confirmed that antidepressant medications reduce brain 5-ht(2) receptors, but the effects of ect on these receptors in individuals with depression are unknown. |
2010-12-01 |
2023-08-12 |
Not clear |
| Andreas Hahn, Rupert Lanzenberger, Wolfgang Wadsak, Christoph Spindelegger, Uirike Moser, Leonhard-Key Mien, Markus Mitterhauser, Siegfried Kaspe. Escitalopram enhances the association of serotonin-1A autoreceptors to heteroreceptors in anxiety disorders. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 43. 2010-11-30. PMID:20980606. |
selective serotonin reuptake inhibitors (ssris) represent one of the most common treatment options in major depression and anxiety disorders. |
2010-11-30 |
2023-08-12 |
human |
| Ikue Nagakura, Tyler W Dunn, Carole Abi Farah, Andrew Heppner, Flora F Li, Wayne S Sossi. Regulation of protein kinase C Apl II by serotonin receptors in Aplysia. Journal of neurochemistry. vol 115. issue 4. 2010-11-23. PMID:20964689. |
serotonin mediates this behavioral change through the reversal of synaptic depression in sensory neurons (sns). |
2010-11-23 |
2023-08-12 |
aplysia |
| Ikue Nagakura, Tyler W Dunn, Carole Abi Farah, Andrew Heppner, Flora F Li, Wayne S Sossi. Regulation of protein kinase C Apl II by serotonin receptors in Aplysia. Journal of neurochemistry. vol 115. issue 4. 2010-11-23. PMID:20964689. |
expression of 5ht(1apl(a)) in sns or genistein, an inhibitor of tyrosine kinases inhibited both pkc translocation and reversal of depression. |
2010-11-23 |
2023-08-12 |
aplysia |
| P M Pitychoutis, A Zisaki, C Dalla, Z Papadopoulou-Daifot. Pharmacogenetic insights into depression and antidepressant response: does sex matter? Current pharmaceutical design. vol 16. issue 20. 2010-11-22. PMID:20459391. |
despite the fact that the contribution of the "genome" remains elusive when it comes to major depression, intriguing evidence has recently emerged pointing to sexually dimorphic influences of certain polymorphisms in genes related to the pathophysiology of major depression and antidepressant response, such as the serotonin transporter (5-htt), serotonin 1a (5ht1a) receptor, monoamine oxidase a (mao-a) and others. |
2010-11-22 |
2023-08-12 |
Not clear |
| Vincent Van Waes, Joel Beverley, Michela Marinelli, Heinz Steine. Selective serotonin reuptake inhibitor antidepressants potentiate methylphenidate (Ritalin)-induced gene regulation in the adolescent striatum. The European journal of neuroscience. vol 32. issue 3. 2010-11-22. PMID:20704593. |
the psychostimulant methylphenidate (ritalin) is used in conjunction with selective serotonin reuptake inhibitors (ssris) in the treatment of medical conditions such as attention-deficit hyperactivity disorder with anxiety/depression comorbidity and major depression. |
2010-11-22 |
2023-08-12 |
rat |
| Giulia Schillani, Elisabetta Martinis, Maria Anna Capozzo, Daniel Era, Tania Cristante, Giorgio Mustacchi, Maria Anna Conte, Maurizio DE Vanna, Luigi Grassi, Tullio Girald. Psychological response to cancer: role of 5-HTTLPR genetic polymorphism of serotonin transporter. Anticancer research. vol 30. issue 9. 2010-11-10. PMID:20944177. |
5-httlpr genetic polymorphism of serotonin transporter (sert) and stressful life events facilitate depression. |
2010-11-10 |
2023-08-12 |
Not clear |
| Mikko Joensuu, Soili Marianne Lehto, Tommi Tolmunen, Pirjo Irmeli Saarinen, Minna Valkonen-Korhonen, Ritva Vanninen, Pasi Ahola, Jari Tiihonen, Jyrki Kuikka, Ullamari Pesonen, Johannes Lehtone. Serotonin-transporter-linked promoter region polymorphism and serotonin transporter binding in drug-naïve patients with major depression. Psychiatry and clinical neurosciences. vol 64. issue 4. 2010-11-09. PMID:20653909. |
serotonin-transporter-linked promoter region polymorphism and serotonin transporter binding in drug-naïve patients with major depression. |
2010-11-09 |
2023-08-12 |
Not clear |
| Mikko Joensuu, Soili Marianne Lehto, Tommi Tolmunen, Pirjo Irmeli Saarinen, Minna Valkonen-Korhonen, Ritva Vanninen, Pasi Ahola, Jari Tiihonen, Jyrki Kuikka, Ullamari Pesonen, Johannes Lehtone. Serotonin-transporter-linked promoter region polymorphism and serotonin transporter binding in drug-naïve patients with major depression. Psychiatry and clinical neurosciences. vol 64. issue 4. 2010-11-09. PMID:20653909. |
both the serotonin transporter and its genetic regulation by the serotonin-transporter-linked polymorphic region have a role in the pathophysiology of depression. |
2010-11-09 |
2023-08-12 |
Not clear |
| Mikko Joensuu, Soili Marianne Lehto, Tommi Tolmunen, Pirjo Irmeli Saarinen, Minna Valkonen-Korhonen, Ritva Vanninen, Pasi Ahola, Jari Tiihonen, Jyrki Kuikka, Ullamari Pesonen, Johannes Lehtone. Serotonin-transporter-linked promoter region polymorphism and serotonin transporter binding in drug-naïve patients with major depression. Psychiatry and clinical neurosciences. vol 64. issue 4. 2010-11-09. PMID:20653909. |
most of the previous studies have found no influence of serotonin-transporter-linked polymorphic region allelic variation on serotonin transporter binding in healthy controls or patients with major depression. |
2010-11-09 |
2023-08-12 |
Not clear |
| T Tencomnao, V Thongrakard, W Phuchana, T Sritharathikhun, S Suttira. No relationship found between -1438A/G polymorphism of the serotonin 2A receptor gene (rs6311) and major depression susceptibility in a northeastern Thai population. Genetics and molecular research : GMR. vol 9. issue 2. 2010-11-05. PMID:20589614. |
no relationship found between -1438a/g polymorphism of the serotonin 2a receptor gene (rs6311) and major depression susceptibility in a northeastern thai population. |
2010-11-05 |
2023-08-12 |
Not clear |