| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Roopali Saxena, Amitabha Chattopadhya. Membrane organization and dynamics of the serotonin1A receptor in live cells. Journal of neurochemistry. vol 116. issue 5. 2011-03-30. PMID:21214564. |
the serotonin(1a) receptor is a representative member of the gpcr superfamily and serves as an important target in the development of therapeutic agents for neuropsychiatric disorders such as anxiety and depression. |
2011-03-30 |
2023-08-12 |
Not clear |
| Akira Kishimoto, Ayako Todani, Junko Miura, Tetsuno Kitagaki, Kenji Hashimot. The opposite effects of fluvoxamine and sertraline in the treatment of psychotic major depression: a case report. Annals of general psychiatry. vol 9. 2011-03-25. PMID:20492642. |
a number of clinical studies have demonstrated the efficacy of the combination of an antidepressant (for example, a tricyclic antidepressant or selective serotonin reuptake inhibitor (ssri)) and an atypical antipsychotic or electroconvulsive therapy (ect) in treating psychotic major depression. |
2011-03-25 |
2023-08-12 |
Not clear |
| Elisabeth A Riksen, Astrid K Stunes, Anne Kalvik, Björn I Gustafsson, Malcolm L Snead, Unni Syversen, Ståle P Lyngstadaas, Janne E Reselan. Serotonin and fluoxetine receptors are expressed in enamel organs and LS8 cells and modulate gene expression in LS8 cells. European journal of oral sciences. vol 118. issue 6. 2011-03-24. PMID:21083617. |
the selective serotonin re-uptake inhibitor (ssri) fluoxetine is widely used in the treatment of depression in children and fertile women, but its effect on developing tissues has been sparsely investigated. |
2011-03-24 |
2023-08-12 |
mouse |
| Abigail Davis, Michael Gilhooley, Mark Agiu. Using non-steroidal anti-inflammatory drugs in the treatment of depression. Psychiatria Danubina. vol 22 Suppl 1. 2011-03-18. PMID:21057403. |
to date four randomised controlled trials have used celecoxib or rofecoxib as adjuncts to serotonin selective reuptake inhibitors in the treatment of depression. |
2011-03-18 |
2023-08-12 |
Not clear |
| Mathieu Seimandi, Joël Bockaert, Philippe Mari. Techniques for studying inverse agonist activity of antidepressants at recombinant nonedited 5-HT(₂C-INI) receptor and native neuronal 5-HT(₂C) receptors. Methods in enzymology. vol 485. 2011-03-11. PMID:21050911. |
antidepressant effects of 5-ht(₂c) antagonists have been attributed to a disinhibition of mesocorticolimbic dopaminergic pathways, which exert a beneficial influence upon mood and cognitive functions altered in depression. |
2011-03-11 |
2023-08-12 |
Not clear |
| A van Velzen, M Tot. Role of maternal 5-HT(1A) receptor in programming offspring emotional and physical development. Genes, brain, and behavior. vol 9. issue 8. 2011-03-02. PMID:20633050. |
serotonin(1a) receptor (5-ht(1a)r) deficiency has been associated with anxiety and depression and mice with genetic receptor inactivation exhibit heightened anxiety. |
2011-03-02 |
2023-08-12 |
mouse |
| Eugenia Kuteeva, Tomas Hökfelt, Tara Wardi, Sven Ove Ogre. Galanin, galanin receptor subtypes and depression-like behaviour. Experientia supplementum (2012). vol 102. 2011-03-01. PMID:21299068. |
galanin is co-expressed with and modulates noradrenaline and serotonin transmission, both implicated in depression. |
2011-03-01 |
2023-08-12 |
rat |
| George S Alexopoulo. Pharmacotherapy for late-life depression. The Journal of clinical psychiatry. vol 72. issue 1. 2011-02-25. PMID:21272511. |
recent evidence continues to support the use of selective serotonin reuptake inhibitors and serotonin-norepinephrine reuptake inhibitors as first-line agents in the elderly, and although the transdermal monoamine oxidase inhibitor selegilene has shown promise in adult patients, it has not been studied in geriatric depression. |
2011-02-25 |
2023-08-12 |
Not clear |
| Christel M Middeldorp, Eco J C de Geus, Gonneke Willemsen, Jouke-Jan Hottenga, P Eline Slagboom, Dorret I Boomsm. The serotonin transporter gene length polymorphism (5-HTTLPR) and life events: no evidence for an interaction effect on neuroticism and anxious depressive symptoms. Twin research and human genetics : the official journal of the International Society for Twin Studies. vol 13. issue 6. 2011-02-24. PMID:21142930. |
the finding of a significant gene by environment interaction effect on depression of the serotonin transporter length polymorphism (5-httlpr) and the number of experienced life events (nle) was not replicated in two large meta-analyses (munafo et al., 2009; risch et al., 2009). |
2011-02-24 |
2023-08-12 |
Not clear |
| Amy Walsh, John McDowall, Gina M Grimsha. Hemispheric specialization for emotional word processing is a function of SSRI responsiveness. Brain and cognition. vol 74. issue 3. 2011-02-23. PMID:20943304. |
vulnerability to depression and non-response to selective serotonin reuptake inhibitors (ssris) are associated with specific neurophysiological characteristics including greater right hemisphere (rh) relative to left hemisphere (lh) activity. |
2011-02-23 |
2023-08-12 |
human |
| Gregory F Oxenkru. Tryptophan kynurenine metabolism as a common mediator of genetic and environmental impacts in major depressive disorder: the serotonin hypothesis revisited 40 years later. The Israel journal of psychiatry and related sciences. vol 47. issue 1. 2011-02-18. PMID:20686200. |
the original 1969 lancet paper proposed in depression the activity of liver tryptophan-pyrrolase is stimulated by raised blood corticosteroids levels, and metabolism of tryptophan is shunted away from serotonin production, and towards kynurenine production. |
2011-02-18 |
2023-08-12 |
Not clear |
| Sergey Raskin, Rimona Durs. Bupropion as the treatment of choice in depression associated with Parkinson's disease and it's various treatments. Medical hypotheses. vol 75. issue 6. 2011-02-18. PMID:20708340. |
several theories try to explain the trigger of depression in pd patients by impaired activity in dopamine, norepinephrine and serotonin systems. |
2011-02-18 |
2023-08-12 |
Not clear |
| L MacGillivray, L M Lagrou, K B Reynolds, P I Rosebush, M F Mazure. Role of serotonin transporter inhibition in the regulation of tryptophan hydroxylase in brainstem raphe nuclei: time course and regional specificity. Neuroscience. vol 171. issue 2. 2011-02-17. PMID:20868730. |
drugs that selectively inhibit the serotonin transporter (sert) are widely prescribed for treatment of depression and a range of anxiety disorders. |
2011-02-17 |
2023-08-12 |
rat |
| Marco Menchetti, Biancamaria Bortolotti, Paola Rucci, Paolo Scocco, Annarosa Bombi, Domenico Berard. Depression in primary care: interpersonal counseling vs selective serotonin reuptake inhibitors. The DEPICS Study. A multicenter randomized controlled trial. Rationale and design. BMC psychiatry. vol 10. 2011-02-17. PMID:21108824. |
depression in primary care: interpersonal counseling vs selective serotonin reuptake inhibitors. |
2011-02-17 |
2023-08-12 |
Not clear |
| Justine M Gatt, Charles B Nemeroff, Peter R Schofield, Robert H Paul, C Richard Clark, Evian Gordon, Leanne M William. Early life stress combined with serotonin 3A receptor and brain-derived neurotrophic factor valine 66 to methionine genotypes impacts emotional brain and arousal correlates of risk for depression. Biological psychiatry. vol 68. issue 9. 2011-02-15. PMID:20728877. |
early life stress combined with serotonin 3a receptor and brain-derived neurotrophic factor valine 66 to methionine genotypes impacts emotional brain and arousal correlates of risk for depression. |
2011-02-15 |
2023-08-12 |
Not clear |
| Fu-zhong Yang, Yan Wu, Wei-guo Zhang, Yi-yun Cai, Shen-xun Sh. [Influence of estradiol on tryptophan hydroxylase and 5-hydroxytryptamine content in raphe nuclei of rats under forced swimming stress]. Zhonghua yi xue za zhi. vol 90. issue 27. 2011-02-03. PMID:20979915. |
to investigate the effect of estradiol (e2) on tryptophan hydroxylase (tph) and 5-hydroxytryptamine (5-ht) content in raphe nuclei of rats under forced swimming stress and explore the role of estrogen and stress in disease mechanism of depression in women. |
2011-02-03 |
2023-08-12 |
rat |
| Pei Chun Hsieh, I Hui Lee, Tzung Lieh Yeh, Kao Chin Chen, Hui Chun Huang, Po See Chen, Yen Kuang Yang, Wei Jen Yao, Ru-Band Lu, Nan Tsing Chi. Distribution volume ratio of serotonin and dopamine transporters in euthymic patients with a history of major depression - a dual-isotope SPECT study. Psychiatry research. vol 184. issue 3. 2011-02-03. PMID:21030217. |
distribution volume ratio of serotonin and dopamine transporters in euthymic patients with a history of major depression - a dual-isotope spect study. |
2011-02-03 |
2023-08-12 |
human |
| Pei Chun Hsieh, I Hui Lee, Tzung Lieh Yeh, Kao Chin Chen, Hui Chun Huang, Po See Chen, Yen Kuang Yang, Wei Jen Yao, Ru-Band Lu, Nan Tsing Chi. Distribution volume ratio of serotonin and dopamine transporters in euthymic patients with a history of major depression - a dual-isotope SPECT study. Psychiatry research. vol 184. issue 3. 2011-02-03. PMID:21030217. |
serotonin transporter (sert) and dopamine transporter (dat) levels differ in patients with major depression who are in a depressed state in comparison with healthy controls. |
2011-02-03 |
2023-08-12 |
human |
| Elsebeth Nylev Stenager, Kurt Bjerregaard Stage, Egon Stenage. [Risk of affective disorder in multiple sclerosis]. Ugeskrift for laeger. vol 173. issue 2. 2011-02-01. PMID:21219844. |
treatment of depression with serotonin reuptake inhibitors and/or cognitive behavioural therapy is recommended, depending on the severity of the illness. |
2011-02-01 |
2023-08-12 |
Not clear |
| Michael E Thase, Andrew A Nierenberg, Peter Vrijland, Helga J J van Oers, Albert-Jan Schutte, John H Simmon. Remission with mirtazapine and selective serotonin reuptake inhibitors: a meta-analysis of individual patient data from 15 controlled trials of acute phase treatment of major depression. International clinical psychopharmacology. vol 25. issue 4. 2011-01-31. PMID:20531012. |
remission with mirtazapine and selective serotonin reuptake inhibitors: a meta-analysis of individual patient data from 15 controlled trials of acute phase treatment of major depression. |
2011-01-31 |
2023-08-12 |
Not clear |