| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H G Ruhé, J Booij, H C van Weert, J B Reitsma, E J Franssen, M C Michel, A Schen. [Dose-escalation of SSRIS in major depressive disorder. Should not be recommended in current guidelines]. Tijdschrift voor psychiatrie. vol 52. issue 9. 2010-11-05. PMID:20862644. |
in cases where patients with unipolar depression do not respond to a standard dose of selective serotonin reuptake inhibitors (ssris), treatment guidelines often recommend a higher dose. |
2010-11-05 |
2023-08-12 |
Not clear |
| L Douglas Ried, Huanguang Jia, Randi Cameon, Hua Feng, Xinping Wang, Michael Tuet. Does prestroke depression impact poststroke depression and treatment? The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry. vol 18. issue 7. 2010-11-03. PMID:20220578. |
to 1) describe the prevalence of before the stroke depression (bsd) and poststroke depression (psd) and 2) serotonin selective reuptake inhibitor (ssri) treatment patterns. |
2010-11-03 |
2023-08-12 |
Not clear |
| Cristian Bonvicini, Alessandra Minelli, Catia Scassellati, Marco Bortolomasi, Matilde Segala, Riccardo Sartori, Mario Giacopuzzi, Massimo Gennarell. Serotonin transporter gene polymorphisms and treatment-resistant depression. Progress in neuro-psychopharmacology & biological psychiatry. vol 34. issue 6. 2010-11-02. PMID:20450949. |
serotonin transporter gene polymorphisms and treatment-resistant depression. |
2010-11-02 |
2023-08-12 |
human |
| Cristian Bonvicini, Alessandra Minelli, Catia Scassellati, Marco Bortolomasi, Matilde Segala, Riccardo Sartori, Mario Giacopuzzi, Massimo Gennarell. Serotonin transporter gene polymorphisms and treatment-resistant depression. Progress in neuro-psychopharmacology & biological psychiatry. vol 34. issue 6. 2010-11-02. PMID:20450949. |
in conclusion, this study reports a protective effect of the l(a)l(a) haplotype on trd, supporting the hypothesis that lower serotonin transporter transcription alleles are correlated to a common resistant depression mechanism. |
2010-11-02 |
2023-08-12 |
human |
| Luigi Grassi, Elena Rossi, Marina Cobianchi, Letizia Aguiari, Marianna Capozzo, Elisabetta Martinis, Maria Giulia Nanni, Giorgio Lelli, Giulia Schillani, Bruno Biancosino, Tullio Girald. Depression and serotonin transporter (5-HTTLPR) polymorphism in breast cancer patients. Journal of affective disorders. vol 124. issue 3. 2010-10-29. PMID:20122741. |
depression and serotonin transporter (5-httlpr) polymorphism in breast cancer patients. |
2010-10-29 |
2023-08-12 |
Not clear |
| Luigi Grassi, Elena Rossi, Marina Cobianchi, Letizia Aguiari, Marianna Capozzo, Elisabetta Martinis, Maria Giulia Nanni, Giorgio Lelli, Giulia Schillani, Bruno Biancosino, Tullio Girald. Depression and serotonin transporter (5-HTTLPR) polymorphism in breast cancer patients. Journal of affective disorders. vol 124. issue 3. 2010-10-29. PMID:20122741. |
mixed evidence in the general population and medically ill patients has suggested that homozygous carriers of the short allele (s/s) of the serotonin transporter gene-linked polymorphic region (5-httlpr) may increase the risk of depression in comparison with carriers of the long allele (l/l) or s/l. |
2010-10-29 |
2023-08-12 |
Not clear |
| Cullen L Schmid, Laura M Boh. Serotonin, but not N-methyltryptamines, activates the serotonin 2A receptor via a ß-arrestin2/Src/Akt signaling complex in vivo. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 40. 2010-10-29. PMID:20926677. |
this demonstration of agonist-directed 5-ht(2a)r signaling in vivo may significantly impact drug discovery efforts for the treatment of disorders wherein hallucinations are part of the etiology, such as schizophrenia, or manifest as side effects of treatment, such as depression. |
2010-10-29 |
2023-08-12 |
mouse |
| Maria Marsella, Elisabetta Ubaldini, Agostina Solinas, Pietro Guerrin. Prenatal exposure to serotonin reuptake inhibitors: a case report. Italian journal of pediatrics. vol 36. 2010-10-28. PMID:20302650. |
selective serotonin reuptake inhibitor (ssri) antidepressants are considered the primary treatments for depression and anxiety in pregnancy. |
2010-10-28 |
2023-08-12 |
Not clear |
| Anna Baffa, Christa Hohoff, Bernhard T Baune, Carsten Müller-Tidow, Nicola Tidow, Christine Freitag, Peter Zwanzger, Jürgen Deckert, Volker Arolt, Katharina Domschk. Norepinephrine and serotonin transporter genes: impact on treatment response in depression. Neuropsychobiology. vol 62. issue 2. 2010-10-28. PMID:20588071. |
norepinephrine and serotonin transporter genes: impact on treatment response in depression. |
2010-10-28 |
2023-08-12 |
Not clear |
| Anna Baffa, Christa Hohoff, Bernhard T Baune, Carsten Müller-Tidow, Nicola Tidow, Christine Freitag, Peter Zwanzger, Jürgen Deckert, Volker Arolt, Katharina Domschk. Norepinephrine and serotonin transporter genes: impact on treatment response in depression. Neuropsychobiology. vol 62. issue 2. 2010-10-28. PMID:20588071. |
the norepinephrine transporter (net) and serotonin transporter (5-htt) genes constitute promising candidate genes in major depression. |
2010-10-28 |
2023-08-12 |
Not clear |
| Chantal Farra, Khalid Yunis, Mohammad Mikati, Nadine Yazbeck, Marianne Majdalani, Johnny Awwa. Goldenhar syndrome associated with prenatal maternal Fluoxetine ingestion: Cause or coincidence? Birth defects research. Part A, Clinical and molecular teratology. vol 88. issue 7. 2010-10-28. PMID:20641101. |
the drug is a selective serotonin re-uptake inhibitor, the most widely prescribed for the treatment of depression. |
2010-10-28 |
2023-08-12 |
Not clear |
| Vincent Flamand, Hongjuan Zhao, Donna M Peeh. Targeting monoamine oxidase A in advanced prostate cancer. Journal of cancer research and clinical oncology. vol 136. issue 11. 2010-10-27. PMID:20204405. |
inhibitors of monoamine oxidase a (maoa), a mitochondrial enzyme that degrades neurotransmitters including serotonin and norepinephrine, are commonly used to treat neurological conditions including depression. |
2010-10-27 |
2023-08-12 |
Not clear |
| Eugene Oh, Takashi Maejima, Chen Liu, Evan Deneris, Stefan Herlitz. Substitution of 5-HT1A receptor signaling by a light-activated G protein-coupled receptor. The Journal of biological chemistry. vol 285. issue 40. 2010-10-26. PMID:20643652. |
the 5-ht(1a) receptor is a metabotropic g protein-coupled receptor linked to the g(i/o) signaling pathway and has been specifically implicated in the pathogenesis of depression and anxiety. |
2010-10-26 |
2023-08-12 |
mouse |
| Leith C R Meyer, Robyn S Hetem, Linda G Fick, Duncan Mitchell, Andrea Fulle. Effects of serotonin agonists and doxapram on respiratory depression and hypoxemia in etorphine-immobilized impala (Aepyceros melampus). Journal of wildlife diseases. vol 46. issue 2. 2010-10-22. PMID:20688644. |
effects of serotonin agonists and doxapram on respiratory depression and hypoxemia in etorphine-immobilized impala (aepyceros melampus). |
2010-10-22 |
2023-08-12 |
Not clear |
| Hiroki Sato, Ivan Skelin, Mirko Diksi. Chronic buspirone treatment decreases 5-HT1B receptor densities and the serotonin transporter but increases the density of 5-HT2A receptors in the bulbectomized rat model of depression: an autoradiographic study. Brain research. vol 1345. 2010-10-21. PMID:20501324. |
chronic buspirone treatment decreases 5-ht1b receptor densities and the serotonin transporter but increases the density of 5-ht2a receptors in the bulbectomized rat model of depression: an autoradiographic study. |
2010-10-21 |
2023-08-12 |
rat |
| Hiroki Sato, Ivan Skelin, Mirko Diksi. Chronic buspirone treatment decreases 5-HT1B receptor densities and the serotonin transporter but increases the density of 5-HT2A receptors in the bulbectomized rat model of depression: an autoradiographic study. Brain research. vol 1345. 2010-10-21. PMID:20501324. |
the deregulation of the serotonergic (5-ht) system is implicated in the pathophysiology of depression. |
2010-10-21 |
2023-08-12 |
rat |
| Hiroki Sato, Ivan Skelin, Mirko Diksi. Chronic buspirone treatment decreases 5-HT1B receptor densities and the serotonin transporter but increases the density of 5-HT2A receptors in the bulbectomized rat model of depression: an autoradiographic study. Brain research. vol 1345. 2010-10-21. PMID:20501324. |
buspirone is a partial agonist of 5-ht(1a) receptors and is used in the treatment of depression and anxiety. |
2010-10-21 |
2023-08-12 |
rat |
| Ramez Ghanbari, Mostafa El Mansari, Pierre Blie. Sustained administration of trazodone enhances serotonergic neurotransmission: in vivo electrophysiological study in the rat brain. The Journal of pharmacology and experimental therapeutics. vol 335. issue 1. 2010-10-21. PMID:20647493. |
the enhanced 5-ht neurotransmission by trazodone is caused in part by reuptake blockade and activation of postsynaptic 5-ht(1a) receptors, which may account for its effectiveness in major depression. |
2010-10-21 |
2023-08-12 |
rat |
| Petros Skapinakis, Eleni Bakola, Georgia Salanti, Glyn Lewis, Athanasios P Kyritsis, Venetsanos Mavrea. Efficacy and acceptability of selective serotonin reuptake inhibitors for the treatment of depression in Parkinson's disease: a systematic review and meta-analysis of randomized controlled trials. BMC neurology. vol 10. 2010-10-19. PMID:20565960. |
efficacy and acceptability of selective serotonin reuptake inhibitors for the treatment of depression in parkinson's disease: a systematic review and meta-analysis of randomized controlled trials. |
2010-10-19 |
2023-08-12 |
Not clear |
| Petros Skapinakis, Eleni Bakola, Georgia Salanti, Glyn Lewis, Athanasios P Kyritsis, Venetsanos Mavrea. Efficacy and acceptability of selective serotonin reuptake inhibitors for the treatment of depression in Parkinson's disease: a systematic review and meta-analysis of randomized controlled trials. BMC neurology. vol 10. 2010-10-19. PMID:20565960. |
selective serotonin reuptake inhibitors (ssris) are the most commonly prescribed antidepressants for the treatment of depression in patients with parkinson's disease (pd) but data on their efficacy are controversial. |
2010-10-19 |
2023-08-12 |
Not clear |