| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Olivier Lambert, Michel Bouri. SNRIs: mechanism of action and clinical features. Expert review of neurotherapeutics. vol 2. issue 6. 2010-06-28. PMID:19810918. |
the double polarity of the reuptake inhibition of serotonin and norepinephrine ensures a profile of effectiveness comparable to tricyclic antidepressants and higher than selective serotonin reuptake inhibitors, especially in severe depression. |
2010-06-28 |
2023-08-12 |
Not clear |
| Olivier Lambert, Michel Bouri. SNRIs: mechanism of action and clinical features. Expert review of neurotherapeutics. vol 2. issue 6. 2010-06-28. PMID:19810918. |
for all these reasons, one can reasonably conclude that serotonin and norepinephrine reuptake inhibitors represent the therapeutic of choice in depression and that their prescription is likely to strongly increase in the years to come. |
2010-06-28 |
2023-08-12 |
Not clear |
| Seth J Gillihan, Hengyi Rao, Jiongjiong Wang, John A Detre, Jessica Breland, Geena Mary V Sankoorikal, Edward S Brodkin, Martha J Fara. Serotonin transporter genotype modulates amygdala activity during mood regulation. Social cognitive and affective neuroscience. vol 5. issue 1. 2010-06-28. PMID:19858108. |
recent studies have implicated the short allele of the serotonin transporter-linked polymorphic region (5-httlpr) in depression vulnerability, particularly in the context of stress. |
2010-06-28 |
2023-08-12 |
human |
| Stuart J Warden, Sean M Hassett, Julie L Bond, Johanna Rydberg, Jamie D Grogg, Erin L Hilles, Elizabeth D Bogenschutz, Heather D Smith, Robyn K Fuchs, M Michael Bliziotes, Charles H Turne. Psychotropic drugs have contrasting skeletal effects that are independent of their effects on physical activity levels. Bone. vol 46. issue 4. 2010-06-28. PMID:20060080. |
the observed negative skeletal effect of 5-htt inhibition, combined with recent findings of direct and indirect effects of 5-ht on bone formation, are of interest given the frequent prescription of ssris for the treatment of depression and other affective disorders. |
2010-06-28 |
2023-08-12 |
mouse |
| Tsutomu Furuse, Kenji Hashimot. Fluvoxamine monotherapy for psychotic depression: the potential role of sigma-1 receptors. Annals of general psychiatry. vol 8. 2010-06-25. PMID:20025739. |
a number of clinical studies have demonstrated the efficacy of the combination of an antidepressant (for example, a tricyclic antidepressant or selective serotonin reuptake inhibitor (ssri)) and an atypical antipsychotic or electroconvulsive therapy in treating psychotic depression. |
2010-06-25 |
2023-08-12 |
Not clear |
| Jiu-yu Tang, Yuan-shan Zeng, Qiao-ge Chen, Ya-jing Qin, Sui-jun Chen, Zhi-qiang Zhon. [Effects of Valerian on the level of 5-hydroxytryptamine, cell proliferation and neurons in cerebral hippocampus of rats with depression induced by chronic mild stress]. Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine. vol 6. issue 3. 2010-06-24. PMID:18334150. |
[effects of valerian on the level of 5-hydroxytryptamine, cell proliferation and neurons in cerebral hippocampus of rats with depression induced by chronic mild stress]. |
2010-06-24 |
2023-08-12 |
rat |
| Jiu-yu Tang, Yuan-shan Zeng, Qiao-ge Chen, Ya-jing Qin, Sui-jun Chen, Zhi-qiang Zhon. [Effects of Valerian on the level of 5-hydroxytryptamine, cell proliferation and neurons in cerebral hippocampus of rats with depression induced by chronic mild stress]. Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine. vol 6. issue 3. 2010-06-24. PMID:18334150. |
to explore the effects of valerian on the level of 5-hydroxytryptamine (5-ht), cell proliferation and neuron number in cerebral hippocampus of rats with depression induced by chronic mild stress. |
2010-06-24 |
2023-08-12 |
rat |
| Justin H G Williams, David I Perrett, Gordon D Waiter, Stephen Peche. Differential effects of tryptophan depletion on emotion processing according to face direction. Social cognitive and affective neuroscience. vol 2. issue 4. 2010-06-23. PMID:18985132. |
these changes could be adaptive in a threatening context and markedly affect empathic function in conditions associated with impaired serotonin function, such as depression and autism. |
2010-06-23 |
2023-08-12 |
Not clear |
| William L Coventry, Michael R James, Lindon J Eaves, Scott D Gordon, Nathan A Gillespie, Leanne Ryan, Andrew C Heath, Grant W Montgomery, Nicholas G Martin, Naomi R Wra. Do 5HTTLPR and stress interact in risk for depression and suicidality? Item response analyses of a large sample. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 153B. issue 3. 2010-06-23. PMID:19911410. |
the reported interaction between the length polymorphism (5httlpr) in the serotonin transporter gene (slc6a4) and stressful life events on depression has led to many attempts to replicate but with inconsistent results. |
2010-06-23 |
2023-08-12 |
human |
| Ulrike Böer, Christine Noll, Irmgard Cierny, Doris Krause, Christoph Hiemke, Willhart Knepe. A common mechanism of action of the selective serotonin reuptake inhibitors citalopram and fluoxetine: reversal of chronic psychosocial stress-induced increase in CRE/CREB-directed gene transcription in transgenic reporter gene mice. European journal of pharmacology. vol 633. issue 1-3. 2010-06-22. PMID:20122921. |
recently, chronic psychosocial stress as animal model of depression has been shown to stimulate creb transcriptional activity in the brain; this stimulation was prevented by treatment with the antidepressant imipramine, which inhibits both noradrenaline and serotonin reuptake. |
2010-06-22 |
2023-08-12 |
mouse |
| Avram J Holmes, Ryan Bogdan, Diego A Pizzagall. Serotonin transporter genotype and action monitoring dysfunction: a possible substrate underlying increased vulnerability to depression. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 35. issue 5. 2010-06-21. PMID:20090673. |
serotonin transporter genotype and action monitoring dysfunction: a possible substrate underlying increased vulnerability to depression. |
2010-06-21 |
2023-08-12 |
human |
| O J Robinson, R Cools, M J Crockett, B J Sahakia. Mood state moderates the role of serotonin in cognitive biases. Journal of psychopharmacology (Oxford, England). vol 24. issue 4. 2010-06-18. PMID:19164497. |
reduction of the monoamine serotonin (5-ht) via the dietary manipulation of tryptophan (acute tryptophan depletion; atd) has been shown to induce negative cognitive biases similar to those found in depression in healthy individuals. |
2010-06-18 |
2023-08-12 |
human |
| H W Chase, A Michael, E T Bullmore, B J Sahakian, T W Robbin. Paradoxical enhancement of choice reaction time performance in patients with major depression. Journal of psychopharmacology (Oxford, England). vol 24. issue 4. 2010-06-18. PMID:19406853. |
this rt difference is sensitive to manipulations and individual differences in the serotonin (5-ht) system, but the crrt task performance has not yet been examined in patients with depression. |
2010-06-18 |
2023-08-12 |
human |
| Mark Berthold-Losleben, Hubertus Himmeric. The TNF-alpha system: functional aspects in depression, narcolepsy and psychopharmacology. Current neuropharmacology. vol 6. issue 3. 2010-06-18. PMID:19506720. |
tnf-alpha might, for example, contribute to the pathogenesis of depression by an activation of the hypothalamo-pituitary-adrenocortical (hpa) axis, an activation of neuronal serotonin transporters and the stimulation of the indoleamine 2,3-dioxygenase which leads to tryptophan depletion. |
2010-06-18 |
2023-08-12 |
Not clear |
| Ramamoorthy Rajkumar, Radhakrishnan Mahes. The auspicious role of the 5-HT3 receptor in depression: a probable neuronal target? Journal of psychopharmacology (Oxford, England). vol 24. issue 4. 2010-06-18. PMID:20123937. |
nevertheless, the reports on polymorphism of serotonin type-3 receptor genes and data from clinical studies (on serotonin type-3 receptor antagonists) were insufficient to corroborate the involvement of this receptor in the neurobiology of depression. |
2010-06-18 |
2023-08-12 |
Not clear |
| Narihiro Toda, Tsugio Kaneko, Hiroshi Koge. Development of an efficient therapeutic agent for Alzheimer's disease: design and synthesis of dual inhibitors of acetylcholinesterase and serotonin transporter. Chemical & pharmaceutical bulletin. vol 58. issue 3. 2010-06-15. PMID:20190429. |
since patients of alzheimer's disease often exhibit depression as well as memory impairment, dual inhibitors of ache and serotonin transporter (sert) would be a better therapeutic method. |
2010-06-15 |
2023-08-12 |
mouse |
| Srijan Sen, Henry R Kranzler, John H Krystal, Heather Speller, Grace Chan, Joel Gelernter, Constance Guill. A prospective cohort study investigating factors associated with depression during medical internship. Archives of general psychiatry. vol 67. issue 6. 2010-06-15. PMID:20368500. |
recent reports of a moderating effect of a genetic polymorphism (5-httlpr) in the serotonin transporter protein gene on the likelihood that life stress will precipitate depression may help to understand the development of mood symptoms in medical interns. |
2010-06-15 |
2023-08-12 |
Not clear |
| Ciro Costagliola, Francesco Parmeggiani, Francesco Semeraro, Adolfo Sebastian. Selective serotonin reuptake inhibitors: a review of its effects on intraocular pressure. Current neuropharmacology. vol 6. issue 4. 2010-06-11. PMID:19587851. |
the increase in serotonin (5-ht) neurotransmission is considered to be one of the most efficacious medical approach to depression and its related disorders. |
2010-06-11 |
2023-08-12 |
Not clear |
| David M Marks, Chi-Un Pae, Ashwin A Patka. Triple reuptake inhibitors: the next generation of antidepressants. Current neuropharmacology. vol 6. issue 4. 2010-06-11. PMID:19587855. |
depression has been associated with impaired neurotransmission of serotonergic, norepinephrinergic, and dopaminergic pathways, although most pharmacologic treatment strategies for depression enhance only serotonin and norepinephrine neurotransmission. |
2010-06-11 |
2023-08-12 |
Not clear |
| Yiyun Huang, Wendol A William. Enhanced selective serotonin re-uptake inhibitors as antidepressants: 2004 - 2006. Expert opinion on therapeutic patents. vol 17. issue 8. 2010-06-09. PMID:20144065. |
the advent of selective serotonin re-uptake inhibitors as antidepressants has been a revolutionary advance in the treatment of depression and related disorders. |
2010-06-09 |
2023-08-12 |
Not clear |