| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jens Drachmann Bukh, Camilla Bock, Maj Vinberg, Thomas Werge, Ulrik Gether, Lars Vedel Kessin. Interaction between genetic polymorphisms and stressful life events in first episode depression. Journal of affective disorders. vol 119. issue 1-3. 2010-01-12. PMID:19339052. |
a polymorphism in the serotonin transporter (5-htt) gene seems to moderate the influence of stressful life events on depression. |
2010-01-12 |
2023-08-12 |
human |
| George S Alexopoulos, Christopher F Murphy, Faith M Gunning-Dixon, Charles E Glatt, Vassilios Latoussakis, Robert E Kelly, Dora Kanellopoulos, Sibel Klimstra, Kelvin O Lim, Robert C Young, Matthew J Hoptma. Serotonin transporter polymorphisms, microstructural white matter abnormalities and remission of geriatric depression. Journal of affective disorders. vol 119. issue 1-3. 2010-01-12. PMID:19375170. |
serotonin transporter polymorphisms, microstructural white matter abnormalities and remission of geriatric depression. |
2010-01-12 |
2023-08-12 |
Not clear |
| George S Alexopoulos, Christopher F Murphy, Faith M Gunning-Dixon, Charles E Glatt, Vassilios Latoussakis, Robert E Kelly, Dora Kanellopoulos, Sibel Klimstra, Kelvin O Lim, Robert C Young, Matthew J Hoptma. Serotonin transporter polymorphisms, microstructural white matter abnormalities and remission of geriatric depression. Journal of affective disorders. vol 119. issue 1-3. 2010-01-12. PMID:19375170. |
this study compared microstructural abnormalities in depressed elders and controls and studied the association of the serotonin transporter gene status to white matter abnormalities and to remission of depression. |
2010-01-12 |
2023-08-12 |
Not clear |
| Laura A León, Jesus Landeira-Fernandez, Fernando P Cardena. Effects of chronic intracerebroventricular 3,4-methylenedioxy-N-methamphetamine (MDMA) or fluoxetine on the active avoidance test in rats with or without exposure to mild chronic stress. Behavioural brain research. vol 205. issue 1. 2010-01-12. PMID:19589359. |
in despite the similarity of mechanisms of action between both selective serotonin reuptake inhibitors (ssri) and mdma (main compound of "ecstasy") there are relatively few reports on the effects of the later on animal models of depression. |
2010-01-12 |
2023-08-12 |
rat |
| Wen-jiao Min, Xiao-hong Ma, Tao Li, Bo Zhang, Xue-li Su. [Association of serotonin and norepinephrine transporter gene polymorphisms with the susceptibility to depression]. Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics. vol 26. issue 4. 2010-01-12. PMID:20017301. |
[association of serotonin and norepinephrine transporter gene polymorphisms with the susceptibility to depression]. |
2010-01-12 |
2023-08-12 |
Not clear |
| Wen-jiao Min, Xiao-hong Ma, Tao Li, Bo Zhang, Xue-li Su. [Association of serotonin and norepinephrine transporter gene polymorphisms with the susceptibility to depression]. Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics. vol 26. issue 4. 2010-01-12. PMID:20017301. |
to determine whether the serotonin transporter (5-htt) and norepinephrine transporter (net) gene polymorphisms were associated with the susceptibility to depression. |
2010-01-12 |
2023-08-12 |
Not clear |
| Agomelatine: new drug. Adverse effects and no proven efficacy. Prescrire international. vol 18. issue 104. 2010-01-12. PMID:20020562. |
(1) when an antidepressant is considered a necessary addition to psychological support in treating patients with depression, the first-line drug is a tricyclic such as clomipramine or a selective serotonin reuptake inhibitor (ssri) such as paroxetine; (2) agomelatine, a melatonin receptor agonist, is approved in the european union for the treatment of depression; (3) available evaluation does not include any clinical trials designed to compare the efficacy of agomelatine with that of a tricyclic or a selective serotonin reuptake inhibitor. |
2010-01-12 |
2023-08-12 |
Not clear |
| Rotraut Mössner, Gerthild Stiens, Inke R König, Diane Schmidt, Anja Platzer, Ullrich Krüger, Kristian Reic. Analysis of a functional serotonin transporter promoter polymorphism in psoriasis vulgaris. Archives of dermatological research. vol 301. issue 6. 2010-01-11. PMID:18979110. |
a functional length polymorphism in the promoter of the serotonin transporter gene (5-httlpr) has been implicated in the genetic background of depression. |
2010-01-11 |
2023-08-12 |
Not clear |
| Dakshayani Kadiyala Babu, Alain Diaz, Thangavel Samikkannu, Kurapati V K Rao, Zainulabedin M Saiyed, Jose W Rodriguez, Madhavan P N Nai. Upregulation of serotonin transporter by alcohol in human dendritic cells: possible implication in neuroimmune deregulation. Alcoholism, clinical and experimental research. vol 33. issue 10. 2010-01-11. PMID:19572987. |
the enzyme monoamine oxidase-a (mao-a) degrades 5-ht that is associated with clinical depression and other neurological disorders. |
2010-01-11 |
2023-08-12 |
human |
| Tultul Nayyar, Michael Bubser, Marcus C Ferguson, M Diana Neely, J Shawn Goodwin, Thomas J Montine, Ariel Y Deutch, Twum A Ansa. Cortical serotonin and norepinephrine denervation in parkinsonism: preferential loss of the beaded serotonin innervation. The European journal of neuroscience. vol 30. issue 2. 2010-01-08. PMID:19659923. |
our findings point to a major loss of the 5-ht and ne innervations of the cortex in mptp-induced parkinsonism, and suggest that loss of the beaded cortical 5-ht innervation is associated with a predisposition to the development of depression in pd. |
2010-01-08 |
2023-08-12 |
mouse |
| Alexandra Schosser, Siegfried Kaspe. The role of pharmacogenetics in the treatment of depression and anxiety disorders. International clinical psychopharmacology. vol 24. issue 6. 2010-01-07. PMID:19738481. |
two functional polymorphisms of the serotonin transporter gene, 5-httlpr and stin2 have been investigated in a large number of pharmacogenetic studies of depression; other candidate genes include serotonin receptor genes, brain-derived neurotrophic factor, p-glycoprotein (located in the blood-brain barrier), g-proteins, tph1 and tph2, maoa, the noradrenaline transporter gene, fkbp5, or cytochrome p450 (cyp450) genes. |
2010-01-07 |
2023-08-12 |
Not clear |
| Phil Skolnick, Piotr Popik, Ramon Trulla. Glutamate-based antidepressants: 20 years on. Trends in pharmacological sciences. vol 30. issue 11. 2010-01-06. PMID:19837463. |
drugs increasing the synaptic availability of serotonin and norepinephrine (biogenic amine-based agents) have been used to treat depression for more than 50 years. |
2010-01-06 |
2023-08-12 |
Not clear |
| John R Cashman, Senait Ghirma. Inhibition of serotonin and norepinephrine reuptake and inhibition of phosphodiesterase by multi-target inhibitors as potential agents for depression. Bioorganic & medicinal chemistry. vol 17. issue 19. 2010-01-04. PMID:19740668. |
inhibition of serotonin and norepinephrine reuptake and inhibition of phosphodiesterase by multi-target inhibitors as potential agents for depression. |
2010-01-04 |
2023-08-12 |
Not clear |
| Michel Bourin, Franck Chenu, Corina Prica, Martine Hascoë. Augmentation effect of combination therapy of aripiprazole and antidepressants on forced swimming test in mice. Psychopharmacology. vol 206. issue 1. 2009-12-29. PMID:19517098. |
a deficiency in brain monoamine systems (serotonin, dopamine, and/or norepinephrine) have long been hypothesized for the pathogenesis of depression. |
2009-12-29 |
2023-08-12 |
mouse |
| Britta Haenisch, Karoline Linsel, Michael Brüss, Ralf Gilsbach, Peter Propping, Markus M Nöthen, Marcella Rietschel, Rolf Fimmers, Wolfgang Maier, Astrid Zobel, Susanne Höfels, Vera Guttenthaler, Manfred Göthert, Heinz Bönisc. Association of major depression with rare functional variants in norepinephrine transporter and serotonin1A receptor genes. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 150B. issue 7. 2009-12-28. PMID:19105200. |
the present study aimed at investigating whether these net and 5-ht(1a) receptor variants are associated with major depression (md). |
2009-12-28 |
2023-08-12 |
human |
| Britta Haenisch, Karoline Linsel, Michael Brüss, Ralf Gilsbach, Peter Propping, Markus M Nöthen, Marcella Rietschel, Rolf Fimmers, Wolfgang Maier, Astrid Zobel, Susanne Höfels, Vera Guttenthaler, Manfred Göthert, Heinz Bönisc. Association of major depression with rare functional variants in norepinephrine transporter and serotonin1A receptor genes. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 150B. issue 7. 2009-12-28. PMID:19105200. |
in conclusion, our results favor the hypothesis that monoaminergic neurotransmission in general and the f528c net and r219l 5-ht(1a) receptor variants in particular are involved in the pathogenesis of depression. |
2009-12-28 |
2023-08-12 |
human |
| P Rucci, V L Nimgaonkar, H Mansour, M Miniati, I Masala, A Fagiolini, G B Cassano, E Fran. Gender moderates the relationship between mania spectrum and serotonin transporter polymorphisms in depression. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 150B. issue 7. 2009-12-28. PMID:19125390. |
gender moderates the relationship between mania spectrum and serotonin transporter polymorphisms in depression. |
2009-12-28 |
2023-08-12 |
Not clear |
| P Rucci, V L Nimgaonkar, H Mansour, M Miniati, I Masala, A Fagiolini, G B Cassano, E Fran. Gender moderates the relationship between mania spectrum and serotonin transporter polymorphisms in depression. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 150B. issue 7. 2009-12-28. PMID:19125390. |
the short (s) variant of the serotonin transporter gene linked functional polymorphic region (5-httlpr) is associated with depression. |
2009-12-28 |
2023-08-12 |
Not clear |
| Laura Thomas, Jean Mulligan, Victoria Mason, Debbie Tallon, Nicola Wiles, Philip Cowen, David Nutt, Michael O'Donovan, Deborah Sharp, Tim Peters, Glyn Lewi. GENetic and clinical predictors of treatment response in depression: the GenPod randomised trial protocol. Trials. vol 9. 2009-12-22. PMID:18498636. |
the most effective pharmacological treatments for depression inhibit the transporters that reuptake serotonin (selective serotonin reuptake inhibitors - ssris) and noradrenaline (noradrenaline reuptake inhibitors - naris) into the presynaptic terminal. |
2009-12-22 |
2023-08-12 |
Not clear |
| Giuseppe Marano, Desiree Harnic, Marzia Lotrionte, Giuseppe Biondi-Zoccai, Antonio Abbate, Enrico Romagnoli, Marianna Mazz. Depression and the cardiovascular system: increasing evidence of a link and therapeutic implications. Expert review of cardiovascular therapy. vol 7. issue 9. 2009-12-21. PMID:19764865. |
tricyclic antidepressants have various effects on the cardiovascular system, while selective serotonin reuptake inhibitors are not associated with adverse cardiac effects and should, therefore, be the preferred choice for the treatment of most patients with comorbid depression and cardiovascular disease. |
2009-12-21 |
2023-08-12 |
Not clear |