| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| E L van Donkelaar, L Ferrington, A Blokland, H W M Steinbusch, J Prickaerts, P A T Kell. Acute tryptophan depletion in rats alters the relationship between cerebral blood flow and glucose metabolism independent of central serotonin. Neuroscience. vol 163. issue 2. 2009-12-14. PMID:19580853. |
depression is associated with both central 5-ht dysfunction and abnormalities in the normal relationship between regional cerebral blood flow (cbf) and glucose metabolism (cmrg). |
2009-12-14 |
2023-08-12 |
rat |
| Ian M Goodyer, Alison Bacon, Maria Ban, Tim Croudace, Joe Herber. Serotonin transporter genotype, morning cortisol and subsequent depression in adolescents. The British journal of psychiatry : the journal of mental science. vol 195. issue 1. 2009-12-11. PMID:19567894. |
serotonin transporter genotype, morning cortisol and subsequent depression in adolescents. |
2009-12-11 |
2023-08-12 |
Not clear |
| Paul T Franci. Biochemical and pathological correlates of cognitive and behavioural change in DLB/PDD. Journal of neurology. vol 256 Suppl 3. 2009-12-11. PMID:19711117. |
in contrast to previous studies of ad, our results indicate that there is no association between depression and the 5-ht transporter, while there was a significant increase in the number of 5-ht1a receptors in those dlb/pdd patients with depression. |
2009-12-11 |
2023-08-12 |
Not clear |
| Eva L van Donkelaar, Daniël L A van den Hove, Arjan Blokland, Harry W M Steinbusch, Jos Prickaert. Stress-mediated decreases in brain-derived neurotrophic factor as potential confounding factor for acute tryptophan depletion-induced neurochemical effects. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 19. issue 11. 2009-12-09. PMID:19640687. |
acute tryptophan depletion (atd) is extensively used to investigate the implication of serotonin (5-hydroxytryptamine; 5-ht) in the onset and treatment of depression and cognitive disorders. |
2009-12-09 |
2023-08-12 |
rat |
| Ming-Ling Wu, Jou-Fang Den. Serotonin toxicity caused by moclobemide too soon after paroxetine-selegiline. Journal of the Chinese Medical Association : JCMA. vol 72. issue 8. 2009-12-09. PMID:19687003. |
physicians managing patients with depression must be aware of the potential for serotonin toxicity and should be able to recognize and treat or, ideally, anticipate and avoid this pharmacodynamically-mediated interaction that may occur between prescribed drugs. |
2009-12-09 |
2023-08-12 |
Not clear |
| Amy L Salisbury, Kathryn L Ponder, James F Padbury, Barry M Leste. Fetal effects of psychoactive drugs. Clinics in perinatology. vol 36. issue 3. 2009-12-08. PMID:19732616. |
this article describes the effects of three drugs with similar molecular targets that involve monoaminergic transmitter systems: cocaine, methamphetamine, and selective serotonin re-uptake inhibitors (ssris) used to treat maternal depression during pregnancy. |
2009-12-08 |
2023-08-12 |
Not clear |
| Amee Krishnakumar, M S Nandhu, C S Paulos. Upregulation of 5-HT2C receptors in hippocampus of pilocarpine-induced epileptic rats: antagonism by Bacopa monnieri. Epilepsy & behavior : E&B. vol 16. issue 2. 2009-12-07. PMID:19700373. |
the present study was carried out to investigate the role of bacopa monnieri extract in hippocampus of pilocarpine-induced temporal lobe epileptic rats through the 5-ht(2c) receptor in relation to depression. |
2009-12-07 |
2023-08-12 |
rat |
| Maria C Rodriguez-Oroz, Marjan Jahanshahi, Paul Krack, Irene Litvan, Raúl Macias, Erwan Bezard, José A Obes. Initial clinical manifestations of Parkinson's disease: features and pathophysiological mechanisms. The Lancet. Neurology. vol 8. issue 12. 2009-12-07. PMID:19909911. |
apathy, anxiety, and depression are the main psychiatric manifestations in untreated pd, which might be caused by ventral striatum dopaminergic deficit and depletion of serotonin and norepinephrine. |
2009-12-07 |
2023-08-12 |
Not clear |
| Susanne Nikolaus, Christina Antke, Hans-Wilhelm Mülle. In vivo imaging of synaptic function in the central nervous system: II. Mental and affective disorders. Behavioural brain research. vol 204. issue 1. 2009-12-01. PMID:19523495. |
results on both dopaminergic and serotonergic neurotransmission are inconsistent in both major depressive disorder and bipolar illness, and fail to clearly agree with the dopamine and/or serotonin hypothesis of depression. |
2009-12-01 |
2023-08-12 |
human |
| Nina Alexander, Yvonne Kuepper, Anja Schmitz, Roman Osinsky, Eva Kozyra, Juergen Henni. Gene-environment interactions predict cortisol responses after acute stress: implications for the etiology of depression. Psychoneuroendocrinology. vol 34. issue 9. 2009-11-24. PMID:19410377. |
growing evidence suggests that the serotonin transporter polymorphism (5-httlpr) interacts with adverse environmental influences to produce an increased risk for the development of depression while the underlying mechanisms of this association remain largely unexplored. |
2009-11-24 |
2023-08-12 |
Not clear |
| Brijesh G Taksande, Nandkishor R Kotagale, Sunil J Tripathi, Rajesh R Ugale, Chandrabhan T Chopd. Antidepressant like effect of selective serotonin reuptake inhibitors involve modulation of imidazoline receptors by agmatine. Neuropharmacology. vol 57. issue 4. 2009-11-24. PMID:19589348. |
recent findings demonstrated the dysregulation of imidazoline receptor binding sites in major depression and their normalization by chronic treatment with antidepressants including selective serotonin reuptake inhibitors (ssris). |
2009-11-24 |
2023-08-12 |
mouse |
| Mitchel A Kling, Victoria H Coleman, Jay Schulki. Glucocorticoid inhibition in the treatment of depression: can we think outside the endocrine hypothalamus? Depression and anxiety. vol 26. issue 7. 2009-11-23. PMID:19133699. |
selective serotonin reuptake inhibitors are commonly prescribed to treat depression, but may not be as effective for more severe or persistent depression. |
2009-11-23 |
2023-08-12 |
Not clear |
| V Trajkovska, M A Santini, A B Marcussen, M S Thomsen, H H Hansen, J D Mikkelsen, L Arneberg, M Kokaia, G M Knudsen, S Azna. BDNF downregulates 5-HT(2A) receptor protein levels in hippocampal cultures. Neurochemistry international. vol 55. issue 7. 2009-11-17. PMID:19563850. |
both brain-derived neurotrophic factor (bdnf) and the serotonin receptor 2a (5-ht(2a)) have been related to depression pathology. |
2009-11-17 |
2023-08-12 |
mouse |
| Alessandra Tamburella, Vincenzo Micale, Andrea Navarria, Filippo Drag. Antidepressant properties of the 5-HT4 receptor partial agonist, SL65.0155: behavioral and neurochemical studies in rats. Progress in neuro-psychopharmacology & biological psychiatry. vol 33. issue 7. 2009-11-17. PMID:19596038. |
these findings give further support to the hypothesis that the stimulation of serotonin 5-ht(4) receptors may be a therapeutic target for depression. |
2009-11-17 |
2023-08-12 |
rat |
| Maria Anna Capozzo, Giulia Schillani, Eugenio Aguglia, Maurizio De Vanna, Luigi Grassi, Maria Anna Conte, Tullio Girald. Serotonin transporter 5-HTTLPR polymorphism and response to citalopram in terminally ill cancer patients: report of twenty-one cases. Tumori. vol 95. issue 4. 2009-11-17. PMID:19856660. |
when the effects of citalopram were analyzed in relation to the 5-httlpr polymorphism, the hads depression score was significantly decreased only in patients with the "l/l" allelic variant of the serotonin transporter conferring high functional activity, while the score of the mini-mac fatalism scale was significantly increased in patients carrying at least one "s" allele. |
2009-11-17 |
2023-08-12 |
Not clear |
| Wenjiao Min, Tao Li, Xiaohong Ma, Zhengyu Li, Tao Yu, Dong Gao, Bo Zhang, Yang Yun, Xueli Su. Monoamine transporter gene polymorphisms affect susceptibility to depression and predict antidepressant response. Psychopharmacology. vol 205. issue 3. 2009-11-16. PMID:19468717. |
we aimed to determine the potential correlations of 5-htt/net gene polymorphisms with the susceptibility to depression and the antidepressant response to selective serotonin reuptake inhibitors (ssris) or dual selective serotonin/norepinephrine reuptake inhibitors (snris). |
2009-11-16 |
2023-08-12 |
Not clear |
| Cecilia Aslund, Jerzy Leppert, Erika Comasco, Niklas Nordquist, Lars Oreland, Kent W Nilsso. Impact of the interaction between the 5HTTLPR polymorphism and maltreatment on adolescent depression. A population-based study. Behavior genetics. vol 39. issue 5. 2009-11-16. PMID:19582567. |
the present study investigated whether a functional polymorphism (5httlpr) of the serotonin transporter gene interacts with maltreatment in the prediction of depression. |
2009-11-16 |
2023-08-12 |
Not clear |
| B-T Lee, H-Y Lee, B-C Lee, C-U Pae, B-J Yoon, S-G Ryu, I-G Choi, M-S Lee, B-J Ha. Impact of the tryptophan hydroxylase 1 gene A218C polymorphism on amygdala activity in response to affective facial stimuli in patients with major depressive disorder. Genes, brain, and behavior. vol 8. issue 5. 2009-11-10. PMID:19500158. |
tryptophan hydroxylase-1 (tph1) is the rate-limiting enzyme in serotonin biosynthesis, and allelic variations at the tph1 locus have been implicated in the pathophysiology of depression. |
2009-11-10 |
2023-08-12 |
human |
| Ulla Knorr, Maj Vinberg, Marianne Klose, Ulla Feldt-Rasmussen, Linda Hilsted, Anders Gade, Eva Haastrup, Olaf Paulson, Jørn Wetterslev, Christian Gluud, Ulrik Gether, Lars Kessin. Rationale and design of the participant, investigator, observer, and data-analyst-blinded randomized AGENDA trial on associations between gene-polymorphisms, endophenotypes for depression and antidepressive intervention: the effect of escitalopram versus placebo on the combined dexamethasone-corticotrophine releasing hormone test and other potential endophenotypes in healthy first-degree relatives of persons with depression. Trials. vol 10. 2009-11-10. PMID:19671139. |
we hypothesize that potential endophenotypes for depression may be affected by selective serotonin re-uptake inhibitor antidepressants in healthy first-degree relatives of depressed patients. |
2009-11-10 |
2023-08-12 |
human |
| Tracy L Skaer, David A Sclar, Linda M Robiso. Trends in prescriptions for antidepressant pharmacotherapy among US children and adolescents diagnosed with depression, 1990 through 2001: an assessment of accordance with treatment recommendations from the American Academy of Child and Adolescent Psychiatry. Clinical therapeutics. vol 31 Pt 1. 2009-11-09. PMID:19698905. |
in 1998, the american academy of child and adolescent psychiatry (aacap) published a position paper supporting the use of selective serotonin reuptake inhibitors (ssris) as first-line pharmacotherapy for the treatment of depression among children and adolescents. |
2009-11-09 |
2023-08-12 |
Not clear |