| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Ebinger, C Sievers, D Ivan, H J Schneider, G K Stall. Is there a neuroendocrinological rationale for testosterone as a therapeutic option in depression? Journal of psychopharmacology (Oxford, England). vol 23. issue 7. 2009-11-04. PMID:18562400. |
many hormones and neurotransmitters are involved in the aetiology and the course of depression including serotonin, dopamine, noradrenaline, vasopressin and cortisol. |
2009-11-04 |
2023-08-12 |
Not clear |
| Marat G Uzbeko. Antidepressant action of tianeptine is connected with acceleration of serotonin turnover in the synapse: a hypothesis. Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology. vol 11. issue 2. 2009-11-04. PMID:19827315. |
based on the results of our investigation of patients with anxious depression under the treatment with serotonergic antidepressants with different mechanism of action on serotonin reuptake we, the first time in the literature, propose the hypothesis about neurochemical mechanism of tianeptine action. |
2009-11-04 |
2023-08-12 |
Not clear |
| Nadja Osterberg, Eleni Rouss. Characterization of primary neurospheres generated from mouse ventral rostral hindbrain. Cell and tissue research. vol 336. issue 1. 2009-11-03. PMID:19224248. |
serotonergic (5-ht) neurons of the reticular formation play a key role in the modulation of behavior, and their dysfunction is associated with severe neurological and psychiatric disorders, such as depression and schizophrenia. |
2009-11-03 |
2023-08-12 |
mouse |
| Rudolf Uher, Patricia Huezo-Diaz, Nader Perroud, Rebecca Smith, Marcella Rietschel, Ole Mors, Joanna Hauser, Wolfgang Maier, Dejan Kozel, Neven Henigsberg, Mara Barreto, Anna Placentino, Mojca Zvezdana Dernovsek, Thomas G Schulze, Petra Kalember, Astrid Zobel, Piotr M Czerski, Erik Roj Larsen, Daniel Souery, Caterina Giovannini, Joanna M Gray, Cathryn M Lewis, Anne Farmer, Katherine J Aitchison, Peter McGuffin, Ian Crai. Genetic predictors of response to antidepressants in the GENDEP project. The pharmacogenomics journal. vol 9. issue 4. 2009-11-02. PMID:19365399. |
the objective of the genome-based therapeutic drugs for depression study is to investigate the function of variations in genes encoding key proteins in serotonin, norepinephrine, neurotrophic and glucocorticoid signaling in determining the response to serotonin-reuptake-inhibiting and norepinephrine-reuptake-inhibiting antidepressants. |
2009-11-02 |
2023-08-12 |
Not clear |
| Julien Mendlewic. Disruption of the circadian timing systems: molecular mechanisms in mood disorders. CNS drugs. vol 23 Suppl 2. 2009-11-02. PMID:19708722. |
in association studies, increased susceptibility to depression has been noted in those with polymorphisms in the following: d-amino-acid-oxidase activator/g30 gene complex, glucocorticoid receptor gene, serotonin transporter gene, tryptophan hydroxylase 2 gene, dopamine transporter gene and g protein-coupled receptor 50 gene. |
2009-11-02 |
2023-08-12 |
Not clear |
| Guy M Goodwi. Clinical studies on the efficacy of agomelatine on depressive symptoms. CNS drugs. vol 23 Suppl 2. 2009-11-02. PMID:19708724. |
the novel mechanism of action of agomelatine, with affinity for melatonergic and 5-ht(2c) receptors, offers the prospect of efficacy in major depression and anxiety with minimal adverse effects. |
2009-11-02 |
2023-08-12 |
Not clear |
| M Dutschmann, H Waki, T Manzke, A E Simms, A E Pickering, D W Richter, J F R Pato. The potency of different serotonergic agonists in counteracting opioid evoked cardiorespiratory disturbances. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. vol 364. issue 1529. 2009-10-30. PMID:19651661. |
serotonin receptor (5-htr) agonists that target 5-ht(4(a))r and 5-ht(1a)r can reverse mu-opioid receptor (mu-or)-evoked respiratory depression. |
2009-10-30 |
2023-08-12 |
rat |
| Thomas Linka, Gudrun Sartory, Markus Gastpar, Norbert Scherbaum, Bernhard W Mülle. Clinical symptoms of major depression are associated with the intensity dependence of auditory event-related potential components. Psychiatry research. vol 169. issue 2. 2009-10-29. PMID:19700202. |
the intensity (loudness) dependent amplitude change (idap) of the auditory event-related potential (erp) has been shown to be associated with the outcome of treatment with selective serotonin reuptake inhibitors in major depression. |
2009-10-29 |
2023-08-12 |
Not clear |
| Zheng Zhou, Juan Zhen, Nathan K Karpowich, Christopher J Law, Maarten E A Reith, Da-Neng Wan. Antidepressant specificity of serotonin transporter suggested by three LeuT-SSRI structures. Nature structural & molecular biology. vol 16. issue 6. 2009-10-27. PMID:19430461. |
sertraline and fluoxetine are selective serotonin re-uptake inhibitors (ssris) that are widely prescribed to treat depression. |
2009-10-27 |
2023-08-12 |
Not clear |
| B T Christian, A S Fox, J A Oler, N T Vandehey, D Murali, J Rogers, T R Oakes, S E Shelton, R J Davidson, N H Kali. Serotonin transporter binding and genotype in the nonhuman primate brain using [C-11]DASB PET. NeuroImage. vol 47. issue 4. 2009-10-15. PMID:19505582. |
the length polymorphism of the serotonin (5-ht) transporter gene promoter region has been implicated in altered 5-ht function and, in turn, neuropsychiatric illnesses, such as anxiety and depression. |
2009-10-15 |
2023-08-12 |
monkey |
| Q G Chen, Y S Zeng, Z Q Qu, J Y Tang, Y J Qin, P Chung, R Wong, U Häg. The effects of Rhodiola rosea extract on 5-HT level, cell proliferation and quantity of neurons at cerebral hippocampus of depressive rats. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 16. issue 9. 2009-10-09. PMID:19403286. |
the purpose of this study was to investigate the effects of rhodiola rosea extract and depression on the serotonin (5-ht) level, cell proliferation and quantity of neurons at cerebral hippocampus of depressive rats induced by chronic mild stress (cms). |
2009-10-09 |
2023-08-12 |
rat |
| Shia T Kent, Leslie A McClure, William L Crosson, Donna K Arnett, Virginia G Wadley, Nalini Sathiakuma. Effect of sunlight exposure on cognitive function among depressed and non-depressed participants: a REGARDS cross-sectional study. Environmental health : a global access science source. vol 8. 2009-10-06. PMID:19638195. |
possible physiological causes for the effect of sunlight on mood are through the suprachiasmatic nuclei and evidenced by serotonin and melatonin regulation and its associations with depression. |
2009-10-06 |
2023-08-12 |
human |
| Oliver J Robinson, Barbara J Sahakia. Acute tryptophan depletion evokes negative mood in healthy females who have previously experienced concurrent negative mood and tryptophan depletion. Psychopharmacology. vol 205. issue 2. 2009-10-05. PMID:19370340. |
we have proposed, based upon the observation that reducing serotonin via acute tryptophan depletion (atd) is more likely to induce negative mood in recovered depressed individuals than never depressed individuals, that this may be because associations form between negative mood and reduced serotonin during an episode of depression (robinson and sahakian, psychol med 38:315-318, 2008b). |
2009-10-05 |
2023-08-12 |
Not clear |
| Oliver J Robinson, Barbara J Sahakia. Acute tryptophan depletion evokes negative mood in healthy females who have previously experienced concurrent negative mood and tryptophan depletion. Psychopharmacology. vol 205. issue 2. 2009-10-05. PMID:19370340. |
such associations would mean that subsequent reductions in serotonin are more likely to provoke depressed mood and hence trigger an episode of depression. |
2009-10-05 |
2023-08-12 |
Not clear |
| John Stud. Why are physicians reluctant to use estrogens for anything--or do they prefer 'PROFOX'? Menopause international. vol 15. issue 2. 2009-10-05. PMID:19465668. |
selective serotonin reuptake inhibitor therapy for depression independently decreases bone density and is also responsible for loss of libido, loss of mental acuity and dependence. |
2009-10-05 |
2023-08-12 |
Not clear |
| Zeina Chemali, Lama M Chahine, Gregory Fricchion. The use of selective serotonin reuptake inhibitors in elderly patients. Harvard review of psychiatry. vol 17. issue 4. 2009-10-01. PMID:19637073. |
the selective serotonin reuptake inhibitors (ssris), which are seen as being among the first-line agents for treatment of depression in elderly patients, have been shown to be effective but carry with them side effects and drug-drug interactions that warrant special attention when these medications are prescribed to older individuals. |
2009-10-01 |
2023-08-12 |
Not clear |
| Guy M Goodwin, Robin Emsley, Sandra Rembry, Frédéric Rouillo. Agomelatine prevents relapse in patients with major depressive disorder without evidence of a discontinuation syndrome: a 24-week randomized, double-blind, placebo-controlled trial. The Journal of clinical psychiatry. vol 70. issue 8. 2009-09-30. PMID:19689920. |
this study evaluates the efficacy of agomelatine, the first antidepressant that is an agonist at mt(1)/mt(2) receptors and an antagonist at 5-ht(2c) receptor, in the prevention of relapse of depression following successful response. |
2009-09-30 |
2023-08-12 |
Not clear |
| Yasuomi Ouchi, Etsuji Yoshikawa, Masami Futatsubashi, Shunsuke Yagi, Takatoshi Ueki, Kazuhiko Nakamur. Altered brain serotonin transporter and associated glucose metabolism in Alzheimer disease. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 50. issue 8. 2009-09-28. PMID:19617327. |
here, we examined in vivo changes in the brain serotoninergic system and glucose metabolism by scanning early- to moderate-stage ad patients with and without depression using pet with a radiotracer for the serotonin transporter, (11)c-3-amino-4-(2-dimethylaminomethylphenylsulfanyl) benzonitrile (dasb), and a metabolic marker, (18)f-fdg. |
2009-09-28 |
2023-08-12 |
Not clear |
| Paul W Andrews, J Anderson Thomso. The bright side of being blue: depression as an adaptation for analyzing complex problems. Psychological review. vol 116. issue 3. 2009-09-28. PMID:19618990. |
in addition, the hypothesis provides explanations for puzzling findings in the depression literature, challenges the belief that serotonin transmission is low in depression, and has implications for treatment. |
2009-09-28 |
2023-08-12 |
Not clear |
| Sh V Vashadz. [Psychological aspects of psychosomatic pathology of large intestine]. Georgian medical news. issue 171. 2009-09-25. PMID:19578211. |
depression in patients with ibs was treated with serotonin selective antidepressants. |
2009-09-25 |
2023-08-12 |
Not clear |