| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Elisabeth A T Evers, Frederik M van der Veen, Jelle Jolles, Nicolaas E P Deutz, Jeroen A J Schmit. The effect of acute tryptophan depletion on performance and the BOLD response during a Stroop task in healthy first-degree relatives of patients with unipolar depression. Psychiatry research. vol 173. issue 1. 2009-08-19. PMID:19442495. |
previous research has shown that low central serotonin, induced by acute tryptophan depletion (atd), results in depressed mood and impairs cognition in healthy volunteers with a predisposition for depression. |
2009-08-19 |
2023-08-12 |
human |
| B P Wann, T M Bah, S Kaloustian, M Boucher, A M Dufort, N Le Marec, R Godbout, G Roussea. Behavioural signs of depression and apoptosis in the limbic system following myocardial infarction: effects of sertraline. Journal of psychopharmacology (Oxford, England). vol 23. issue 4. 2009-08-18. PMID:18562428. |
these results establish the bases of a rat model of depression following mi and show for the first time that a selective serotonin reuptake inhibitor prevents both behavioural and biochemical markers in this model. |
2009-08-18 |
2023-08-12 |
rat |
| Eleonora Calcagno, Sara Guzzetti, Alessandro Canetta, Claudia Fracasso, Silvio Caccia, Luigi Cervo, Roberto W Invernizz. Enhancement of cortical extracellular 5-HT by 5-HT1A and 5-HT2C receptor blockade restores the antidepressant-like effect of citalopram in non-responder mice. The international journal of neuropsychopharmacology. vol 12. issue 6. 2009-08-18. PMID:19123962. |
the results confirm that impaired 5-ht transmission accounts for the lack of effect of citalopram in the fst and suggest that enhancing the effect of ssris on extracellular 5-ht, through selective blockade of 5-ht1a and 5-ht2c receptors, could be a useful strategy to restore the response in treatment-resistant depression. |
2009-08-18 |
2023-08-12 |
mouse |
| Christine Firk, C Rob Marku. Differential effects of 5-HTTLPR genotypes on mood, memory, and attention bias following acute tryptophan depletion and stress exposure. Psychopharmacology. vol 203. issue 4. 2009-08-17. PMID:19083208. |
polymorphisms of the serotonin transporter gene (5-httlpr) may be associated with increased vulnerability to acute tryptophan depletion (atd) and depression vulnerability especially following stressful life events. |
2009-08-17 |
2023-08-12 |
Not clear |
| Jae-Min Kim, Robert Stewart, Sung-Wan Kim, Su-Jin Yang, Il-Seon Shin, Jin-Sang Yoo. Modification by two genes of associations between general somatic health and incident depressive syndrome in older people. Psychosomatic medicine. vol 71. issue 3. 2009-08-14. PMID:19251870. |
to investigate the modifying effects of two candidate genes (serotonin transporter gene linked promoter region (5-httlpr) and methylenetetrahydrofolate reductase (mthfr) c677t polymorphisms) on the associations between general somatic morbidity and incidence of depression in an east asian population with high frequencies of potential risk alleles. |
2009-08-14 |
2023-08-12 |
Not clear |
| S Bejerot, E Mörtber. Do autistic traits play a role in the bullying of obsessive-compulsive disorder and social phobia sufferers? Psychopathology. vol 42. issue 3. 2009-08-14. PMID:19276643. |
social phobia and obsessive-compulsive disorder (ocd) share several similarities: both are categorized as anxiety disorders, avoidant personality disorder and depression are common in both, they have a similar age of onset and course, and both disorders respond to treatments with serotonin reuptake inhibitors and cognitive behavioural therapy. |
2009-08-14 |
2023-08-12 |
Not clear |
| Lawson R Wulsin, Dominique Musselman, Christian Otte, Erica Bruce, Sadia Ali, Mary A Whoole. Depression and whole blood serotonin in patients with coronary heart disease from the Heart and Soul Study. Psychosomatic medicine. vol 71. issue 3. 2009-08-14. PMID:19297311. |
depression and whole blood serotonin in patients with coronary heart disease from the heart and soul study. |
2009-08-14 |
2023-08-12 |
Not clear |
| Lawson R Wulsin, Dominique Musselman, Christian Otte, Erica Bruce, Sadia Ali, Mary A Whoole. Depression and whole blood serotonin in patients with coronary heart disease from the Heart and Soul Study. Psychosomatic medicine. vol 71. issue 3. 2009-08-14. PMID:19297311. |
to evaluate whether depression is associated with whole blood serotonin in outpatients with stable coronary heart disease (chd). |
2009-08-14 |
2023-08-12 |
Not clear |
| Lawson R Wulsin, Dominique Musselman, Christian Otte, Erica Bruce, Sadia Ali, Mary A Whoole. Depression and whole blood serotonin in patients with coronary heart disease from the Heart and Soul Study. Psychosomatic medicine. vol 71. issue 3. 2009-08-14. PMID:19297311. |
dysregulation of peripheral serotonin, common to both depression and chd, may contribute to this association. |
2009-08-14 |
2023-08-12 |
Not clear |
| Minati Singh, M Bridget Zimmerman, Terry G Beltz, Alan Kim Johnso. Affect-related behaviors in mice misexpressing the RNA editing enzyme ADAR2. Physiology & behavior. vol 97. issue 3-4. 2009-08-12. PMID:19361536. |
misediting of the serotonin (5ht) 2c receptor (5ht(2c)r) has been implicated in both depression and anxiety. |
2009-08-12 |
2023-08-12 |
mouse |
| Tiffany Field, Miguel Diego, Maria Hernandez-Reif, Barbara Figueiredo, Osvelia Deeds, Angela Ascencio, Saul Schanberg, Cynthia Kuh. Prenatal dopamine and neonatal behavior and biochemistry. Infant behavior & development. vol 31. issue 4. 2009-08-11. PMID:18774177. |
thus, prenatal maternal dopamine levels appear to be negatively related to prenatal depression scores and positively related to neonatal dopamine and behavioral regulation, although these effects are confounded by elevated serotonin levels. |
2009-08-11 |
2023-08-12 |
Not clear |
| Stefan Wüst, Robert Kumsta, Jens Treutlein, Josef Frank, Sonja Entringer, Thomas G Schulze, Marcella Rietsche. Sex-specific association between the 5-HTT gene-linked polymorphic region and basal cortisol secretion. Psychoneuroendocrinology. vol 34. issue 7. 2009-08-11. PMID:19249159. |
a key regulator of serotonergic neurotransmission is the serotonin transporter (5-htt) and a common 5htt gene promoter polymorphism, termed 5httlpr, is associated with phenotypes related to anxiety and depression. |
2009-08-11 |
2023-08-12 |
Not clear |
| Joshua M Carlson, David G Gilbert, Hege Riise, Norka E Rabinovich, Chihiro Sugai, Brett Froelige. Serotonin transporter genotype and depressive symptoms moderate effects of nicotine on spatial working memory. Experimental and clinical psychopharmacology. vol 17. issue 3. 2009-08-11. PMID:19586232. |
although the serotonin neurotransmitter system is closely associated with depression and the effects of nicotine, the authors are not aware of any studies that have evaluated the possible role of individual differences in serotonin transporter (5-htt) genotype and depressive symptoms as moderators of the effects of nrt on swm. |
2009-08-11 |
2023-08-12 |
Not clear |
| M Danet S Lapiz-Bluhm, Alexandra E Soto-Piña, Julie G Hensler, David A Morila. Chronic intermittent cold stress and serotonin depletion induce deficits of reversal learning in an attentional set-shifting test in rats. Psychopharmacology. vol 202. issue 1-3. 2009-08-05. PMID:18587666. |
chronic stress perturbs modulatory brain neurotransmitter systems, including serotonin (5-ht), and is a risk factor for psychiatric disorders such as depression. |
2009-08-05 |
2023-08-12 |
rat |
| Leilei Guo, Suiyu H. PI-PLC signal pathway: a possible pathogenesis link post-myocardial infarction to depression. Medical hypotheses. vol 73. issue 2. 2009-08-05. PMID:19398169. |
considering the similar changes in serotonin(5-ht) and platelet activation through phosphoinositide (pi)-phospholipase c(plc) pathway, we guess that pi-plc signal transduction pathway is a common pathogenesis between depression and post-mi, which mediated by 5-ht resulting in the platelet activation. |
2009-08-05 |
2023-08-12 |
Not clear |
| Maria Fe Lanfranco, Patricia K Seitz, Michael V Morabito, Ronald B Emeson, Elaine Sanders-Bush, Kathryn A Cunningha. An innovative real-time PCR method to measure changes in RNA editing of the serotonin 2C receptor (5-HT(2C)R) in brain. Journal of neuroscience methods. vol 179. issue 2. 2009-08-04. PMID:19428534. |
the serotonin 2c receptor (5-ht(2c)r) plays a significant role in psychiatric disorders (e.g., depression) and is a target for pharmacotherapy. |
2009-08-04 |
2023-08-12 |
mouse |
| Hideki Miura, Tetsuya Shirokawa, Kenichi Isobe, Norio Ozak. Shifting the balance of brain tryptophan metabolism elicited by isolation housing and systemic administration of lipopolysaccharide in mice. Stress (Amsterdam, Netherlands). vol 12. issue 3. 2009-08-03. PMID:19006008. |
thus, we considered that shifting the balance between the kyn and 5-ht systems in the brain to the kyn pathway closely relate to the etiology of depression. |
2009-08-03 |
2023-08-12 |
mouse |
| Monique J Bijl, Hendrika J Luijendijk, Julia F van den Berg, Loes E Visser, Ron H N van Schaik, Albert Hofman, Arnold G Vulto, Teun van Gelder, Henning Tiemeier, Bruno H Ch Stricke. Association between the CYP2D6*4 polymorphism and depression or anxiety in the elderly. Pharmacogenomics. vol 10. issue 4. 2009-07-31. PMID:19374513. |
relative to extensive metabolizers, these poor metabolizers may have lower baseline serotonin concentrations in various brain regions, and may be more prone to depression or anxiety. |
2009-07-31 |
2023-08-12 |
Not clear |
| Eliyahu Dremencov, Mostafa El Mansari, Pierre Blie. Effects of sustained serotonin reuptake inhibition on the firing of dopamine neurons in the rat ventral tegmental area. Journal of psychiatry & neuroscience : JPN. vol 34. issue 3. 2009-07-30. PMID:19448853. |
selective serotonin (5-ht) reuptake inhibitors (ssris) are efficacious in depression because of their ability to increase 5-ht neurotransmission. |
2009-07-30 |
2023-08-12 |
rat |
| Khanh Q Nguyen, Yoshihiro Tohyama, Arata Watanabe, Shu Hasegawa, Ivan Skelin, Mirko Diksi. Acute effects of combining citalopram and pindolol on regional brain serotonin synthesis in sham operated and olfactory bulbectomized rats. Neurochemistry international. vol 54. issue 3-4. 2009-07-28. PMID:19073228. |
moreover, 5-ht(1a/b) autoreceptor feedback is stronger in obx rats and may underlie the delay of ssri effects in obx rats and, correspondingly, in human depression. |
2009-07-28 |
2023-08-12 |
human |