| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shripad B Deshpande, Amar N Maurya, Jitendra N Sing. 5-HT-induced depression of the spinal monosynaptic reflex potential utilizes different types of 5-HT receptors depending on Mg2+ availability. Pharmacological reports : PR. vol 61. issue 2. 2009-07-14. PMID:19443937. |
at 30 microm of 5-ht, the depression was 57% and 95% for msp and psp, respectively, and no further depression was seen at 50 microm. |
2009-07-14 |
2023-08-12 |
rat |
| Shripad B Deshpande, Amar N Maurya, Jitendra N Sing. 5-HT-induced depression of the spinal monosynaptic reflex potential utilizes different types of 5-HT receptors depending on Mg2+ availability. Pharmacological reports : PR. vol 61. issue 2. 2009-07-14. PMID:19443937. |
the 5-ht-induced depression of the reflexes in the mg(2+)-free medium was blocked by ondansetron (5-ht(3) receptor antagonist), but not by spiperone (5-ht(2a/2c) antagonist). |
2009-07-14 |
2023-08-12 |
rat |
| Shripad B Deshpande, Amar N Maurya, Jitendra N Sing. 5-HT-induced depression of the spinal monosynaptic reflex potential utilizes different types of 5-HT receptors depending on Mg2+ availability. Pharmacological reports : PR. vol 61. issue 2. 2009-07-14. PMID:19443937. |
at 10 microm of 5-ht, there was approximately 20% depression and at 50 microm the depression was 100%. |
2009-07-14 |
2023-08-12 |
rat |
| Shripad B Deshpande, Amar N Maurya, Jitendra N Sing. 5-HT-induced depression of the spinal monosynaptic reflex potential utilizes different types of 5-HT receptors depending on Mg2+ availability. Pharmacological reports : PR. vol 61. issue 2. 2009-07-14. PMID:19443937. |
the results indicate that the 5-ht-induced depression of msp involves 5-ht(3) receptors in the mg(2+)-free medium and 5-ht(2a/2c) in the presence of mg(2+) when nmda receptors are in the closed state. |
2009-07-14 |
2023-08-12 |
rat |
| Siegfried Kasper, Michel Hamo. Beyond the monoaminergic hypothesis: agomelatine, a new antidepressant with an innovative mechanism of action. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry. vol 10. issue 2. 2009-07-13. PMID:19255935. |
agomelatine, with its melatonergic agonistic (at both mt(1) an mt(2) receptors) and 5-ht(2c) antagonistic properties, represents a new concept for the treatment of depression. |
2009-07-13 |
2023-08-12 |
Not clear |
| Yi Zhu, Qun-ying Liu, Lian-shi Zhu. [Influence of electroacupuncture of "Baihui" (GV 20) and "Sanyinjiao" (SP 6) on hippocampal 5-HT and AChE immuno-activity in chronic depression rats]. Zhen ci yan jiu = Acupuncture research. vol 34. issue 1. 2009-07-09. PMID:19526802. |
[influence of electroacupuncture of "baihui" (gv 20) and "sanyinjiao" (sp 6) on hippocampal 5-ht and ache immuno-activity in chronic depression rats]. |
2009-07-09 |
2023-08-12 |
rat |
| Yi Zhu, Qun-ying Liu, Lian-shi Zhu. [Influence of electroacupuncture of "Baihui" (GV 20) and "Sanyinjiao" (SP 6) on hippocampal 5-HT and AChE immuno-activity in chronic depression rats]. Zhen ci yan jiu = Acupuncture research. vol 34. issue 1. 2009-07-09. PMID:19526802. |
to investigate the influence of electroacupuncture (ea) on 5-serotonin (5-ht) and acetyl cholinesterase (ache) activities in hippocampus tissue in chronic stressed-induced depression rats. |
2009-07-09 |
2023-08-12 |
rat |
| C Spadon. [Severe forms of depression: the efficacy of escitalopram]. L'Encephale. vol 35. issue 2. 2009-07-07. PMID:19393384. |
several studies have compared escitalopram to another specific serotonin recapture inhibitor (ssri) in severe depression. |
2009-07-07 |
2023-08-12 |
Not clear |
| Yoshihiko Kunisato, Go Okada, Yasumasa Okamot. [Reinforcement learning by striatum]. Brain and nerve = Shinkei kenkyu no shinpo. vol 61. issue 4. 2009-07-01. PMID:19378810. |
further examinations are required in future to assess the relation between the disturbance of reward prediction caused by low serotonin and mental disorders related to serotonin such as depression. |
2009-07-01 |
2023-08-12 |
Not clear |
| Michael T Isaa. Treating depression with SNRIs: who will benefit most? CNS spectrums. vol 13. issue 7 Suppl 11. 2009-06-30. PMID:18622370. |
there is evidence that the serotonin norepinephrine reuptake inhibitors (snris) venlafaxine, milnacipran, and duloxetine, have probable superior antidepressant activity to most selective serotonin reuptake inhibitors (ssris), especially in more severe depression. |
2009-06-30 |
2023-08-12 |
Not clear |
| John J B Allen, Katherine M McKnight, Francisco A Moreno, Heath A Demaree, Pedro L Delgad. Alteration of frontal EEG asymmetry during tryptophan depletion predicts future depression. Journal of affective disorders. vol 115. issue 1-2. 2009-06-25. PMID:18801582. |
tryptophan depletion (td) reduces brain serotonin and may induce acute depressive symptomatology, especially among those with a history of major depression. |
2009-06-25 |
2023-08-12 |
Not clear |
| Eduard Maron, Anu Tammiste, Kristi Kallassalu, Triin Eller, Veiko Vasar, David J Nutt, Andres Metspal. Serotonin transporter promoter region polymorphisms do not influence treatment response to escitalopram in patients with major depression. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 19. issue 6. 2009-06-25. PMID:19272758. |
serotonin transporter promoter region polymorphisms do not influence treatment response to escitalopram in patients with major depression. |
2009-06-25 |
2023-08-12 |
Not clear |
| Eduard Maron, Anu Tammiste, Kristi Kallassalu, Triin Eller, Veiko Vasar, David J Nutt, Andres Metspal. Serotonin transporter promoter region polymorphisms do not influence treatment response to escitalopram in patients with major depression. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 19. issue 6. 2009-06-25. PMID:19272758. |
several studies and meta-analyses have implicated a polymorphism in the promoter region of the serotonin transporter (5-htt) gene, 5-httlpr in treatment outcomes of selective serotonin re-uptake inhibitors in patients with major depression. |
2009-06-25 |
2023-08-12 |
Not clear |
| Neil Risch, Richard Herrell, Thomas Lehner, Kung-Yee Liang, Lindon Eaves, Josephine Hoh, Andrea Griem, Maria Kovacs, Jurg Ott, Kathleen Ries Merikanga. Interaction between the serotonin transporter gene (5-HTTLPR), stressful life events, and risk of depression: a meta-analysis. JAMA. vol 301. issue 23. 2009-06-25. PMID:19531786. |
interaction between the serotonin transporter gene (5-httlpr), stressful life events, and risk of depression: a meta-analysis. |
2009-06-25 |
2023-08-12 |
Not clear |
| Neil Risch, Richard Herrell, Thomas Lehner, Kung-Yee Liang, Lindon Eaves, Josephine Hoh, Andrea Griem, Maria Kovacs, Jurg Ott, Kathleen Ries Merikanga. Interaction between the serotonin transporter gene (5-HTTLPR), stressful life events, and risk of depression: a meta-analysis. JAMA. vol 301. issue 23. 2009-06-25. PMID:19531786. |
substantial resources are being devoted to identify candidate genes for complex mental and behavioral disorders through inclusion of environmental exposures following the report of an interaction between the serotonin transporter linked polymorphic region (5-httlpr) and stressful life events on an increased risk of major depression. |
2009-06-25 |
2023-08-12 |
Not clear |
| Laura R Hofto, Caroline E Lee, Mauricio Cafier. The importance of aromatic-type interactions in serotonin synthesis: protein-ligand interactions in tryptophan hydroxylase and aromatic amino acid decarboxylase. Journal of computational chemistry. vol 30. issue 7. 2009-06-24. PMID:18942733. |
mutations that decrease substrate binding can result in a decrease in serotonin production and thus can lead to depression and related disorders. |
2009-06-24 |
2023-08-12 |
Not clear |
| Vibe G Frokjaer, Maj Vinberg, David Erritzoe, Claus Svarer, William Baaré, Esben Budtz-Joergensen, Karine Madsen, Jacob Madsen, Lars V Kessing, Gitte M Knudse. High familial risk for mood disorder is associated with low dorsolateral prefrontal cortex serotonin transporter binding. NeuroImage. vol 46. issue 2. 2009-06-24. PMID:19233297. |
changes in the serotonin transporter (sert) binding may therefore occur in depressive patients and in subjects at risk for developing depression. |
2009-06-24 |
2023-08-12 |
human |
| Christophe Wersinger, Anita Sidh. Partial regulation of serotonin transporter function by gamma-synuclein. Neuroscience letters. vol 453. issue 3. 2009-06-22. PMID:19429025. |
these studies document a novel physiological role for gamma-syn in regulating 5-ht synaptic availability and homeostasis, and may be of relevance in depression and mood disorders, where sert function is dysregulated. |
2009-06-22 |
2023-08-12 |
human |
| Cecilie L Licht, Anders B Marcussen, Gregers Wegener, David H Overstreet, Susana Aznar, Gitte M Knudse. The brain 5-HT4 receptor binding is down-regulated in the Flinders Sensitive Line depression model and in response to paroxetine administration. Journal of neurochemistry. vol 109. issue 5. 2009-06-15. PMID:19476548. |
the 5-hydroxytryptamine (5-ht(4)) receptor may be implicated in depression and is a new potential target for antidepressant treatment. |
2009-06-15 |
2023-08-12 |
rat |
| Cecilie L Licht, Anders B Marcussen, Gregers Wegener, David H Overstreet, Susana Aznar, Gitte M Knudse. The brain 5-HT4 receptor binding is down-regulated in the Flinders Sensitive Line depression model and in response to paroxetine administration. Journal of neurochemistry. vol 109. issue 5. 2009-06-15. PMID:19476548. |
we have investigated the brain 5-ht(4) receptor [(3)h]sb207145 binding in the flinders sensitive line rat depression model by quantitative receptor autoradiography, and related this to 5-ht transporter (s)-[n-methyl-(3)h]citalopram binding. |
2009-06-15 |
2023-08-12 |
rat |