| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| He Yu, Zhong-Mei He, Kun Shi, Yan Zhao, Ying Zong, Jian-Ming Li, Wei-Jia Chen, Rui D. [Study on antidepressant effect of total alkaloids of Fibraurea recisa]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 46. issue 14. 2021-08-18. PMID:34402292. |
this study aimed to investigate the antidepressant effects of total alkaloids of fibraurea recisa in ht22 cells damaged by corticosterone (cort) in vitro and in a mouse model of chronic unpredictable mild stress (cums) as well as the underlying mechanisms.in cellular experiments,the viability of cort-damaged ht22 cells was detected using cell counting kit-8 (cck-8),and the cell apoptosis was detected by hoechst 33258 staining.in animal experiments,c57bl/6n mice were randomly divided into the control group,model group,low (100 mg·kg~(-1)),medium (200 mg·kg~(-1)) and high (400 mg·kg~(-1))-dose of total alkaloids of f.recisa groups,and positive control group.after 21 days of cums exposure,their depressive behaviors were observed in behavioral and morris water maze tests.the serum levels of 5-hydroxytryptamine (5-ht),dopamine (da),and norepinephrine (ne) were assessed by elisa.the expression levels of apoptosis-related proteins bcl-2,bax and cleaved caspase-3 in ht22 cells and mouse hippocampus were detected by western blot.the results suggested that total alkaloids of f.recisa alleviated the damage of ht22 cells induced by cort in a dose-dependent manner.the hoechst 33258 staining uncovered that total alkaloids of f.recisa better reduced the blue spots and inhibited cell apoptosis.the results of animal experiments showed that total alkaloids of f.recisa significantly improved the depression-like behaviors of mice and increased the serum levels of 5-ht,da and ne as compared with those in the model group.the western blot assays revealed a significant up-regulation of bcl-2 protein expression,but an obvious reduction in bax and cleaved caspase-3protein expression in the total alkaloids of f.recisa group.in conclusion,total alkaloids of f.recisa inhibited depression possibly by regulating the apoptosis-related protein expression or elevating the monoamine neurotransmitter levels in the brain. |
2021-08-18 |
2023-08-13 |
mouse |
| Francesca De Faveri, Walter Marcotti, Federico Cerian. Sensory adaptation at ribbon synapses in the zebrafish lateral line. The Journal of physiology. vol 599. issue 15. 2021-08-10. PMID:34047358. |
the glutamate-induced increase in afferent neuron firing rate adapts over time, which is mirrored by the depression of neurotransmitter release, without preventing phase-locking. |
2021-08-10 |
2023-08-13 |
zebrafish |
| Jingying Xu, Jiangang Tao, Lili Su, Jidong Wang, Tifeng Jia. A Critical Review of Carbon Quantum Dots: From Synthesis toward Applications in Electrochemical Biosensors for the Determination of a Depression-Related Neurotransmitter. Materials (Basel, Switzerland). vol 14. issue 14. 2021-07-29. PMID:34300909. |
quantitative assessment of depression-related neurotransmitter concentrations in human fluids is highly desirable for diagnosis, monitoring disease, and therapeutic interventions of depression. |
2021-07-29 |
2023-08-13 |
human |
| Marina Rieder, Nadine Gauchel, Christoph Bode, Daniel Duerschmie. Serotonin: a platelet hormone modulating cardiovascular disease. Journal of thrombosis and thrombolysis. vol 52. issue 1. 2021-07-21. PMID:33155668. |
serotonin 5-hydroxytryptamin (5-ht), a biogenic amine acting as a neurotransmitter and a peripheral hormone, is involved in the pathogenesis of both, cardiovascular disease and depression. |
2021-07-21 |
2023-08-13 |
Not clear |
| Konstantin A Demin, Dmitry A Smagin, Irina L Kovalenko, Tatyana Strekalova, David S Galstyan, Tatyana O Kolesnikova, Murilo S De Abreu, Anna G Galyamina, Alim Bashirzade, Allan V Kaluef. CNS genomic profiling in the mouse chronic social stress model implicates a novel category of candidate genes integrating affective pathogenesis. Progress in neuro-psychopharmacology & biological psychiatry. vol 105. 2021-07-19. PMID:32889031. |
overall, while in the day 10 (anxiety) group both brain regions showed major genomic alterations in various neurotransmitter signaling pathways, the day 15 (transitional) group revealed uniquely downregulated astrocyte-related genes, and the day 20 (depression) group demonstrated multiple downregulated genes of cell adhesion, inflammation and ion transport pathways. |
2021-07-19 |
2023-08-13 |
mouse |
| Gordana Nedic Erjavec, Marina Sagud, Matea Nikolac Perkovic, Dubravka Svob Strac, Marcela Konjevod, Lucija Tudor, Sandra Uzun, Nela Piva. Depression: Biological markers and treatment. Progress in neuro-psychopharmacology & biological psychiatry. vol 105. 2021-07-19. PMID:33068682. |
nowadays depression is considered as a systemic illness with different biological mechanisms involved in its etiology, including inflammatory response, hypothalamic-pituitary-adrenal (hpa) axis dysregulation and neurotransmitter and neurotrophic systems imbalance. |
2021-07-19 |
2023-08-13 |
Not clear |
| Gordana Nedic Erjavec, Marina Sagud, Matea Nikolac Perkovic, Dubravka Svob Strac, Marcela Konjevod, Lucija Tudor, Sandra Uzun, Nela Piva. Depression: Biological markers and treatment. Progress in neuro-psychopharmacology & biological psychiatry. vol 105. 2021-07-19. PMID:33068682. |
article discusses how activated inflammation processes and increased cytokine levels, as well as disturbed neurotransmitter systems can contribute to different stages of depression and could specific metabolomic and glycomic species be considered as potential biomarkers of depression. |
2021-07-19 |
2023-08-13 |
Not clear |
| Xu-Meng Han, Feng Huang, Ming-Li Jiao, Hui-Ru Liu, Zheng-Hang Zhao, He-Qin Zhan, Shi-Yu Gu. Antidepressant Activity of Euparin: Involvement of Monoaminergic Neurotransmitters and SAT1/NMDAR2B/BDNF Signal Pathway. Biological & pharmaceutical bulletin. vol 43. issue 10. 2021-07-05. PMID:32788507. |
meanwhile, all doses of euparin were found to increase the contents of monoamine neurotransmitter and decrease monoamine oxidase and reactive oxygen species (ros) levels in brain of depression mice. |
2021-07-05 |
2023-08-13 |
mouse |
| Vera J Erchinger, Jeremy Miller, Thomas Jones, Ute Kessler, Juan Bustillo, Jan Haavik, Jonathan Petrillo, Gregory Ziomek, Åsa Hammar, Ketil J Oedegaard, Vince D Calhoun, Shawn M McClintock, Lars Ersland, Leif Oltedal, Christopher C Abbot. Anterior cingulate gamma-aminobutyric acid concentrations and electroconvulsive therapy. Brain and behavior. vol 10. issue 11. 2021-06-24. PMID:32940003. |
results of prior studies investigating the role of the inhibitory neurotransmitter gamma-aminobutyric acid ("gaba+", gaba and coedited macromolecules) in the pathophysiology and treatment of depression remain inconclusive. |
2021-06-24 |
2023-08-13 |
human |
| Mostafa Ajaman, Reza Naserzadeh, Behnam Ghorbanzade. Pharmacological evaluation of NO/cGMP/KATP channels pathway in the antidepressant-like effect of carbamazepine in mice. Behavioural pharmacology. vol 32. issue 1. 2021-06-21. PMID:33290345. |
nitric oxide (no) is a neurotransmitter in the central nervous system and has been involved in a variety of diseases including depression. |
2021-06-21 |
2023-08-13 |
mouse |
| Peng Wang, Xiaoxia Gao, Fang Zhao, Yao Gao, Kexin Wang, Jun-Sheng Tian, Zhenyu Li, Xue-Mei Qi. Study of the Neurotransmitter Changes Adjusted by Circadian Rhythm in Depression Based on Liver Transcriptomics and Correlation Analysis. ACS chemical neuroscience. vol 12. issue 12. 2021-06-21. PMID:34060807. |
study of the neurotransmitter changes adjusted by circadian rhythm in depression based on liver transcriptomics and correlation analysis. |
2021-06-21 |
2023-08-13 |
rat |
| Peng Wang, Xiaoxia Gao, Fang Zhao, Yao Gao, Kexin Wang, Jun-Sheng Tian, Zhenyu Li, Xue-Mei Qi. Study of the Neurotransmitter Changes Adjusted by Circadian Rhythm in Depression Based on Liver Transcriptomics and Correlation Analysis. ACS chemical neuroscience. vol 12. issue 12. 2021-06-21. PMID:34060807. |
studies have shown that liver injury caused by chronic stress is relevant to depression and neurotransmitter changes. |
2021-06-21 |
2023-08-13 |
rat |
| Peng Wang, Xiaoxia Gao, Fang Zhao, Yao Gao, Kexin Wang, Jun-Sheng Tian, Zhenyu Li, Xue-Mei Qi. Study of the Neurotransmitter Changes Adjusted by Circadian Rhythm in Depression Based on Liver Transcriptomics and Correlation Analysis. ACS chemical neuroscience. vol 12. issue 12. 2021-06-21. PMID:34060807. |
it is essential to clarify the relationship between neurotransmitter changes and hepatic gene expression in depression. |
2021-06-21 |
2023-08-13 |
rat |
| Paul J Fitzgerald, Pho J Hale, Anjesh Ghimire, Brendon O Watso. The cholinesterase inhibitor donepezil has antidepressant-like properties in the mouse forced swim test. Translational psychiatry. vol 10. issue 1. 2021-06-18. PMID:32712627. |
furthermore, the classically engaged monoaminergic neurotransmitter systems in depression treatment-serotonin, norepinephrine, and dopamine-interact directly at times with cholinergic signaling. |
2021-06-18 |
2023-08-13 |
mouse |
| Kimberly R Wiersielis, Benjamin A Samuels, Troy A Roepk. Perinatal exposure to bisphenol A at the intersection of stress, anxiety, and depression. Neurotoxicology and teratology. vol 79. 2021-05-26. PMID:32289443. |
previous studies suggest that perinatal exposure to bpa alters several neurotransmitter systems and disrupts behaviors associated with depression and anxiety in the rodent offspring later in life. |
2021-05-26 |
2023-08-13 |
Not clear |
| Anett Schumacher, Marlen Haegele, Jakob Spyth, Andreas Mose. Electrical high frequency stimulation of the nucleus accumbens shell does not modulate depressive-like behavior in rats. Behavioural brain research. vol 378. 2021-04-29. PMID:31589894. |
we therefore used unilateral high frequency stimulation of the nac shell in rats to verify its effectiveness in treating depression and study involved neurotransmitter systems. |
2021-04-29 |
2023-08-13 |
rat |
| Sari Goldstein Ferber, Aron Weller, Gal Yadid, Alexander Friedma. Discovering the Lost Reward: Critical Locations for Endocannabinoid Modulation of the Cortico-Striatal Loop That Are Implicated in Major Depression. International journal of molecular sciences. vol 22. issue 4. 2021-04-15. PMID:33668515. |
recent studies in humans and in animal models relate major depression occurrence and reoccurrence to alterations in dopaminergic activity, in addition to other neurotransmitter systems. |
2021-04-15 |
2023-08-13 |
Not clear |
| Rona R Ramsay, Livia Basile, Antonin Maniquet, Stefanie Hagenow, Matteo Pappalardo, Maria Chiara Saija, Sharon D Bryant, Alen Albreht, Salvatore Guccion. Parameters for Irreversible Inactivation of Monoamine Oxidase. Molecules (Basel, Switzerland). vol 25. issue 24. 2021-04-14. PMID:33322203. |
the irreversible inhibitors of monoamine oxidases (mao) slow neurotransmitter metabolism in depression and neurodegenerative diseases. |
2021-04-14 |
2023-08-13 |
human |
| Chengping Luo, Huimin Fan, Shaojun Li, Yuling Zo. Therapeutic of Candesartan and Music Therapy in Diabetic Retinopathy with Depression in Rats. Evidence-based complementary and alternative medicine : eCAM. vol 2021. 2021-04-10. PMID:33833815. |
especially, music therapy further improved the effects of candesartan on retina cell apoptosis and neurotransmitter release in diabetic retinopathy rats with depression. |
2021-04-10 |
2023-08-13 |
rat |
| b' Marion Falabr\\xc3\\xa8gue, Anne-Claire Boschat, Romain Jouffroy, Marieke Derquennes, Haidar Djemai, Sylvia Sanquer, Robert Barouki, Xavier Coumoul, Jean-Fran\\xc3\\xa7ois Toussaint, Olivier Hermine, Philippe Noirez, Francine C\\xc3\\xb4t\\xc3\\xa. Lack of Skeletal Muscle Serotonin Impairs Physical Performance. International journal of tryptophan research : IJTR. vol 14. 2021-04-06. PMID:33814916.' |
low levels of the neurotransmitter serotonin have been associated with the onset of depression. |
2021-04-06 |
2023-08-13 |
mouse |