| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Naotsugu Kaneko, Atsushi Sasaki, Kai Lon Fok, Hikaru Yokoyama, Kimitaka Nakazawa, Kei Masan. Motor point stimulation activates fewer Ia-sensory nerves than peripheral nerve stimulation in human soleus muscle. Journal of neurophysiology. 2024-08-28. PMID:39196676. |
this paradigm induces post-activation depression of spinal reflexes associated with transient decreases in neurotransmitter release from ia-afferent terminals, allowing us to examine the ia-sensory input amount from pns and mps based on the depression degree. |
2024-08-28 |
2024-08-31 |
human |
| Yasemin Tekşen, Meliha Koldemir Gündüz, Derya Berikten, Fikriye Yasemin Özatik, Hasan Emre Aydı. Peganum harmala L. seed extract attenuates anxiety and depression in rats by reducing neuroinflammation and restoring the BDNF/TrkB signaling pathway and monoamines after exposure to chronic unpredictable mild stress. Metabolic brain disease. 2024-08-22. PMID:39172328. |
in conclusion, p. harmala at a dose of 150 mg/kg is more effective in preventing depressive-like behavior in cums-exposed rats by improving neurotransmitter levels, reducing oxidative stress, suppressing neuroinflammation and activating the bdnf/trkb pathway, all of which are important in the pathogenesis of depression. |
2024-08-22 |
2024-08-24 |
rat |
| Siyu Li, Xiaoli Fen. Dynamic quantitative monitoring of cerebrospinal fluid monoamine neurotransmitter markers during the modeling process of chronic stress-induced depression in monkeys (Macaca mulatta). Brain and behavior. vol 14. issue 8. 2024-08-22. PMID:39169445. |
dynamic quantitative monitoring of cerebrospinal fluid monoamine neurotransmitter markers during the modeling process of chronic stress-induced depression in monkeys (macaca mulatta). |
2024-08-22 |
2024-08-24 |
monkey |
| Shiyan Qu, Zijin Yu, Yaxuan Zhou, Shiyi Wang, Minqi Jia, Ti Chen, Xiaojie Zhan. Gut microbiota modulates neurotransmitter and gut-brain signaling. Microbiological research. vol 287. 2024-08-06. PMID:39106786. |
accumulating evidence suggests that the gut microbiota modulates intestinal neurotransmitter metabolism and gut-to-brain signaling, shedding light on the crucial role of the gut microbiota in brain function and the pathogenesis of various neuropsychiatric diseases, such as major depression disorder (mdd), anxiety, addiction and parkinson's disease (pd). |
2024-08-06 |
2024-08-09 |
Not clear |
| Kelley M Swanberg, Hetty Prinsen, Christopher L Averill, Leonardo Campos, Abhinav V Kurada, John H Krystal, Ismene L Petrakis, Lynnette A Averill, Douglas L Rothman, Chadi G Abdallah, Christoph Juche. Medial prefrontal cortex neurotransmitter abnormalities in posttraumatic stress disorder with and without comorbidity to major depression. NMR in biomedicine. 2024-07-26. PMID:39054694. |
medial prefrontal cortex neurotransmitter abnormalities in posttraumatic stress disorder with and without comorbidity to major depression. |
2024-07-26 |
2024-07-28 |
Not clear |
| Xingli Pan, Yuxin Gao, Kaifu Guan, Jing Chen, Bingyuan J. Ghrelin/GHSR System in Depressive Disorder: Pathologic Roles and Therapeutic Implications. Current issues in molecular biology. vol 46. issue 7. 2024-07-26. PMID:39057075. |
by combining several neuropeptides and traditional neurotransmitter systems to construct neural networks, this hormone modifies signals connected to depression. |
2024-07-26 |
2024-07-28 |
Not clear |
| Ningning Guo, Xin Wang, Muran Xu, Jie Bai, Hao Yu, Le Zhan. PI3K/AKT signaling pathway: Molecular mechanisms and therapeutic potential in depression. Pharmacological research. 2024-07-11. PMID:38992850. |
numerous studies have found that depression may be closely related to decreased neurogenesis, neuroinflammation, neurotransmitter imbalance, and synaptic plasticity dysfunction. |
2024-07-11 |
2024-07-14 |
Not clear |
| Weixing Ding, Lulu Wang, Lei Li, Hongyan Li, Jianfa Wu, Jing Zhang, Jing Wan. Pathogenesis of depression and the potential for traditional Chinese medicine treatment. Frontiers in pharmacology. vol 15. 2024-07-10. PMID:38983910. |
contemporary research has explored the potential pathogenesis of depression from various angles, encompassing genetics, neurotransmitter systems, neurotrophic factors, the hypothalamic-pituitary-adrenal axis, inflammation, and intestinal flora, among other contributing factors. |
2024-07-10 |
2024-07-12 |
Not clear |
| Ji-Woon Kim, Benjamin Kleinfelter, Ege T Kavalali, Lisa M Monteggi. Distinct synaptic mechanisms drive the behavioral response to acute stress and rapid correction by ketamine. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2024-07-02. PMID:38956176. |
prevailing hypotheses on the mechanisms of antidepressant action posit that antidepressants directly counteract deficiencies in major neurotransmitter signaling systems that underlie depression. |
2024-07-02 |
2024-07-06 |
mouse |
| Cem Yamali, Merve Nenni, Mehtap Tugrak Sakarya, Hasan Alper Kapla. Pharmaceutical Studies on Piperazine-Based Compounds Targeting Serotonin Receptors and Serotonin Reuptake Transporters. Mini reviews in medicinal chemistry. 2024-06-24. PMID:38910275. |
multiple factors, such as genetic factors and abnormalities in neurotransmitter levels, contribute to the development of depression. |
2024-06-24 |
2024-06-26 |
Not clear |
| Jie Yu, Yujie Zhang, Hao Yao, Ziping Zhang, Xiao Yang, Wei Zhu, Jie X. ERβ activation improves nonylphenol-induced depression and neurotransmitter secretion disruption via the TPH2/5-HT pathway. Ecotoxicology and environmental safety. vol 280. 2024-06-08. PMID:38850708. |
erβ activation improves nonylphenol-induced depression and neurotransmitter secretion disruption via the tph2/5-ht pathway. |
2024-06-08 |
2024-06-11 |
rat |
| Kaustav Nag, Deepak Solanki, Muthukumar Serva Peddha, Seema Mehdi, Rajan Logesh, Tamsheel Fatima Roohi, Nabeel Kinattingal, Faiyaz Shakee. Effect of cyclodextrin-complexed lyophilized nanosuspension of Nigella sativa seeds oleoresin on chronic unpredictable mild stress (CUMS)-induced depression in mice. Neuroscience letters. 2024-05-31. PMID:38821203. |
these results suggest that nano-nsor ameliorates cums-induced depression by modulating neurotransmitter levels, reducing inflammation, and enhancing neuroprotection. |
2024-05-31 |
2024-06-02 |
mouse |
| Nasar Ullah Khan Niazi, Chengyi Huang, Zhiyou Yang, Yongping Zhang, Cai Son. Comparison between sub-chronic and chronic sleep deprivation-induced behavioral and neuroimmunological abnormalities in mice: focusing on glial cell phenotype polarization. Behavioural brain research. 2024-05-25. PMID:38795845. |
although neuroinflammation triggered by microglial phenotype m1 activation, leading to neurotransmitter dysfunction and aβ aggregation, is considered as the leading cause of depression and ad, whether and how sub-chronic or chronic sleep deprivation (sd) contribute to the onset and development of these diseases remains unclear. |
2024-05-25 |
2024-05-31 |
mouse |
| Shashi B Singh, Atit Tiwari, Maanya R Katta, Riju Kafle, Cyrus Ayubcha, Krishna H Patel, Yash Bhattarai, Thomas J Werner, Abass Alavi, Mona-Elisabeth Revhei. The utility of PET imaging in depression. Frontiers in psychiatry. vol 15. 2024-05-08. PMID:38711875. |
studies have revealed alterations in neurotransmitter systems such as serotonin, dopamine, gaba, and glutamate, which are linked to the pathophysiology of depression. |
2024-05-08 |
2024-05-27 |
Not clear |
| Victoria Jiménez Carretero, Ninfa Liccardi, Maria Arribas Tejedor, Ricardo de Pascual, Jorge Hernández Campano, Jesús M Hernández-Guij. Lead exerts a depression of neurotransmitter release through a blockade of voltage dependent calcium channels in chromaffin cells. Toxicology. 2024-04-22. PMID:38648961. |
lead exerts a depression of neurotransmitter release through a blockade of voltage dependent calcium channels in chromaffin cells. |
2024-04-22 |
2024-04-26 |
cattle |
| Liuting Xu, Sizhe Wang, Linlin Wu, Hui Cao, Yichun Fan, Xi Wang, Zheng Yu, Manfei Zhou, Rong Gao, Jun Wan. Coprococcus eutactus screened from healthy adolescent attenuates chronic restraint stress-induced depression-like changes in adolescent mice: Potential roles in the microbiome and neurotransmitter modulation. Journal of affective disorders. 2024-04-22. PMID:38649105. |
it is becoming evident that neurotransmitter imbalance and gut microbiota dysbiosis are prominent causes of depression. |
2024-04-22 |
2024-04-26 |
mouse |
| Aletta Me Millen, William Mu Daniels, Sooraj Baijnat. Depression, an unmet health need in Africa: Understanding the promise of ketamine. Heliyon. vol 10. issue 7. 2024-04-11. PMID:38601594. |
despite this, the treatment of depression is one-dimensional focussing on outdated theories of depression and mainly targeting dysfunctional neurotransmitter pathways. |
2024-04-11 |
2024-04-13 |
Not clear |
| Rajagopal Kalirajan, Khare Rishabh, Jupudi Srikanth, Modi Niharika, Negi Preeya, Islam Rezau. Molecular Docking, MM-GBSA, and Molecular Dynamics Approach: 5-MeO-DMT Analogues as Potential Antidepressants. Archives of Razi Institute. vol 78. issue 5. 2024-04-09. PMID:38590677. |
the neurotransmitter serotonin has drawn the most attention concerning depression. |
2024-04-09 |
2024-04-11 |
Not clear |
| Mingliang Zhao, Zhenxing Ren, Aihua Zhao, Yajun Tang, Junliang Kuang, Mengci Li, Tianlu Chen, Shouli Wang, Jieyi Wang, Huiheng Zhang, Jijun Wang, Tianhong Zhang, Jiahui Zeng, Xiaohua Liu, Guoxiang Xie, Penghong Liu, Ning Sun, Tianhao Bao, Tongtong Nie, Jingchao Lin, Ping Liu, Yuanyi Zheng, Xiaojiao Zheng, Tiemin Liu, Wei Ji. Gut bacteria-driven homovanillic acid alleviates depression by modulating synaptic integrity. Cell metabolism. 2024-04-06. PMID:38582087. |
we observed depleted gut bacterial species, including bifidobacterium longum and roseburia intestinalis, and the neurotransmitter homovanillic acid (hva) in individuals with depression and mouse depression models. |
2024-04-06 |
2024-04-10 |
mouse |
| Lina Bukowski, Markus Emanuel Strøm, Jens Lindengren Andersen, Jannick Bang Maesen, Lin Tian, Steffen Sinnin. 5-HT_FAsTR: a versatile, label-free, high-throughput, fluorescence-based microplate assay to quantify serotonin transport and release. Scientific reports. vol 14. issue 1. 2024-03-20. PMID:38504103. |
the neurotransmitter serotonin plays a pivotal role in mood and depression. |
2024-03-20 |
2024-03-23 |
Not clear |