| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Maurizio Fav. The role of the serotonergic and noradrenergic neurotransmitter systems in the treatment of psychological and physical symptoms of depression. The Journal of clinical psychiatry. vol 64 Suppl 13. 2004-01-20. PMID:14552653. |
the role of the serotonergic and noradrenergic neurotransmitter systems in the treatment of psychological and physical symptoms of depression. |
2004-01-20 |
2023-08-12 |
Not clear |
| Maurizio Fav. The role of the serotonergic and noradrenergic neurotransmitter systems in the treatment of psychological and physical symptoms of depression. The Journal of clinical psychiatry. vol 64 Suppl 13. 2004-01-20. PMID:14552653. |
although the pathophysiology of depression is still unknown, there is significant evidence for abnormalities of the norepinephrine (ne) and serotonin (5-ht) neurotransmitter systems in depressive disorders. |
2004-01-20 |
2023-08-12 |
Not clear |
| Tanya Sippy, Alberto Cruz-Martín, Andreas Jeromin, Felix E Schweize. Acute changes in short-term plasticity at synapses with elevated levels of neuronal calcium sensor-1. Nature neuroscience. vol 6. issue 10. 2003-12-05. PMID:12947410. |
here we show, in rat hippocampal cell cultures, that increases in the calcium binding protein neuronal calcium sensor-1 (ncs-1) can switch paired-pulse depression to facilitation without altering basal synaptic transmission or initial neurotransmitter release probability. |
2003-12-05 |
2023-08-12 |
rat |
| Stephan A Chalon, Luc-André Granier, François R Vandenhende, Peter R Bieck, Frank P Bymaster, Melissa J Joliat, Christine Hirth, William Z Potte. Duloxetine increases serotonin and norepinephrine availability in healthy subjects: a double-blind, controlled study. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 28. issue 9. 2003-10-06. PMID:12784100. |
evidence suggests that compounds that increase the synaptic availability of more than one neurotransmitter have greater efficacy in the treatment of depression than single-acting drugs. |
2003-10-06 |
2023-08-12 |
human |
| Masanori Yamauchi, Steven G Shimada, Hiroshi Sekiyama, J G Collin. Neither spinal gamma-aminobutyric acid-A nor strychnine-sensitive glycine receptor systems are the sole mediators of halothane depression of spinal dorsal horn sensory neurons. Anesthesia and analgesia. vol 97. issue 2. 2003-08-22. PMID:12873928. |
part of that depression may be mediated by anesthetic interactions with gamma-aminobutyric acid type a (gaba(a)) and strychnine-sensitive glycine inhibitory neurotransmitter systems. |
2003-08-22 |
2023-08-12 |
rat |
| Veronika Butterwec. Mechanism of action of St John's wort in depression : what is known? CNS drugs. vol 17. issue 8. 2003-07-28. PMID:12775192. |
in vivo st john's wort extract leads to a downregulation of beta-adrenergic receptors and an upregulation of serotonin 5-ht(2) receptors in the rat frontal cortex and causes changes in neurotransmitter concentrations in brain areas that are implicated in depression. |
2003-07-28 |
2023-08-12 |
rat |
| Frank Padberg, Hans-Jürgen Mölle. Repetitive transcranial magnetic stimulation : does it have potential in the treatment of depression? CNS drugs. vol 17. issue 6. 2003-07-01. PMID:12696999. |
rtms has also been found to exert effects on neurotransmitter systems involved in the pathophysiology of major depression (e.g. |
2003-07-01 |
2023-08-12 |
Not clear |
| Hymie Anisman, Zul Meral. Cytokines, stress and depressive illness: brain-immune interactions. Annals of medicine. vol 35. issue 1. 2003-06-26. PMID:12693607. |
essentially, a relationship between cytokines and depression is based on the findings that: 1) proinflammatory cytokines (interleukin-1, interleukin-6, tumor necrosis factor-alpha) and bacterial endotoxins elicit sickness behaviors (e.g., fatigue, soporific effects) and symptoms of anxiety/depression that may be attenuated by chronic antidepressant treatment, 2) cytokines induce neuroendocrine and central neurotransmitter changes reminiscent of those implicated in depression, and these effects are exacerbated by stressors, 3) severe depressive illness is accompanied by signs of immune activation and by elevations of cytokine production or levels, and 4) immunotherapy, using interleukin-2 or interferon-alpha, promotes depressive symptoms that are attenuated by antidepressant treatment. |
2003-06-26 |
2023-08-12 |
human |
| Hymie Anisman, Zul Meral. Cytokines, stress and depressive illness: brain-immune interactions. Annals of medicine. vol 35. issue 1. 2003-06-26. PMID:12693607. |
it is argued that cytokine synthesis and release, elicited upon activation of the inflammatory response system, provoke neuroendocrine and brain neurotransmitter changes that are interpreted by the brain as being stressors, and contribute to the development of depression. |
2003-06-26 |
2023-08-12 |
human |
| Wayne C Drevet. Neuroimaging abnormalities in the amygdala in mood disorders. Annals of the New York Academy of Sciences. vol 985. 2003-06-17. PMID:12724175. |
taken together with converging evidence from neuroendocrine, lesion analysis, and postmortem studies of clinically depressed subjects, these data suggest that emotional/stress-response systems that include the amygdala are pathologically activated in major depression and that this activity is associated with dysfunction of the prefrontal cortex and monoamine neurotransmitter systems that normally modulate such responses. |
2003-06-17 |
2023-08-12 |
human |
| Cai Son. The effect of thymectomy and IL-1 on memory: implications for the relationship between immunity and depression. Brain, behavior, and immunity. vol 16. issue 5. 2003-05-28. PMID:12401469. |
in this paper, the relationships between thymectomy, increased il-1 levels, and changes in corticosterone and neurotransmitter concentrations in rats are discussed, as well as their implications for memory impairments and depression. |
2003-05-28 |
2023-08-12 |
rat |
| Bernhard Widner, Andreas Laich, Barbara Sperner-Unterweger, Maximilian Ledochowski, Dietmar Fuch. Neopterin production, tryptophan degradation, and mental depression--what is the link? Brain, behavior, and immunity. vol 16. issue 5. 2003-05-28. PMID:12401473. |
disturbed metabolism of tryptophan affects biosynthesis of neurotransmitter 5-hydroxytryptamine (serotonin), and it appears to be associated with an increased susceptibility for depression. |
2003-05-28 |
2023-08-12 |
human |
| Ray Norbury, William J Cutter, Jacqueline Compton, Dene M Robertson, Michael Craig, Malcolm Whitehead, Declan G Murph. The neuroprotective effects of estrogen on the aging brain. Experimental gerontology. vol 38. issue 1-2. 2003-05-12. PMID:12543268. |
evidence is presented for the wide-ranging actions of estrogen in the brain at the cellular, metabolic and neurotransmitter levels as well as from the cognitive, ad, depression and cerebrovascular perspectives. |
2003-05-12 |
2023-08-12 |
Not clear |
| B Leonar. Stress, depression and the activation of the immune system. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry. vol 1. issue 1. 2003-04-02. PMID:12607229. |
this review attempts to show how the immune, endocrine and neurotransmitter systems are integrated and how the result of such integration may be causally involved in the aetiology of depression. |
2003-04-02 |
2023-08-12 |
Not clear |
| E I Gusev, V I Skvortsov. [Glutamate neurotransmission and calcium metabolism in cerebral ischaemia and under normal conditions]. Uspekhi fiziologicheskikh nauk. vol 33. issue 4. 2003-02-12. PMID:12449809. |
the great attention is paid to the role of astroglia in energy metabolism and glutamate neurotransmission, to the mechanisms of regulation of concentrations of neurotransmitter amino acids in the synaptic cleft, as well as to the mechanisms of spreading depression waves and zinc neurotoxicity. |
2003-02-12 |
2023-08-12 |
Not clear |
| Daphna Laifenfeld, Ehud Klein, Dorit Ben-Shacha. Norepinephrine alters the expression of genes involved in neuronal sprouting and differentiation: relevance for major depression and antidepressant mechanisms. Journal of neurochemistry. vol 83. issue 5. 2003-01-16. PMID:12437576. |
taken together, the results support a role for ne in processes of synaptic connectivity, and may point to a role for this neurotransmitter in mediating the suggested neuronal plasticity in depression and in antidepressant treatment. |
2003-01-16 |
2023-08-12 |
human |
| E Nocerino, M Amato, A A Izz. Cannabis and cannabinoid receptors. Fitoterapia. vol 71 Suppl 1. 2003-01-01. PMID:10930707. |
cb(1) receptors have been detected in the central nervous system (where they are responsible for the characteristic effects of cannabis, including catalepsy, depression of motor activity, analgesia and feelings of relaxation and well being) and in peripheral neurons (where their activation produces a suppression in neurotransmitter release in the heart, bladder, intestine and vas deferens). |
2003-01-01 |
2023-08-12 |
Not clear |
| Andres M Kanner, Susan Pala. Neuropsychiatric complications of epilepsy. Current neurology and neuroscience reports. vol 2. issue 4. 2002-11-22. PMID:12044256. |
furthermore, similar neurotransmitter changes have been identified in depression and epilepsy, suggesting the possibility that these two disorders share common pathogenic mechanisms. |
2002-11-22 |
2023-08-12 |
Not clear |
| J H Chin, K Harris, D MacTavish, J H Jhamanda. Nociceptin/orphanin FQ modulation of ionic conductances in rat basal forebrain neurons. The Journal of pharmacology and experimental therapeutics. vol 303. issue 1. 2002-10-21. PMID:12235250. |
because n-type and l-type ca(2+) channels are important in the context of neurotransmitter release, our observations indicate that n/ofq inhibition of ca(2+)-dependent conductances in cholinergic neurons would be expected to result in depression of acetylcholine release, which may explain the behavioral actions of n/ofq in the brain. |
2002-10-21 |
2023-08-12 |
rat |
| Valeria Ayelli Edgar, Graciela A Cremaschi, Leonor Sterin-Borda, Ana María Genar. Altered expression of autonomic neurotransmitter receptors and proliferative responses in lymphocytes from a chronic mild stress model of depression: effects of fluoxetine. Brain, behavior, and immunity. vol 16. issue 4. 2002-08-22. PMID:12096882. |
altered expression of autonomic neurotransmitter receptors and proliferative responses in lymphocytes from a chronic mild stress model of depression: effects of fluoxetine. |
2002-08-22 |
2023-08-12 |
Not clear |