| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R-M Karlsson, A Holme. Galanin as a modulator of anxiety and depression and a therapeutic target for affective disease. Amino acids. vol 31. issue 3. 2008-02-20. PMID:16733616. |
galanin is a 29 amino-acid (30 in humans) neuropeptide with a close functional relationship with neurotransmitter systems implicated in the pathophysiology and treatment of depression and anxiety disorders. |
2008-02-20 |
2023-08-12 |
Not clear |
| David M Lovinge. Presynaptic modulation by endocannabinoids. Handbook of experimental pharmacology. issue 184. 2008-02-20. PMID:18064422. |
endocannabinoids and the cb1 receptor also play a key role in one form of long-term synaptic depression (ltd) that involves a longlasting decrease in neurotransmitter release. |
2008-02-20 |
2023-08-12 |
Not clear |
| Brian E Leonar. Psychopathology of depression. Drugs of today (Barcelona, Spain : 1998). vol 43. issue 10. 2008-01-31. PMID:17987223. |
in addition to explaining the link between defective neurotransmitter function and the symptoms of depression, changes in the endocrine and immune axes also help to explain the link between major depression and physical ill health. |
2008-01-31 |
2023-08-12 |
Not clear |
| Trevor Sharp, Laura Boothman, Josie Raley, Philip Quéré. Important messages in the 'post': recent discoveries in 5-HT neurone feedback control. Trends in pharmacological sciences. vol 28. issue 12. 2008-01-29. PMID:17996955. |
the neurotransmitter 5-hydroxytryptamine (5-ht, serotonin) mediates important brain functions and contributes to the pathophysiology and successful drug treatment of many common psychiatric disorders, especially depression. |
2008-01-29 |
2023-08-12 |
Not clear |
| Brian A McMillen, J Elizabeth Shank, Kirstin B Jordan, Helen L Williams, A S Basil. Effect of DOV 102,677 on the volitional consumption of ethanol by Myers' high ethanol-preferring rat. Alcoholism, clinical and experimental research. vol 31. issue 11. 2008-01-22. PMID:17908267. |
however, the evidence that single (serotonin) or dual (serotonin-norepinephrine) neurotransmitter uptake inhibitors can treat ethanol abuse, either as a comorbidity with depression or as a separate entity, is inconsistent. |
2008-01-22 |
2023-08-12 |
rat |
| Yue-Hua Li, Hua-Hui Liu, Lan-Feng Zhan. [Current situation of research and problems in diagnosis and treatment of senile depression with integrative traditional Chinese and Western medicine]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine. vol 26. issue 3. 2007-12-27. PMID:16613281. |
it is pointed out that it's necessary to expand the study with senior electrocerebral neurotransmitter analysis technique (set) for the diagnosis and efficacy evaluation of senile depression by either traditional chinese or western medicine. |
2007-12-27 |
2023-08-12 |
Not clear |
| J Szelényi, E S Viz. The catecholamine cytokine balance: interaction between the brain and the immune system. Annals of the New York Academy of Sciences. vol 1113. 2007-12-20. PMID:17584982. |
our results showed that depression is related both to changes in peripheral and in hippocampal inflammatory cytokine production and to monoamine neurotransmitter levels. |
2007-12-20 |
2023-08-12 |
mouse |
| Yoshiaki Maruyama, Mitsuhiko Yamad. [TREK-1: a potential target for novel antidepressants]. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology. vol 27. issue 4. 2007-10-30. PMID:17879592. |
the neurotransmitter serotonin (5-ht: 5-hydroxytryptamin) was suggested to be involved in the pathogenesis of depression as well as in the mechanisms of antidepressant treatments. |
2007-10-30 |
2023-08-12 |
mouse |
| b' A Barroso, L Oliveira, E Campesatto-Mella, C Silva, M A Tim\\xc3\\xb3teo, M T Magalh\\xc3\\xa3es-Cardoso, W Alves-do-Prado, P Correia-de-S\\xc3\\xa. L-citrulline inhibits [3H]acetylcholine release from rat motor nerve terminals by increasing adenosine outflow and activation of A1 receptors. British journal of pharmacology. vol 151. issue 4. 2007-08-07. PMID:17401439.' |
nitric oxide (no) production and depression of neuromuscular transmission are closely related, but little is known about the role of l-citrulline, a co-product of no biosynthesis, on neurotransmitter release. |
2007-08-07 |
2023-08-12 |
rat |
| Michael R Irwin, Andrew H Mille. Depressive disorders and immunity: 20 years of progress and discovery. Brain, behavior, and immunity. vol 21. issue 4. 2007-07-17. PMID:17360153. |
increasing data now indicate that activated inflammatory processes can influence multiple aspects of cns function including neurotransmitter metabolism, neuroendocrine function, and information processing leading to behavioral changes in humans that bespeak depression. |
2007-07-17 |
2023-08-12 |
Not clear |
| Marshal Folstein, Timothy Liu, Inga Peter, Jennifer Buell, Jennifer Buel, Lisa Arsenault, Tammy Scott, Wendy W Qi. The homocysteine hypothesis of depression. The American journal of psychiatry. vol 164. issue 6. 2007-07-12. PMID:17541043. |
a plausible hypothesis for these associations is that high homocysteine levels cause cerebral vascular disease and neurotransmitter deficiency, which cause depression of mood. |
2007-07-12 |
2023-08-12 |
Not clear |
| Daniela Pietrobo. Familial hemiplegic migraine. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. vol 4. issue 2. 2007-07-06. PMID:17395138. |
these studies show the following: (1) fhm1 mutations produce gain-of-function of the ca(v)2.1 channel and, as a consequence, increased ca(v)2.1-dependent neurotransmitter release from cortical neurons and facilitation of in vivo induction and propagation of cortical spreading depression (csd: the phenomenon underlying migraine aura); (2) fhm2 mutations produce loss-of-function of the alpha2 na+,k+-atpase; and (3) the fhm3 mutation accelerates recovery from fast inactivation of na(v)1.5 (and presumably na(v)1.1) channels. |
2007-07-06 |
2023-08-12 |
mouse |
| S Weis, I C Llenos, J R Dulay, N Verma, S Sabunciyan, R H Yolke. Changes in region- and cell type-specific expression patterns of neutral amino acid transporter 1 (ASCT-1) in the anterior cingulate cortex and hippocampus in schizophrenia, bipolar disorder and major depression. Journal of neural transmission (Vienna, Austria : 1996). vol 114. issue 2. 2007-06-13. PMID:16897601. |
although, the pathogenetic mechanisms of schizophrenia, bipolar disorder, and major depression are not clearly understood, various neurotransmitter systems are reported to have altered expression patterns of their receptor and transporter proteins. |
2007-06-13 |
2023-08-12 |
Not clear |
| J W Schwartz, D Piston, L J DeFelic. Molecular microfluorometry: converting arbitrary fluorescence units into absolute molecular concentrations to study binding kinetics and stoichiometry in transporters. Handbook of experimental pharmacology. issue 175. 2007-05-23. PMID:16722229. |
transport inhibition with tricyclic antidepressants prolongs neurotransmitter presence in the synaptic cleft, potentially alleviating symptoms of depression. |
2007-05-23 |
2023-08-12 |
Not clear |
| M Mlynarik, D Zelena, G Bagdy, G B Makara, D Jezov. Signs of attenuated depression-like behavior in vasopressin deficient Brattleboro rats. Hormones and behavior. vol 51. issue 3. 2007-05-21. PMID:17258216. |
vasopressin, a peptide hormone functioning also as a neurotransmitter, neuromodulator and regulator of the stress response is considered to be one of the factors related to the development and course of depression. |
2007-05-21 |
2023-08-12 |
rat |
| Charles B Nemerof. Recent advances in the neurobiology of depression. Psychopharmacology bulletin. vol 36 Suppl 2. 2007-05-03. PMID:12490820. |
substantial evidence has accrued, including changes in neurotransmitter and neurotransmitter metabolite concentrations, reuptake sites, and receptors, to support the hypothesis that alteration in neuronal serotonergic and noradrenergic function occurs in the central nervous system of patients with major depression. |
2007-05-03 |
2023-08-12 |
Not clear |
| Marcus Ising, Florian Holsboe. Genetics of stress response and stress-related disorders. Dialogues in clinical neuroscience. vol 8. issue 4. 2007-02-26. PMID:17290801. |
the major findings regarding the genetics of stress response and stress-related disorders are: (i) variations in genes involved in the sympathetic system or in the hypothalamic-pituitary-adrenocortical axis are associated with altered stress responses; (ii) genes related to the renin-angiotensin-aldosterone system or inflammation/immune response show associations with cardiovascular disorders; (iii) genes involved in monoaminergic neurotransmitter systems are associated with bipolar disorder and unipolar depression. |
2007-02-26 |
2023-08-12 |
Not clear |
| Mert Ertunc, Yildirim Sara, ChiHye Chung, Deniz Atasoy, Tuhin Virmani, Ege T Kavalal. Fast synaptic vesicle reuse slows the rate of synaptic depression in the CA1 region of hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 2. 2007-02-02. PMID:17215395. |
here, by blocking the vacuolar atpase, alkalinizing the extracellular ph, or exposing hippocampal slices to ph buffers, we impaired neurotransmitter refilling, and electrophysiologically tested the role of vesicle reuse in synaptic depression. |
2007-02-02 |
2023-08-12 |
Not clear |
| Mert Ertunc, Yildirim Sara, ChiHye Chung, Deniz Atasoy, Tuhin Virmani, Ege T Kavalal. Fast synaptic vesicle reuse slows the rate of synaptic depression in the CA1 region of hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 2. 2007-02-02. PMID:17215395. |
at 20 hz, compromising neurotransmitter refilling increased depression within 300 ms reaching completion within 2 s, suggesting a minimal contribution of reserve vesicles to neurotransmission. |
2007-02-02 |
2023-08-12 |
Not clear |
| Amy Aloysi, Kathleen Van Dyk, Mary San. Women's cognitive and affective health and neuropsychiatry. The Mount Sinai journal of medicine, New York. vol 73. issue 7. 2007-02-01. PMID:17195882. |
gender differences in other psychiatric conditions including depression and anxiety have been attributed to hormones, and the neurotransmitter systems that are implicated in affective disorders may have an impact on cognitive impairment as well. |
2007-02-01 |
2023-08-12 |
Not clear |