| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Catherine Heurteaux, Guillaume Lucas, Nicolas Guy, Malika El Yacoubi, Susanne Thümmler, Xiao-Dong Peng, Florence Noble, Nicolas Blondeau, Catherine Widmann, Marc Borsotto, Gabriella Gobbi, Jean-Marie Vaugeois, Guy Debonnel, Michel Lazdunsk. Deletion of the background potassium channel TREK-1 results in a depression-resistant phenotype. Nature neuroscience. vol 9. issue 9. 2006-11-14. PMID:16906152. |
the neurotransmitter serotonin or 5-hydroxytryptamine (5-ht) is involved in the pathophysiology of depression and in the effects of antidepressant treatments. |
2006-11-14 |
2023-08-12 |
mouse |
| V-P Bob Grover, M-Alex Dresner, Daniel-M Forton, Serena Counsell, David-J Larkman, Nayna Patel, Howard-C Thomas, Simon-D Taylor-Robinso. Current and future applications of magnetic resonance imaging and spectroscopy of the brain in hepatic encephalopathy. World journal of gastroenterology. vol 12. issue 19. 2006-07-18. PMID:16718775. |
research interest has focused on the role of circulating gut-derived toxins, particularly ammonia, the development of brain swelling and changes in cerebral neurotransmitter systems that lead to global cns depression and disordered function. |
2006-07-18 |
2023-08-12 |
Not clear |
| Jing Qian, Jeffrey L Noebel. Exocytosis of vesicular zinc reveals persistent depression of neurotransmitter release during metabotropic glutamate receptor long-term depression at the hippocampal CA3-CA1 synapse. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 22. 2006-06-23. PMID:16738253. |
exocytosis of vesicular zinc reveals persistent depression of neurotransmitter release during metabotropic glutamate receptor long-term depression at the hippocampal ca3-ca1 synapse. |
2006-06-23 |
2023-08-12 |
Not clear |
| Alain Gardie. [Mechanism of action of antidepressant drugs: importance of genetically modified mice in the pharmacological in vivo approach]. Therapie. vol 60. issue 5. 2006-03-28. PMID:16433012. |
these recent findings suggest that instead of being rejected, the monoaminergic hypothesis of depression should be improved, corrected and completed by studying the role of other neurotransmitter, neuromodulatory compounds (substance p, bdnf [brain-derived neurotrophic factor]). |
2006-03-28 |
2023-08-12 |
mouse |
| Ronald M Salomon, Benjamin W Johnson, Dennis E Schmid. Central neurochemical ultradian variability in depression. Disease markers. vol 22. issue 1-2. 2006-03-17. PMID:16410652. |
this study examined intrinsic variability in brain neurotransmitter function, since it may be a source of blunted behavior and neuroendocrine function in depression and a marker for the illness, and has not previously been analyzed using wavelet decomposition. |
2006-03-17 |
2023-08-12 |
Not clear |
| Ying Xu, Bao-Shan Ku, Hai-Yan Yao, Yan-Hua Lin, Xing Ma, Yong-He Zhang, Xue-Jun L. Antidepressant effects of curcumin in the forced swim test and olfactory bulbectomy models of depression in rats. Pharmacology, biochemistry, and behavior. vol 82. issue 1. 2006-01-17. PMID:16171853. |
these results confirm the antidepressant effects of curcumin in the forced swim and the ob models of depression in rats, and suggest that these antidepressant effects may be mediated by actions in the central monoaminergic neurotransmitter systems. |
2006-01-17 |
2023-08-12 |
rat |
| Richard M Sobel, Susan Lotkowski, Steven Mande. Update on depression in neurologic illness: stroke, epilepsy, and multiple sclerosis. Current psychiatry reports. vol 7. issue 5. 2006-01-10. PMID:16216161. |
depression can share pathophysiologic aspects of the comorbid illness, such as neurotransmitter pathway disturbances, hypothalamus-pituitary-adrenal pathway disturbances, and changes in immunologic function. |
2006-01-10 |
2023-08-12 |
Not clear |
| John A Tsiouri. Metabolic depression in hibernation and major depression: an explanatory theory and an animal model of depression. Medical hypotheses. vol 65. issue 5. 2005-10-27. PMID:16061329. |
hibernation in bears and major depression with melancholic features are characterized by withdrawal from the environment, lack of energy, loss of weight from not eating and burning stored fat, changes in sleep pattern, and the following similar neurobiological findings: reversible subclinical hypothyroidism; increased concentration of serum cortisol; acute phase protein response; low respiratory quotient; oxidative stress response; decreased neurotransmitter levels; and changes in cyclic-adenosine monophosphate-binding activity. |
2005-10-27 |
2023-08-12 |
human |
| J Vignau, L Karila, O Costisella, V Canv. [Hepatitis C, interferon a and depression: main physiopathologic hypothesis]. L'Encephale. vol 31. issue 3. 2005-10-25. PMID:16142050. |
second, keeping in mind that serotonin is a monoaminergic neurotransmitter classically involved in depression pathophysiology, other works have demonstrated that ifnalpha modulates the peripheral activity of indolamine-dioxygenase -- a regulating enzyme of serotonin metabolism -- possibly through lymphocyte t cd4 activation. |
2005-10-25 |
2023-08-12 |
human |
| Vicente Varea, Javier Martín de Carpi, Conchita Puig, José Angel Alda, Eva Camacho, Aida Ormazabal, Rafael Artuch, Lilianne Góme. Malabsorption of carbohydrates and depression in children and adolescents. Journal of pediatric gastroenterology and nutrition. vol 40. issue 5. 2005-09-15. PMID:15861016. |
as serotonin is the most important neurotransmitter involved in depressive disorders, its depletion could lead to the onset of depression. |
2005-09-15 |
2023-08-12 |
Not clear |
| Toshikazu Sait. [Study on mental diseases: neural stem cells]. Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica. vol 107. issue 6. 2005-09-13. PMID:16048110. |
the neurosciences to understand the pathophysiology of psychiatric disorders such as depression and schizophrenia were started from the analysis of neurotransmitter function change, and proceed to the cellular signaling change in the brains. |
2005-09-13 |
2023-08-12 |
Not clear |
| Iu V Karaulova, A A Shuto. [Serum serotonin in patients with tension headaches]. Klinicheskaia meditsina. vol 83. issue 6. 2005-09-13. PMID:16075647. |
the leading role in its pathogenesis is played by depression and dysmetabolism of the neurotransmitter serotonin. |
2005-09-13 |
2023-08-12 |
human |
| Manabu Ichikawa, Yuko Okamura-Oho, Rie Okunishi, Mutsumi Kanamori, Harukazu Suzuki, Akishige Ritani, Hiroaki Nitta, Naomi Eguchi, Yoshihiro Urade, Yoshihide Hayashizak. Expression analysis of genes responsible for serotonin signaling in the brain. Neurobiology of disease. vol 19. issue 3. 2005-08-25. PMID:16023580. |
using functional annotated cdna clones (fantom), we examined the gene expression patterns of the serotonin neurotransmitter system, which is involved in psychiatric diseases such as depression. |
2005-08-25 |
2023-08-12 |
Not clear |
| Ping-Yue Pan, Qian Cai, Lin Lin, Pei-Hua Lu, Shumin Duan, Zu-Hang Shen. SNAP-29-mediated modulation of synaptic transmission in cultured hippocampal neurons. The Journal of biological chemistry. vol 280. issue 27. 2005-08-16. PMID:15890653. |
whereas neurotransmitter release was unaffected during intensive stimulation, recovery after synaptic depression was impaired by snap-29. |
2005-08-16 |
2023-08-12 |
Not clear |
| Cai Song, Brian E Leonar. The olfactory bulbectomised rat as a model of depression. Neuroscience and biobehavioral reviews. vol 29. issue 4-5. 2005-08-16. PMID:15925697. |
bilateral olfactory bulbectomy results in changes in behavior, and in the endocrine, immune and neurotransmitter systems, that simulates many of those seen in patients with major depression. |
2005-08-16 |
2023-08-12 |
rat |
| Yamima Osher, Yuly Bersudsky, R H Belmake. Omega-3 eicosapentaenoic acid in bipolar depression: report of a small open-label study. The Journal of clinical psychiatry. vol 66. issue 6. 2005-08-04. PMID:15960565. |
this proposition is supported by a series of biochemical and pharmacologic studies that have suggested that fatty acids may modulate neurotransmitter metabolism and cell signal trans-duction in humans and that abnormalities in fatty acid and eicosanoid metabolism may play a causal role in depression. |
2005-08-04 |
2023-08-12 |
Not clear |
| J Baranyi, N Bakos, J Halle. Social instability in female rats: the relationship between stress-related and anxiety-like consequences. Physiology & behavior. vol 84. issue 4. 2005-07-26. PMID:15811385. |
it is generally believed that anxiety and depression develop in response to stressful events that chronically increase glucocorticoid production (which in turn affects various neurotransmitter systems). |
2005-07-26 |
2023-08-12 |
human |
| T D Perera, S H Lisanb. Neurogenesis and depression. Journal of psychiatric practice. vol 6. issue 6. 2005-07-13. PMID:15990493. |
stress, neuroendocrine activation, neurotransmitter systems, and other factors can down-regulate the process of neurogenesis and may contribute to certain morphological changes seen in depression. |
2005-07-13 |
2023-08-12 |
Not clear |
| Ying Wu, Fumiko Kawasaki, Richard W Ordwa. Properties of short-term synaptic depression at larval neuromuscular synapses in wild-type and temperature-sensitive paralytic mutants of Drosophila. Journal of neurophysiology. vol 93. issue 5. 2005-06-13. PMID:15845998. |
this form of synaptic depression, referred to here as low-frequency short-term depression (lf-std), results from an activity-dependent reduction in neurotransmitter release. |
2005-06-13 |
2023-08-12 |
drosophila_melanogaster |
| Ying Wu, Fumiko Kawasaki, Richard W Ordwa. Properties of short-term synaptic depression at larval neuromuscular synapses in wild-type and temperature-sensitive paralytic mutants of Drosophila. Journal of neurophysiology. vol 93. issue 5. 2005-06-13. PMID:15845998. |
however, in contrast to the predictions of depletion models, the degree of depression was independent of the initial level of neurotransmitter release over a range of extracellular calcium concentrations. |
2005-06-13 |
2023-08-12 |
drosophila_melanogaster |