| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Martyn D Wood, David R Thomas, Jeannette M Watso. Therapeutic potential of serotonin antagonists in depressive disorders. Expert opinion on investigational drugs. vol 11. issue 4. 2002-08-15. PMID:11922855. |
although the precise neurochemical imbalances in depression are still unknown, a role for the neurotransmitter 5-hydroxytryptamine (serotonin) has been implicated since the identification of the first effective antidepressants, imipramine and iproniazid. |
2002-08-15 |
2023-08-12 |
rat |
| C Nocjar, B L Roth, E A Pehe. Localization of 5-HT(2A) receptors on dopamine cells in subnuclei of the midbrain A10 cell group. Neuroscience. vol 111. issue 1. 2002-07-18. PMID:11955720. |
considerable evidence suggests that a dysfunction of the dopamine and serotonin (5-hydroxytryptamine or 5-ht) neurotransmitter systems contributes to a diverse range of pathological conditions including schizophrenia, depression and drug abuse. |
2002-07-18 |
2023-08-12 |
rat |
| Jordan G Wood, Peter R Joyce, Allison L Miller, Roger T Mulder, Martin A Kenned. A polymorphism in the dopamine beta-hydroxylase gene is associated with "paranoid ideation" in patients with major depression. Biological psychiatry. vol 51. issue 5. 2002-05-13. PMID:11904130. |
dopamine beta-hydroxylase (dbetah) catalyses the key step in biosynthesis of the neurotransmitter noradrenaline from dopamine, and low dbetah activity is a possible risk factor for developing psychotic depression. |
2002-05-13 |
2023-08-12 |
Not clear |
| Seong Who Kim, So Yeon Park, Onyou Hwan. Up-regulation of tryptophan hydroxylase expression and serotonin synthesis by sertraline. Molecular pharmacology. vol 61. issue 4. 2002-04-11. PMID:11901216. |
the neurotransmitter serotonin is involved in a variety of brain functions, and abnormal changes in serotonin neurotransmission are associated with an array of psychiatric disorders, including depression. |
2002-04-11 |
2023-08-12 |
rat |
| Yildirim Sara, Marina G Mozhayeva, Xinran Liu, Ege T Kavalal. Fast vesicle recycling supports neurotransmission during sustained stimulation at hippocampal synapses. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 5. 2002-03-22. PMID:11880491. |
high-intensity stimulation of neurotransmitter release was induced by hyperosmolarity, high potassium, or action potential firing at 30 hz to produce synaptic depression. |
2002-03-22 |
2023-08-12 |
Not clear |
| G N Pandey, X Ren, S C Pandey, Y Dwivedi, R Sharma, P G Janica. Hyperactive phosphoinositide signaling pathway in platelets of depressed patients: effect of desipramine treatment. Psychiatry research. vol 105. issue 1-2. 2002-02-26. PMID:11740972. |
there is some evidence to suggest that certain neurotransmitter receptors, such as adrenergic and serotonergic receptors and receptor-linked signaling systems, may be altered in depression. |
2002-02-26 |
2023-08-12 |
human |
| Adam G Carter, Kaspar E Vogt, Kelly A Foster, Wade G Regeh. Assessing the role of calcium-induced calcium release in short-term presynaptic plasticity at excitatory central synapses. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 1. 2002-02-04. PMID:11756484. |
depletion of internal calcium stores with thapsigargin and prevention of cicr with ryanodine have no effect on paired-pulse facilitation, delayed release of neurotransmitter, or calcium-dependent recovery from depression. |
2002-02-04 |
2023-08-12 |
rat |
| J Kaufman, D Charne. Effects of early stress on brain structure and function: implications for understanding the relationship between child maltreatment and depression. Development and psychopathology. vol 13. issue 3. 2002-01-10. PMID:11523843. |
the preclinical studies demonstrate that stress early in life can alter the development multiple neurotransmitter systems and promote structural and functional alterations in brain regions similar to those seen in adults with depression. |
2002-01-10 |
2023-08-12 |
Not clear |
| H K Strüder, H Weicke. Physiology and pathophysiology of the serotonergic system and its implications on mental and physical performance. Part II. International journal of sports medicine. vol 22. issue 7. 2001-12-11. PMID:11590475. |
impairment of neuromodulation and neuronal network in the brain with transient dysfunctions or permanent substantial deficits at manifestation of various types of depression results from prevalent impairment of 5-ht neurotransmission and its central interaction with other neurotransmitter systems. |
2001-12-11 |
2023-08-12 |
Not clear |
| K W Raines, F J Seidler, T A Slotki. Alterations in serotonin transporter expression in brain regions of rats exposed neonatally to chlorpyrifos. Brain research. Developmental brain research. vol 130. issue 1. 2001-12-04. PMID:11557094. |
because the cpf effects involve 5ht, a neurotransmitter intimately involved in the control of mood, we suggest the need to evaluate behaviors that typify animal models of depression. |
2001-12-04 |
2023-08-12 |
rat |
| C S Yos. Tandem pore domain K channels: an important site of volatile anesthetic action? Current drug targets. vol 1. issue 2. 2001-08-30. PMID:11465071. |
although enhanced activity of inhibitory neurotransmitter systems (gabaa) and depression of excitatory neurotransmitter systems (nmda) probably contribute to the anesthetic state, the role of other ion channels families have also been studied. |
2001-08-30 |
2023-08-12 |
Not clear |
| K J Ressler, C B Nemerof. Role of serotonergic and noradrenergic systems in the pathophysiology of depression and anxiety disorders. Depression and anxiety. vol 12 Suppl 1. 2001-08-23. PMID:11098410. |
there is abundant evidence for abnormalities of the norepinephrine (ne) and serotonin (5ht) neurotransmitter systems in depression and anxiety disorders. |
2001-08-23 |
2023-08-12 |
Not clear |
| J Pamidimukkala, M Ha. Frequency dependence of endocytosis in aortic baroreceptor neurons and role of group III mGluRs. American journal of physiology. Heart and circulatory physiology. vol 281. issue 1. 2001-07-26. PMID:11406507. |
reductions in neurotransmitter release and alterations in mechanisms regulating synaptic transmission are hypothesized to be involved in the activity-dependent depression observed in baroreceptor afferent neurons. |
2001-07-26 |
2023-08-12 |
Not clear |
| L Lykouras, M Markianos, J Hatzimanolis, P Oulis, G Christodoulo. Prolactin secretion in response to haloperidol challenge in delusional (psychotic) and non-delusional depression. European psychiatry : the journal of the Association of European Psychiatrists. vol 15. issue 8. 2001-07-12. PMID:11175925. |
certain studies on measures related to central neurotransmitter activity have demonstrated that in delusional (psychotic) depression there is a dopaminergic dysregulation which distinguishes it from non-psychotic depression. |
2001-07-12 |
2023-08-12 |
Not clear |
| Y Humeau, F Doussau, F Vitiello, P Greengard, F Benfenati, B Poulai. Synapsin controls both reserve and releasable synaptic vesicle pools during neuronal activity and short-term plasticity in Aplysia. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 12. 2001-07-12. PMID:11404405. |
when endogenous synapsin was neutralized by the injection of specific anti-synapsin antibodies, the amount of neurotransmitter released per impulse was unaffected, but marked changes in the secretory response to high-frequency stimulation were observed, including the disappearance of post-tetanic potentiation (ptp) that was substituted by post-tetanic depression (ptd), and increased rate and extent of synaptic depression. |
2001-07-12 |
2023-08-12 |
aplysia |
| E A Jone. Pathogenesis of hepatic encephalopathy. Clinics in liver disease. vol 4. issue 2. 2001-05-24. PMID:11232201. |
its manifestations are most consistent with a global depression of cns function, which could arise as a consequence of a net increase in inhibitory neurotransmission, due to an imbalance between the functional status of inhibitory (e.g., gaba) and excitatory (e.g., glutamate) neurotransmitter systems. |
2001-05-24 |
2023-08-12 |
Not clear |
| J Ong, D I Ker. Recent advances in GABAB receptors: from pharmacology to molecular biology. Acta pharmacologica Sinica. vol 21. issue 2. 2001-05-10. PMID:11263257. |
bicuculline-insensitive receptors for the inhibitory neurotransmitter gamma-aminobutyric acid (gaba), gabab receptors, are a distinct subclass of receptors that mediate depression of synaptic transmission and contribute to neuronal inhibition. |
2001-05-10 |
2023-08-12 |
Not clear |
| P Boye. Do anxiety and depression have a common pathophysiological mechanism? Acta psychiatrica Scandinavica. Supplementum. issue 406. 2001-02-22. PMID:11131467. |
to review, examine and propose a common mechanism for anxiety and depression based on modifications observed in neurotransmitter systems (mainly noradrenergic and serotonergic) and dysregulation of the hypothalamic-pituitary-adrenal (hpa) axis. |
2001-02-22 |
2023-08-12 |
Not clear |
| S Bertrand, J R Cazalets, W Buñ. N- and P/Q-type Ca(2+) channels are involved in neurotransmitter release but not in synaptic depression in the spinal cord of the neonatal rat. Neuroscience letters. vol 295. issue 1-2. 2001-01-09. PMID:11078929. |
n- and p/q-type ca(2+) channels are involved in neurotransmitter release but not in synaptic depression in the spinal cord of the neonatal rat. |
2001-01-09 |
2023-08-12 |
rat |
| K S Hsu, Y C Liang, C C Huan. Influence of an extracellular acidosis on excitatory synaptic transmission and long-term potentiation in the CA1 region of rat hippocampal slices. Journal of neuroscience research. vol 62. issue 3. 2000-12-22. PMID:11054810. |
these results suggest that the extracellular acidosis -induced synaptic depression is likely to result from an inhibition of presynaptic na (+) conductance, thereby decreasing the amplitude of action potentials in individual afferent fibers or the number of afferent fiber activation to stimuli and then indirectly affecting the signaling processes contributing to trigger neurotransmitter release. |
2000-12-22 |
2023-08-12 |
rat |