| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Y I Shelin. 3D MRI studies of neuroanatomic changes in unipolar major depression: the role of stress and medical comorbidity. Biological psychiatry. vol 48. issue 8. 2000-12-07. PMID:11063975. |
combining mri studies with functional studies has the potential to localize abnormalities in blood flow, metabolism, and neurotransmitter receptors and provide a better integrated model of depression. |
2000-12-07 |
2023-08-12 |
Not clear |
| C Murr, B Widner, B Sperner-Unterweger, M Ledochowski, C Schubert, D Fuch. Immune reaction links disease progression in cancer patients with depression. Medical hypotheses. vol 55. issue 2. 2000-10-13. PMID:10904430. |
because tryptophan is precursor for the biosynthesis of the neurotransmitter serotonin (= 5-hydroxytryptamine, 5ht), low tryptophan concentrations will lead to decreased availability of serotonin which finally increases the susceptibility for the development of mood disturbances and depression in the patients. |
2000-10-13 |
2023-08-12 |
Not clear |
| C Murr, B Widner, B Sperner-Unterweger, M Ledochowski, C Schubert, D Fuch. Immune reaction links disease progression in cancer patients with depression. Medical hypotheses. vol 55. issue 2. 2000-10-13. PMID:10904430. |
in conclusion, a more aggressive tumour rather than depression will be responsible for worse outcome of cancer patients and will be associated with a more drastic challenge of the immune system, as a side effect leading to neurotransmitter disturbances. |
2000-10-13 |
2023-08-12 |
Not clear |
| E Quattrocki, A Baird, D Yurgelun-Tod. Biological aspects of the link between smoking and depression. Harvard review of psychiatry. vol 8. issue 3. 2000-10-12. PMID:10973935. |
the neurotransmitter systems affected by cigarette smoke mirror the neurotransmitter pathways thought to be involved in the biological mechanisms of depression. |
2000-10-12 |
2023-08-12 |
Not clear |
| W Zhang, K W Perry, D T Wong, B D Potts, J Bao, G D Tollefson, F P Bymaste. Synergistic effects of olanzapine and other antipsychotic agents in combination with fluoxetine on norepinephrine and dopamine release in rat prefrontal cortex. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 23. issue 3. 2000-10-11. PMID:10942849. |
to understand the mechanism of the clinical efficacy of olanzapine and fluoxetine combination therapy for treatment-resistant depression (trd), we studied the effects of olanzapine and other antipsychotics in combination with the selective serotonin uptake inhibitors fluoxetine or sertraline on neurotransmitter release in rat prefrontal cortex (pfc) using microdialysis. |
2000-10-11 |
2023-08-12 |
rat |
| M E Thas. Treatment issues related to sleep and depression. The Journal of clinical psychiatry. vol 61 Suppl 11. 2000-08-04. PMID:10926055. |
the same neurotransmitter systems that regulate mood, interest, energy, and other functions that may be disturbed in depression also regulate sleep. |
2000-08-04 |
2023-08-12 |
Not clear |
| A Anand, D S Charne. Norepinephrine dysfunction in depression. The Journal of clinical psychiatry. vol 61 Suppl 10. 2000-07-27. PMID:10910013. |
the study of the noradrenergic neurotransmitter system remains one of the cornerstones of depression research. |
2000-07-27 |
2023-08-12 |
Not clear |
| A Mansilla, H Barajas, R Argüer. Theoretical aspects of the neurobiological integration of memory. Medical hypotheses. vol 54. issue 1. 2000-06-23. PMID:10790724. |
two different processes regulate short-term memory: (1) homosynaptic depression that inhibits neurotransmitter release by means of a decrease in ca++ inflow, and an increase in calmodulin affinity for synaptic vesicles; and (2) heterosynaptic facilitation that triggers neurotransmitter release, whenever serotonin activates a proteinkinase a. |
2000-06-23 |
2023-08-12 |
Not clear |
| D L Brody, D T Yu. Release-independent short-term synaptic depression in cultured hippocampal neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 7. 2000-05-16. PMID:10729328. |
(1) reduction of neurotransmitter release probability with cd(2+), a blocker of voltage-gated calcium channels, did not change depression. |
2000-05-16 |
2023-08-12 |
Not clear |
| H K Chaturvedi, D Chandra, J S Bapn. Interaction between N-methyl-D-aspartate receptor antagonists and imipramine in shock-induced depression. Indian journal of experimental biology. vol 37. issue 10. 2000-05-15. PMID:10783752. |
these findings suggest an antidepressant effect of the nmda receptor antagonists, and a complexity of neurotransmitter mechanisms, which are responsible for the occurrence of behavioural effects in shock-induced depression model. |
2000-05-15 |
2023-08-12 |
mouse |
| S Meyer. Use of neurotransmitter precursors for treatment of depression. Alternative medicine review : a journal of clinical therapeutic. vol 5. issue 1. 2000-03-28. PMID:10696120. |
use of neurotransmitter precursors for treatment of depression. |
2000-03-28 |
2023-08-12 |
Not clear |
| S Meyer. Use of neurotransmitter precursors for treatment of depression. Alternative medicine review : a journal of clinical therapeutic. vol 5. issue 1. 2000-03-28. PMID:10696120. |
the nature of the studies makes it difficult to draw firm conclusions regarding the efficacy of neurotransmitter precursors for treating depression. |
2000-03-28 |
2023-08-12 |
Not clear |
| S Meyer. Use of neurotransmitter precursors for treatment of depression. Alternative medicine review : a journal of clinical therapeutic. vol 5. issue 1. 2000-03-28. PMID:10696120. |
however, the evidence suggests neurotransmitter precursors can be helpful in patients with mild or moderate depression. |
2000-03-28 |
2023-08-12 |
Not clear |
| P L Delgado, F A Moren. Role of norepinephrine in depression. The Journal of clinical psychiatry. vol 61 Suppl 1. 2000-03-09. PMID:10703757. |
this article reviews the role of norepinephrine (ne) and serotonin (5-ht) in depression and the therapeutic effects of antidepressant drugs from the perspective of human neurotransmitter depletion studies. |
2000-03-09 |
2023-08-12 |
human |
| J M Gorman, G Sulliva. Noradrenergic approaches to antidepressant therapy. The Journal of clinical psychiatry. vol 61 Suppl 1. 2000-03-09. PMID:10703758. |
this increased understanding of the interrelationship between neurotransmitter systems has renewed interest in the role of neurotransmitters other than serotonin in the treatment of depression. |
2000-03-09 |
2023-08-12 |
Not clear |
| J M Gorman, G Sulliva. Noradrenergic approaches to antidepressant therapy. The Journal of clinical psychiatry. vol 61 Suppl 1. 2000-03-09. PMID:10703758. |
clinicians now have a range of antidepressants with variable neurotransmitter effects, different side effect profiles, and some interesting differences in functional utility in their armamentarium for treating depression. |
2000-03-09 |
2023-08-12 |
Not clear |
| C Ayata, M Shimizu-Sasamata, E H Lo, J L Noebels, M A Moskowit. Impaired neurotransmitter release and elevated threshold for cortical spreading depression in mice with mutations in the alpha1A subunit of P/Q type calcium channels. Neuroscience. vol 95. issue 3. 2000-03-01. PMID:10670432. |
impaired neurotransmitter release and elevated threshold for cortical spreading depression in mice with mutations in the alpha1a subunit of p/q type calcium channels. |
2000-03-01 |
2023-08-12 |
mouse |
| R T Rubin, S M O'Toole, M E Rhodes, L K Sekula, R K Czambe. Hypothalamo-pituitary-adrenal cortical responses to low-dose physostigmine and arginine vasopressin administration: sex differences between major depressives and matched control subjects. Psychiatry research. vol 89. issue 1. 2000-02-18. PMID:10643873. |
of heuristic value in understanding the neurochemistry of major depression is whether the hypothalamo-pituitary-adrenocortical (hpa) axis hyperactivity that occurs in this illness can be related to putative neurotransmitter dysfunction(s). |
2000-02-18 |
2023-08-12 |
human |
| G Sanacora, G F Mason, D L Rothman, K L Behar, F Hyder, O A Petroff, R M Berman, D S Charney, J H Krysta. Reduced cortical gamma-aminobutyric acid levels in depressed patients determined by proton magnetic resonance spectroscopy. Archives of general psychiatry. vol 56. issue 11. 1999-11-23. PMID:10565505. |
in this study we used in vivo proton magnetic resonance spectroscopy to investigate the hypothesis that abnormalities in the gaba neurotransmitter system are associated with the neurobiologic processes of depression. |
1999-11-23 |
2023-08-12 |
Not clear |
| T Heinbockel, H C Pap. Modulatory effects of adenosine on inhibitory postsynaptic potentials in the lateral amygdala of the rat. British journal of pharmacology. vol 128. issue 1. 1999-11-22. PMID:10498851. |
adenosine can presynaptically downregulate inhibitory postsynaptic responses and could exert dampening effects likely by depression of both excitatory and inhibitory neurotransmitter release. |
1999-11-22 |
2023-08-12 |
rat |