| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| John G Mielke, Tarun K Ahuja, Tanya Comas, Geoffrey A R Mealin. Choline-mediated depression of hippocampal synaptic transmission. Nutritional neuroscience. vol 14. issue 5. 2011-12-20. PMID:22005282. |
the ability of choline to increase paired-pulse facilitation, and the inability of applied gamma-aminobutyric acid (gaba) to mediate further depression of fepsps, suggests that the principal mechanism of choline's action was on the facilitation of neurotransmitter release. |
2011-12-20 |
2023-08-12 |
Not clear |
| Diasynou Fioravante, Wade G Regeh. Short-term forms of presynaptic plasticity. Current opinion in neurobiology. vol 21. issue 2. 2011-09-12. PMID:21353526. |
short-term depression suppresses neurotransmitter release for hundreds of milliseconds to tens of seconds; facilitation and post-tetanic potentiation lead to synaptic enhancement lasting hundreds of milliseconds to minutes. |
2011-09-12 |
2023-08-12 |
Not clear |
| Y A Khadrawy, K A I El-Shamy, S I Mohame. Nicotine restores monoamine neurotransmitter changes in the cortex and hippocampus of reserpinized rats as a model of depression. European review for medical and pharmacological sciences. vol 15. issue 8. 2011-09-06. PMID:21845795. |
nicotine restores monoamine neurotransmitter changes in the cortex and hippocampus of reserpinized rats as a model of depression. |
2011-09-06 |
2023-08-12 |
rat |
| Alan R Prossin, Alisa E Koch, Phillip L Campbell, Melvin G McInnis, Steven S Zalcman, Jon-Kar Zubiet. Association of plasma interleukin-18 levels with emotion regulation and μ-opioid neurotransmitter function in major depression and healthy volunteers. Biological psychiatry. vol 69. issue 8. 2011-08-08. PMID:21145535. |
association of plasma interleukin-18 levels with emotion regulation and μ-opioid neurotransmitter function in major depression and healthy volunteers. |
2011-08-08 |
2023-08-12 |
human |
| Jufang Shan, Jonathan A Javitch, Lei Shi, Harel Weinstei. The substrate-driven transition to an inward-facing conformation in the functional mechanism of the dopamine transporter. PloS one. vol 6. issue 1. 2011-08-02. PMID:21298009. |
the dopamine transporter (dat), a member of the neurotransmitter:na(+) symporter (nss) family, terminates dopaminergic neurotransmission and is a major molecular target for psychostimulants such as cocaine and amphetamine, and for the treatment of attention deficit disorder and depression. |
2011-08-02 |
2023-08-12 |
Not clear |
| Meera Narasimhan, Nioaka Campbel. A tale of two comorbidities: Understanding the neurobiology of depression and pain. Indian journal of psychiatry. vol 52. issue 2. 2011-07-14. PMID:20838499. |
the biological underpinnings of major depression and chronic pain have considerable overlap in the areas of genetic, structural, functional, neuroendocrine and neurotransmitter functionality. |
2011-07-14 |
2023-08-12 |
Not clear |
| Talley J Lambert, Daniel R Storm, Jane M Sulliva. MicroRNA132 modulates short-term synaptic plasticity but not basal release probability in hippocampal neurons. PloS one. vol 5. issue 12. 2011-07-05. PMID:21206919. |
here we show that overexpression of mir132 increases the paired-pulse ratio and decreases synaptic depression in cultured mouse hippocampal neurons without affecting the initial probability of neurotransmitter release, the calcium sensitivity of release, the amplitude of excitatory postsynaptic currents or the size of the readily releasable pool of synaptic vesicles. |
2011-07-05 |
2023-08-12 |
mouse |
| Igor Branch. The double edged sword of neural plasticity: increasing serotonin levels leads to both greater vulnerability to depression and improved capacity to recover. Psychoneuroendocrinology. vol 36. issue 3. 2011-06-21. PMID:20875703. |
here, i propose a new theoretical framework, the undirected susceptibility to change model, potentially accounting for the experimental and clinical results concerning the role of this neurotransmitter in depression. |
2011-06-21 |
2023-08-12 |
Not clear |
| J M Hansen, M Bolla, D Magis, V de Pasqua, M Ashina, L L Thomsen, J Olesen, J Schoene. Habituation of evoked responses is greater in patients with familial hemiplegic migraine than in controls: a contrast with the common forms of migraine. European journal of neurology. vol 18. issue 3. 2011-05-31. PMID:20727009. |
the mutated fhm genes code for ion transport proteins that animal and cellular studies have associated with disturbed ion homeostasis, altered cellular excitability, neurotransmitter release, and decreased threshold for cortical spreading depression. |
2011-05-31 |
2023-08-12 |
Not clear |
| Adam W Oaks, Anita Sidh. Synuclein modulation of monoamine transporters. FEBS letters. vol 585. issue 7. 2011-05-26. PMID:21396366. |
a key regulatory component of monoamine neurotransmission is re-uptake of neurotransmitter by the dopamine transporter, norepinephrine transporter, and serotonin transporter, which are common drug targets in the treatment of depression and other mood disorders. |
2011-05-26 |
2023-08-12 |
Not clear |
| Richard C Shelton, Andrew H Mille. Inflammation in depression: is adiposity a cause? Dialogues in clinical neuroscience. vol 13. issue 1. 2011-05-12. PMID:21485745. |
mechanisms by which cytokines access the brain and influence neurotransmitter systems relevant to depression have also been described, as have preliminary findings indicating that antagonizing inflammatory pathways may improve depressive symptoms. |
2011-05-12 |
2023-08-12 |
Not clear |
| Cliona M O'Mahony, Gerard Clarke, Sinead Gibney, Timothy G Dinan, John F Crya. Strain differences in the neurochemical response to chronic restraint stress in the rat: relevance to depression. Pharmacology, biochemistry, and behavior. vol 97. issue 4. 2011-04-25. PMID:21110995. |
the neurochemical basis of depression focuses on alterations in the monoaminergic and amino acid neurotransmitter systems. |
2011-04-25 |
2023-08-12 |
rat |
| Darius B Schwenger, Thomas Kune. Acute genetic perturbation of exocyst function in the rat calyx of Held impedes structural maturation, but spares synaptic transmission. The European journal of neuroscience. vol 32. issue 6. 2011-03-14. PMID:20849529. |
neither perturbation changed the characteristics of spontaneous and evoked neurotransmitter release, short-term depression or recovery from depression. |
2011-03-14 |
2023-08-12 |
rat |
| Y Lei, S M Tejani-But. N-methyl-d-aspartic acid receptors are altered by stress and alcohol in Wistar-Kyoto rat brain. Neuroscience. vol 169. issue 1. 2011-03-04. PMID:20466039. |
given that the glutamate neurotransmitter system has been implicated in depression and addiction, the goals of the present study were to investigate the effects of stress and stress-alcohol interactions on n-methyl-d-aspartate (nmda) receptors in the rat brain. |
2011-03-04 |
2023-08-12 |
rat |
| E Prieto, J A Micó, J J Meana, S Majada. Neurobiological bases of quetiapine antidepresant effect in the bipolar disorder. Actas espanolas de psiquiatria. vol 38. issue 1. 2011-02-28. PMID:20931407. |
quetiapine is the first drug in europe that has obtained a specific indication for the treatment of bipolar depression, due to a pharmacologic profile that makes it to act on the three neurotransmitter systems involved in bipolar depression neurobiology. |
2011-02-28 |
2023-08-12 |
Not clear |
| Kou Takahashi, Hiroyasu Murasawa, Kazumasa Yamaguchi, Misa Yamada, Akiko Nakatani, Masumi Yoshida, Takashi Iwai, Masatoshi Inagaki, Mitsuhiko Yamada, Akiyoshi Saito. Riluzole rapidly attenuates hyperemotional responses in olfactory bulbectomized rats, an animal model of depression. Behavioural brain research. vol 216. issue 1. 2011-02-18. PMID:20620171. |
growing evidence indicates that the glutamatergic neurotransmitter system is central to the neurobiology and treatment of depression. |
2011-02-18 |
2023-08-12 |
rat |
| A V Kulikov, V S Naumenko, A S Tsybko, N A Siniakova, D V Bazovkina, N K Popov. [The role of the glycoprotein gp130 in serotonin mediator system in mouse brain]. Molekuliarnaia biologiia. vol 44. issue 5. 2010-12-17. PMID:21090245. |
il-6 and brain neurotransmitter serotonin are involved in the mechanism of depression. |
2010-12-17 |
2023-08-12 |
mouse |
| Dervila Glynn, Helen E Gibson, Michael K Harte, Kerstin Reim, Susan Jones, Gavin P Reynolds, A Jennifer Morto. Clorgyline-mediated reversal of neurological deficits in a Complexin 2 knockout mouse. Human molecular genetics. vol 19. issue 17. 2010-11-16. PMID:20584925. |
complexin 2 is a protein modulator of neurotransmitter release that is downregulated in humans suffering from depression, animal models of depression and neurological disorders such as huntington's disease in which depression is a major symptom. |
2010-11-16 |
2023-08-12 |
mouse |
| Dervila Glynn, Helen E Gibson, Michael K Harte, Kerstin Reim, Susan Jones, Gavin P Reynolds, A Jennifer Morto. Clorgyline-mediated reversal of neurological deficits in a Complexin 2 knockout mouse. Human molecular genetics. vol 19. issue 17. 2010-11-16. PMID:20584925. |
our data strongly support the idea that complexin 2 is a key player in normal neurological function, and that downregulation of complexin 2 could lead to changes in neurotransmitter release sufficient to cause significant behavioural abnormalities such as depression. |
2010-11-16 |
2023-08-12 |
mouse |
| Sang-Young Kim, Yun-Jung Lee, Hyeonjin Kim, Do-Wan Lee, Dong-Cheol Woo, Chi-Bong Choi, Jeong-Ho Chae, Bo-Young Cho. Desipramine attenuates forced swim test-induced behavioral and neurochemical alterations in mice: an in vivo(1)H-MRS study at 9.4T. Brain research. vol 1348. 2010-11-09. PMID:20542016. |
our results suggest that glutamatergic activity and glial cell dysfunction may contribute to the pathophysiological mechanisms underlying depression and that modulation of synaptic neurotransmitter concentrations represents a potential target for antidepressant drug development. |
2010-11-09 |
2023-08-12 |
mouse |