| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Adrian L Lopresti, Sean D Hood, Peter D Drummon. A review of lifestyle factors that contribute to important pathways associated with major depression: diet, sleep and exercise. Journal of affective disorders. vol 148. issue 1. 2013-11-08. PMID:23415826. |
this review summarises animal- and human-based studies on the relationship between these three lifestyle factors and major depressive disorder, and their influence on dysregulated pathways associated with depression: namely neurotransmitter processes, immuno-inflammatory pathways, hypothalamic-pituitary-adrenal (hpa) axis disturbances, oxidative stress and antioxidant defence systems, neuroprogression, and mitochondrial disturbances. |
2013-11-08 |
2023-08-12 |
Not clear |
| Thomas J Younts, Vivien Chevaleyre, Pablo E Castill. CA1 pyramidal cell theta-burst firing triggers endocannabinoid-mediated long-term depression at both somatic and dendritic inhibitory synapses. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 34. 2013-10-28. PMID:23966696. |
endocannabinoids (ecbs) are retrograde lipid messengers that, by targeting presynaptic type 1 cannabinoid receptors (cb1rs), mediate short- and long-term synaptic depression of neurotransmitter release throughout the brain. |
2013-10-28 |
2023-08-12 |
rat |
| Rona R Ramsa. Inhibitor design for monoamine oxidases. Current pharmaceutical design. vol 19. issue 14. 2013-09-26. PMID:23116392. |
inhibitors alleviate depression by increasing neurotransmitter levels in the brain. |
2013-09-26 |
2023-08-12 |
Not clear |
| Oliver Weihberger, Samora Okujeni, Jarno E Mikkonen, Ulrich Eger. Quantitative examination of stimulus-response relations in cortical networks in vitro. Journal of neurophysiology. vol 109. issue 7. 2013-09-17. PMID:23274313. |
we discuss short-term synaptic depression due to depletion of neurotransmitter vesicles as an underlying mechanism. |
2013-09-17 |
2023-08-12 |
Not clear |
| Gail D Tillman, Clifford S Calley, Timothy A Green, Virginia I Buhl, Melanie M Biggs, Jeffrey S Spence, Richard W Briggs, Robert W Haley, Michael A Kraut, John Har. Visual event-related potentials as markers of hyperarousal in Gulf War illness: evidence against a stress-related etiology. Psychiatry research. vol 211. issue 3. 2013-09-09. PMID:23149040. |
although many factors may contribute to p3b amplitude differences - most notably depression and poor sleep quality, symptoms that are prevalent in the gw syndrome groups - our findings in context of previous studies on this population are consistent with the contention that dysfunction in cholinergic and dopaminergic neurotransmitter systems, and in white matter and basal ganglia may be contributing to impairments in gw veterans. |
2013-09-09 |
2023-08-12 |
Not clear |
| Richard M O'Connor, John F Crya. The effects of mGlu₇ receptor modulation in behavioural models sensitive to antidepressant action in two mouse strains. Behavioural pharmacology. vol 24. issue 2. 2013-08-28. PMID:23455446. |
there is increasing evidence suggesting a role of the neurotransmitter glutamate in depression. |
2013-08-28 |
2023-08-12 |
mouse |
| Klaudia Ziemiańska, Anna Konopka, Grzegorz M Wilczyńsk. [The role of extracellular proteolysis in synaptic plasticity of the central nervous system]. Postepy higieny i medycyny doswiadczalnej (Online). vol 66. 2013-08-27. PMID:23687215. |
the functional changes include modifications of receptor function in the postsynaptic part of the synapse, as well as the potentiation or depression of neurotransmitter secretion by the presynaptic site. |
2013-08-27 |
2023-08-12 |
Not clear |
| Patricia A Zunszain, Nilay Hepgul, Carmine M Pariant. Inflammation and depression. Current topics in behavioral neurosciences. vol 14. 2013-08-08. PMID:22553073. |
this is based on several observations: subsets of mdd patients have an altered peripheral immune system, with impaired cellular immunity and increased levels of proinflammatory cytokines; cytokines can influence neurotransmitter metabolism, neuroendocrine function and regional brain activity, all of which are relevant to depression; acute administration of cytokines causes sickness behaviour which shares features with depression, and patients undergoing cytokine treatment develop depressive symptoms. |
2013-08-08 |
2023-08-12 |
Not clear |
| Chung-Feng Kao, Peilin Jia, Zhongming Zhao, Po-Hsiu Ku. Enriched pathways for major depressive disorder identified from a genome-wide association study. The international journal of neuropsychopharmacology. vol 15. issue 10. 2013-07-15. PMID:22243633. |
in conclusion, our comprehensive pathway analyses identified promising pathways for depression that are related to neurotransmitter and neuronal systems, immune system and inflammatory response, which may be involved in the pathophysiological mechanisms underlying depression. |
2013-07-15 |
2023-08-12 |
Not clear |
| Richard M O'Connor, Matteo M Pusceddu, Olivia F O'Leary, Helene M Savignac, Javier A Bravo, Malika El Yacoubi, Jean-Marie Vaugeois, Timothy G Dinan, John F Crya. Hippocampal group III mGlu receptor mRNA levels are not altered in specific mouse models of stress, depression and antidepressant action. Pharmacology, biochemistry, and behavior. vol 103. issue 3. 2013-07-09. PMID:23059104. |
the neurotransmitter glutamate is increasingly being implicated as playing a role in the molecular pathology underlying depression. |
2013-07-09 |
2023-08-12 |
mouse |
| P Baldinger, G Kranz, A Höflich, M Savli, P Stein, R Lanzenberger, S Kaspe. [The effects of hormone replacement therapy on mind and brain]. Der Nervenarzt. vol 84. issue 1. 2013-06-26. PMID:22318360. |
the important role of the neurotransmitter serotonin in the pathogenesis of anxiety disorders and major depression is unquestioned, but only little is known about the influence of sex hormones on the serotonergic system. |
2013-06-26 |
2023-08-12 |
Not clear |
| Robert Rosenbaum, Jonathan E Rubin, Brent Doiro. Short-term synaptic depression and stochastic vesicle dynamics reduce and shape neuronal correlations. Journal of neurophysiology. vol 109. issue 2. 2013-06-26. PMID:23114215. |
synapses throughout the cortex exhibit a form of short-term depression where increased presynaptic firing rates deplete neurotransmitter vesicles, which transiently reduces synaptic efficacy. |
2013-06-26 |
2023-08-12 |
Not clear |
| Francesc Artiga. Serotonin receptors involved in antidepressant effects. Pharmacology & therapeutics. vol 137. issue 1. 2013-06-20. PMID:23022360. |
the neurotransmitter serotonin (5-hdroxytryptamine; 5-ht) has been implicated in the pathophysiology and treatment of major depression since the serendipitous discovery of antidepressant drugs in the 1950s. |
2013-06-20 |
2023-08-12 |
Not clear |
| Güliz Gürel, Megan A Gustafson, Judy S Pepper, H Robert Horvitz, Michael R Koell. Receptors and other signaling proteins required for serotonin control of locomotion in Caenorhabditis elegans. Genetics. vol 192. issue 4. 2013-06-03. PMID:23023001. |
a better understanding of the molecular mechanisms of signaling by the neurotransmitter serotonin is required to assess the hypothesis that defects in serotonin signaling underlie depression in humans. |
2013-06-03 |
2023-08-12 |
caenorhabditis_elegans |
| Alkistis Skalkidou, Charlotte Hellgren, Erika Comasco, Sara Sylvén, Inger Sundström Poroma. Biological aspects of postpartum depression. Women's health (London, England). vol 8. issue 6. 2013-05-23. PMID:23181531. |
in light of the normal physiology, the authors also attempt to describe the current evidence of the biological changes associated with the development of depression in the postpartum period, including ovarian steroids, the hypothalamic-pituitary-adrenal axis, the serotonergic neurotransmitter system, the thyroid system and inflammatory markers. |
2013-05-23 |
2023-08-12 |
Not clear |
| Ulrike Hoffmann, Inna Sukhotinsky, Katharina Eikermann-Haerter, Cenk Ayat. Glucose modulation of spreading depression susceptibility. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 33. issue 2. 2013-03-25. PMID:22968322. |
spreading depression of leão is an intense spreading depolarization (sd) wave associated with massive transmembrane ionic, water, and neurotransmitter shifts. |
2013-03-25 |
2023-08-12 |
rat |
| Dorotea Muck-Seler, Nela Pivac, Mirko Diksi. Acute treatment with fluvoxamine elevates rat brain serotonin synthesis in some terminal regions: an autoradiographic study. Nuclear medicine and biology. vol 39. issue 7. 2013-02-12. PMID:22560971. |
a considerable body of evidence indicates the involvement of the neurotransmitter serotonin (5-ht) in the pathogenesis and treatment of depression. |
2013-02-12 |
2023-08-12 |
rat |
| A K Smith, J S Simon, E L Gustafson, S Noviello, J F Cubells, M P Epstein, D J Devlin, P Qiu, J K Albrecht, C A Brass, M S Sulkowski, J G McHutchinson, A H Mille. Association of a polymorphism in the indoleamine- 2,3-dioxygenase gene and interferon-α-induced depression in patients with chronic hepatitis C. Molecular psychiatry. vol 17. issue 8. 2013-01-21. PMID:21691274. |
multiple mechanisms have been implicated in ifn-α-induced depression including immune, neuroendocrine and neurotransmitter pathways. |
2013-01-21 |
2023-08-12 |
human |
| Steven Wishart, Graeme J A Macphe. Evaluation and management of the non-motor features of Parkinson's disease. Therapeutic advances in chronic disease. vol 2. issue 2. 2012-12-20. PMID:23251743. |
other nms such as dementia and severe depression may be unresponsive to dopaminergic treatment and may reflect perturbations in cholinergic, serotonergic or noradrenergic neurotransmitter function. |
2012-12-20 |
2023-08-12 |
Not clear |
| Konstantinos N Fountoulakis, John R Kelsoe, Hagop Akiska. Receptor targets for antidepressant therapy in bipolar disorder: an overview. Journal of affective disorders. vol 138. issue 3. 2012-11-20. PMID:21601292. |
our exhaustive review is compatible with a complex model with multiple levels of interaction between the major neurotransmitter systems without a single target being either necessary or sufficient to elicit the antidepressant effect in bipolar depression. |
2012-11-20 |
2023-08-12 |
Not clear |