| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shira Weizman, Xenia Gonda, Peter Dome, Gabor Falud. Pharmacogenetics of antidepressive drugs: a way towards personalized treatment of major depressive disorder. Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology. vol 14. issue 2. 2012-10-25. PMID:22710850. |
similarly, the employed pharmaceutical agents in the treatment of depression also effect multiple neurotransmitter systems in the brain. |
2012-10-25 |
2023-08-12 |
Not clear |
| Robert Rosenbaum, Jonathan Rubin, Brent Doiro. Short term synaptic depression imposes a frequency dependent filter on synaptic information transfer. PLoS computational biology. vol 8. issue 6. 2012-10-25. PMID:22737062. |
depletion of synaptic neurotransmitter vesicles induces a form of short term depression in synapses throughout the nervous system. |
2012-10-25 |
2023-08-12 |
Not clear |
| Susanne Nikolaus, Hubertus Hautzel, Alexander Heinzel, Hans-Wilhelm Mülle. Key players in major and bipolar depression--a retrospective analysis of in vivo imaging studies. Behavioural brain research. vol 232. issue 2. 2012-10-22. PMID:22483788. |
in the present study, we evaluated the contribution of the individual synaptic constituents of all assessed neurotransmitter systems by subjecting all available in vivo imaging studies on patients with unipolar major depressive disorder (mdd) and bipolar depression (bd) to a retrospective analysis. |
2012-10-22 |
2023-08-12 |
Not clear |
| R S El-Mallakh, J L Barrett, R Jed Wyat. The Na,K-ATPase Hypothesis for Bipolar Disorder: Implications of Normal Development. Journal of child and adolescent psychopharmacology. vol 3. issue 1. 2012-10-02. PMID:19630595. |
the na,k-atpase hypothesis of bipolar disorder proposes that manic symptoms are related to a modest decrease in na,k pump activity and a consequent increase in neuronal excitability, whereas bipolar depression is consequent to a greater decrease in pump activity and a resultant decrease in neurotransmitter release. |
2012-10-02 |
2023-08-12 |
human |
| B E Leonar. Current status of the biogenic amine theory of depression. Neurochemistry international. vol 4. issue 5. 2012-10-02. PMID:20487885. |
an attempt has been made to assess critically the clinical and experimental evidence that implicates a malfunctioning of amine neurotransmitter systems in the aetiology of depression. |
2012-10-02 |
2023-08-12 |
Not clear |
| F R Ferreira, A M Oliveira, A R Dinarte, D G Pinheiro, L J Greene, W A Silva, S R Joca, F S Guimarãe. Changes in hippocampal gene expression by 7-nitroindazole in rats submitted to forced swimming stress. Genes, brain, and behavior. vol 11. issue 3. 2012-09-10. PMID:22142142. |
nitric oxide (no) is an atypical neurotransmitter that has been related to the pathophysiology of major depression disorder. |
2012-09-10 |
2023-08-12 |
rat |
| L Wang, A Ashley-Koch, D C Steffens, K R R Krishnan, W D Taylo. Impact of BDNF Val66Met and 5-HTTLPR polymorphism variants on neural substrates related to sadness and executive function. Genes, brain, and behavior. vol 11. issue 3. 2012-09-10. PMID:22225729. |
one possible explanation is an epistatic relationship with other neurotransmitter genes associated with depression risk, such as the serotonin-transporter-linked promotor region (5-httlpr). |
2012-09-10 |
2023-08-12 |
human |
| Sahabeh Etebary, Sara Nikseresht, Hamid Reza Sadeghipour, Mohammad Reza Zarrindas. Postpartum depression and role of serum trace elements. Iranian journal of psychiatry. vol 5. issue 2. 2012-09-06. PMID:22952489. |
various pathophysiologies are proposed for postpartum depression: nutritional deficiencies, iron deficiency anemia, rapid decrease in the levels of reproductive hormones following delivery, alterations in hypothalamic-pituitary-adernocortical mechanism and alterations in neurotransmitter levels. |
2012-09-06 |
2023-08-12 |
Not clear |
| Bao-Hong Lee, Tzu-Ming Pa. Benefit of Monascus-fermented products for hypertension prevention: a review. Applied microbiology and biotechnology. vol 94. issue 5. 2012-09-05. PMID:22526810. |
γ-aminobutyric acid (gaba) has been reported to play a neurotransmitter in the central nervous system thereby exerting an inhibition in nerve impulse, in turn ameliorating depression; in addition, recent study also reveals the anti-hypertensive effect of gaba in vivo. |
2012-09-05 |
2023-08-12 |
Not clear |
| Ulla Knorr, Maj Vinberg, Erik Lykke Mortensen, Per Winkel, Christian Gluud, Jørn Wetterslev, Ulrik Gether, Lars Vedel Kessin. Effect of chronic escitalopram versus placebo on personality traits in healthy first-degree relatives of patients with depression: a randomized trial. PloS one. vol 7. issue 2. 2012-07-23. PMID:22393376. |
the serotonergic neurotransmitter system is closely linked to depression and personality traits. |
2012-07-23 |
2023-08-12 |
Not clear |
| Nunzio Pomara, Davide Bruno, Antero S Sarreal, Raymundo T Hernando, Jay Nierenberg, Eva Petkova, John J Sidtis, Thomas M Wisniewski, Pankaj D Mehta, Domenico Pratico, Henrik Zetterberg, Kaj Blenno. Lower CSF amyloid beta peptides and higher F2-isoprostanes in cognitively intact elderly individuals with major depressive disorder. The American journal of psychiatry. vol 169. issue 5. 2012-07-05. PMID:22764362. |
amyloid beta peptides also induce a depressive state in rodents and disrupt major neurotransmitter systems linked to depression. |
2012-07-05 |
2023-08-12 |
human |
| Pablo E Castill. Presynaptic LTP and LTD of excitatory and inhibitory synapses. Cold Spring Harbor perspectives in biology. vol 4. issue 2. 2012-06-12. PMID:22147943. |
ubiquitous forms of long-term potentiation (ltp) and depression (ltd) are caused by enduring increases or decreases in neurotransmitter release. |
2012-06-12 |
2023-08-12 |
Not clear |
| Vincenza Frisardi, Francesco Panza, Akhlaq A Farooqu. Late-life depression and Alzheimer's disease: the glutamatergic system inside of this mirror relationship. Brain research reviews. vol 67. issue 1-2. 2012-05-30. PMID:21570126. |
l-glutamic acid and γ-aminobutyric acid are the principal excitatory and inhibitory neurotransmitters in the central nervous system, respectively, and increasing evidence suggests that alterations in this neurotransmitter system may contribute to the neurobiology linking depression and cognitive impairment. |
2012-05-30 |
2023-08-12 |
human |
| Jussi Hirvonen, Jarmo Hietala, Jaana Kajander, Juha Markkula, Helena Rasi-Hakala, Jouko K Salminen, Kjell Någren, Sargo Aalto, Hasse Karlsso. Effects of antidepressant drug treatment and psychotherapy on striatal and thalamic dopamine D2/3 receptors in major depressive disorder studied with [11C]raclopride PET. Journal of psychopharmacology (Oxford, England). vol 25. issue 10. 2012-04-06. PMID:20829308. |
antidepressant drug treatment and psychotherapy are both effective in treating major depression, but there are no published studies comparing the effects of these two treatments on the dopaminergic neurotransmitter system in major depression. |
2012-04-06 |
2023-08-12 |
Not clear |
| Maurizio De Pittà, Vladislav Volman, Hugues Berry, Eshel Ben-Jaco. A tale of two stories: astrocyte regulation of synaptic depression and facilitation. PLoS computational biology. vol 7. issue 12. 2012-03-28. PMID:22162957. |
but this global effect usually coexists with the opposite local effect on paired pulses: with release-decreasing astrocytes most paired pulses become facilitated, namely the amount of neurotransmitter released upon spike i+1 is larger than that at spike i, while paired-pulse depression becomes prominent under release-increasing astrocytes. |
2012-03-28 |
2023-08-12 |
Not clear |
| Salah Gariball. Testing homocysteine-induced neurotransmitter deficiency, and depression of mood hypothesis in clinical practice. Age and ageing. vol 40. issue 6. 2012-03-26. PMID:21771745. |
testing homocysteine-induced neurotransmitter deficiency, and depression of mood hypothesis in clinical practice. |
2012-03-26 |
2023-08-12 |
Not clear |
| Salah Gariball. Testing homocysteine-induced neurotransmitter deficiency, and depression of mood hypothesis in clinical practice. Age and ageing. vol 40. issue 6. 2012-03-26. PMID:21771745. |
high total plasma homocysteine (thcy) levels may cause neurotransmitter deficiency, and consequently depression of mood. |
2012-03-26 |
2023-08-12 |
Not clear |
| G Parker, H Brotchi. Mood effects of the amino acids tryptophan and tyrosine: 'Food for Thought' III. Acta psychiatrica Scandinavica. vol 124. issue 6. 2012-03-14. PMID:21488845. |
reflecting increased scientific interest in any nutritional contribution to the onset and treatment of mood disorders, we overview research into two neurotransmitter precursors - the amino acids tryptophan and tyrosine - particularly examining whether any deficiency increases risk to depression and whether those amino acids have any antidepressant properties. |
2012-03-14 |
2023-08-12 |
Not clear |
| Ashish Dhir, Sneh Malik, S V Kessar, K N Singh, S K Kulkarn. Evaluation of antidepressant activity of 1-(7-methoxy-2-methyl-1,2,3,4-tetrahydro-isoquinolin-4-YL)-cyclohexanol, a β-substituted phenylethylamine in mice. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 21. issue 9. 2012-02-23. PMID:21277753. |
in conclusion, 1-(7-methoxy-2-methyl-1,2,3,4-tetrahydro-isoquinolin-4-yl)-cyclohexanol, possess antidepressant-like activity in animal models of depression by modulating the neurotransmitter levels in the brain. |
2012-02-23 |
2023-08-12 |
mouse |
| Maria Waselus, Rita J Valentino, Elisabeth J Van Bockstael. Collateralized dorsal raphe nucleus projections: a mechanism for the integration of diverse functions during stress. Journal of chemical neuroanatomy. vol 41. issue 4. 2012-02-22. PMID:21658442. |
the midbrain dorsal raphe nucleus (dr) is the origin of the central serotonin (5-ht) system, a key neurotransmitter system that has been implicated in the expression of normal behaviors and in diverse psychiatric disorders, particularly affective disorders such as depression and anxiety. |
2012-02-22 |
2023-08-12 |
Not clear |