| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rainbo Hultman, Udhaya Kumari, Nadine Michel, Patrick J Case. Gαz regulates BDNF-induction of axon growth in cortical neurons. Molecular and cellular neurosciences. vol 58. 2014-09-25. PMID:24321455. |
the disruption of neurotransmitter and neurotrophic factor signaling in the central nervous system (cns) is implicated as the root cause of neuropsychiatric disorders, including schizophrenia, epilepsy, chronic pain, and depression. |
2014-09-25 |
2023-08-12 |
mouse |
| Ronise M Santiago, Janaína Barbiero, Raisa W Gradowski, Suelen Bochen, Marcelo M S Lima, Cláudio Da Cunha, Roberto Andreatini, Maria A B F Vita. Induction of depressive-like behavior by intranigral 6-OHDA is directly correlated with deficits in striatal dopamine and hippocampal serotonin. Behavioural brain research. vol 259. 2014-08-04. PMID:24183944. |
the neurotransmitter deficiency hypothesis of pd considers that low serotonin (5-hydroxytryptamine [5-ht]) activity in the brain in pd patients is a risk factor for depression. |
2014-08-04 |
2023-08-12 |
rat |
| Brian E Leonar. Impact of inflammation on neurotransmitter changes in major depression: an insight into the action of antidepressants. Progress in neuro-psychopharmacology & biological psychiatry. vol 48. 2014-08-01. PMID:24189118. |
impact of inflammation on neurotransmitter changes in major depression: an insight into the action of antidepressants. |
2014-08-01 |
2023-08-12 |
Not clear |
| Brian E Leonar. Impact of inflammation on neurotransmitter changes in major depression: an insight into the action of antidepressants. Progress in neuro-psychopharmacology & biological psychiatry. vol 48. 2014-08-01. PMID:24189118. |
evidence is provided that pro-inflammatory cytokines, together with dysfunctional endocrine and neurotransmitter systems, provide a network of changes that underlie depression and may ultimately contribute to the neurodegenerative changes that characterise depression in the elderly. |
2014-08-01 |
2023-08-12 |
Not clear |
| David Papke, Claudio Grosma. The role of intracellular linkers in gating and desensitization of human pentameric ligand-gated ion channels. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 21. 2014-07-11. PMID:24849357. |
however, when the effects of mutations were assessed with 50 hz trains of ∼1 ms pulses of saturating neurotransmitter, some mutations led to much more, and others to much less, peak-current depression than observed for the wild-type channels, suggesting that these mutations could affect the fidelity of fast synaptic transmission. |
2014-07-11 |
2023-08-13 |
human |
| U W Preuss, F M Wurst, M Ridinger, D Rujescu, C Fehr, G Koller, B Bondy, N Wodarz, M Soyka, P Zil. Association of functional DBH genetic variants with alcohol dependence risk and related depression and suicide attempt phenotypes: results from a large multicenter association study. Drug and alcohol dependence. vol 133. issue 2. 2014-06-23. PMID:23906995. |
dbh, located on chromosome 9q34.2 has variants with potential functional consequences which may be related to alterations of neurotransmitter function and several psychiatric phenotypes, including alcohol dependence (ad), depression (md) and suicidal behavior (sa). |
2014-06-23 |
2023-08-12 |
Not clear |
| Clark A Lindgren, Zachary L Newman, Jamie J Morford, Steven B Ryan, Kathryn A Battani, Zheng S. Cyclooxygenase-2, prostaglandin E2 glycerol ester and nitric oxide are involved in muscarine-induced presynaptic enhancement at the vertebrate neuromuscular junction. The Journal of physiology. vol 591. issue 19. 2014-06-20. PMID:23818695. |
previous work has demonstrated that activation of muscarinic acetylcholine receptors at the lizard neuromuscular junction (nmj) induces a biphasic modulation of evoked neurotransmitter release: an initial depression followed by a delayed enhancement. |
2014-06-20 |
2023-08-12 |
Not clear |
| J G Rahol. Antidepressants: pharmacological profile and clinical consequences. International journal of psychiatry in clinical practice. vol 5. issue 1. 2014-06-19. PMID:24936991. |
three neurotransmitter systems are implicated in the biological basis of depression: the serotonergic system is thought to be a major component in the development of depression and in the efficacy of antidepressant drugs, while the noradrenergic and dopaminergic systems play lesser roles, but are important in the development of antidepressant side-effects. |
2014-06-19 |
2023-08-13 |
Not clear |
| Andrea de Bartolomeis, Livia Avvisati, Felice Iasevoli, Carmine Tomasett. Intracellular pathways of antipsychotic combined therapies: implication for psychiatric disorders treatment. European journal of pharmacology. vol 718. issue 1-3. 2014-06-10. PMID:23834777. |
dysfunctions in the interplay among multiple neurotransmitter systems have been implicated in the wide range of behavioral, emotional and cognitive symptoms displayed by major psychiatric disorders, such as schizophrenia, bipolar disorder or major depression. |
2014-06-10 |
2023-08-12 |
Not clear |
| Karan Makhija, Satish Karunakara. The role of inflammatory cytokines on the aetiopathogenesis of depression. The Australian and New Zealand journal of psychiatry. vol 47. issue 9. 2014-06-02. PMID:23636913. |
the article will describe how inflammatory cytokines contribute to depression via action on three major pathways in the brain: the neuroendocrine; neurotransmitter depletion; and neuroprogression pathways. |
2014-06-02 |
2023-08-12 |
Not clear |
| Ling-ling Lu, Xiao-Heng Shen, Jing-xian Che. [Xuefu zhuyu oral liquid intervened stress-stimulated depression model rats]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine. vol 33. issue 5. 2014-04-18. PMID:23905383. |
to observe effects of xuefu zhuyu oral liquid (xzol) on the brain behavior and monoamine neurotransmitter 5-ht, and brain derived neurotrophic factor (bdnf) content on depression model rats. |
2014-04-18 |
2023-08-12 |
rat |
| Kaitlyn Rechenberg, Debbie Humphrie. Nutritional interventions in depression and perinatal depression. The Yale journal of biology and medicine. vol 86. issue 2. 2014-02-26. PMID:23766734. |
the treatment of depression in conventional medicine has focused on physiological factors that lead to impaired neurotransmitter function and treatments to improve neurotransmitter function. |
2014-02-26 |
2023-08-12 |
Not clear |
| J C Felger, F E Lotric. Inflammatory cytokines in depression: neurobiological mechanisms and therapeutic implications. Neuroscience. vol 246. 2014-02-24. PMID:23644052. |
however, chronic exposure to elevated inflammatory cytokines and persistent alterations in neurotransmitter systems can lead to neuropsychiatric disorders and depression. |
2014-02-24 |
2023-08-12 |
Not clear |
| J C Felger, F E Lotric. Inflammatory cytokines in depression: neurobiological mechanisms and therapeutic implications. Neuroscience. vol 246. 2014-02-24. PMID:23644052. |
this review explores the idea that specific gene polymorphisms and neurotransmitter systems can confer protection from or vulnerability to specific symptom dimensions of cytokine-related depression. |
2014-02-24 |
2023-08-12 |
Not clear |
| Alex D Bird, Magnus J E Richardso. Long-term plasticity determines the postsynaptic response to correlated afferents with multivesicular short-term synaptic depression. Frontiers in computational neuroscience. vol 8. 2014-02-13. PMID:24523691. |
using approximate forms for the postsynaptic firing rate in the limits of low and high correlations, we demonstrate that short-term depression leads to a maximum response for an intermediate number of presynaptic release sites, and that this leads to a tuning-curve response peaked at an optimal presynaptic synchrony set by the number of neurotransmitter release sites per presynaptic neuron. |
2014-02-13 |
2023-08-12 |
Not clear |
| Salah Gariball. Extending the homocysteine-induced neurotransmitter deficiency and depression of mood hypothesis to quality of life in older patients. International journal of geriatric psychiatry. vol 28. issue 8. 2014-01-31. PMID:23832546. |
extending the homocysteine-induced neurotransmitter deficiency and depression of mood hypothesis to quality of life in older patients. |
2014-01-31 |
2023-08-12 |
Not clear |
| Michael I Kerr, Mark J Wall, Magnus J E Richardso. Adenosine A1 receptor activation mediates the developmental shift at layer 5 pyramidal cell synapses and is a determinant of mature synaptic strength. The Journal of physiology. vol 591. issue 13. 2014-01-28. PMID:23613526. |
during the first postnatal month glutamatergic synapses between layer 5 pyramidal cells in the rodent neocortex switch from an immature state exhibiting a high probability of neurotransmitter release, large unitary amplitude and synaptic depression to a mature state with decreased probability of release, smaller unitary amplitude and synaptic facilitation. |
2014-01-28 |
2023-08-12 |
rat |
| Charles L Raison, Andrew H Mille. Malaise, melancholia and madness: the evolutionary legacy of an inflammatory bias. Brain, behavior, and immunity. vol 31. 2014-01-16. PMID:23639523. |
neurotransmitter systems that mediate effects of the immune system on behavior are also described along with interactions of the inflammatory bias with depression and their convergent impact on the response to stress and medical illness. |
2014-01-16 |
2023-08-12 |
Not clear |
| Pierre Blie. Neurotransmitter targeting in the treatment of depression. The Journal of clinical psychiatry. vol 74 Suppl 2. 2014-01-07. PMID:24191974. |
neurotransmitter targeting in the treatment of depression. |
2014-01-07 |
2023-08-12 |
Not clear |
| Aravind Penmatsa, Kevin H Wang, Eric Gouau. X-ray structure of dopamine transporter elucidates antidepressant mechanism. Nature. vol 503. issue 7474. 2013-12-12. PMID:24037379. |
antidepressants targeting na(+)/cl(-)-coupled neurotransmitter uptake define a key therapeutic strategy to treat clinical depression and neuropathic pain. |
2013-12-12 |
2023-08-12 |
drosophila_melanogaster |