| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Myrthe Mampay, Melanie S Flint, Graham K Sherida. Tumour brain: Pretreatment cognitive and affective disorders caused by peripheral cancers. British journal of pharmacology. vol 178. issue 19. 2021-10-25. PMID:34029379. |
tumour-induced activation of the immune system, blood-brain barrier breakdown and chronic neuroinflammation can lead to circadian rhythm dysfunction, sleep disturbances, aberrant glucocorticoid production, decreased hippocampal neurogenesis and dysregulation of neural network activity, resulting in depression and memory impairments. |
2021-10-25 |
2023-08-13 |
Not clear |
| Shivani Agarwal, Preeti Vyas, Nikita Nirwan, Divya Vohor. Effect of lacosamide on neuroinflammation-mediated seizures comorbid with depression in C57BL/6 mice- Role of kynurenine pathway. Epilepsy & behavior : E&B. vol 123. 2021-10-25. PMID:34425328. |
lacosamide has shown positive effects against neuroinflammation-mediated model of seizures comorbid with depression by reducing hippocampal kynurenine levels. |
2021-10-25 |
2023-08-13 |
Not clear |
| Gali Umschweif, Lucian Medrihan, Andrés Guillén-Samander, Wei Wang, Yotam Sagi, Paul Greengar. Identification of Neurensin-2 as a novel modulator of emotional behavior. Molecular psychiatry. vol 26. issue 7. 2021-10-24. PMID:33742167. |
recent studies suggested a key role for hippocampal gabaergic interneurons both in depression and in the response to its treatments. |
2021-10-24 |
2023-08-13 |
Not clear |
| Cristiano Bombardi, Annamaria Grandis, Nela Pivac, Marina Sagud, Guillaume Lucas, Abdeslam Chagraoui, Valérie Lemaire-Mayo, Philippe De Deurwaerdère, Giuseppe Di Giovann. Serotonin modulation of hippocampal functions: From anatomy to neurotherapeutics. Progress in brain research. vol 261. 2021-10-22. PMID:33785139. |
preclinical and clinical studies indicate that hippocampal dysfunctions are involved in learning and memory deficits, dementia, alzheimer's disease, epilepsy and mood disorders such as anxiety, depression and post-traumatic syndrome disorder, whereas the hippocampus participates also in the therapeutic mechanisms of numerous medicines. |
2021-10-22 |
2023-08-13 |
Not clear |
| Zhaohui Zhang, Pengge Fei, Junlin Mu, Haoliang Wang, Wenqiang Li, Jinggui Son. Decreased expression of neuronal Per-Arnt-Sim domain protein 4 gene in the hippocampus of a post-stroke depression rat model. Experimental and therapeutic medicine. vol 7. issue 4. 2021-10-21. PMID:24669275. |
decreased expression of neuronal per-arnt-sim domain protein 4 gene in the hippocampus of a post-stroke depression rat model. |
2021-10-21 |
2023-08-12 |
rat |
| Zhaohui Zhang, Pengge Fei, Junlin Mu, Haoliang Wang, Wenqiang Li, Jinggui Son. Decreased expression of neuronal Per-Arnt-Sim domain protein 4 gene in the hippocampus of a post-stroke depression rat model. Experimental and therapeutic medicine. vol 7. issue 4. 2021-10-21. PMID:24669275. |
the psd rats displayed neuropsychopathic disorders and the npas4 mrna expression levels in the hippocampus were significantly lower in the depression and psd groups compared with the control group. |
2021-10-21 |
2023-08-12 |
rat |
| Asia Afzal, Zehra Batool, Sadia Sadir, Laraib Liaquat, Sidrah Shahzad, Saiqa Tabassum, Saara Ahmad, Noor Kamil, Tahira Perveen, Saida Haide. Therapeutic Potential of Curcumin in Reversing the Depression and Associated Pseudodementia via Modulating Stress Hormone, Hippocampal Neurotransmitters, and BDNF Levels in Rats. Neurochemical research. vol 46. issue 12. 2021-10-21. PMID:34409523. |
therapeutic potential of curcumin in reversing the depression and associated pseudodementia via modulating stress hormone, hippocampal neurotransmitters, and bdnf levels in rats. |
2021-10-21 |
2023-08-13 |
rat |
| Philip W Gol. The PPARg System in Major Depression: Pathophysiologic and Therapeutic Implications. International journal of molecular sciences. vol 22. issue 17. 2021-10-20. PMID:34502154. |
we now know that depression is associated with neurodegeneration in the subgenual prefrontal cortex and hippocampus, decreased neuroplasticity, and defective neurogenesis. |
2021-10-20 |
2023-08-13 |
Not clear |
| Xin-Yun Tian, Jing-Wei Xing, Qiao-Qi Zheng, Peng-Fei Ga. 919 Syrup Alleviates Postpartum Depression by Modulating the Structure and Metabolism of Gut Microbes and Affecting the Function of the Hippocampal GABA/Glutamate System. Frontiers in cellular and infection microbiology. vol 11. 2021-10-18. PMID:34490139. |
919 syrup alleviates postpartum depression by modulating the structure and metabolism of gut microbes and affecting the function of the hippocampal gaba/glutamate system. |
2021-10-18 |
2023-08-13 |
mouse |
| Xin-Yun Tian, Jing-Wei Xing, Qiao-Qi Zheng, Peng-Fei Ga. 919 Syrup Alleviates Postpartum Depression by Modulating the Structure and Metabolism of Gut Microbes and Affecting the Function of the Hippocampal GABA/Glutamate System. Frontiers in cellular and infection microbiology. vol 11. 2021-10-18. PMID:34490139. |
we therefore hypothesized that 919 syrup could improve the symptoms of postpartum depression by affecting the structure and function of the intestinal flora, thereby altering hippocampal metabolism. |
2021-10-18 |
2023-08-13 |
mouse |
| Kensuke Nakajima, Shigeru Ois. Upregulating Effect of Wheat on Brain-Derived Neurotrophic Factor in Human Lung Adenocarcinoma A549 Cells. Journal of oleo science. vol 70. issue 6. 2021-10-15. PMID:33967169. |
peripheral bdnf can traverse the blood-brain barrier and reach the hippocampus; accordingly, substances that upregulate bdnf production in peripheral tissues may be useful in the treatment of depression. |
2021-10-15 |
2023-08-13 |
human |
| Jian Liu, Lin Liu, Yuan-Shan Han, Jian Yi, Chun Guo, Hong-Qing Zhao, Jia Ling, Yu-Hong Wan. The molecular mechanism underlying mitophagy-mediated hippocampal neuron apoptosis in diabetes-related depression. Journal of cellular and molecular medicine. vol 25. issue 15. 2021-10-15. PMID:34213839. |
the molecular mechanism underlying mitophagy-mediated hippocampal neuron apoptosis in diabetes-related depression. |
2021-10-15 |
2023-08-13 |
rat |
| Jian Liu, Lin Liu, Yuan-Shan Han, Jian Yi, Chun Guo, Hong-Qing Zhao, Jia Ling, Yu-Hong Wan. The molecular mechanism underlying mitophagy-mediated hippocampal neuron apoptosis in diabetes-related depression. Journal of cellular and molecular medicine. vol 25. issue 15. 2021-10-15. PMID:34213839. |
we hypothesized that diabetes-related depression might be associated with the mitophagy-mediated hippocampal neuron apoptosis, triggered by aberrant glu-glutamate receptor2 (glur2)-parkin pathway. |
2021-10-15 |
2023-08-13 |
rat |
| Wenbo Xu, Xiaoxiao Yao, Fangyi Zhao, Haisheng Zhao, Ziqian Cheng, Wei Yang, Ranji Cui, Songbai Xu, Bingjin L. Changes in Hippocampal Plasticity in Depression and Therapeutic Approaches Influencing These Changes. Neural plasticity. vol 2020. 2021-10-14. PMID:33293948. |
changes in hippocampal plasticity in depression and therapeutic approaches influencing these changes. |
2021-10-14 |
2023-08-13 |
human |
| Wenbo Xu, Xiaoxiao Yao, Fangyi Zhao, Haisheng Zhao, Ziqian Cheng, Wei Yang, Ranji Cui, Songbai Xu, Bingjin L. Changes in Hippocampal Plasticity in Depression and Therapeutic Approaches Influencing These Changes. Neural plasticity. vol 2020. 2021-10-14. PMID:33293948. |
the hippocampus is an important anatomical area associated with depression. |
2021-10-14 |
2023-08-13 |
human |
| Wenbo Xu, Xiaoxiao Yao, Fangyi Zhao, Haisheng Zhao, Ziqian Cheng, Wei Yang, Ranji Cui, Songbai Xu, Bingjin L. Changes in Hippocampal Plasticity in Depression and Therapeutic Approaches Influencing These Changes. Neural plasticity. vol 2020. 2021-10-14. PMID:33293948. |
studies have shown that some antidepressants can treat depression by changing the plasticity of the hippocampus. |
2021-10-14 |
2023-08-13 |
human |
| Wenbo Xu, Xiaoxiao Yao, Fangyi Zhao, Haisheng Zhao, Ziqian Cheng, Wei Yang, Ranji Cui, Songbai Xu, Bingjin L. Changes in Hippocampal Plasticity in Depression and Therapeutic Approaches Influencing These Changes. Neural plasticity. vol 2020. 2021-10-14. PMID:33293948. |
in this review, we summarize the latest research, focusing on changes in the plasticity of hippocampal neurons and glial cells in depression and the role of bdnf in the changes in hippocampal plasticity in depression, as well as caloric restriction and mitochondrial plasticity. |
2021-10-14 |
2023-08-13 |
human |
| Yu Liu, Jie Meng, Kangcheng Wang, Kaixiang Zhuang, Qunlin Chen, Wenjing Yang, Jiang Qiu, Dongtao We. Morphometry of the Hippocampus Across the Adult Life-Span in Patients with Depressive Disorders: Association with Neuroticism. Brain topography. vol 34. issue 5. 2021-10-14. PMID:33988780. |
however, it remains unclear to what extent hippocampal abnormalities are linked with age and neuroticism changes in people with depression through the adult life span. |
2021-10-14 |
2023-08-13 |
human |
| Yu Liu, Jie Meng, Kangcheng Wang, Kaixiang Zhuang, Qunlin Chen, Wenjing Yang, Jiang Qiu, Dongtao We. Morphometry of the Hippocampus Across the Adult Life-Span in Patients with Depressive Disorders: Association with Neuroticism. Brain topography. vol 34. issue 5. 2021-10-14. PMID:33988780. |
the hippocampal atrophy was dynamically impacted by depression at the early stages of adult life. |
2021-10-14 |
2023-08-13 |
human |
| Yu Liu, Jie Meng, Kangcheng Wang, Kaixiang Zhuang, Qunlin Chen, Wenjing Yang, Jiang Qiu, Dongtao We. Morphometry of the Hippocampus Across the Adult Life-Span in Patients with Depressive Disorders: Association with Neuroticism. Brain topography. vol 34. issue 5. 2021-10-14. PMID:33988780. |
hippocampal volume reduction as a vulnerability factor for early-onset and major geriatric depression may have a distinct endophenotype. |
2021-10-14 |
2023-08-13 |
human |