| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chao-Ke-Tu Saiyin, Li-Ya Ai, Mei-Li Song, Tong Luo, Jun Zhao, Na Aru, Tao-Tu-Ge Den. [Mongolian medicine three acupoints balance needling improves depressive behavior by regulating p11/tPA/BDNF pathway and miRNA-16 of hippocampus and middle raphe nucleus in depression model rats]. Zhen ci yan jiu = Acupuncture research. vol 46. issue 9. 2021-09-27. PMID:34558239. |
[mongolian medicine three acupoints balance needling improves depressive behavior by regulating p11/tpa/bdnf pathway and mirna-16 of hippocampus and middle raphe nucleus in depression model rats]. |
2021-09-27 |
2023-08-13 |
rat |
| Chao-Ke-Tu Saiyin, Li-Ya Ai, Mei-Li Song, Tong Luo, Jun Zhao, Na Aru, Tao-Tu-Ge Den. [Mongolian medicine three acupoints balance needling improves depressive behavior by regulating p11/tPA/BDNF pathway and miRNA-16 of hippocampus and middle raphe nucleus in depression model rats]. Zhen ci yan jiu = Acupuncture research. vol 46. issue 9. 2021-09-27. PMID:34558239. |
to observe the effect of mongolian medicine three-acupoints balance needling on the expression of p11/tpa/bdnf pathway and mirna-16 in the hippocampus and middle raphe nucleus (mrn) in chronic stress depression model rats, so as to explore its mechanisms underlying improvement of depression. |
2021-09-27 |
2023-08-13 |
rat |
| Zheng Liu, Jianli Yang, Qing Fang, Hua Shao, Dalu Yang, Junfang Sun, Lizhi Ga. MiRNA-199a-5p targets WNT2 to regulate depression through the CREB/BDNF signaling in hippocampal neuron. Brain and behavior. vol 11. issue 8. 2021-09-22. PMID:34333859. |
mirna-199a-5p targets wnt2 to regulate depression through the creb/bdnf signaling in hippocampal neuron. |
2021-09-22 |
2023-08-13 |
Not clear |
| Kathrin Weidacker, Seung-Goo Kim, Camilla L Nord, Catarina Rua, Christopher T Rodgers, Valerie Voo. Avoiding monetary loss: A human habenula functional MRI ultra-high field study. Cortex; a journal devoted to the study of the nervous system and behavior. vol 142. 2021-09-21. PMID:34186462. |
functional connectivity between the right habenula and the ipsilateral hippocampus and subcallosal cingulate (regions implicated in memory and depression pathophysiology) was enhanced when anticipating potential losses compared to anticipating neutral outcomes. |
2021-09-21 |
2023-08-13 |
human |
| Garima Virmani, Priyal D'almeida, Arnab Nandi, Swananda Marath. Subfield-specific effects of chronic mild unpredictable stress on hippocampal astrocytes. The European journal of neuroscience. vol 54. issue 5. 2021-09-17. PMID:33866634. |
given the central role that hippocampus plays in the pathophysiology of depression and in the action of antidepressant drugs, changes in hippocampal astrocyte density and physiology may have a significant effect on behavioral symptoms of mdd. |
2021-09-17 |
2023-08-13 |
mouse |
| Zhang Huan, Zhu Mei, Huang Na, Ma Xinxin, Wang Yaping, Liu Ling, Wang Lei, Zhang Kejin, Liu Yana. lncRNA MIR155HG Alleviates Depression-Like Behaviors in Mice by Regulating the miR-155/BDNF Axis. Neurochemical research. vol 46. issue 4. 2021-09-14. PMID:33511575. |
our current work found that lncrna mir155hg and bdnf levels decreased while mir-155 levels increased in the hippocampal region of cums (chronic unpredictable mild stress) mice, a well-accepted mouse model of depression. |
2021-09-14 |
2023-08-13 |
mouse |
| Maxon V Knott, Laura B Ngwenya, Erika A Correll, Judy Bohnert, Noah J Ziemba, Emily Allgire, Tracy Hopkins, Jennifer L McGuir. Lack of Glutamate Receptor Subunit Expression Changes in Hippocampal Dentate Gyrus after Experimental Traumatic Brain Injury in a Rodent Model of Depression. International journal of molecular sciences. vol 22. issue 15. 2021-09-14. PMID:34360865. |
lack of glutamate receptor subunit expression changes in hippocampal dentate gyrus after experimental traumatic brain injury in a rodent model of depression. |
2021-09-14 |
2023-08-13 |
rat |
| Yang Fang, Boyu Shi, Xiaobo Liu, Jie Luo, Zhili Rao, Rong Liu, Nan Zen. Xiaoyao Pills Attenuate Inflammation and Nerve Injury Induced by Lipopolysaccharide in Hippocampal Neurons In Vitro. Neural plasticity. vol 2020. 2021-09-13. PMID:33014035. |
lipopolysaccharides (lps) are proinflammation mediators that can induce the inflammatory model of the hippocampal neuron, and neuroinflammation participates in the pathophysiology of depression. |
2021-09-13 |
2023-08-13 |
Not clear |
| Christopher L Averill, Ritvij M Satodiya, J Cobb Scott, Kristen M Wrocklage, Brian Schweinsburg, Lynnette A Averill, Teddy J Akiki, Timothy Amoroso, Steven M Southwick, John H Krystal, Chadi G Abdalla. Posttraumatic Stress Disorder and Depression Symptom Severities Are Differentially Associated With Hippocampal Subfield Volume Loss in Combat Veterans. Chronic stress (Thousand Oaks, Calif.). vol 1. 2021-09-10. PMID:29520395. |
posttraumatic stress disorder and depression symptom severities are differentially associated with hippocampal subfield volume loss in combat veterans. |
2021-09-10 |
2023-08-13 |
human |
| Junming Wang, Rongxing Chen, Chen Liu, Xiaohui Wu, Yueyue Zhan. Antidepressant mechanism of catalpol: Involvement of the PI3K/Akt/Nrf2/HO-1 signaling pathway in rat hippocampus. European journal of pharmacology. vol 909. 2021-09-10. PMID:34332921. |
taken together, this study confirmed for the first time that the antidepressant effect of catalpol on cums-induced depression involved the upregulation of the pi3k/akt/nrf2/ho-1 signaling pathway, thereby improving the hippocampal neurotrophic, neuroprotective, and antioxidant levels. |
2021-09-10 |
2023-08-13 |
rat |
| Fan Bu, Mingming Yuan, Dongqing Ma, Ying Zhu, Minyan Wan. Inhibition of NR2A reduces calcitonin gene-related peptide gene expression induced by cortical spreading depression in rat amygdala. Neuropeptides. vol 84. 2021-09-06. PMID:33059243. |
this study investigated whether cgrp production machinery exists in the two key limbic regions including hippocampus and amygdala using cortical spreading depression (csd) as a model of migraine and whether such alteration by csd is sensitive to n-methyl-d-aspartate (nmda) receptor regulation in rats. |
2021-09-06 |
2023-08-13 |
rat |
| Katarzyna Głombik, Jan Detka, Bartosz Bobula, Joanna Bąk, Magdalena Kusek, Krzysztof Tokarski, Bogusława Budziszewsk. Contribution of Hypothyroidism to Cognitive Impairment and Hippocampal Synaptic Plasticity Regulation in an Animal Model of Depression. International journal of molecular sciences. vol 22. issue 4. 2021-09-06. PMID:33562494. |
contribution of hypothyroidism to cognitive impairment and hippocampal synaptic plasticity regulation in an animal model of depression. |
2021-09-06 |
2023-08-13 |
rat |
| Katarzyna Głombik, Jan Detka, Bartosz Bobula, Joanna Bąk, Magdalena Kusek, Krzysztof Tokarski, Bogusława Budziszewsk. Contribution of Hypothyroidism to Cognitive Impairment and Hippocampal Synaptic Plasticity Regulation in an Animal Model of Depression. International journal of molecular sciences. vol 22. issue 4. 2021-09-06. PMID:33562494. |
obtained results show that thyroid hormones are less involved in the inhibition of glutamate release and/or excitability of the postsynaptic neurons in wky rats, which may indicate a lower sensitivity of the hippocampus to the action of thyroid hormones in depression. |
2021-09-06 |
2023-08-13 |
rat |
| Huan Cao, Chengchao Zuo, Yaqi Huang, Liudi Zhu, Jianling Zhao, Yuyan Yang, Yongsheng Jiang, Furong Wan. Hippocampal proteomic analysis reveals activation of necroptosis and ferroptosis in a mouse model of chronic unpredictable mild stress-induced depression. Behavioural brain research. vol 407. 2021-09-02. PMID:33775778. |
hippocampal proteomic analysis reveals activation of necroptosis and ferroptosis in a mouse model of chronic unpredictable mild stress-induced depression. |
2021-09-02 |
2023-08-13 |
mouse |
| Cheng-Niu Wang, Sheng-Nan Gong, Wei Guan, Jin-Liang Wang, Ting-Ting Gao, Yuan Wang, Fei Sun, Bo Jian. Hippocampal overexpression of chordin protects against the chronic social defeat stress-induced depressive-like effects in mice. Brain research bulletin. vol 158. 2021-08-31. PMID:32105677. |
collectively, hippocampal chordin could be a novel antidepressant target, and this study further highlights the importance of the hippocampal bmp system in the pathophysiology of depression. |
2021-08-31 |
2023-08-13 |
mouse |
| Chunmei Geng, Guoxian Hao, Qiao Yi, Yujin Guo, Dan Chen, Wenxiu Han, Jun Zhang, Mengqi Yang, Pei Jian. The impact of Dl-3-n-butylphthalide on the lipidomics of the hippocampus in a rat model of lipopolysaccharide-induced depression. Prostaglandins & other lipid mediators. vol 150. 2021-08-31. PMID:32464175. |
the impact of dl-3-n-butylphthalide on the lipidomics of the hippocampus in a rat model of lipopolysaccharide-induced depression. |
2021-08-31 |
2023-08-13 |
rat |
| Chunmei Geng, Guoxian Hao, Qiao Yi, Yujin Guo, Dan Chen, Wenxiu Han, Jun Zhang, Mengqi Yang, Pei Jian. The impact of Dl-3-n-butylphthalide on the lipidomics of the hippocampus in a rat model of lipopolysaccharide-induced depression. Prostaglandins & other lipid mediators. vol 150. 2021-08-31. PMID:32464175. |
therefore, our study performed an untargeted lipidomics approach of ultra-performance liquid chromatography coupled with mass spectrometry (uplc-ms) to reveal the potential discriminating lipid profile of the hippocampus for nbp involvement in lipopolysaccharide (lps)-induced depression. |
2021-08-31 |
2023-08-13 |
rat |
| Olha Zapukhliak, Olga Netsyk, Artur Romanov, Oleksandr Maximyuk, Murat Oz, Gregory L Holmes, Oleg Krishtal, Dmytro Isae. Mecamylamine inhibits seizure-like activity in CA1-CA3 hippocampus through antagonism to nicotinic receptors. PloS one. vol 16. issue 3. 2021-08-31. PMID:33711021. |
the ability of mecamylamine to decrease hippocampal network synchronization might be associated with its therapeutic effects in a wide variety of cns disorders including addiction, depression and anxiety. |
2021-08-31 |
2023-08-13 |
Not clear |
| Jessica Mingardi, Luca La Via, Paolo Tornese, Giulia Carini, Kalevi Trontti, Mara Seguini, Daniela Tardito, Federica Bono, Chiara Fiorentini, Leonardo Elia, Iiris Hovatta, Maurizio Popoli, Laura Musazzi, Alessandro Barbo. miR-9-5p is involved in the rescue of stress-dependent dendritic shortening of hippocampal pyramidal neurons induced by acute antidepressant treatment with ketamine. Neurobiology of stress. vol 15. 2021-08-31. PMID:34458512. |
on the other hand, the rapid antidepressant effect of acute ketamine is consistently reported to occur together with the rescue of dendritic atrophy and reduction of spine number induced by chronic stress in the hippocampus and prefrontal cortex of animal models of depression. |
2021-08-31 |
2023-08-13 |
rat |
| Keaton A Unroe, Matthew E Glover, Elizabeth A Shupe, Ningping Feng, Sarah M Clinto. Perinatal SSRI Exposure Disrupts G Protein-coupled Receptor BAI3 in Developing Dentate Gyrus and Adult Emotional Behavior: Relevance to Psychiatric Disorders. Neuroscience. vol 471. 2021-08-25. PMID:34293414. |
to determine translational implications of this work, we examined expression of bai3 and related molecules in hippocampus and prefrontal cortex from patients that suffered with depression or schizophrenia relative to healthy control subjects. |
2021-08-25 |
2023-08-13 |
human |