| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ning-Xi Zeng, Hui-Zhen Li, Han-Zhang Wang, Kai-Ge Liu, Xia-Yu Gong, Wu-Long Luo, Can Yan, Li-Li W. Exploration of the mechanism by which icariin modulates hippocampal neurogenesis in a rat model of depression. Neural regeneration research. vol 17. issue 3. 2021-11-02. PMID:34380904. |
exploration of the mechanism by which icariin modulates hippocampal neurogenesis in a rat model of depression. |
2021-11-02 |
2023-08-13 |
rat |
| Ning-Xi Zeng, Hui-Zhen Li, Han-Zhang Wang, Kai-Ge Liu, Xia-Yu Gong, Wu-Long Luo, Can Yan, Li-Li W. Exploration of the mechanism by which icariin modulates hippocampal neurogenesis in a rat model of depression. Neural regeneration research. vol 17. issue 3. 2021-11-02. PMID:34380904. |
icariin (ica) has a significant capacity to protect against depression and hippocampal injury, but it cannot effectively cross the blood-brain barrier and accumulate in the brain. |
2021-11-02 |
2023-08-13 |
rat |
| Ning-Xi Zeng, Hui-Zhen Li, Han-Zhang Wang, Kai-Ge Liu, Xia-Yu Gong, Wu-Long Luo, Can Yan, Li-Li W. Exploration of the mechanism by which icariin modulates hippocampal neurogenesis in a rat model of depression. Neural regeneration research. vol 17. issue 3. 2021-11-02. PMID:34380904. |
therefore, the mechanism by which ica protects against hippocampal injury in depression remains unclear. |
2021-11-02 |
2023-08-13 |
rat |
| Ning-Xi Zeng, Hui-Zhen Li, Han-Zhang Wang, Kai-Ge Liu, Xia-Yu Gong, Wu-Long Luo, Can Yan, Li-Li W. Exploration of the mechanism by which icariin modulates hippocampal neurogenesis in a rat model of depression. Neural regeneration research. vol 17. issue 3. 2021-11-02. PMID:34380904. |
in this study, we performed proteomics analysis of cerebrospinal fluid to investigate the mechanism by which ica prevents dysfunctional hippocampal neurogenesis in depression. |
2021-11-02 |
2023-08-13 |
rat |
| Ning-Xi Zeng, Hui-Zhen Li, Han-Zhang Wang, Kai-Ge Liu, Xia-Yu Gong, Wu-Long Luo, Can Yan, Li-Li W. Exploration of the mechanism by which icariin modulates hippocampal neurogenesis in a rat model of depression. Neural regeneration research. vol 17. issue 3. 2021-11-02. PMID:34380904. |
these findings suggest that ica can prevent depression and dysfunctional hippocampal neurogenesis through regulating the expression of certain proteins found in the cerebrospinal fluid. |
2021-11-02 |
2023-08-13 |
rat |
| Malte Bieler, Suleman Hussain, Elise S B Daaland, Martine M Mirrione, Fritz A Henn, Svend Davange. Changes in concentrations of NMDA receptor subunit GluN2B, Arc and syntaxin-1 in dorsal hippocampus Schaffer collateral synapses in a rat learned helplessness model of depression. The Journal of comparative neurology. vol 529. issue 12. 2021-11-01. PMID:33843051. |
changes in concentrations of nmda receptor subunit glun2b, arc and syntaxin-1 in dorsal hippocampus schaffer collateral synapses in a rat learned helplessness model of depression. |
2021-11-01 |
2023-08-13 |
rat |
| Sidi Mohamed Coulibaly, Abdelhalem Mesfioui, Inssaf Berkiks, Abdeljabbar Ennaciri, Yassine Chahirou, Yacouba Diagana, Ali Ouichou, Adil El Midaoui, Aboubaker El Hessn. Effects of the Methyl Donors Supplementation on Hippocampal Oxidative Stress, Depression and Anxiety in Chronically High Fructose-treated Rats. Neuroscience. vol 476. 2021-11-01. PMID:34543673. |
effects of the methyl donors supplementation on hippocampal oxidative stress, depression and anxiety in chronically high fructose-treated rats. |
2021-11-01 |
2023-08-13 |
rat |
| Sidi Mohamed Coulibaly, Abdelhalem Mesfioui, Inssaf Berkiks, Abdeljabbar Ennaciri, Yassine Chahirou, Yacouba Diagana, Ali Ouichou, Adil El Midaoui, Aboubaker El Hessn. Effects of the Methyl Donors Supplementation on Hippocampal Oxidative Stress, Depression and Anxiety in Chronically High Fructose-treated Rats. Neuroscience. vol 476. 2021-11-01. PMID:34543673. |
the aim of the present study was to investigate whether methyl donors supplementation could exert beneficial effects on hippocampal oxidative stress, anxiety and depression in chronically high fructose-treated rats, a new animal model of anxiety and mood disorders. |
2021-11-01 |
2023-08-13 |
rat |
| Sidi Mohamed Coulibaly, Abdelhalem Mesfioui, Inssaf Berkiks, Abdeljabbar Ennaciri, Yassine Chahirou, Yacouba Diagana, Ali Ouichou, Adil El Midaoui, Aboubaker El Hessn. Effects of the Methyl Donors Supplementation on Hippocampal Oxidative Stress, Depression and Anxiety in Chronically High Fructose-treated Rats. Neuroscience. vol 476. 2021-11-01. PMID:34543673. |
these findings demonstrate that high fructose induced depression in association with the induction of a hippocampal oxidative stress. |
2021-11-01 |
2023-08-13 |
rat |
| Wei Guo, Xi Xiao, Yu-Tao Tian, Jia-Jia Yan. [The role and mechanism of SIRT1 gene in depression]. Sheng li xue bao : [Acta physiologica Sinica]. vol 73. issue 5. 2021-10-29. PMID:34708240. |
therefore, this review mainly summarizes the relevant research progress on the role and mechanism of sirt1 gene in the hippocampus, prefrontal cortex, amygdala, hypothalamic suprachiasmatic nucleus, and nucleus accumbens in depression, in order to provide new ideas for exploring the mechanism and prevention of depression. |
2021-10-29 |
2023-08-13 |
Not clear |
| Sandeep K Mishra, Mahendra Kumar Hidau, Shivika Ra. Memantine treatment exerts an antidepressant-like effect by preventing hippocampal mitochondrial dysfunction and memory impairment via upregulation of CREB/BDNF signaling in the rat model of chronic unpredictable stress-induced depression. Neurochemistry international. vol 142. 2021-10-27. PMID:33290797. |
memantine treatment exerts an antidepressant-like effect by preventing hippocampal mitochondrial dysfunction and memory impairment via upregulation of creb/bdnf signaling in the rat model of chronic unpredictable stress-induced depression. |
2021-10-27 |
2023-08-13 |
rat |
| Aarti Patel, Ryoichi Kimura, Wen Fu, Rania Soudy, David MacTavish, David Westaway, Jing Yang, Rachel A Davey, Jeffrey D Zajac, Jack H Jhamanda. Genetic Depletion of Amylin/Calcitonin Receptors Improves Memory and Learning in Transgenic Alzheimer's Disease Mouse Models. Molecular neurobiology. vol 58. issue 10. 2021-10-27. PMID:34312771. |
these compound transgenic ad mice demonstrated attenuated responses to human amylin- and aβ-induced depression of hippocampal long-term potentiation (ltp) in keeping with the genetic depletion of amylin receptors. |
2021-10-27 |
2023-08-13 |
mouse |
| Jin-Lei Zhao, Wan-Ting Jiang, Xing Wang, Zhi-Dong Cai, Zu-Hong Liu, Guo-Rong Li. Exercise, brain plasticity, and depression. CNS neuroscience & therapeutics. vol 26. issue 9. 2021-10-26. PMID:32491278. |
exercise has been proven to reshape the brain structure of depression patients, activate the function of related brain areas, promote behavioral adaptation changes, and maintain the integrity of hippocampal and white matter volume, thus improving the brain neuroprocessing and delaying cognitive degradation in depression patients. |
2021-10-26 |
2023-08-13 |
Not clear |
| Daniela A Espinoza Oyarce, Marnie E Shaw, Khawlah Alateeq, Nicolas Cherbui. Volumetric brain differences in clinical depression in association with anxiety: a systematic review with meta-analysis. Journal of psychiatry & neuroscience : JPN. vol 45. issue 6. 2021-10-26. PMID:32726102. |
structural differences associated with depression have not been confirmed in brain regions apart from the hippocampus. |
2021-10-26 |
2023-08-13 |
Not clear |
| Huixiang Ge, Mengyun Sun, Xingyu Wei, Mingming Zhang, Hongcheng Tu, Yuanzhen Hao, Ruxin Chen, Miao Ye, Yun Ga. Protective effects of dihydromyricetin on primary hippocampal astrocytes from cytotoxicity induced by comorbid diabetic neuropathic pain and depression. Purinergic signalling. vol 16. issue 4. 2021-10-26. PMID:33155081. |
protective effects of dihydromyricetin on primary hippocampal astrocytes from cytotoxicity induced by comorbid diabetic neuropathic pain and depression. |
2021-10-26 |
2023-08-13 |
Not clear |
| Huixiang Ge, Mengyun Sun, Xingyu Wei, Mingming Zhang, Hongcheng Tu, Yuanzhen Hao, Ruxin Chen, Miao Ye, Yun Ga. Protective effects of dihydromyricetin on primary hippocampal astrocytes from cytotoxicity induced by comorbid diabetic neuropathic pain and depression. Purinergic signalling. vol 16. issue 4. 2021-10-26. PMID:33155081. |
culturing with hg + sp + cort resulted in damage to primary hippocampal astrocytes, which simulates the clinical damage caused by comorbidity of diabetic neuropathic pain and depression. |
2021-10-26 |
2023-08-13 |
Not clear |
| Cédric Bertrand, Chloé Deschamps, Kevin Rabiant, Stéphane Peineau, Johann Antol, Margaret Martinetti, Mickael Naassila, Catherine Vilpoux, Olivier Pierrefich. Patch-Clamp Recording of Low Frequency Stimulation-induced Long-Term Synaptic Depression in Rat Hippocampus Slices During Early and Late Neurodevelopment. Alcoholism, clinical and experimental research. vol 45. issue 2. 2021-10-26. PMID:33196109. |
patch-clamp recording of low frequency stimulation-induced long-term synaptic depression in rat hippocampus slices during early and late neurodevelopment. |
2021-10-26 |
2023-08-13 |
human |
| Bruno Carabelli, Ana Márcia Delattre, Ana Paula Farias Waltrick, Giulia Araújo, Deborah Suchecki, Ricardo Borges Machado, Luiz Eduardo Rizzo de Souza, Silvio M Zanata, Janaína Menezes Zanoveli, Anete Curte Ferra. Fish-oil supplementation decreases Indoleamine-2,3-Dioxygenase expression and increases hippocampal serotonin levels in the LPS depression model. Behavioural brain research. vol 390. 2021-10-25. PMID:32407816. |
fish-oil supplementation decreases indoleamine-2,3-dioxygenase expression and increases hippocampal serotonin levels in the lps depression model. |
2021-10-25 |
2023-08-13 |
Not clear |
| Osamu Nakagawasai, Kotaro Yamada, Kohei Takahashi, Takayo Odaira, Wakana Sakuma, Daisuke Ishizawa, Naruya Takahashi, Kentaro Onuma, Chikako Hozumi, Wataru Nemoto, Koichi Tan-N. Liver hydrolysate prevents depressive-like behavior in an animal model of colitis: Involvement of hippocampal neurogenesis via the AMPK/BDNF pathway. Behavioural brain research. vol 390. 2021-10-25. PMID:32434062. |
our previous research in an animal model of major depression suggests that liver hydrolysate (lh) has an antidepressant effect and combats physical fatigue by enhancement via the hippocampal or peripheral p-ampk pathway. |
2021-10-25 |
2023-08-13 |
mouse |
| Barbara Planchez, Natalia Lagunas, Anne-Marie Le Guisquet, Marc Legrand, Alexandre Surget, René Hen, Catherine Belzun. Increasing Adult Hippocampal Neurogenesis Promotes Resilience in a Mouse Model of Depression. Cells. vol 10. issue 5. 2021-10-25. PMID:33919292. |
increasing adult hippocampal neurogenesis promotes resilience in a mouse model of depression. |
2021-10-25 |
2023-08-13 |
mouse |