| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Cory Langreck, Eric Wauson, Dakota Nerland, Brad Lamb, Tyler Folkerts, Lori Winter, Eileen Lu, Sarah Tague, Kenneth E McCarson, Jonathan E Ploski, Mounira Banasr, Ronald S Duman, Miranda M Roland, Victor Babich, Francesca Di Sole, Vanja Duri. Hippocampal mitogen-activated protein kinase phosphatase-1 regulates behavioral and systemic effects of chronic corticosterone administration. Biochemical pharmacology. vol 190. 2021-11-16. PMID:34023293. |
in the current study, we investigated whether activation of hippocampal mitogen-activated protein kinase phosphatase-1 (mkp-1), a key factor in depression pathophysiology, also acts as a mediator of systemic effects of stress. |
2021-11-16 |
2023-08-13 |
rat |
| Alyssia Wilson, Kristina Gicas, W Dale Stevens, Lauren Sergio, Magdalena Wojtowic. Substance use is associated with worse mental health and altered resting state functional connectivity in female university athletes at baseline: A pilot study. PloS one. vol 16. issue 6. 2021-11-16. PMID:34138920. |
rsfc differences were observed between users and non-users in orbital frontal cortex (ofc) and bilateral hippocampal seeds, and negative associations between depression symptoms and rsfc in the left hippocampus and posterior cingulate cortex were observed in cannabis users. |
2021-11-16 |
2023-08-13 |
Not clear |
| Fotini-Heleni Karachaliou, Kyriaki Karavanaki, Aristofania Simatou, Eleni Tsintzou, Nikitas S Skarakis, Christina Kanaka-Gatenbei. Association of growth hormone deficiency (GHD) with anxiety and depression: experimental data and evidence from GHD children and adolescents. Hormones (Athens, Greece). vol 20. issue 4. 2021-11-16. PMID:34195937. |
the growth hormone/insulin-like growth factor 1 (gh/igf1) axis seems to exert a regulatory effect on brain function and neurogenesis, especially in the hippocampus, a brain region associated with mental and emotional disorders, such as depression and anxiety. |
2021-11-16 |
2023-08-13 |
Not clear |
| b' Ivana Peri\\xc4\\x87, Victor Costina, Sne\\xc5\\xbeana Djordjevi\\xc4\\x87, Peter Gass, Peter Findeisen, Drago\\xc5\\xa1 Inta, Stefan Borgwardt, Dragana Filipovi\\xc4\\x8. Tianeptine modulates synaptic vesicle dynamics and favors synaptic mitochondria processes in socially isolated rats. Scientific reports. vol 11. issue 1. 2021-11-16. PMID:34493757.' |
we conducted a proteomic study on the hippocampal synaptosomal fractions of adult male wistar rats exposed to chronic social isolation (csis, 6 weeks), an animal model of depression and after chronic tian treatment in controls (nootropic effect) and csis-exposed rats (lasting 3 weeks of 6-week csis) (therapeutic effect). |
2021-11-16 |
2023-08-13 |
rat |
| Cuiqin Fan, Ye Li, Tian Lan, Wenjing Wang, Xueqin Mao, Shu Yan Y. Prophylactic treatment of curcumin in a rat model of depression by attenuating hippocampal synaptic loss. Food & function. vol 12. issue 22. 2021-11-16. PMID:34636389. |
prophylactic treatment of curcumin in a rat model of depression by attenuating hippocampal synaptic loss. |
2021-11-16 |
2023-08-13 |
rat |
| Tian Rui Zhang, Evelyn Guilherme, Aydan Kesici, Alyssa M Ash, Fidel Vila-Rodriguez, Jason S Snyde. Electroconvulsive Shock, but Not Transcranial Magnetic Stimulation, Transiently Elevates Cell Proliferation in the Adult Mouse Hippocampus. Cells. vol 10. issue 8. 2021-11-15. PMID:34440859. |
hippocampal plasticity is hypothesized to play a role in the etiopathogenesis of depression and the antidepressant effect of medications. |
2021-11-15 |
2023-08-13 |
mouse |
| Hong Wang, Zhaowu Ma, Hongyuan Shen, Zijun Wu, Lian Liu, Boxu Ren, Peiyan Wong, Gautam Sethi, Fengru Tan. Early Life Irradiation-Induced Hypoplasia and Impairment of Neurogenesis in the Dentate Gyrus and Adult Depression Are Mediated by MicroRNA- 34a-5p/T-Cell Intracytoplasmic Antigen-1 Pathway. Cells. vol 10. issue 9. 2021-11-15. PMID:34572124. |
we induced adult depression by irradiation of mice at postnatal day 3 (p3) to reveal hippocampal neuropathological changes and investigate their molecular mechanism, focusing on microrna (mir) and its target mrna and protein. |
2021-11-15 |
2023-08-13 |
mouse |
| Chen Li, Fantao Meng, Yun Lei, Jing Liu, Jing Liu, Jingyan Zhang, Fang Liu, Cuilan Liu, Ming Guo, Xin-Yun L. Leptin regulates exon-specific transcription of the Bdnf gene via epigenetic modifications mediated by an AKT/p300 HAT cascade. Molecular psychiatry. vol 26. issue 8. 2021-11-11. PMID:33106599. |
here, we show that the leptin receptor (leprb) colocalizes with brain-derived neurotrophic factor (bdnf), a key player in the pathophysiology of major depression and the action of antidepressants, in the dentate gyrus of the hippocampus. |
2021-11-11 |
2023-08-13 |
Not clear |
| Noreen Samad, Natasha Manzoor, Zahra Muneer, Sheraz A Bhatti, Imran Imra. Reserpine-induced altered neuro-behavioral, biochemical and histopathological assessments prevent by enhanced antioxidant defence system of thymoquinone in mice. Metabolic brain disease. vol 36. issue 8. 2021-11-11. PMID:34309746. |
the present study is aimed to evaluate the effect of tq on reserpine (rsp)-induced behavioral (anxiety and/or depression) and, memory deficit; hippocampal inflammatory markers, oxidative markers, antioxidant enzymes, acetylcholinesterase (ache) activity and histopathology in male mice. |
2021-11-11 |
2023-08-13 |
mouse |
| Andreas Fink, Karl Koschutnig, Thomas Zussner, Corinna M Perchtold-Stefan, Christian Rominger, Mathias Benedek, Ilona Papouse. A two-week running intervention reduces symptoms related to depression and increases hippocampal volume in young adults. Cortex; a journal devoted to the study of the nervous system and behavior. vol 144. 2021-11-11. PMID:34653905. |
a two-week running intervention reduces symptoms related to depression and increases hippocampal volume in young adults. |
2021-11-11 |
2023-08-13 |
human |
| Yin-Qiong Huang, Yaofeng Wang, Keyue Hu, Shu Lin, Xia-Hong Li. Hippocampal Glycerol-3-Phosphate Acyltransferases 4 and BDNF in the Progress of Obesity-Induced Depression. Frontiers in endocrinology. vol 12. 2021-11-10. PMID:34054732. |
hippocampal glycerol-3-phosphate acyltransferases 4 and bdnf in the progress of obesity-induced depression. |
2021-11-10 |
2023-08-13 |
Not clear |
| Amrita Benoy, Mohammad Zaki Bin Ibrahim, Thomas Behnisch, Sreedharan Sajikuma. Metaplastic Reinforcement of Long-Term Potentiation in Hippocampal Area CA2 by Cholinergic Receptor Activation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 41. issue 44. 2021-11-09. PMID:34561235. |
we show that cholinergic receptor activation with the nonselective cholinergic agonist, carbachol (cch), triggers a protein synthesis-dependent and nmdar-independent long-term synaptic depression (cch-ltd) at entorhinal cortical (ec)-ca2 and schaffer collateral (sc)-ca2 synapses in the hippocampus of adult male wistar rats. |
2021-11-09 |
2023-08-13 |
rat |
| Wei Li, Yang Xu, Zhenghai Liu, Mengmeng Shi, Yuan Zhang, Yingcheng Deng, Xiaolin Zhong, Ling Chen, Jie He, Jiayu Zeng, Mingying Luo, Wenyu Cao, Wei Wa. TRPV4 inhibitor HC067047 produces antidepressant-like effect in LPS-induced depression mouse model. Neuropharmacology. vol 201. 2021-11-09. PMID:34637786. |
here, for the first time, we found that there was a significant increase in trpv4 in the hippocampus in a depression mouse model induced by lps. |
2021-11-09 |
2023-08-13 |
mouse |
| Brunno Rocha Levone, John F Cryan, Olivia F O'Lear. Specific sub-regions of the longitudinal axis of the hippocampus mediate behavioural responses to chronic psychosocial stress. Neuropharmacology. vol 201. 2021-11-09. PMID:34666075. |
however, the roles of specific sub-regions of the longitudinal axis of the hippocampus in the response to chronic stress, a risk factor for depression and anxiety disorders, has not yet been investigated. |
2021-11-09 |
2023-08-13 |
mouse |
| Jun Hu, Jiahui Liu, Yu Liu, Xianran Wu, Kaixiang Zhuang, Qunlin Chen, Wenjing Yang, Peng Xie, Jiang Qiu, Dongtao We. Dysfunction of the anterior and intermediate hippocampal functional network in major depressive disorders across the adult lifespan. Biological psychology. vol 165. 2021-11-08. PMID:34555480. |
the results revealed that patients with mdd showed lower rsfc between the right anterior hippocampus and the insula, and the rsfc was inversely correlated with anxiety symptoms of depression. |
2021-11-08 |
2023-08-13 |
Not clear |
| Jun Hu, Jiahui Liu, Yu Liu, Xianran Wu, Kaixiang Zhuang, Qunlin Chen, Wenjing Yang, Peng Xie, Jiang Qiu, Dongtao We. Dysfunction of the anterior and intermediate hippocampal functional network in major depressive disorders across the adult lifespan. Biological psychology. vol 165. 2021-11-08. PMID:34555480. |
depressed patients also showed decreased rsfc between the bilateral intermediate hippocampus and left nucleus accumbens (nacc), and the hippocampus-nacc circuit was negatively correlated with core symptoms of depression. |
2021-11-08 |
2023-08-13 |
Not clear |
| Jun Hu, Jiahui Liu, Yu Liu, Xianran Wu, Kaixiang Zhuang, Qunlin Chen, Wenjing Yang, Peng Xie, Jiang Qiu, Dongtao We. Dysfunction of the anterior and intermediate hippocampal functional network in major depressive disorders across the adult lifespan. Biological psychology. vol 165. 2021-11-08. PMID:34555480. |
these findings suggest that the functional network of hippocampal subfields may underlie anxiety and core depression symptoms. |
2021-11-08 |
2023-08-13 |
Not clear |
| Josiane Budni, Morgana Moretti, Andiara E Freitas, Vivian B Neis, Camille M Ribeiro, Grasiela de Oliveira Balen, Débora K Rieger, Rodrigo B Leal, Ana Lúcia S Rodrigue. Behavioral and neurochemical effects of folic acid in a mouse model of depression induced by TNF-α. Behavioural brain research. vol 414. 2021-11-04. PMID:34358572. |
this study examined: a) the efficacy of folic acid in a mouse model of depression induced by tumor necrosis factor (tnf-α); b) whether the administration of subthreshold doses of folic acid and antidepressants (fluoxetine, imipramine, and bupropion), mk-801, or 7-nitroindazole cause antidepressant-like effects; c) the effects of tnf-α and/or folic acid on hippocampal p38 |
2021-11-04 |
2023-08-13 |
mouse |
| Zhi Zhang, Samiha Ishrat, Megan O'Bryan, Brandon Klein, Manda Saraswati, Courtney Robertson, Sujatha Kanna. Pediatric Traumatic Brain Injury Causes Long-Term Deficits in Adult Hippocampal Neurogenesis and Cognition. Journal of neurotrauma. vol 37. issue 14. 2021-11-03. PMID:32079496. |
impairment of adult hippocampal neurogenesis is associated with cognitive deficits and depression. |
2021-11-03 |
2023-08-13 |
rabbit |
| Amber M Leaver, Megha Vasavada, Antoni Kubicki, Benjamin Wade, Joana Loureiro, Gerhard Hellemann, Shantanu H Joshi, Roger P Woods, Randall Espinoza, Katherine L Nar. Hippocampal subregions and networks linked with antidepressant response to electroconvulsive therapy. Molecular psychiatry. vol 26. issue 8. 2021-11-02. PMID:32029885. |
this magnetic resonance imaging (mri) study tracks changes in separate hippocampal subregions and hippocampal networks in patients with depression (n = 44, 23 female) to determine their relationship, if any, with improvement after ect. |
2021-11-02 |
2023-08-13 |
Not clear |