| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhiqiang Liu, Yongzhou Zou, Min He, Ping Yang, Xinhui Qu, Lijun X. Hydroxysafflor yellow A can improve depressive behavior by inhibiting hippocampal inflammation and oxidative stress through regulating HPA axis. Journal of biosciences. vol 47. 2022-01-29. PMID:35092409. |
in conclusion, these findings indicted that hsya can improve depressive behavior through inhibiting hpa signaling, repressing hippocampal inflammation and oxidative stress, which will provide a new therapeutic method for treating depression. |
2022-01-29 |
2023-08-13 |
rat |
| Lanxiang Liu, Haiyang Wang, Xueyi Chen, Yangdong Zhang, Wenxia Li, Xuechen Rao, Yiyun Liu, Libo Zhao, Juncai Pu, Siwen Gui, Deyu Yang, Liang Fang, Peng Xi. Integrative Analysis of Long Non-coding RNAs, Messenger RNAs, and MicroRNAs Indicates the Neurodevelopmental Dysfunction in the Hippocampus of Gut Microbiota-Dysbiosis Mice. Frontiers in molecular neuroscience. vol 14. 2022-01-28. PMID:35087377. |
herein, the differentially expressed hippocampal long non-coding rnas (lncrnas), messenger rnas (mrnas), and micrornas (mirnas) between mice inoculated with gut microbiota from major depressive disorder patients or healthy controls were detected, to identify the effects of gut microbiota-dysbiosis on gene regulation patterns at the transcriptome level, and in further to explore the microbial-regulated pathological mechanisms of depression. |
2022-01-28 |
2023-08-13 |
mouse |
| Wen-Jing Cheng, Peng Li, Wen-Ya Huang, Yang Huang, Wen-Jie Chen, Yi-Ping Chen, Jun-Liang Shen, Jian-Kun Chen, Na-Sha Long, Xian-Jun Men. Acupuncture Relieves Stress-Induced Depressive Behavior by Reducing Oxidative Stress and Neuroapoptosis in Rats. Frontiers in behavioral neuroscience. vol 15. 2022-01-21. PMID:35058758. |
in order to explore the mechanism of the antidepressant effect of acupuncture, this study performed acupuncture prevention on chronic unpredictable mild stress (cums) depression model rats, and observed the effect of acupuncture on hippocampal oxidative stress and nrf2 signaling pathway. |
2022-01-21 |
2023-08-13 |
rat |
| Giuseppe Caruso, Margherita Grasso, Annamaria Fidilio, Sebastiano Alfio Torrisi, Nicolò Musso, Federica Geraci, Maria Rosaria Tropea, Anna Privitera, Fabio Tascedda, Daniela Puzzo, Salvatore Salomone, Filippo Drago, Gian Marco Leggio, Filippo Carac. Antioxidant Activity of Fluoxetine and Vortioxetine in a Non-Transgenic Animal Model of Alzheimer's Disease. Frontiers in pharmacology. vol 12. 2022-01-10. PMID:35002742. |
aim of our study was to test flx and vtx for their ability to prevent oxidative stress in the hippocampus of aβ-injected mice, a brain area strongly affected in both depression and ad. |
2022-01-10 |
2023-08-13 |
mouse |
| Hua-Hsin Tai, Jungho Cha, Faezeh Vedaei, Boadie W Dunlop, W Edward Craighead, Helen S Mayberg, Ki Sueng Cho. Treatment-Specific Hippocampal Subfield Volume Changes With Antidepressant Medication or Cognitive-Behavior Therapy in Treatment-Naive Depression. Frontiers in psychiatry. vol 12. 2022-01-10. PMID:35002790. |
treatment-specific hippocampal subfield volume changes with antidepressant medication or cognitive-behavior therapy in treatment-naive depression. |
2022-01-10 |
2023-08-13 |
Not clear |
| Guo-Liang Dai, Xin-Yi Yang, Shan-Shan Chen, Yi-Qing Wang, Mei-Chen Liu, Yang Cao, Fei-Ran Li, Cheng-Yao Ma, Wen-Zheng J. [Effects of Jiaotai Pills on CUMS-induced depression model in mice based on changes of SIRT1 expression in hippocampus]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 46. issue 24. 2022-01-07. PMID:34994144. |
[effects of jiaotai pills on cums-induced depression model in mice based on changes of sirt1 expression in hippocampus]. |
2022-01-07 |
2023-08-13 |
mouse |
| Guo-Liang Dai, Xin-Yi Yang, Shan-Shan Chen, Yi-Qing Wang, Mei-Chen Liu, Yang Cao, Fei-Ran Li, Cheng-Yao Ma, Wen-Zheng J. [Effects of Jiaotai Pills on CUMS-induced depression model in mice based on changes of SIRT1 expression in hippocampus]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 46. issue 24. 2022-01-07. PMID:34994144. |
in conclusion, the results showed that jiaotai pills could improve the depression behaviors of model mice with cums-induced depression, and the underlying mechanism was related to the up-regulation of sirt1 in the hippocampus of mice to exert anti-inflammatory and anti-oxidative stress effects. |
2022-01-07 |
2023-08-13 |
mouse |
| Zhuoyu Ren, Mingling Wang, Mokhtar Aldhabi, Rui Zhang, Yongxin Liu, Shaoyan Liu, Rundong Tang, Zuolei Che. Low-dose S-ketamine exerts antidepressant-like effects via enhanced hippocampal synaptic plasticity in postpartum depression rats. Neurobiology of stress. vol 16. 2022-01-03. PMID:34977283. |
low-dose s-ketamine exerts antidepressant-like effects via enhanced hippocampal synaptic plasticity in postpartum depression rats. |
2022-01-03 |
2023-08-13 |
rat |
| Li Wei, Yupeng Du, Yirui Xie, Xiaopeng Yu, Hui Chen, Yunqing Qi. Lipocalin-2 Regulates Hippocampal Microglial Activation in Poststroke Depression. Frontiers in aging neuroscience. vol 13. 2021-12-30. PMID:34966272. |
lipocalin-2 regulates hippocampal microglial activation in poststroke depression. |
2021-12-30 |
2023-08-13 |
Not clear |
| Wei Jing, Tongmei Zhang, Jiaying Liu, Xian Huang, Quntao Yu, Hongyan Yu, Qingping Zhang, Hao Li, Manfei Deng, Ling-Qiang Zhu, Huiyun Du, Youming L. A circuit of COCH neurons encodes social-stress-induced anxiety via MTF1 activation of Cacna1h. Cell reports. vol 37. issue 13. 2021-12-29. PMID:34965426. |
hippocampal dysfunction can lead to persistent anxiety and/or depression. |
2021-12-29 |
2023-08-13 |
Not clear |
| Joshua Hendrikse, Yann Chye, Sarah Thompson, Nigel C Rogasch, Chao Suo, James P Coxon, Murat Yüce. Regular aerobic exercise is positively associated with hippocampal structure and function in young and middle-aged adults. Hippocampus. 2021-12-28. PMID:34961996. |
the hippocampus plays a critical role in memory function, and is altered in a number of psychiatric disorders associated with memory impairments (e.g., depression and schizophrenia), as well as healthy aging. |
2021-12-28 |
2023-08-13 |
Not clear |
| Michelle R Dickerson, Susan F Murphy, Michael J Urban, Zakar White, Pamela J VandeVor. Chronic Anxiety- and Depression-Like Behaviors Are Associated With Glial-Driven Pathology Following Repeated Blast Induced Neurotrauma. Frontiers in behavioral neuroscience. vol 15. 2021-12-27. PMID:34955781. |
the hippocampus and motor cortex (mc) have been regions of interest when studying cognitive deficits following blast exposure, but clinical studies of mood disorders such as major depressive disorder (mdd) report that these two regions also play a role in the manifestation of anxiety and depression. |
2021-12-27 |
2023-08-13 |
rat |
| Michelle R Dickerson, Susan F Murphy, Michael J Urban, Zakar White, Pamela J VandeVor. Chronic Anxiety- and Depression-Like Behaviors Are Associated With Glial-Driven Pathology Following Repeated Blast Induced Neurotrauma. Frontiers in behavioral neuroscience. vol 15. 2021-12-27. PMID:34955781. |
with anxiety and depression being common long-term outcomes following btbi, it is imperative to study how chronic pathological changes within the hippocampus and/or mc due to blast contribute to the development of these psychiatric impairments. |
2021-12-27 |
2023-08-13 |
rat |
| b' Lale G\\xc3\\xb6nenir Erbay, R\\xc4\\xb1fat Karl\\xc4\\xb1da\\xc4\\x9f, M\\xc3\\xbccahit Oru\\xc3\\xa7, Y\\xc4\\xb1lmaz \\xc3\\x87i\\xc4\\x9fremi\\xc5\\x9f, Osman Celbi\\xc5\\x9. Association of BDNF / TrkB and NGF / TrkA Levels in Postmortem Brain with Major Depression and Suicide. Psychiatria Danubina. vol 33. issue 4. 2021-12-20. PMID:34928896.' |
this study was conducted to examine whether bdnf and / or trkb as well as ngf and / or trka expression profiles were changed in the hippocampus of postmortem brain of individuals with depression who committed suicide. |
2021-12-20 |
2023-08-13 |
Not clear |
| Nathália Stela Visoná de Figueiredo, Anaclara Prada Jardim, Lenon Mazetto, Jeana Torres Corso Duarte, Sandra Mara Comper, Neide Barreira Alonso, Maria Helena da Silva Noffs, Carla Alessandra Scorza, Esper Abrão Cavalheiro, Ricardo Silva Centeno, Gerardo Maria de Araújo Filho, Elza Márcia Targas Yacubia. Do Hippocampal Neurons Really Count for Comorbid Depression in Patients With Mesial Temporal Lobe Epilepsy and Hippocampal Sclerosis? A Histopathological Study. Frontiers in integrative neuroscience. vol 15. 2021-12-17. PMID:34916913. |
do hippocampal neurons really count for comorbid depression in patients with mesial temporal lobe epilepsy and hippocampal sclerosis? |
2021-12-17 |
2023-08-13 |
Not clear |
| Nathália Stela Visoná de Figueiredo, Anaclara Prada Jardim, Lenon Mazetto, Jeana Torres Corso Duarte, Sandra Mara Comper, Neide Barreira Alonso, Maria Helena da Silva Noffs, Carla Alessandra Scorza, Esper Abrão Cavalheiro, Ricardo Silva Centeno, Gerardo Maria de Araújo Filho, Elza Márcia Targas Yacubia. Do Hippocampal Neurons Really Count for Comorbid Depression in Patients With Mesial Temporal Lobe Epilepsy and Hippocampal Sclerosis? A Histopathological Study. Frontiers in integrative neuroscience. vol 15. 2021-12-17. PMID:34916913. |
depression is the most frequent psychiatric comorbidity seen in mesial temporal lobe epilepsy (mtle) patients with hippocampal sclerosis (hs). |
2021-12-17 |
2023-08-13 |
Not clear |
| Nathália Stela Visoná de Figueiredo, Anaclara Prada Jardim, Lenon Mazetto, Jeana Torres Corso Duarte, Sandra Mara Comper, Neide Barreira Alonso, Maria Helena da Silva Noffs, Carla Alessandra Scorza, Esper Abrão Cavalheiro, Ricardo Silva Centeno, Gerardo Maria de Araújo Filho, Elza Márcia Targas Yacubia. Do Hippocampal Neurons Really Count for Comorbid Depression in Patients With Mesial Temporal Lobe Epilepsy and Hippocampal Sclerosis? A Histopathological Study. Frontiers in integrative neuroscience. vol 15. 2021-12-17. PMID:34916913. |
this study aimed to verify if patients with unilateral mtle-hs and the co-occurrence of depression have differences in neuronal density of the hippocampal sectors ca1-ca4. |
2021-12-17 |
2023-08-13 |
Not clear |
| Nathália Stela Visoná de Figueiredo, Anaclara Prada Jardim, Lenon Mazetto, Jeana Torres Corso Duarte, Sandra Mara Comper, Neide Barreira Alonso, Maria Helena da Silva Noffs, Carla Alessandra Scorza, Esper Abrão Cavalheiro, Ricardo Silva Centeno, Gerardo Maria de Araújo Filho, Elza Márcia Targas Yacubia. Do Hippocampal Neurons Really Count for Comorbid Depression in Patients With Mesial Temporal Lobe Epilepsy and Hippocampal Sclerosis? A Histopathological Study. Frontiers in integrative neuroscience. vol 15. 2021-12-17. PMID:34916913. |
however, we found no difference in hippocampal neuronal density when depression co-occurs in patients with epilepsy. |
2021-12-17 |
2023-08-13 |
Not clear |
| Yi-Ling Lu, Helen E Scharfma. New Insights and Methods for Recording and Imaging Spontaneous Spreading Depolarizations and Seizure-Like Events in Mouse Hippocampal Slices. Frontiers in cellular neuroscience. vol 15. 2021-12-13. PMID:34899190. |
it is followed by depression of neuronal activity, and it slowly propagates across brain regions like cortex or hippocampus. |
2021-12-13 |
2023-08-13 |
mouse |
| Shijia Chen, Fengpei Chen, Nashwa Amin, Qiannan Ren, Shan Ye, Zhiying Hu, Xiaoning Tan, Mizu Jiang, Marong Fan. Defects of parvalbumin-positive interneurons in the ventral dentate gyrus region are implicated depression-like behavior in mice. Brain, behavior, and immunity. vol 99. 2021-12-11. PMID:34562597. |
however, the relationship between depression and hippocampal pvis remains unclear. |
2021-12-11 |
2023-08-13 |
mouse |