| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shi-Yu Shen, Rui Yu, Wei Li, Ling-Feng Liang, Qiu-Qin Han, Hui-Jie Huang, Bing Li, Shi-Fen Xu, Gen-Cheng Wu, Yu-Qiu Zhang, Jin Y. The neuroprotective effects of GPR55 against hippocampal neuroinflammation and impaired adult neurogenesis in CSDS mice. Neurobiology of disease. 2022-05-01. PMID:35490927. |
our research demonstrated that downregulation of gpr55 expression in the hippocampus might mediate csds-induced depression- and anxiety-like phenotypes, and activation and upregulation of gpr55, which might be correlated with its anti-inflammatory and subsequent neuroprotective effects, could be a potential treatment for depression. |
2022-05-01 |
2023-08-13 |
mouse |
| Chong Gao, Meiling Wu, Qiaohui Du, Jiagang Deng, Jiangang She. Naringin Mediates Adult Hippocampal Neurogenesis for Antidepression via Activating CREB Signaling. Frontiers in cell and developmental biology. vol 10. 2022-04-28. PMID:35478969. |
in cort-induced depression mouse model, naringin treatment promoted neuronal differentiation and maturation of nspcs for hippocampal neurogenesis. |
2022-04-28 |
2023-08-13 |
mouse |
| Wenxia Jiang, Jianjun Chen, Lei Gong, Fang Liu, Huan Zhao, Jun M. Alteration of Glycerophospholipid Metabolism in Hippocampus of Post-stroke Depression Rats. Neurochemical research. 2022-04-26. PMID:35469367. |
alteration of glycerophospholipid metabolism in hippocampus of post-stroke depression rats. |
2022-04-26 |
2023-08-13 |
rat |
| Yeonggwang Hwang, Hyoung-Chun Kim, Eun-Joo Shi. BKM120 alters the migration of doublecortin-positive cells in the dentate gyrus of mice. Pharmacological research. 2022-04-23. PMID:35460881. |
although abnormal changes in hippocampal neurogenesis have been suggested to, at least in part, associated with the pathogenesis of depression and anxiety, bkm120 did not affect the incorporation of 5-bromo-2'-deoxyuridine or the expression of doublecortin (dcx); however, it significantly enhanced the radial migration of dcx-positive cells in the dentate gyrus. |
2022-04-23 |
2023-08-13 |
mouse |
| Meishar Shahoha, Ronni Cohen, Yoav Ben-Simon, Uri Asher. cAMP-Dependent Synaptic Plasticity at the Hippocampal Mossy Fiber Terminal. Frontiers in synaptic neuroscience. vol 14. 2022-04-21. PMID:35444523. |
in the hippocampal mossy fiber (mf) synapse, camp mediates presynaptic long-term potentiation and depression. |
2022-04-21 |
2023-08-13 |
Not clear |
| Alexandria N Tartt, Madeline B Mariani, Rene Hen, J John Mann, Maura Boldrin. Dysregulation of adult hippocampal neuroplasticity in major depression: pathogenesis and therapeutic implications. Molecular psychiatry. 2022-03-31. PMID:35354926. |
dysregulation of adult hippocampal neuroplasticity in major depression: pathogenesis and therapeutic implications. |
2022-03-31 |
2023-08-13 |
Not clear |
| Xiuhua Mao, Dandan Cai, Wei Lo. Music alleviates pain perception in depression mouse models by promoting the release of glutamate in the hippocampus of mice to act on GRIK5. Nucleosides, nucleotides & nucleic acids. 2022-03-31. PMID:35357273. |
music alleviates pain perception in depression mouse models by promoting the release of glutamate in the hippocampus of mice to act on grik5. |
2022-03-31 |
2023-08-13 |
mouse |
| Peng Wang, Peiyu Guo, Yanhui Wang, Xiangyun Teng, Huaqi Zhang, Lirui Sun, Meilan Xue, Hui Lian. Propolis Ameliorates Alcohol-Induced Depressive Symptoms in C57BL/6J Mice by Regulating Intestinal Mucosal Barrier Function and Inflammatory Reaction. Nutrients. vol 14. issue 6. 2022-03-26. PMID:35334870. |
in addition, propolis attenuates the injury of nerve cells in the hippocampal region and restores the serum levels of brain-derived neurotrophic factor (bdnf) and dopamine (da) in mice with alcohol-induced depression. |
2022-03-26 |
2023-08-13 |
mouse |
| Jialin Liu, Yichao Fang, Lixun Cui, Zhongzhao Wang, Yusha Luo, Congcong Gao, Wen Ge, Taohong Huang, Jun Wen, Tingting Zho. Butyrate emerges as a crucial effector of Zhi-Zi-Chi decoctions to ameliorate depression via multiple pathways of brain-gut axis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 149. 2022-03-26. PMID:35339110. |
a classic depression model of chronic mild unpredictable stress (cums) was established in rats based on the results of behavioral tests and hippocampal histomorphology. |
2022-03-26 |
2023-08-13 |
rat |
| Jeonghwan Lee, Gawon Ju, Hyemi Park, Seungwon Chung, Jung-Woo Son, Chul-Jin Shin, Sang Ick Lee, Siekyeong Ki. Hippocampal Subfields and White Matter Connectivity in Patients with Subclinical Geriatric Depression. Brain sciences. vol 12. issue 3. 2022-03-25. PMID:35326285. |
hippocampal subfields and white matter connectivity in patients with subclinical geriatric depression. |
2022-03-25 |
2023-08-13 |
human |
| Jeonghwan Lee, Gawon Ju, Hyemi Park, Seungwon Chung, Jung-Woo Son, Chul-Jin Shin, Sang Ick Lee, Siekyeong Ki. Hippocampal Subfields and White Matter Connectivity in Patients with Subclinical Geriatric Depression. Brain sciences. vol 12. issue 3. 2022-03-25. PMID:35326285. |
we aimed to investigate early alterations in hippocampal microstructure and identify their associations with memory function in geriatric patients with subclinical depression. |
2022-03-25 |
2023-08-13 |
human |
| Jeonghwan Lee, Gawon Ju, Hyemi Park, Seungwon Chung, Jung-Woo Son, Chul-Jin Shin, Sang Ick Lee, Siekyeong Ki. Hippocampal Subfields and White Matter Connectivity in Patients with Subclinical Geriatric Depression. Brain sciences. vol 12. issue 3. 2022-03-25. PMID:35326285. |
our findings indicated that the volumes of whole bilateral hippocampus, cornus ammonis (ca) 1, molecular layer, left subiculum, ca3, hippocampal tail, right ca4, and granule cell/molecular layers of the dentate gyrus (gc-ml-dg) were significantly smaller in the subclinical depression group than in the control group. |
2022-03-25 |
2023-08-13 |
human |
| Jeonghwan Lee, Gawon Ju, Hyemi Park, Seungwon Chung, Jung-Woo Son, Chul-Jin Shin, Sang Ick Lee, Siekyeong Ki. Hippocampal Subfields and White Matter Connectivity in Patients with Subclinical Geriatric Depression. Brain sciences. vol 12. issue 3. 2022-03-25. PMID:35326285. |
in the subclinical depression group, verbal learning was positively correlated with the volumes of the ca1, gc-ml-dg, molecular layer, and whole hippocampus in the right hemisphere. |
2022-03-25 |
2023-08-13 |
human |
| Jeonghwan Lee, Gawon Ju, Hyemi Park, Seungwon Chung, Jung-Woo Son, Chul-Jin Shin, Sang Ick Lee, Siekyeong Ki. Hippocampal Subfields and White Matter Connectivity in Patients with Subclinical Geriatric Depression. Brain sciences. vol 12. issue 3. 2022-03-25. PMID:35326285. |
our results suggest that hippocampal microstructure is disrupted and associated with memory in patients with subclinical depression. |
2022-03-25 |
2023-08-13 |
human |
| Ruiping Zheng, Yuan Chen, Yu Jiang, Bingqian Zhou, Shaoqiang Han, Yarui Wei, Caihong Wang, Jingliang Chen. Abnormal voxel-wise whole-brain functional connectivity in first-episode, drug-naïve adolescents with major depression disorder. European child & adolescent psychiatry. 2022-03-23. PMID:35318540. |
furthermore, the dc values in the bilateral hippocampus were correlated with the hamilton depression rating scale score and duration of disease (all p < 0.05, false discovery rate corrected). |
2022-03-23 |
2023-08-13 |
Not clear |
| Zhe Wang, Yating Cheng, Ye Lu, Guoqiang Sun, Lin Pe. Baicalin coadministration with lithium chloride enhanced neurogenesis via GSK3β pathway in corticosterone induced PC-12 cells. Biological & pharmaceutical bulletin. 2022-03-17. PMID:35296580. |
accumulating studies suggest that hippocampal neurogenesis plays a crucial role in the pathological mechanism of depression. |
2022-03-17 |
2023-08-13 |
Not clear |
| Monika Bijata, Ewa Bączyńska, Franziska E Müller, Krystian Bijata, Julia Masternak, Adam Krzystyniak, Bernadeta Szewczyk, Marcin Siwiec, Svitlana Antoniuk, Matylda Roszkowska, Izabela Figiel, Marta Magnowska, Krzysztof H Olszyński, Agnieszka D Wardak, Adam Hogendorf, Błażej Ruszczycki, Nataliya Gorinski, Josephine Labus, Tomasz Stępień, Sylwia Tarka, Andrzej J Bojarski, Krzysztof Tokarski, Robert K Filipkowski, Evgeni Ponimaskin, Jakub Wlodarczy. Activation of the 5-HT7 receptor and MMP-9 signaling module in the hippocampal CA1 region is necessary for the development of depressive-like behavior. Cell reports. vol 38. issue 11. 2022-03-16. PMID:35294881. |
we show that acute 5-ht7r activation induces depressive-like behavior in mice in an mmp-9-dependent manner and that post mortem brain samples from human individuals with depression reveal increased mmp-9 enzymatic activity in the hippocampus. |
2022-03-16 |
2023-08-13 |
mouse |
| Zihu Tan, Guang Yang, Jing Qiu, Wenjing Yan, Yu Liu, Zhengling Ma, Jia Li, Jing Liu, Nan Sha. Quercetin Alleviates Demyelination Through Regulating Microglial Phenotype Transformation to Mitigate Neuropsychiatric Symptoms in Mice with Vascular Dementia. Molecular neurobiology. 2022-03-10. PMID:35267135. |
collectively, the results demonstrated that that quercetin mediated microglial transformation into anti-inflammatory phenotype to reduce demyelination in ventral hippocampus (vhip), thereafter mitigating neuropsychiatric deficits (including anxiety and depression). |
2022-03-10 |
2023-08-13 |
mouse |
| Gülin Özdamar Ünal, Kuyaş Hekimler Öztürk, Gamze Erkılınç, Feyza Dönmez, Duygu Kumbul Doğuç, Özlem Özmen, Mekin Sezi. Maternal prenatal stress and depression-like behavior associated with hippocampal and cortical neuroinflammation in the offspring: An experimental study. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 2022-03-09. PMID:35261075. |
compared to controls, exposure to prenatal stress was associated with increased depression and anxiety-like behavior, hippocampal nlrp3 inflammasome activation (p=0.022 and p=0.035 for female and male pups, respectively), neuronal degeneration and increased cas-3, mtor, and trpm immunostaining in the prefrontal and temporal cortices of both female and male offspring (p<0.05 for all comparisons except p<0.01 for cas-3 in the male cortex and female temporal cortex). |
2022-03-09 |
2023-08-13 |
rat |
| Jiamei Guo, Tian Qiu, Lixia Wang, Lei Shi, Ming Ai, Zhu Xia, Zhiping Peng, Anhai Zheng, Xiao Li, Li Kuan. Microglia Loss and Astrocyte Activation Cause Dynamic Changes in Hippocampal [ Frontiers in cellular neuroscience. vol 16. 2022-03-07. PMID:35250485. |
microglia loss and astrocyte activation cause dynamic changes in hippocampal [ major depression is a serious and chronic mental illness. |
2022-03-07 |
2023-08-13 |
mouse |