| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bradley S Peterson, Tejal Kaur, Maria Andrea Baez, Ronald C Whiteman, Siddhant Sawardekar, Juan Sanchez-Peña, Xuejun Hao, Kristin W Klahr, Ardesheer Talati, Priya Wickramaratne, Myrna M Weissman, Ravi Bansa. Morphological Biomarkers in the Amygdala and Hippocampus of Children and Adults at High Familial Risk for Depression. Diagnostics (Basel, Switzerland). vol 12. issue 5. 2022-05-28. PMID:35626374. |
whether morphological markers of risk for familial depression are present in the hippocampus or amygdala is unknown. |
2022-05-28 |
2023-08-13 |
human |
| Bradley S Peterson, Tejal Kaur, Maria Andrea Baez, Ronald C Whiteman, Siddhant Sawardekar, Juan Sanchez-Peña, Xuejun Hao, Kristin W Klahr, Ardesheer Talati, Priya Wickramaratne, Myrna M Weissman, Ravi Bansa. Morphological Biomarkers in the Amygdala and Hippocampus of Children and Adults at High Familial Risk for Depression. Diagnostics (Basel, Switzerland). vol 12. issue 5. 2022-05-28. PMID:35626374. |
we compared surface morphological features of the hippocampus and amygdala across risk groups and assessed their associations with depression severity. |
2022-05-28 |
2023-08-13 |
human |
| Xu-Dong Yu, Dan Zhang, Chu-Li Xiao, Yu Zhou, Xing Li, Le Wang, Zhiming He, James Reilly, Zhi-Yong Xiao, Xinhua Sh. P-Coumaric Acid Reverses Depression-Like Behavior and Memory Deficit Via Inhibiting AGE-RAGE-Mediated Neuroinflammation. Cells. vol 11. issue 10. 2022-05-28. PMID:35626632. |
western blotting showed cort-induced activation of the advanced glycation end product (age)-receptor of age (rage) (age-rage) signaling and increased expression of the proinflammatory cytokines interleukin-1 beta (il-1β) and tumor necrosis factor-alpha (tnfα) in the hippocampus, while p-ca treatment inactivated age-rage signaling and decreased the levels of il-1β and tnfα, suggesting that protection against depression and memory impairment by p-ca is mediated by the inhibition of inflammation, mainly via the age-rage signaling pathway. |
2022-05-28 |
2023-08-13 |
mouse |
| Yan-Mei Chen, Hua Fan, Jie Huang, Tian-Shun Shi, Wei-Yu Li, Cheng-Niu Wang, Bo Jiang, Jian-Feng Li. Hippocampal F3/Contactin plays a role in chronic stress-induced depressive-like effects and the antidepressant actions of vortioxetine in mice. Biochemical pharmacology. 2022-05-24. PMID:35609645. |
currently, it has been demonstrated that besides monoaminergic dysfunction, depression is accompanied by several other important pathological phenomena such as impaired neurogenesis and decreased brain-derived neurotrophic factor (bdnf)-camp response element binding protein (creb) signaling cascade in the hippocampus. |
2022-05-24 |
2023-08-13 |
mouse |
| Yan-Mei Chen, Hua Fan, Jie Huang, Tian-Shun Shi, Wei-Yu Li, Cheng-Niu Wang, Bo Jiang, Jian-Feng Li. Hippocampal F3/Contactin plays a role in chronic stress-induced depressive-like effects and the antidepressant actions of vortioxetine in mice. Biochemical pharmacology. 2022-05-24. PMID:35609645. |
collectively, hippocampal f3/contactin is implicated in depression and could be a novel antidepressant target. |
2022-05-24 |
2023-08-13 |
mouse |
| Chen-Yue Liu, Jian-Bei Chen, Yue-Yun Liu, Xue-Ming Zhou, Man Zhang, You-Ming Jiang, Qing-Yu Ma, Zhe Xue, Zong-Yao Zhao, Xiao-Juan Li, Jia-Xu Che. Saikosaponin D exerts antidepressant effect by regulating Homer1-mGluR5 and mTOR signaling in a rat model of chronic unpredictable mild stress. Chinese medicine. vol 17. issue 1. 2022-05-24. PMID:35610650. |
many studies about depression have focused on the dysfunctional synaptic signaling in the hippocampus that drives the pathophysiology of depression. |
2022-05-24 |
2023-08-13 |
rat |
| Rintaro Fujii, Keita Watanabe, Naomichi Okamoto, Tomoya Natsuyama, Hirofumi Tesen, Ryohei Igata, Yuki Konishi, Atsuko Ikenouchi, Shingo Kakeda, Reiji Yoshimur. Hippocampal Volume and Plasma Brain-Derived Neurotrophic Factor Levels in Patients With Depression and Healthy Controls. Frontiers in molecular neuroscience. vol 15. 2022-05-23. PMID:35600081. |
hippocampal volume and plasma brain-derived neurotrophic factor levels in patients with depression and healthy controls. |
2022-05-23 |
2023-08-13 |
Not clear |
| Rintaro Fujii, Keita Watanabe, Naomichi Okamoto, Tomoya Natsuyama, Hirofumi Tesen, Ryohei Igata, Yuki Konishi, Atsuko Ikenouchi, Shingo Kakeda, Reiji Yoshimur. Hippocampal Volume and Plasma Brain-Derived Neurotrophic Factor Levels in Patients With Depression and Healthy Controls. Frontiers in molecular neuroscience. vol 15. 2022-05-23. PMID:35600081. |
the aim of the present study was to investigate associations between hippocampal subfield volumes and plasma levels of brain-derived neurotrophic factor (bdnf) in patients experiencing a first episode of major depression (md) ( |
2022-05-23 |
2023-08-13 |
Not clear |
| Franziska Bracke, Helge Frieling, Andreas Leffle. Antidepressants Are Poor Inhibitors of Heat-Evoked Ion Currents Mediated by TRPM2. Pharmacology. 2022-05-18. PMID:35584608. |
the heat and redox-sensitive ion channel trpm2 was reported to be a causative mechanism for depression in a mouse model and to be upregulated in the hippocampus in patients suffering from depressive disorders. |
2022-05-18 |
2023-08-13 |
mouse |
| Qing Zhu, Pan Meng, Yuanshan Han, Hui Yang, Qin Yang, Zhuo Liu, Yuhong Wang, Minghui Lon. Luteolin Induced Hippocampal Neuronal Pyroptosis Inhibition by Regulation of miR-124-3p/TNF- Evidence-based complementary and alternative medicine : eCAM. vol 2022. 2022-05-16. PMID:35571739. |
luteolin induced hippocampal neuronal pyroptosis inhibition by regulation of mir-124-3p/tnf- breast-cancer-related depression (bcrd) is associated with an increased mortality rate among breast cancer (bc) survivors. |
2022-05-16 |
2023-08-13 |
Not clear |
| Dezhu Li, Qi Liao, Yang Tao, Saiqi Ni, Chuang Wang, Dingli Xu, Dongsheng Zhou, Xingxing Li, Xinchun Jin, Xiaowei Chen, Wei Cui, Junfang Zhan. Downregulation of CRTC1 Is Involved in CUMS-Induced Depression-Like Behavior in the Hippocampus and Its RNA Sequencing Analysis. Molecular neurobiology. 2022-05-13. PMID:35556215. |
the decreased level of creb (camp-responsive element binding)-regulated transcription coactivator 1 (crtc1) expression in hippocampus may be involved in depression-like behavior in some stress-induced depression models. |
2022-05-13 |
2023-08-13 |
mouse |
| Ji-Yu Zhao, Jing Yan, Hong-Yang Wang, Qing-Qing Liu, Tian-Sheng Zhang, Chong-Yao Ha. [Effect of wheat-grain moxibustion on the expression of 5-HT and cortisol in the serum, and MR and GR in the hippocampus in rats with hypothyroidism complicated with depression]. Zhongguo zhen jiu = Chinese acupuncture & moxibustion. vol 42. issue 5. 2022-05-11. PMID:35543943. |
[effect of wheat-grain moxibustion on the expression of 5-ht and cortisol in the serum, and mr and gr in the hippocampus in rats with hypothyroidism complicated with depression]. |
2022-05-11 |
2023-08-13 |
rat |
| Ji-Yu Zhao, Jing Yan, Hong-Yang Wang, Qing-Qing Liu, Tian-Sheng Zhang, Chong-Yao Ha. [Effect of wheat-grain moxibustion on the expression of 5-HT and cortisol in the serum, and MR and GR in the hippocampus in rats with hypothyroidism complicated with depression]. Zhongguo zhen jiu = Chinese acupuncture & moxibustion. vol 42. issue 5. 2022-05-11. PMID:35543943. |
to observe the effect of wheat-grain moxibustion on behavior, 5-hydroxytryptamine (5-ht) and cortisol in the serum, mineralocorticoid receptor (mr) and glucocorticoid receptor (gr) in the hippocampus in rats with hypothyroidism complicated with depression, and to explore the possible mechanism of wheat-grain moxibustion on improving depression in rats with hypothyroidism. |
2022-05-11 |
2023-08-13 |
rat |
| Lin-Ru Zhao, Pan He, Jie Li, Ya-Jun Zhang, Jing-Xing Jiang, Ying-Ru Wu, Yue Zhang, Jia Li, Cong Liu, Xu-Liang Ha. [Sleep-improving mechanism of Chaiqin Ningshen Granules in insomnia rats: based on hippocampal metabonomics]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 47. issue 7. 2022-05-09. PMID:35534263. |
parachlorophenylalanine(pcpa, ip) and chronic stimulation were combined to induce insomnia of liver depression pattern in rats, and the effect of cng on the macroscopic signs, hemorheology, and neurotransmitters in the hippocampus of insomnia rats of liver depression syndrome was observed. |
2022-05-09 |
2023-08-13 |
rat |
| Max P Herzberg, Rebecca Tillman, Sridhar Kandala, Deanna M Barch, Joan Lub. Preschool depression and hippocampal volume: The moderating role of family income. Journal of the American Academy of Child and Adolescent Psychiatry. 2022-05-06. PMID:35523377. |
preschool depression and hippocampal volume: the moderating role of family income. |
2022-05-06 |
2023-08-13 |
Not clear |
| Max P Herzberg, Rebecca Tillman, Sridhar Kandala, Deanna M Barch, Joan Lub. Preschool depression and hippocampal volume: The moderating role of family income. Journal of the American Academy of Child and Adolescent Psychiatry. 2022-05-06. PMID:35523377. |
depression and low socioeconomic status have both been associated with hippocampal volume alterations. |
2022-05-06 |
2023-08-13 |
Not clear |
| Max P Herzberg, Rebecca Tillman, Sridhar Kandala, Deanna M Barch, Joan Lub. Preschool depression and hippocampal volume: The moderating role of family income. Journal of the American Academy of Child and Adolescent Psychiatry. 2022-05-06. PMID:35523377. |
the authors investigated family income as a moderator of the relationship between depression and hippocampal volume in a longitudinal sample. |
2022-05-06 |
2023-08-13 |
Not clear |
| Trieu-Duc Vu, Naoki Ito, Kenshiro Oshima, Akiko Maruko, Akinori Nishi, Kazushige Mizoguchi, Hiroshi Odaguchi, Yoshinori Kobayashi, Norihiro Okad. Intron retention is a stress response in sensor genes and is restored by Japanese herbal medicines: A basis for future clinical applications. Gene. 2022-05-03. PMID:35504437. |
by analyzing rna-sequencing data generated from the hippocampus of the 19-week-old samp8 mouse, a model for studying age-related depression and alzheimer's disease, we showed that genes with increased ir are generally involved in multiple metabolic pathways and have pivotal roles in sensing homeostasis. |
2022-05-03 |
2023-08-13 |
mouse |
| Shi-Yu Shen, Rui Yu, Wei Li, Ling-Feng Liang, Qiu-Qin Han, Hui-Jie Huang, Bing Li, Shi-Fen Xu, Gen-Cheng Wu, Yu-Qiu Zhang, Jin Y. The neuroprotective effects of GPR55 against hippocampal neuroinflammation and impaired adult neurogenesis in CSDS mice. Neurobiology of disease. 2022-05-01. PMID:35490927. |
our research demonstrated that downregulation of gpr55 expression in the hippocampus might mediate csds-induced depression- and anxiety-like phenotypes, and activation and upregulation of gpr55, which might be correlated with its anti-inflammatory and subsequent neuroprotective effects, could be a potential treatment for depression. |
2022-05-01 |
2023-08-13 |
mouse |
| Chong Gao, Meiling Wu, Qiaohui Du, Jiagang Deng, Jiangang She. Naringin Mediates Adult Hippocampal Neurogenesis for Antidepression via Activating CREB Signaling. Frontiers in cell and developmental biology. vol 10. 2022-04-28. PMID:35478969. |
in cort-induced depression mouse model, naringin treatment promoted neuronal differentiation and maturation of nspcs for hippocampal neurogenesis. |
2022-04-28 |
2023-08-13 |
mouse |