| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Elissa Freberg, Giulio Taglialatel. Exercise as a Potential Therapeutic Strategy to Target the Clinical Link Between Depression and Alzheimer's Disease: A Narrative Review. Journal of Alzheimer's disease : JAD. 2022-08-14. PMID:35964173. |
we searched pubmed for relevant review articles published since 2000 encompassing the topics of hippocampal neurogenesis and exercise in relation to depression and ad, including novel clinical trials if they contributed information not in the chosen reviews. |
2022-08-14 |
2023-08-14 |
Not clear |
| Xiuting Yao, Chenxi Yang, Conghui Wang, Hong Li, Jingyi Zhao, Xiaomin Kang, Zhuodong Liu, Lingyan Chen, Xinyu Chen, Tianshu Pu, Qinyang Li, Lijie Li. High-Fat Diet Consumption in Adolescence Induces Emotional Behavior Alterations and Hippocampal Neurogenesis Deficits Accompanied by Excessive Microglial Activation. International journal of molecular sciences. vol 23. issue 15. 2022-08-12. PMID:35955450. |
hfd mice exhibited elevated levels of depression and anxiety, decreased hippocampal neurogenesis, and excessive microglial activation in the ventral hippocampus. |
2022-08-12 |
2023-08-14 |
mouse |
| Peilin Zhu, Jing Tang, Xin Liang, Yanmin Luo, Jin Wang, Yue Li, Kai Xiao, Jing Li, Yuhui Deng, Lin Jiang, Qian Xiao, Yingqiang Qi, Yuhan Xie, Hao Yang, Lin Zhu, Yong Tang, Chunxia Huan. Activation of liver X receptors protects oligodendrocytes in CA3 of stress-induced mice. Frontiers in pharmacology. vol 13. 2022-08-12. PMID:35959443. |
oligodendrocyte (ol) dysfunction is associated with the pathogenesis of depression and the promotion of hippocampal oligodendrocyte maturation and myelination could be a novel therapeutic strategy for ameliorating depressive behaviors. |
2022-08-12 |
2023-08-14 |
mouse |
| Peilin Zhu, Jing Tang, Xin Liang, Yanmin Luo, Jin Wang, Yue Li, Kai Xiao, Jing Li, Yuhui Deng, Lin Jiang, Qian Xiao, Yingqiang Qi, Yuhan Xie, Hao Yang, Lin Zhu, Yong Tang, Chunxia Huan. Activation of liver X receptors protects oligodendrocytes in CA3 of stress-induced mice. Frontiers in pharmacology. vol 13. 2022-08-12. PMID:35959443. |
recent studies have shown that activation of liver x receptors (lxrs) by gw3965 improves depressive phenotypes, but the effects of gw3965 on ol function and myelination in the hippocampus of depression remain relatively unclear. |
2022-08-12 |
2023-08-14 |
mouse |
| Katarzyna Głombik, Jan Detka, Magdalena Kukla-Bartoszek, Alicja Maciejska, Bogusława Budziszewsk. Changes in regulators of lipid metabolism in the brain: a study of animal models of depression and hypothyroidism. Pharmacological reports : PR. 2022-08-11. PMID:35951260. |
in contrast to glucose metabolism, the link between altered brain lipids and the pathogenesis of depression is poorly understood, therefore in the present study, we determine transcription factors and enzymes regulating cholesterol and fatty acid biosynthesis in the brain structures in an animal model of depression, hypothyroidism and the coexistence of these diseases.in used model of depression, a decrease in the active form of the transcription factor srebp-2 in the hippocampus was demonstrated, thus suggesting a reduction in cholesterol biosynthesis. |
2022-08-11 |
2023-08-14 |
rat |
| Katarzyna Głombik, Jan Detka, Magdalena Kukla-Bartoszek, Alicja Maciejska, Bogusława Budziszewsk. Changes in regulators of lipid metabolism in the brain: a study of animal models of depression and hypothyroidism. Pharmacological reports : PR. 2022-08-11. PMID:35951260. |
moreover, the identified changes in the levels of snap-25, glp-1r and glp-2r pointed to disturbances in synaptic plasticity and neuroprotection mechanisms in the examined brain structures.in conclusion, a reduction in cholesterol synthesis in the hippocampus in the model of depression may be the reason for the reduction of synaptic plasticity, whereas a lower level of ldl-r occurring in the frontal cortex in rats from the model of depression and hypothyroidism coexistence could be the reason of anxiogenic and depression-like behaviors. |
2022-08-11 |
2023-08-14 |
rat |
| Gulin Ozdamar Unal, Arif Demirdas, Mustafa Nazıroglu, Ishak Suat Ove. Agomelatine attenuates calcium signaling and apoptosis via the inhibition of TRPV1 channel in the hippocampal neurons of rats with chronic mild stress depression model. Behavioural brain research. 2022-08-01. PMID:35914635. |
agomelatine attenuates calcium signaling and apoptosis via the inhibition of trpv1 channel in the hippocampal neurons of rats with chronic mild stress depression model. |
2022-08-01 |
2023-08-14 |
rat |
| Camilla Borgsted, Emma Hoegsted, Susanne Henningsson, Anja Pinborg, Melanie Ganz, Vibe G Frokjae. Hippocampal volume changes in a pharmacological sex-hormone manipulation risk model for depression in women. Hormones and behavior. vol 145. 2022-07-29. PMID:35905507. |
hippocampal volume changes in a pharmacological sex-hormone manipulation risk model for depression in women. |
2022-07-29 |
2023-08-14 |
Not clear |
| Gaofeng Wu, Jiaqi Zhou, Maohong Yang, Chang Xu, Huiping Pang, Xia Qin, Shumei Lin, Jiancheng Yang, Jianmin H. The Regulatory Effects of Taurine on Neurogenesis and Apoptosis of Neural Stem Cells in the Hippocampus of Rats. Advances in experimental medicine and biology. vol 1370. 2022-07-26. PMID:35882810. |
the promotion of neurogenesis from neural stem cells (nscs) in the hippocampus was found to be the most fundamental and effective therapy for depression. |
2022-07-26 |
2023-08-14 |
rat |
| Qiaoli Song, Weiming Huang, Wenbin Ye, Huan Yan, Liting Wang, Yan Yang, Xi Cheng, Weiqiang Zhang, Jie Zheng, Ping He, Yaojuan He, Dajun Fang, Xinjia Ha. Neuroprotective Effects of Estrogen Through BDNF-Transient Receptor Potential Channels 6 Signaling Pathway in the Hippocampus in a Rat Model of Perimenopausal Depression. Frontiers in aging neuroscience. vol 14. 2022-07-25. PMID:35875795. |
neuroprotective effects of estrogen through bdnf-transient receptor potential channels 6 signaling pathway in the hippocampus in a rat model of perimenopausal depression. |
2022-07-25 |
2023-08-14 |
rat |
| Zi-Rong Li, De-Guo Liu, Sheng Xie, Yu-Hong Wang, Yuan-Shan Han, Chun-Yan Li, Man-Shu Zou, Hai-Xing Jian. Sleep deprivation leads to further impairment of hippocampal synaptic plasticity by suppressing melatonin secretion in the pineal gland of chronically unpredictable stress rats. European journal of pharmacology. 2022-07-25. PMID:35878808. |
although depression and insomnia impair hippocampal synaptic plasticity, the mechanism by which this happens remains a mystery. |
2022-07-25 |
2023-08-14 |
rat |
| Zi-Rong Li, De-Guo Liu, Sheng Xie, Yu-Hong Wang, Yuan-Shan Han, Chun-Yan Li, Man-Shu Zou, Hai-Xing Jian. Sleep deprivation leads to further impairment of hippocampal synaptic plasticity by suppressing melatonin secretion in the pineal gland of chronically unpredictable stress rats. European journal of pharmacology. 2022-07-25. PMID:35878808. |
this study aimed to investigate the pathogenesis of insomnia comorbidity in depression and the regulatory effect of venlafaxine combined with melatonin on hippocampal synaptic plasticity in chronic unpredictable mild stress (cums) with sleep deprivation (sd) rats. |
2022-07-25 |
2023-08-14 |
rat |
| Wendy Luo, Katherine J Pryzbyl, Eileen H Bigio, Sandra Weintraub, M-Marsel Mesulam, Eva E Rede. Reduced Hippocampal and Anterior Cingulate Expression of Antioxidant Enzymes and Membrane Progesterone Receptors in Alzheimer's Disease with Depression. Journal of Alzheimer's disease : JAD. 2022-07-24. PMID:35871353. |
reduced hippocampal and anterior cingulate expression of antioxidant enzymes and membrane progesterone receptors in alzheimer's disease with depression. |
2022-07-24 |
2023-08-14 |
Not clear |
| Felipe Fagundes Leão, Ana Paula Farias Waltrick, Waldiceu Aparecido Verri, Joice Maria da Cunha, Janaina Menezes Zanovel. Resolvin D5 disrupts anxious- and depressive-like behaviors in a type 1 diabetes mellitus animal model. Naunyn-Schmiedeberg's archives of pharmacology. 2022-07-19. PMID:35852551. |
using an animal model of t1dm, we aimed to evaluate the effect of a specific specialized pro-resolving lipid mediator resolvin d5 (rvd5), in preventing behaviors related to depression and anxiety, investigating its influence on inflammasome in interleukin (il)-1β in the hippocampus and prefrontal cortex. |
2022-07-19 |
2023-08-14 |
rat |
| Angelo D Flores, Wing Shan Yu, Man-Lung Fung, Lee Wei Li. Neuromodulation and Hippocampal Neurogenesis in Depression: A Scoping Review. Brain research bulletin. 2022-07-19. PMID:35853529. |
neuromodulation and hippocampal neurogenesis in depression: a scoping review. |
2022-07-19 |
2023-08-14 |
Not clear |
| Angelo D Flores, Wing Shan Yu, Man-Lung Fung, Lee Wei Li. Neuromodulation and Hippocampal Neurogenesis in Depression: A Scoping Review. Brain research bulletin. 2022-07-19. PMID:35853529. |
the 'neurogenesis hypothesis of depression' emphasizes the importance of upregulated hippocampal neurogenesis for the efficacy of antidepressant treatment. |
2022-07-19 |
2023-08-14 |
Not clear |
| Christian Berthou, Jean Paul Iliou, Denis Barb. Iron, neuro-bioavailability and depression. EJHaem. vol 3. issue 1. 2022-07-18. PMID:35846210. |
noradrenaline also has impact on neuroplasticity via brain-derived neurotrophic factor (bdnf), which is key for prefrontal and hippocampus neurons playing a role in depression. |
2022-07-18 |
2023-08-14 |
Not clear |
| Amanda Larosa, Tak Pan Won. The hippocampus in stress susceptibility and resilience: Reviewing molecular and functional markers. Progress in neuro-psychopharmacology & biological psychiatry. 2022-07-16. PMID:35842073. |
this article focuses on the hippocampus as a region that is highly influenced by chronic stress exposure and that has strong ties to the development of related disorders, such as depression and post-traumatic stress disorder. |
2022-07-16 |
2023-08-14 |
Not clear |
| Lin-Sheng Shi, Chun-Hui Ji, Wen-Qian Tang, Yue Liu, Wei Zhang, Wei Gua. Hippocampal miR-124 participates in the pathogenesis of depression via regulating the expression of BDNF in a Chronic Social Defeat Stress model of depression. Current neurovascular research. 2022-07-15. PMID:35838216. |
hippocampal mir-124 participates in the pathogenesis of depression via regulating the expression of bdnf in a chronic social defeat stress model of depression. |
2022-07-15 |
2023-08-14 |
mouse |
| Lin-Sheng Shi, Chun-Hui Ji, Wen-Qian Tang, Yue Liu, Wei Zhang, Wei Gua. Hippocampal miR-124 participates in the pathogenesis of depression via regulating the expression of BDNF in a Chronic Social Defeat Stress model of depression. Current neurovascular research. 2022-07-15. PMID:35838216. |
genetic knockdown of hippocampal mir-124 produced significant antidepressant-like effects in the csds model of depression. |
2022-07-15 |
2023-08-14 |
mouse |