| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ying He, Yuanshan Han, Xiaolin Liao, Manshu Zou, Yuhong Wan. Biology of cyclooxygenase-2: An application in depression therapeutics. Frontiers in psychiatry. vol 13. 2022-11-28. PMID:36440427. |
this paper summarizes the relationship between cox-2 and depression in terms of neuroinflammation, intestinal flora, neurotransmitters, hpa axis, mitochondrial dysfunction and hippocampal neuronal damage, which can provide a reference for further preventive control, clinical treatment and scientific research on depression. |
2022-11-28 |
2023-08-14 |
Not clear |
| Karla Sánchez-Huerta, Rosaura Debbie Saldaña-Salinas, Pablo Edson Bustamante-Nieves, Adriana Jiménez, Alejandro Corzo-Cruz, Marina Martínez-Vargas, Rosalinda Guevara-Guzmán, Iván Velasco, Enrique Estudill. Sucrose Consumption during Late Adolescence Impairs Adult Neurogenesis of the Ventral Dentate Gyrus without Inducing an Anxiety-like Behavior. International journal of molecular sciences. vol 23. issue 22. 2022-11-26. PMID:36430654. |
data concerning sucrose consumption during late adolescence are lacking, and the effect of sucrose intake on the ventral dentate gyrus of the hippocampus (which modulates anxiety and depression) remains elusive. |
2022-11-26 |
2023-08-14 |
rat |
| Xuanjun Liu, Chun Lin, Shuangyan Wang, Xiaoqi Yu, Yanbin Jia, Jinglong Che. Effects of high levels of copper on the depression-related memory disorders. The journals of gerontology. Series A, Biological sciences and medical sciences. 2022-11-25. PMID:36426545. |
these results suggested that high levels of copper suppressed glun2b and psd95 levels in hippocampus, damaged synaptic function, and caused memory disorders in depression. |
2022-11-25 |
2023-08-14 |
mouse |
| Gema Lordén, Jacob M Wozniak, Kim Doré, Lara E Dozier, Chelsea Cates-Gatto, Gentry N Patrick, David J Gonzalez, Amanda J Roberts, Rudolph E Tanzi, Alexandra C Newto. Enhanced activity of Alzheimer disease-associated variant of protein kinase Cα drives cognitive decline in a mouse model. Nature communications. vol 13. issue 1. 2022-11-23. PMID:36418293. |
analysis of hippocampal neurons from pkcα m489v mice reveals enhanced amyloid-β-induced synaptic depression and reduced spine density compared to wild-type mice. |
2022-11-23 |
2023-08-14 |
mouse |
| Karen M Ryan, Paul Smyth, Gordon Blackshields, Laura Kranaster, Alexander Sartorius, Orla Sheils, Declan M McLoughli. Electroconvulsive Stimulation in Rats Induces Alterations in the Hippocampal miRNome: Translational Implications for Depression. Molecular neurobiology. 2022-11-22. PMID:36414911. |
electroconvulsive stimulation in rats induces alterations in the hippocampal mirnome: translational implications for depression. |
2022-11-22 |
2023-08-14 |
rat |
| Satoshi Deyama, Katsuyuki Kaned. Role of neurotrophic and growth factors in the rapid and sustained antidepressant actions of ketamine. Neuropharmacology. 2022-11-20. PMID:36403852. |
the neurotrophic hypothesis of depression proposes that reduced levels of brain-derived neurotrophic factor (bdnf) and vascular endothelial growth factor (vegf) contribute to neuronal atrophy or loss in the prefrontal cortex (pfc) and hippocampus and impaired hippocampal adult neurogenesis, which are associated with depressive symptoms. |
2022-11-20 |
2023-08-14 |
mouse |
| Laifa Wang, Xueqin Wang, Ling Deng, Hui Zhang, Binsheng He, Wenyu Cao, Yanhui Cu. Pexidartinib (PLX3397) through restoring hippocampal synaptic plasticity ameliorates social isolation-induced mood disorders. International immunopharmacology. vol 113. issue Pt B. 2022-11-17. PMID:36395673. |
these findings suggest that inhibition of microglia in the hippocampus could ameliorate mood disorders in mice, providing a new perspective for the treatment of psychiatric disorders such as depression. |
2022-11-17 |
2023-08-14 |
mouse |
| Robert C Lorenz, Oisin Butler, Gerd Willmund, Ulrich Wesemann, Peter Zimmermann, Jürgen Gallinat, Simone Küh. Effects of stress on neural processing of combat-related stimuli in deployed soldiers: an fMRI study. Translational psychiatry. vol 12. issue 1. 2022-11-17. PMID:36396623. |
however, extracted roi values of the group by time interaction of amygdala and hippocampus were positively associated with the change in depression symptom scores in the combat group, but not in the control group. |
2022-11-17 |
2023-08-14 |
Not clear |
| Aileen MacLellan, Basma Nazal, Lauren Young, Georgia Maso. Waking inactivity as a welfare indicator in laboratory mice: investigating postures, facial expressions and depression-like states. Royal Society open science. vol 9. issue 11. 2022-11-07. PMID:36340516. |
we then extended this research to three other signs of depression: changes in weight and sleep, and reduced hippocampal volume. |
2022-11-07 |
2023-08-14 |
mouse |
| Yi Tian, Meihui Li, Shanshan Zhang, Juntao Hu, Haoran Wu, Mitchell Wan, Jingxin Xue, Leilei Wang, Honglei Xiao, Guomin Zhou, Kaidi Wang, Qiong Li. Microglia activation in the hippocampus mediates retinal degeneration-induced depressive-like behaviors via the NLRP3/IL-1β pathway. Brain research bulletin. 2022-11-04. PMID:36332880. |
excessive neuroinflammation has been shown to participate in glaucoma-induced retinal degeneration and hippocampal neural apoptosis in depression. |
2022-11-04 |
2023-08-14 |
mouse |
| Hao-Yuan Li, Jing Wang, Ling-Feng Liang, Shi-Yu Shen, Wei Li, Xiao-Rong Chen, Bing Li, Yu-Qiu Zhang, Jin Y. Sirtuin 3 Plays a Critical Role in the Antidepressant- and Anxiolytic-like Effects of Kaempferol. Antioxidants (Basel, Switzerland). vol 11. issue 10. 2022-10-27. PMID:36290610. |
the results show that kaempferol has potential beneficial effects on vcd-induced rodent model of menopausal depression and produces antioxidant effects as well as increases the deacetylation of superoxide dismutase 2 (sod2) and the protein level of sirtuin3 (sirt3) in the hippocampus. |
2022-10-27 |
2023-08-14 |
Not clear |
| Marta Kot, Pawan Kumar Neglur, Anna Pietraszewska, Leonora Buzansk. Boosting Neurogenesis in the Adult Hippocampus Using Antidepressants and Mesenchymal Stem Cells. Cells. vol 11. issue 20. 2022-10-27. PMID:36291101. |
however, dysregulation of hippocampal neurogenesis with aging, injury, depression and neurodegenerative disease leads to debilitating cognitive impacts. |
2022-10-27 |
2023-08-14 |
human |
| Clara G Zundel, Patrick Ryan, Cole Brokamp, Autumm Heeter, Yaoxian Huang, Jeffrey R Strawn, Hilary A Marusa. Air Pollution, Depressive and Anxiety Disorders, and Brain Effects: A Systematic Review. Neurotoxicology. 2022-10-24. PMID:36280190. |
we systematically reviewed the medline database in september 2021 for original articles reporting effects of air pollution on 1) internalizing symptoms and behaviors (anxiety or depression) and 2) frontolimbic brain regions (i.e., hippocampus, amygdala, prefrontal cortex). |
2022-10-24 |
2023-08-14 |
human |
| Hua Xu, Yingpeng Ding, Xinyang Qi, Zhi-Jun Zhang, Jianhua S. Ameliorated Neurogenesis Deficits in Dentate Gyrus May Underly the Pronounced Antidepressant Effect of TREK-1 Potassium Channel Blockade in Rats with Depressive-like Behavior. ACS chemical neuroscience. 2022-10-21. PMID:36269040. |
depression is considered to be the most common mental disorder and is probed by several studies that chronic mild stress contributes to depression, and fortunately, most antidepressants ameliorate depressive-like behavior accompanied with reversed hippocampal neurogenesis defects. |
2022-10-21 |
2023-08-14 |
rat |
| John A Wolugbom, Stephanie E Areloegbe, Kehinde S Olaniy. Protective Role of Acetate Against Depressive-Like Behaviour Associated with Letrozole-Induced PCOS Rat Model: Involvement of HDAC2 and DNA Methylation. Molecular neurobiology. 2022-10-21. PMID:36269541. |
the study demonstrates that pcos-associated depression is characterised by neuroinflammation and elevated ach levels, accompanied by increased expression of hdac2/dna methyltransferase in pfc and hippocampus. |
2022-10-21 |
2023-08-14 |
rat |
| John A Wolugbom, Stephanie E Areloegbe, Kehinde S Olaniy. Protective Role of Acetate Against Depressive-Like Behaviour Associated with Letrozole-Induced PCOS Rat Model: Involvement of HDAC2 and DNA Methylation. Molecular neurobiology. 2022-10-21. PMID:36269541. |
besides, the study suggests that acetate protects against pcos-associated depression through suppression of prefrontal and hippocampal dna methylation and prefrontal but not hippocampal hdac2 expression. |
2022-10-21 |
2023-08-14 |
rat |
| Somayeh Dashti, Arezo Nahavand. Neuroprotective effects of aripiprazole in stress-induced depressive-like behavior: possible role of CACNA1C. Journal of chemical neuroanatomy. 2022-10-21. PMID:36270562. |
based on the data indicating the aripiprazole's effects on intracellular calcium levels, this study aimed to investigate the mechanisms of therapeutic effect of aripiprazole in the hippocampus of rat stress-induced model of depression by a focus on the modulation of cacna1c expression. |
2022-10-21 |
2023-08-14 |
rat |
| Di Qu, Zichen Ye, Wenli Zhang, Bing Dai, Guo Chen, Li Wang, Xiaolong Shao, An Xiang, Zifan Lu, Juan Sh. Cyanidin Chloride Improves LPS-Induced Depression-Like Behavior in Mice by Ameliorating Hippocampal Inflammation and Excitotoxicity. ACS chemical neuroscience. 2022-10-18. PMID:36254458. |
neuroinflammation and disturbance of glutamate metabolism in brain regions, such as the hippocampus, play vital roles in the development of depression. |
2022-10-18 |
2023-08-14 |
mouse |
| Di Qu, Zichen Ye, Wenli Zhang, Bing Dai, Guo Chen, Li Wang, Xiaolong Shao, An Xiang, Zifan Lu, Juan Sh. Cyanidin Chloride Improves LPS-Induced Depression-Like Behavior in Mice by Ameliorating Hippocampal Inflammation and Excitotoxicity. ACS chemical neuroscience. 2022-10-18. PMID:36254458. |
we investigated the role of cycl in lipopolysaccharide (lps)-induced depression and examined the influence of the drug on central inflammation and the expression of excitatory amino acid transporters in the hippocampus. |
2022-10-18 |
2023-08-14 |
mouse |
| Tamás Gaszner, József Farkas, Dániel Kun, Balázs Ujvári, Nóra Füredi, László Ákos Kovács, Hitoshi Hashimoto, Dóra Reglődi, Viktória Kormos, Balázs Gaszne. Epigenetic and Neuronal Activity Markers Suggest the Recruitment of the Prefrontal Cortex and Hippocampus in the Three-Hit Model of Depression in Male PACAP Heterozygous Mice. International journal of molecular sciences. vol 23. issue 19. 2022-10-14. PMID:36233039. |
epigenetic and neuronal activity markers suggest the recruitment of the prefrontal cortex and hippocampus in the three-hit model of depression in male pacap heterozygous mice. |
2022-10-14 |
2023-08-14 |
mouse |