| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hidehito Saito-Takatsuji, Yasuo Yoshitomi, Ryo Yamamoto, Takafumi Furuyama, Yasuhito Ishigaki, Nobuo Kato, Hideto Yonekura, Takayuki Iked. Transthyretin Is Commonly Upregulated in the Hippocampus of Two Stress-Induced Depression Mouse Models. International journal of molecular sciences. vol 24. issue 4. 2023-02-25. PMID:36835151. |
therefore, this study examines hippocampal gene expression in two mouse models of depression induced by forced swim stress (fss) and repeated social defeat stress (r-sds). |
2023-02-25 |
2023-08-14 |
mouse |
| Judy Alper, Rui Feng, Gaurav Verma, Sarah Rutter, Kuang-Han Huang, Long Xie, Paul Yushkevich, Yael Jacob, Stephanie Brown, Marin Kautz, Molly Schneider, Hung-Mo Lin, Lazar Fleysher, Bradley N Delman, Patrick R Hof, James W Murrough, Priti Balchandan. Stress-related reduction of hippocampal subfield volumes in major depressive disorder: A 7-Tesla study. Frontiers in psychiatry. vol 14. 2023-02-23. PMID:36816419. |
the objective of this study was to assess volumetric differences in hippocampal subfields between mdd patients globally and healthy controls (hc) as well as between a subset of treatment-resistant depression (trd) patients and hc using automatic segmentation of hippocampal subfields (ashs) software and ultra-high field mri. |
2023-02-23 |
2023-08-14 |
Not clear |
| Yanru Zhu, Feng Wang, Jiatong Han, Yunli Zhao, Miao Yu, Mingyan Ma, Zhiguo Y. Untargeted and targeted mass spectrometry reveal the effects of theanine on the central and peripheral metabolomics of chronic unpredictable mild stress-induced depression in juvenile rats. Journal of pharmaceutical analysis. vol 13. issue 1. 2023-02-23. PMID:36816539. |
given the complexity of the pathogenesis of depression, this study investigated the preventive effect and mechanism of l-theanine on depression in juvenile rats by combining serum and hippocampal metabolomic strategies. |
2023-02-23 |
2023-08-14 |
rat |
| Gaoyou Pei, Liguo Xu, Wenhao Huang, Jianjun Yi. Retraction notice to "The protective role of microRNA-133b in restricting hippocampal neurons apoptosis and inflammatory injury in rats with depression by suppressing CTGF" [Int. Immunopharmacol. 78 (2020) 106076]. International immunopharmacology. vol 117. 2023-02-23. PMID:36822080. |
retraction notice to "the protective role of microrna-133b in restricting hippocampal neurons apoptosis and inflammatory injury in rats with depression by suppressing ctgf" [int. |
2023-02-23 |
2023-08-14 |
rat |
| Zhen Zeng, Yingying Dong, Linxuan Zou, Donghao Xu, Xunrong Luo, Tongpeng Chu, Jing Wang, Qingfa Ren, Quanyuan Liu, Xianglin L. GluCEST Imaging and Structural Alterations of the Bilateral Hippocampus in First-Episode and Early-Onset Major Depression Disorder. Journal of magnetic resonance imaging : JMRI. 2023-02-22. PMID:36808678. |
glucest imaging and structural alterations of the bilateral hippocampus in first-episode and early-onset major depression disorder. |
2023-02-22 |
2023-08-14 |
Not clear |
| Danying Wang, George Parish, Kimron L Shapiro, Simon Hanslmay. Interaction between theta-phase and spike-timing dependent plasticity simulates theta induced memory effects. eNeuro. 2023-02-22. PMID:36810147. |
rodent studies suggest that spike timing relative to hippocampal theta activity determines whether potentiation or depression of synapses arise. |
2023-02-22 |
2023-08-14 |
human |
| Lei Shi, Zhu Xia, Jiamei Guo, Lixia Wang, Zhiping Peng, Dachuan Qiu, Yi Zhou, Dongdong Zhou, Li Kuang, Tian Qi. Maresin-1 improves LPS-induced depressive-like behavior by inhibiting hippocampal microglial activation. Journal of affective disorders. 2023-02-22. PMID:36813041. |
); tspo petct scanning showed that maresin-1 reduced the standardized uptake value (suv) of [18 f] dpa-714 in brain regions associated with depression (e.g., hippocampus and pre-frontal cortex), while immunofluorescence of hippocampal and indicated that maresin-1 inhibited microglial activation reducing the expression of the pro-inflammatory cytokine il-1β and nlrp3. |
2023-02-22 |
2023-08-14 |
mouse |
| Ben Chen, Mingfeng Yang, Xiaomei Zhong, Qiang Wang, Huarong Zhou, Meiling Liu, Min Zhang, Le Hou, Zhangying Wu, Si Zhang, Gaohong Lin, Yuping Nin. Disrupted dynamic functional connectivity of hippocampal subregions mediated the slowed information processing speed in late-life depression. Psychological medicine. 2023-02-21. PMID:36803969. |
disrupted dynamic functional connectivity of hippocampal subregions mediated the slowed information processing speed in late-life depression. |
2023-02-21 |
2023-08-14 |
Not clear |
| Ben Chen, Mingfeng Yang, Xiaomei Zhong, Qiang Wang, Huarong Zhou, Meiling Liu, Min Zhang, Le Hou, Zhangying Wu, Si Zhang, Gaohong Lin, Yuping Nin. Disrupted dynamic functional connectivity of hippocampal subregions mediated the slowed information processing speed in late-life depression. Psychological medicine. 2023-02-21. PMID:36803969. |
the hippocampus is an important link between depression and dementia, and it may be involved in ips slowing in lld. |
2023-02-21 |
2023-08-14 |
Not clear |
| Kuo Zhang, Fan Wang, Mengying Zhai, Meiyao He, Yuxuan Hu, Lijin Feng, Yuting Li, Jingyu Yang, Chunfu W. Hyperactive neuronal autophagy depletes BDNF and impairs adult hippocampal neurogenesis in a corticosterone-induced mouse model of depression. Theranostics. vol 13. issue 3. 2023-02-16. PMID:36793868. |
hyperactive neuronal autophagy depletes bdnf and impairs adult hippocampal neurogenesis in a corticosterone-induced mouse model of depression. |
2023-02-16 |
2023-08-14 |
mouse |
| Chen-Chen Li, Fan Ye, Chen-Xi Xu, Ning Jiang, Qi Chang, Xin-Min Liu, Rui-Le Pa. Tryptophan-kynurenine metabolic characterization in the gut and brain of depressive-like rats induced by chronic restraint stress. Journal of affective disorders. 2023-02-06. PMID:36746244. |
after depression behavior tests, seven segments (cortex, hippocampus, striatum, hypothalamus, serum, cecum, and colon) along the gut-brain axis were collected to characterize their kp metabolism. |
2023-02-06 |
2023-08-14 |
rat |
| Guo-Liang Dai, Hua-Xi Hang, Pei-Yao Chen, Sheng-Wei Hong, Mei-Juan Xu, Cheng-Yao Ma, Qian Huang, Yu Ye, Mei-Shuang Yu, Wen-Zheng J. [Anti-depression mechanism of Zuojin Pills:based on UHPLC-TOF-MS, network pharmacology, and experimental verification]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 1. 2023-02-01. PMID:36725270. |
furthermore, the results of animal experiments showed that zuojin pills could significantly improve the depression behaviors of depression, reduce the levels of il-1β, il-6 and tnf-α in hippocampus and serum, activate ampk/sirt1 signaling, and reduce the protein expression of nlrp3. |
2023-02-01 |
2023-08-14 |
mouse |
| Guo-Liang Dai, Hua-Xi Hang, Pei-Yao Chen, Sheng-Wei Hong, Mei-Juan Xu, Cheng-Yao Ma, Qian Huang, Yu Ye, Mei-Shuang Yu, Wen-Zheng J. [Anti-depression mechanism of Zuojin Pills:based on UHPLC-TOF-MS, network pharmacology, and experimental verification]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 1. 2023-02-01. PMID:36725270. |
in conclusion, zuojin pills may play a role in the treatment of depression by activating ampk/sirt1 signaling pathway, and inhibiting nlrp3 activation and neuroinflammation in the hippocampus of mice. |
2023-02-01 |
2023-08-14 |
mouse |
| Shuo Wu, Kuan Ning, Yujun Wang, Lesha Zhang, Jinggen Li. Up-regulation of BDNF/TrkB signaling by δ opioid receptor agonist SNC80 modulates depressive-like behaviors in chronic restraint-stressed mice. European journal of pharmacology. 2023-01-28. PMID:36708979. |
it was found that the hippocampus and amygdala were involved in crs-induced depression. |
2023-01-28 |
2023-08-14 |
mouse |
| Shuo Wu, Kuan Ning, Yujun Wang, Lesha Zhang, Jinggen Li. Up-regulation of BDNF/TrkB signaling by δ opioid receptor agonist SNC80 modulates depressive-like behaviors in chronic restraint-stressed mice. European journal of pharmacology. 2023-01-28. PMID:36708979. |
therefore, the present study demonstrates that snc80 exerts anti-depressant effects by up-regulating the bdnf/trkb signaling pathway in the hippocampus and amygdala in crs-induced depression and provides evidence that δor's agonists may be potential anti-depressant therapeutic agents. |
2023-01-28 |
2023-08-14 |
mouse |
| Jie Huang, Hua Fan, Yan-Mei Chen, Cheng-Niu Wang, Wei Guan, Wei-Yu Li, Tian-Shun Shi, Wei-Jia Chen, Bao-Lun Zhu, Jian-Feng Liu, Bo Jian. The salt-inducible kinases inhibitor HG-9-91-01 exhibits antidepressant-like actions in mice exposed to chronic unpredictable mild stress. Neuropharmacology. 2023-01-26. PMID:36702294. |
we have previously demonstrated that hippocampal salt-inducible kinase 2 (sik2) plays a role in the pathogenesis of depression via regulating the downstream creb-regulated transcription coactivator 1 (crtc1)-camp response element-binding protein (creb)-brain derived neurotrophic factor (bdnf) pathway. |
2023-01-26 |
2023-08-14 |
mouse |
| Maryam Kheirdeh, Maryam Koushkie Jahromi, Mohammad Hemmatinafar, Javad Nemat. Additive beneficial effects of aerobic training and royal jelly on hippocampal inflammation and function in experimental autoimmune encephalomyelitis rats. Multiple sclerosis and related disorders. vol 70. 2023-01-25. PMID:36696832. |
the present study aimed to investigate the impact of at and rj on inflammatory factors in the hippocampus, as well as depression and anxiety in the experimental autoimmune encephalomyelitis (eae). |
2023-01-25 |
2023-08-14 |
rat |
| Salman Zeb, Huan Ye, Yuan Liu, Hua-Ping Du, Yi Guo, Yong-Ming Zhu, Yong Ni, Hui-Ling Zhang, Yuan X. Necroptotic kinases are involved in the reduction of depression-induced astrocytes and fluoxetine's inhibitory effects on necroptotic kinases. Frontiers in pharmacology. vol 13. 2023-01-23. PMID:36686688. |
increasing evidence indicates that decreased astrocyte numbers in the hippocampus may be associated with depression, but the role of necroptosis in depression is unknown. |
2023-01-23 |
2023-08-14 |
mouse |
| Renrui Lu, Li Zhang, Huihui Wang, Meng Li, Weisheng Feng, Xiaoke Zhen. Echinacoside exerts antidepressant-like effects through enhancing BDNF-CREB pathway and inhibiting neuroinflammation Frontiers in pharmacology. vol 13. 2023-01-23. PMID:36686689. |
in conclusion, echinacoside may be beneficial for the treatment of depression diseases through regulating the microglia balance by inhibiting the polarization of microglia to m1 phenotype, and improving hippocampal neurogenesis by the creb-bdnf signaling pathway. |
2023-01-23 |
2023-08-14 |
mouse |
| Lun Cai, Qianchao He, Huazheng Luo, Xiongbin Gui, Liping Wei, Yongjing Lu, Jie Liu, Anna Su. Is depression in patients with temporal lobe epilepsy related to hippocampal sclerosis? A meta-analysis. Clinical neurology and neurosurgery. vol 225. 2023-01-23. PMID:36689793. |
is depression in patients with temporal lobe epilepsy related to hippocampal sclerosis? |
2023-01-23 |
2023-08-14 |
Not clear |