| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mai A Ebeid, Mohamed Z Habib, Ahmed M Mohamed, Yasser El Faramawy, Sherin S T Saad, Omnyah A El-Kharashi, Hekmat M El Magdoub, Hadwa A Abd-Alkhalek, Sawsan Aboul-Fotouh, Ahmed M Abdel-Tawa. Cognitive effects of the GSK-3 inhibitor "lithium" in LPS/chronic mild stress rat model of depression: Hippocampal and cortical neuroinflammation and tauopathy. Neurotoxicology. vol 83. 2021-11-26. PMID:33417987. |
cognitive effects of the gsk-3 inhibitor "lithium" in lps/chronic mild stress rat model of depression: hippocampal and cortical neuroinflammation and tauopathy. |
2021-11-26 |
2023-08-13 |
rat |
| Acieh Alizadeh Makvandi, Mohsen Khalili, Mehrdad Roghani, Sara Amiri Moghadda. Hesperetin ameliorates electroconvulsive therapy-induced memory impairment through regulation of hippocampal BDNF and oxidative stress in a rat model of depression. Journal of chemical neuroanatomy. vol 117. 2021-11-26. PMID:34246766. |
hesperetin ameliorates electroconvulsive therapy-induced memory impairment through regulation of hippocampal bdnf and oxidative stress in a rat model of depression. |
2021-11-26 |
2023-08-13 |
rat |
| Chun-Hui Ji, Jiang-Hong Gu, Yue Liu, Wen-Qian Tang, Wei Guan, Jie Huang, Yan-Mei Chen, Da-Wei Xu, Bo Jian. Hippocampal MSK1 regulates the behavioral and biological responses of mice to chronic social defeat stress: Involving of the BDNF-CREB signaling and neurogenesis. Biochemical pharmacology. 2021-11-24. PMID:34774532. |
therefore, hippocampal msk1 participates in the pathogenesis of depression and is a feasible and potential antidepressant target. |
2021-11-24 |
2023-08-13 |
mouse |
| Seneca N Ellis, Jennifer A Honeycut. Sex Differences in Affective Dysfunction and Alterations in Parvalbumin in Rodent Models of Early Life Adversity. Frontiers in behavioral neuroscience. vol 15. 2021-11-23. PMID:34803622. |
because anxiety and depression are thought to involve dysregulation in the balance of excitatory and inhibitory signaling in ela-vulnerable brain regions (e.g., prefrontal cortex, amygdala, hippocampus), outcomes are likely driven by alterations in local and/or circuit-specific inhibitory activity. |
2021-11-23 |
2023-08-13 |
Not clear |
| Tian Tian, Yongtao Yang, Bing Xu, Yinhua Qin, Guangchao Zang, Chanjuan Zhou, Peng Zheng, Jin Chen, Ke Cheng, Jianjun Chen, Xue Gong, Peng Xi. Pigment epithelium-derived factor alleviates depressive-like behaviors in mice by modulating adult hippocampal synaptic growth and Wnt pathway. Progress in neuro-psychopharmacology & biological psychiatry. vol 98. 2021-11-22. PMID:31676463. |
animal research indicated that pedf was decreased in the periphery and hippocampus of two well-known depression rodent models (the chronic unpredictable mild stress (cums) rat model and chronic social defeat stress (csds) mouse model). |
2021-11-22 |
2023-08-13 |
mouse |
| Krzysztof Gbyl, Egill Rostrup, Jayachandra Mitta Raghava, Carsten Andersen, Raben Rosenberg, Henrik Bo Wiberg Larsson, Poul Videbec. Volume of hippocampal subregions and clinical improvement following electroconvulsive therapy in patients with depression. Progress in neuro-psychopharmacology & biological psychiatry. vol 104. 2021-11-22. PMID:32730916. |
volume of hippocampal subregions and clinical improvement following electroconvulsive therapy in patients with depression. |
2021-11-22 |
2023-08-13 |
Not clear |
| Chirag Upreti, Caitlin M Woodruff, Xiao-Lei Zhang, Michael J Yim, Zhen-Yu Zhou, Andrew M Pagano, Dina S Rehanian, Deqi Yin, Eric R Kandel, Patric K Stanton, Russell E Nicholl. Loss of retinoid X receptor gamma subunit impairs group 1 mGluR mediated electrophysiological responses and group 1 mGluR dependent behaviors. Scientific reports. vol 11. issue 1. 2021-11-22. PMID:33692389. |
here we show that mice lacking the retinoid x receptor subunit, rxrγ, exhibit impairments in group 1 mglur-mediated electrophysiological responses at hippocampal schaffer collateral-ca1 pyramidal cell synapses, including impaired group 1 mglur-dependent long-term synaptic depression (ltd), reduced group 1 mglur-induced calcium release, and loss of group 1 mglur-activated voltage-sensitive currents. |
2021-11-22 |
2023-08-13 |
mouse |
| Xuan Kang, Li Jiang, Fang Lan, Yi-Yun Tang, Ping Zhang, Wei Zou, Yong-Jun Chen, Xiao-Qing Tan. Hydrogen sulfide antagonizes sleep deprivation-induced depression- and anxiety-like behaviors by inhibiting neuroinflammation in a hippocampal Sirt1-dependent manner. Brain research bulletin. vol 177. 2021-11-18. PMID:34624463. |
increasing evidence confirms that sleep deprivation (sd), which induces hippocampal neuroinflammation, is a risk factor for depression. |
2021-11-18 |
2023-08-13 |
Not clear |
| Jing-Yang Gu, Yao-Wei Xu, Lai-Peng Feng, Jiao Dong, Li-Qin Zhao, Cong Liu, Hui-Ying Wang, Xiang-Yang Zhang, Cai Song, Chang-Hong Wan. Enriched environment mitigates depressive behavior by changing the inflammatory activation phenotype of microglia in the hippocampus of depression model rats. Brain research bulletin. vol 177. 2021-11-18. PMID:34653561. |
enriched environment mitigates depressive behavior by changing the inflammatory activation phenotype of microglia in the hippocampus of depression model rats. |
2021-11-18 |
2023-08-13 |
rat |
| Il Bin Kim, Seon-Cheol Par. The Entorhinal Cortex and Adult Neurogenesis in Major Depression. International journal of molecular sciences. vol 22. issue 21. 2021-11-18. PMID:34769155. |
as adult neurogenesis operates in an activity-dependent manner, disruption of hippocampal neurogenesis in depression may be a consequence of neural circuitry impairments. |
2021-11-18 |
2023-08-13 |
Not clear |
| Il Bin Kim, Seon-Cheol Par. The Entorhinal Cortex and Adult Neurogenesis in Major Depression. International journal of molecular sciences. vol 22. issue 21. 2021-11-18. PMID:34769155. |
taken together, these findings may provide a better understanding of the entorhinal cortex-regulated hippocampal neurogenesis model of depression. |
2021-11-18 |
2023-08-13 |
Not clear |
| Patrícia Patrício, António Mateus-Pinheiro, Ana Rita Machado-Santos, Nuno Dinis Alves, Joana Sofia Correia, Mónica Morais, João Miguel Bessa, Ana João Rodrigues, Nuno Sousa, Luísa Pint. Cell Cycle Regulation of Hippocampal Progenitor Cells in Experimental Models of Depression and after Treatment with Fluoxetine. International journal of molecular sciences. vol 22. issue 21. 2021-11-18. PMID:34769232. |
cell cycle regulation of hippocampal progenitor cells in experimental models of depression and after treatment with fluoxetine. |
2021-11-18 |
2023-08-13 |
Not clear |
| Patrícia Patrício, António Mateus-Pinheiro, Ana Rita Machado-Santos, Nuno Dinis Alves, Joana Sofia Correia, Mónica Morais, João Miguel Bessa, Ana João Rodrigues, Nuno Sousa, Luísa Pint. Cell Cycle Regulation of Hippocampal Progenitor Cells in Experimental Models of Depression and after Treatment with Fluoxetine. International journal of molecular sciences. vol 22. issue 21. 2021-11-18. PMID:34769232. |
changes in adult hippocampal cell proliferation and genesis have been largely implicated in depression and antidepressant action, though surprisingly, the underlying cell cycle mechanisms are largely undisclosed. |
2021-11-18 |
2023-08-13 |
Not clear |
| Masashi Sakurai, Ryoi Iwasa, Yusuke Sakai, Masahiro Morimot. Minocycline prevents depression-like behavior in streptozotocin-induced diabetic mice. Neuropathology : official journal of the Japanese Society of Neuropathology. vol 41. issue 2. 2021-11-17. PMID:33230848. |
impaired hippocampal neurogenesis was observed in diabetic mice; however, this may not be involved in the pathogenesis of depression. |
2021-11-17 |
2023-08-13 |
mouse |
| Samantha M Vervoordt, Peter Arnett, Christopher Engeland, Amanda R Rabinowitz, Frank G Hillar. Depression associated with APOE status and hippocampal volume but not cognitive decline in older adults aging with traumatic brain injury. Neuropsychology. vol 35. issue 8. 2021-11-17. PMID:34570541. |
depression associated with apoe status and hippocampal volume but not cognitive decline in older adults aging with traumatic brain injury. |
2021-11-17 |
2023-08-13 |
Not clear |
| Samantha M Vervoordt, Peter Arnett, Christopher Engeland, Amanda R Rabinowitz, Frank G Hillar. Depression associated with APOE status and hippocampal volume but not cognitive decline in older adults aging with traumatic brain injury. Neuropsychology. vol 35. issue 8. 2021-11-17. PMID:34570541. |
to examine the relationship between depression and cognition, genetic risk, and hippocampal differences in a sample of older adults with a history of traumatic brain injury (tbi). |
2021-11-17 |
2023-08-13 |
Not clear |
| María Camila Cortés-Albornoz, Danna Paola García-Guáqueta, Alberto Velez-van-Meerbeke, Claudia Talero-Gutiérre. Maternal Nutrition and Neurodevelopment: A Scoping Review. Nutrients. vol 13. issue 10. 2021-11-17. PMID:34684531. |
we concluded that inadequate nutrient intake during pregnancy was associated with brain defects (diminished cerebral volume, spina bifida, alteration of hypothalamic and hippocampal pathways), an increased risk of abnormal behavior, neuropsychiatric disorders (asd, adhd, schizophrenia, anxiety, depression), altered cognition, visual impairment, and motor deficits. |
2021-11-17 |
2023-08-13 |
Not clear |
| Shao-Tsu Chen, Chung-Pin Hsieh, Mei-Yi Lee, Liao-Chen Chen, Chien-Min Huang, Hwei-Hsien Chen, Ming-Huan Cha. Betaine prevents and reverses the behavioral deficits and synaptic dysfunction induced by repeated ketamine exposure in mice. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 144. 2021-11-17. PMID:34715446. |
these results demonstrated that both co-treatment and post-treatment with betaine could effectively prevent and reverse the adverse behavioral manifestations and hippocampal synaptic plasticity after repeated ketamine use, suggesting that betaine can be used as a novel adjunct therapy with ketamine for treatment-resistant depression and provide benefits for ketamine use disorders. |
2021-11-17 |
2023-08-13 |
mouse |
| Zhigang Xiao, Zhuoqing Cao, Jiali Yang, Zhixia Jia, Yuru Du, Guoqiang Sun, Ye Lu, Lin Pe. Baicalin promotes hippocampal neurogenesis via the Wnt/β-catenin pathway in a chronic unpredictable mild stress-induced mouse model of depression. Biochemical pharmacology. vol 190. 2021-11-16. PMID:33964281. |
baicalin promotes hippocampal neurogenesis via the wnt/β-catenin pathway in a chronic unpredictable mild stress-induced mouse model of depression. |
2021-11-16 |
2023-08-13 |
mouse |
| Zhigang Xiao, Zhuoqing Cao, Jiali Yang, Zhixia Jia, Yuru Du, Guoqiang Sun, Ye Lu, Lin Pe. Baicalin promotes hippocampal neurogenesis via the Wnt/β-catenin pathway in a chronic unpredictable mild stress-induced mouse model of depression. Biochemical pharmacology. vol 190. 2021-11-16. PMID:33964281. |
the results indicated that baicalin alleviated cums-induced depression-like behaviour, and improved the nerve cells' survival of the hippocampal dentate gyrus (dg) in cums-induced depression of model mice and increased ki-67- and doublecortin (dcx)-positive cells to restore cums-induced suppression of hippocampal neurogenesis. |
2021-11-16 |
2023-08-13 |
mouse |