| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shijia Chen, Fengpei Chen, Nashwa Amin, Qiannan Ren, Shan Ye, Zhiying Hu, Xiaoning Tan, Mizu Jiang, Marong Fan. Defects of parvalbumin-positive interneurons in the ventral dentate gyrus region are implicated depression-like behavior in mice. Brain, behavior, and immunity. vol 99. 2021-12-11. PMID:34562597. |
these findings facilitate us better understand the role of hippocampal pvis in depression. |
2021-12-11 |
2023-08-13 |
mouse |
| Azam Moosavi Sohroforouzani, Saeed Shakerian, Mohsen Ghanbarzadeh, Hojjatallah Alae. Effect of forced treadmill exercise on stimulation of BDNF expression, depression symptoms, tactile memory and working memory in LPS-treated rats. Behavioural brain research. vol 418. 2021-12-11. PMID:34743949. |
this study aimed to investigate the effect of forced treadmill exercise on hippocampal bdnf expression levels, depression symptoms, tactile memory and working memory in lipopolysaccharide (lps)-treated rats. |
2021-12-11 |
2023-08-13 |
rat |
| Shu Liu, Jianbo Xiu, Caiyun Zhu, Kexin Meng, Chen Li, Rongrong Han, Tingfu Du, Lanlan Li, Lingdan Xu, Renjie Liu, Wanwan Zhu, Yan Shen, Qi X. Fat mass and obesity-associated protein regulates RNA methylation associated with depression-like behavior in mice. Nature communications. vol 12. issue 1. 2021-12-11. PMID:34836959. |
here, we report that expression of the fat mass and obesity associated gene (fto), an rna demethylase, is downregulated in the hippocampus of patients with mdd and mouse models of depression. |
2021-12-11 |
2023-08-13 |
mouse |
| Amalia Dávila-Hernández, Roberto González-González, Sonia Guzmán-Velázquez, Olivia Tania Hernández Hernández, Sergio R Zamudio, Lucía Martínez-Mot. Antidepressant-like effects of acupuncture via modulation of corticosterone, sex hormones, and hippocampal BDNF expression in male rats. Brain research bulletin. vol 173. 2021-12-09. PMID:33991609. |
post-weaning social isolated rodents exhibit pathophysiological changes associated with depression including adrenal axis hyperactivity, gonadal hormone level disturbances, molecular alterations in hippocampus, and immobility behavior in the forced swimming test (fst). |
2021-12-09 |
2023-08-13 |
rat |
| Zhiping Xie, Shaoxin Huang, Shenke Xie, Wu Zhou, Chengcai Li, Zelong Xing, Zhihua Wang, Zhiwu Wu, Meihua L. Potential Correlation Between Depression-like Behavior and the Mitogen-Activated Protein Kinase Pathway in the Rat Hippocampus Following Spinal Cord Injury. World neurosurgery. vol 154. 2021-12-09. PMID:34271150. |
depression induced by spinal cord injury (sci) has been demonstrated in clinical and experimental studies; it significantly impacts patients' lives and may be associated with changes in the hippocampus. |
2021-12-09 |
2023-08-13 |
rat |
| Oktay Genel, Carmine M Pariante, Alessandra Borsin. The role of AQP4 in the pathogenesis of depression, and possible related mechanisms. Brain, behavior, and immunity. vol 98. 2021-12-09. PMID:34474133. |
while in post-mortem and ex vivo studies of depression aqp4 expression was usually decreased in the hippocampus, prefrontal cortex and locus coeruleus, in clinical studies, where mrna aqp4 expression or serum aqp4 autoantibodies were measured, there were no differences in depressed patients when compared with controls. |
2021-12-09 |
2023-08-13 |
Not clear |
| Yuechen Guan, Junming Wang, Xiaohui Wu, Lingling Song, Yanmei Wang, Mingzhu Gong, Bingyin L. Quercetin reverses chronic unpredictable mild stress-induced depression-like behavior in vivo by involving nuclear factor-E2-related factor 2. Brain research. vol 1772. 2021-12-09. PMID:34529966. |
collectively, the present study confirmed for the first time that quercetin weakened cums-induced depression in vivo, and its mechanism was at least partially attributable to the upregulation of hippocampal nrf2 and the inhibition of inos, thereby correcting the central inflammatory response, and the imbalance between oxidation and antioxidant. |
2021-12-09 |
2023-08-13 |
mouse |
| Jing Tang, Xin Liang, Xiaoyun Dou, Yingqiang Qi, Chunmao Yang, Yanmin Luo, Fenglei Chao, Lei Zhang, Qian Xiao, Lin Jiang, Chunni Zhou, Yong Tan. Exercise rather than fluoxetine promotes oligodendrocyte differentiation and myelination in the hippocampus in a male mouse model of depression. Translational psychiatry. vol 11. issue 1. 2021-12-09. PMID:34880203. |
exercise rather than fluoxetine promotes oligodendrocyte differentiation and myelination in the hippocampus in a male mouse model of depression. |
2021-12-09 |
2023-08-13 |
mouse |
| Wei Guan, Da-Wei Xu, Chun-Hui Ji, Cheng-Niu Wang, Yue Liu, Wen-Qian Tang, Jiang-Hong Gu, Yan-Mei Chen, Jie Huang, Jian-Feng Liu, Bo Jian. Hippocampal miR-206-3p participates in the pathogenesis of depression via regulating the expression of BDNF. Pharmacological research. vol 174. 2021-12-07. PMID:34628001. |
hippocampal mir-206-3p participates in the pathogenesis of depression via regulating the expression of bdnf. |
2021-12-07 |
2023-08-13 |
mouse |
| Wei Guan, Da-Wei Xu, Chun-Hui Ji, Cheng-Niu Wang, Yue Liu, Wen-Qian Tang, Jiang-Hong Gu, Yan-Mei Chen, Jie Huang, Jian-Feng Liu, Bo Jian. Hippocampal miR-206-3p participates in the pathogenesis of depression via regulating the expression of BDNF. Pharmacological research. vol 174. 2021-12-07. PMID:34628001. |
in contrast, both genetic knockdown of hippocampal mir-206-3p and intranasal administration of antagomir-206-3p produced significant antidepressant-like effects in the csds model of depression. |
2021-12-07 |
2023-08-13 |
mouse |
| Wei Guan, Da-Wei Xu, Chun-Hui Ji, Cheng-Niu Wang, Yue Liu, Wen-Qian Tang, Jiang-Hong Gu, Yan-Mei Chen, Jie Huang, Jian-Feng Liu, Bo Jian. Hippocampal miR-206-3p participates in the pathogenesis of depression via regulating the expression of BDNF. Pharmacological research. vol 174. 2021-12-07. PMID:34628001. |
taken together, hippocampal mir-206-3p participates in the pathogenesis of depression by regulating bdnf biosynthesis and is a feasible antidepressant target. |
2021-12-07 |
2023-08-13 |
mouse |
| Lai Shunkai, Ting Su, Shuming Zhong, Guangmao Chen, Yiliang Zhang, Hui Zhao, Pan Chen, Guixian Tang, Zhangzhang Qi, Jiali He, Yunxia Zhu, Sihui Lv, Zijin Song, Haofei Miao, Yilei Hu, Yanbin Jia, Ying Wan. Abnormal dynamic functional connectivity of hippocampal subregions associated with working memory impairment in melancholic depression. Psychological medicine. 2021-12-06. PMID:34870570. |
abnormal dynamic functional connectivity of hippocampal subregions associated with working memory impairment in melancholic depression. |
2021-12-06 |
2023-08-13 |
Not clear |
| Xunrong Luo, Qingfa Ren, Mingfang Luo, Tianping Li, Yijie Lv, Yan Liu, Kang Rong, Wei Zhang, Xianglin L. Glutamate Chemical Exchange Saturation Transfer Imaging and Functional Alterations of Hippocampus in Rat Depression Model: A Pilot Study. Journal of magnetic resonance imaging : JMRI. vol 54. issue 6. 2021-12-01. PMID:34291854. |
glutamate chemical exchange saturation transfer imaging and functional alterations of hippocampus in rat depression model: a pilot study. |
2021-12-01 |
2023-08-13 |
rat |
| Yihang Zhou, Haifeng Wan. Editorial for "Glutamate Chemical Exchange Saturation Transfer Imaging and Functional Alterations of Hippocampus in Rat Depression Model: A Pilot Study". Journal of magnetic resonance imaging : JMRI. vol 54. issue 6. 2021-12-01. PMID:34505749. |
editorial for "glutamate chemical exchange saturation transfer imaging and functional alterations of hippocampus in rat depression model: a pilot study". |
2021-12-01 |
2023-08-13 |
rat |
| Zhifang Li, Hexiang Xu, Yi Xu, Guanfeng Lu, Qiwei Peng, Jiefang Chen, Rentang Bi, Jianzhuang Li, Shengcai Chen, Hongkai Li, Huijuan Jin, Bo H. Morinda officinalis oligosaccharides alleviate depressive-like behaviors in post-stroke rats via suppressing NLRP3 inflammasome to inhibit hippocampal inflammation. CNS neuroscience & therapeutics. vol 27. issue 12. 2021-12-01. PMID:34559953. |
in this study, we investigated whether moos can ameliorate depressive-like behaviors in post-stroke depression (psd) rats and further explored its mechanism by suppressing microglial nlrp3 inflammasome activation to inhibit hippocampal inflammation. |
2021-12-01 |
2023-08-13 |
rat |
| Mamoru Tanaka, Takeshi Sakaba, Takafumi Mik. Quantal analysis estimates docking site occupancy determining short-term depression at hippocampal glutamatergic synapses. The Journal of physiology. vol 599. issue 23. 2021-12-01. PMID:34705277. |
quantal analysis estimates docking site occupancy determining short-term depression at hippocampal glutamatergic synapses. |
2021-12-01 |
2023-08-13 |
Not clear |
| Mamoru Tanaka, Takeshi Sakaba, Takafumi Mik. Quantal analysis estimates docking site occupancy determining short-term depression at hippocampal glutamatergic synapses. The Journal of physiology. vol 599. issue 23. 2021-12-01. PMID:34705277. |
based on these results, we suggest that the occupancy probability is a crucial determinant of short-term synaptic depression at glutamatergic synapses in the hippocampus. |
2021-12-01 |
2023-08-13 |
Not clear |
| Anna Lydia Shuster, Fernanda Emilia Rocha, Sheila Wayszceyk, Daniela Delwing de Lima, Sara Cristiane Barauna, Bruna Gonçalves Lopes, Michele Debiasi Alberton, Débora Delwing Dal Magr. Protective effect of Myrcia pubipetala Miq. against the alterations in oxidative stress parameters in an animal model of depression induced by corticosterone. Brain research. vol 1774. 2021-11-29. PMID:34785258. |
exerts antioxidant effects in the cerebral cortex and hippocampus of mice induced to depression by cort. |
2021-11-29 |
2023-08-13 |
mouse |
| Kun Zhang, Ran Liu, Jingruo Zhang, Xifang Wei, Yuan Gao, Wen Ma, Yijing Li, Wa Cai, Weidong She. Electroacupuncture Ameliorates Depression-Like Behaviour in Rats by Enhancing Synaptic Plasticity via the GluN2B/CaMKII/CREB Signalling Pathway. Evidence-based complementary and alternative medicine : eCAM. vol 2021. 2021-11-27. PMID:34777532. |
hippocampal synaptic plasticity during the pathological process of depression has received increasing attention. |
2021-11-27 |
2023-08-13 |
rat |
| Kun Zhang, Ran Liu, Jingruo Zhang, Xifang Wei, Yuan Gao, Wen Ma, Yijing Li, Wa Cai, Weidong She. Electroacupuncture Ameliorates Depression-Like Behaviour in Rats by Enhancing Synaptic Plasticity via the GluN2B/CaMKII/CREB Signalling Pathway. Evidence-based complementary and alternative medicine : eCAM. vol 2021. 2021-11-27. PMID:34777532. |
hippocampal neuron atrophy and the reduction in synaptic density induced by chronic stress are important pathological mechanisms of depression. |
2021-11-27 |
2023-08-13 |
rat |