| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Keaton A Unroe, Matthew E Glover, Elizabeth A Shupe, Ningping Feng, Sarah M Clinto. Perinatal SSRI Exposure Disrupts G Protein-coupled Receptor BAI3 in Developing Dentate Gyrus and Adult Emotional Behavior: Relevance to Psychiatric Disorders. Neuroscience. vol 471. 2021-08-25. PMID:34293414. |
together these results suggest that abnormal bai3 signaling may contribute to molecular mechanisms that drive adverse effects of perinatal ssri exposure, and show evidence for alterations of bai3 signaling in the hippocampus of patients that suffer depression and schizophrenia. |
2021-08-25 |
2023-08-13 |
human |
| Isabella Hoi Kei Leung, Kathryn Mary Broadhouse, Loren Mowszowski, Haley M LaMonica, Jake Robert Palmer, Ian B Hickie, Sharon L Naismith, Shantel Leigh Duff. Association between lifetime depression history, hippocampal volume and memory in non-amnestic mild cognitive impairment. The European journal of neuroscience. vol 54. issue 3. 2021-08-20. PMID:33765347. |
association between lifetime depression history, hippocampal volume and memory in non-amnestic mild cognitive impairment. |
2021-08-20 |
2023-08-13 |
Not clear |
| Isabella Hoi Kei Leung, Kathryn Mary Broadhouse, Loren Mowszowski, Haley M LaMonica, Jake Robert Palmer, Ian B Hickie, Sharon L Naismith, Shantel Leigh Duff. Association between lifetime depression history, hippocampal volume and memory in non-amnestic mild cognitive impairment. The European journal of neuroscience. vol 54. issue 3. 2021-08-20. PMID:33765347. |
hippocampal subfield volume loss in older adults with amnestic mild cognitive impairment (amci) and depression history are associated with amyloid beta and tau pathology, thereby increasing the risk for alzheimer's disease (ad). |
2021-08-20 |
2023-08-13 |
Not clear |
| Isabella Hoi Kei Leung, Kathryn Mary Broadhouse, Loren Mowszowski, Haley M LaMonica, Jake Robert Palmer, Ian B Hickie, Sharon L Naismith, Shantel Leigh Duff. Association between lifetime depression history, hippocampal volume and memory in non-amnestic mild cognitive impairment. The European journal of neuroscience. vol 54. issue 3. 2021-08-20. PMID:33765347. |
however, no studies have exclusively examined distinct alterations in hippocampal subfields in non-amnestic mci (namci) in relation to depression history. |
2021-08-20 |
2023-08-13 |
Not clear |
| Isabella Hoi Kei Leung, Kathryn Mary Broadhouse, Loren Mowszowski, Haley M LaMonica, Jake Robert Palmer, Ian B Hickie, Sharon L Naismith, Shantel Leigh Duff. Association between lifetime depression history, hippocampal volume and memory in non-amnestic mild cognitive impairment. The European journal of neuroscience. vol 54. issue 3. 2021-08-20. PMID:33765347. |
here, we used both longitudinal and transverse hippocampal segmentation methods using the automated freesurfer software to examine whether a lifetime depression history is associated with differences in hippocampal head/body/tail (h/b/t) and key subfield volumes (ca1, subiculum, dentate gyrus) in older adults with namci. |
2021-08-20 |
2023-08-13 |
Not clear |
| Isabella Hoi Kei Leung, Kathryn Mary Broadhouse, Loren Mowszowski, Haley M LaMonica, Jake Robert Palmer, Ian B Hickie, Sharon L Naismith, Shantel Leigh Duff. Association between lifetime depression history, hippocampal volume and memory in non-amnestic mild cognitive impairment. The European journal of neuroscience. vol 54. issue 3. 2021-08-20. PMID:33765347. |
further, we explored whether differences in hippocampal h/b/t and subfield volumes were associated with structured and unstructured verbal encoding and retention, comparing those with and without a depression history. |
2021-08-20 |
2023-08-13 |
Not clear |
| Rong Ma, Eric Hanse, Bengt Gustafsso. Homosynaptic frequency-dependent depression by release site inactivation at neonatal hippocampal synapses in the stratum lacunosum-moleculare. The European journal of neuroscience. vol 54. issue 3. 2021-08-20. PMID:34137082. |
homosynaptic frequency-dependent depression by release site inactivation at neonatal hippocampal synapses in the stratum lacunosum-moleculare. |
2021-08-20 |
2023-08-13 |
rat |
| Wenjuan Wang, Yong Qiao, Huiying Qu, Lin Zhu, Linlin Mu, Chunyue Li, Jie Fang, Hong Lia. The protective role of Neuregulin1-ErbB4 signaling in a chronic social defeat stress model. Neuroreport. vol 31. issue 9. 2021-08-18. PMID:32427713. |
brain structural mri and postmortem studies on patients with depression have revealed changes in the anatomy and functionality in various brain regions, including the amygdala, thalamus, hippocampus, and prefrontal cortex (pfc). |
2021-08-18 |
2023-08-13 |
mouse |
| Krzysztof Gbyl, Mette Marie Støttrup, Jayachandra Mitta Raghava, Song Xue Jie, Poul Videbec. Hippocampal volume and memory impairment after electroconvulsive therapy in patients with depression. Acta psychiatrica Scandinavica. vol 143. issue 3. 2021-08-18. PMID:33251575. |
hippocampal volume and memory impairment after electroconvulsive therapy in patients with depression. |
2021-08-18 |
2023-08-13 |
Not clear |
| He Yu, Zhong-Mei He, Kun Shi, Yan Zhao, Ying Zong, Jian-Ming Li, Wei-Jia Chen, Rui D. [Study on antidepressant effect of total alkaloids of Fibraurea recisa]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 46. issue 14. 2021-08-18. PMID:34402292. |
this study aimed to investigate the antidepressant effects of total alkaloids of fibraurea recisa in ht22 cells damaged by corticosterone (cort) in vitro and in a mouse model of chronic unpredictable mild stress (cums) as well as the underlying mechanisms.in cellular experiments,the viability of cort-damaged ht22 cells was detected using cell counting kit-8 (cck-8),and the cell apoptosis was detected by hoechst 33258 staining.in animal experiments,c57bl/6n mice were randomly divided into the control group,model group,low (100 mg·kg~(-1)),medium (200 mg·kg~(-1)) and high (400 mg·kg~(-1))-dose of total alkaloids of f.recisa groups,and positive control group.after 21 days of cums exposure,their depressive behaviors were observed in behavioral and morris water maze tests.the serum levels of 5-hydroxytryptamine (5-ht),dopamine (da),and norepinephrine (ne) were assessed by elisa.the expression levels of apoptosis-related proteins bcl-2,bax and cleaved caspase-3 in ht22 cells and mouse hippocampus were detected by western blot.the results suggested that total alkaloids of f.recisa alleviated the damage of ht22 cells induced by cort in a dose-dependent manner.the hoechst 33258 staining uncovered that total alkaloids of f.recisa better reduced the blue spots and inhibited cell apoptosis.the results of animal experiments showed that total alkaloids of f.recisa significantly improved the depression-like behaviors of mice and increased the serum levels of 5-ht,da and ne as compared with those in the model group.the western blot assays revealed a significant up-regulation of bcl-2 protein expression,but an obvious reduction in bax and cleaved caspase-3protein expression in the total alkaloids of f.recisa group.in conclusion,total alkaloids of f.recisa inhibited depression possibly by regulating the apoptosis-related protein expression or elevating the monoamine neurotransmitter levels in the brain. |
2021-08-18 |
2023-08-13 |
mouse |
| Sukjin Ko, Won Seuk Jang, Ji-Hyun Jeong, Ji Woong Ahn, Young-Hwan Kim, Sohyun Kim, Hyeon Kyeong Chae, Seungsoo Chun. (-)-Gallocatechin gallate from green tea rescues cognitive impairment through restoring hippocampal silent synapses in post-menopausal depression. Scientific reports. vol 11. issue 1. 2021-08-17. PMID:33441611. |
(-)-gallocatechin gallate from green tea rescues cognitive impairment through restoring hippocampal silent synapses in post-menopausal depression. |
2021-08-17 |
2023-08-13 |
rat |
| Marzia Soligo, Virginia Protto, Antonio Chiaretti, Sonia Piccinin, Maria Egle De Stefano, Robert Nisticò, Luisa Bracci-Laudiero, Luigi Mann. Effects of intranasally-delivered pro-nerve growth factors on the septo-hippocampal system in healthy and diabetic rats. Neuropharmacology. vol 176. 2021-08-13. PMID:32681844. |
exogenous prongf-b induces depression of hippocampal dg-ltp and impairment of hippocampal neurogenesis in healthy animals, with concomitant decrease in basal forebrain cholinergic neurons and cholinergic fibers projecting to the hippocampus. |
2021-08-13 |
2023-08-13 |
mouse |
| b' Ivana Peri\\xc4\\x87, Victor Costina, Peter Gass, Peter Findeisen, Dragana Filipovi\\xc4\\x8. Hippocampal synaptoproteomic changes of susceptibility and resilience of male rats to chronic social isolation. Brain research bulletin. vol 166. 2021-08-11. PMID:33238171.' |
to explore the neurobiological underpinnings and identify candidate biomarkers of susceptibility or resilience to csis, a comparative proteomic approach was used to map hippocampal synaptic protein alterations of rats exposed to 6 weeks of csis, an animal model of depression. |
2021-08-11 |
2023-08-13 |
rat |
| Janik Goltermann, Nils Opel, Ronny Redlich, Jonathan Repple, Claas Kaehler, Dominik Grotegerd, Katharina Dohm, Elisabeth J Leehr, Joscha Böhnlein, Katharina Förster, Susanne Meinert, Verena Enneking, Daniel Emden, Ramona Leenings, Nils R Winter, Tim Hahn, Sami Mikhail, Andreas Jansen, Axel Krug, Igor Nenadić, Marcella Rietschel, Stephanie H Witt, Stefanie Heilmann-Heimbach, Per Hoffmann, Andreas J Forstner, Markus M Nöthen, Bernhard T Baune, Tilo Kircher, Udo Dannlowsk. Replication of a hippocampus specific effect of the tescalcin regulating variant rs7294919 on gray matter structure. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 36. 2021-08-10. PMID:32451266. |
no interaction effects of rs7294919 with depression nor with childhood trauma on hippocampal morphometry could be detected. |
2021-08-10 |
2023-08-13 |
human |
| Bruna Stefânia Ferreira Mello, Adriano José Maia Chaves Filho, Charllyany Sabino Custódio, Patrícia de Araújo Rodrigues, Jaqueline V Carletti, Silvânia Maria Mendes Vasconcelos, Francisca Cléa Florenço de Sousa, Lia Lira Olivier Sanders, Danielle S Maced. Doxycycline at subantimicrobial dose combined with escitalopram reverses depressive-like behavior and neuroinflammatory hippocampal alterations in the lipopolysaccharide model of depression. Journal of affective disorders. vol 292. 2021-08-05. PMID:34161892. |
doxycycline at subantimicrobial dose combined with escitalopram reverses depressive-like behavior and neuroinflammatory hippocampal alterations in the lipopolysaccharide model of depression. |
2021-08-05 |
2023-08-13 |
mouse |
| Yunxuan Xu, Lingyun Lian. Vitamin D3/vitamin D receptor signaling mitigates symptoms of post-stroke depression in mice by upregulating hippocampal BDNF expression. Neuroscience research. vol 170. 2021-08-04. PMID:32882254. |
vitamin d3/vitamin d receptor signaling mitigates symptoms of post-stroke depression in mice by upregulating hippocampal bdnf expression. |
2021-08-04 |
2023-08-13 |
mouse |
| Qiuju Peng, Lei Shi, Yanying Kong, Yuan Yan, Jielin Zhan, Yuguan Wen, Wenyi Liu, Dexian Yu, Zhijian Zhou, Huacheng Ya. CX3CL1 rs170364 gene polymorphism has a protective effect against major depression by enhancing its transcriptional activity. Brain research. vol 1738. 2021-07-30. PMID:32234515. |
studies have shown that adult hippocampal neurogenesis may be a cause of depression. |
2021-07-30 |
2023-08-13 |
human |
| Zuotian Wu, Ling Xiao, Huiling Wang, Gaohua Wan. Neurogenic hypothesis of positive psychology in stress-induced depression: Adult hippocampal neurogenesis, neuroinflammation, and stress resilience. International immunopharmacology. vol 97. 2021-07-30. PMID:33915495. |
neurogenic hypothesis of positive psychology in stress-induced depression: adult hippocampal neurogenesis, neuroinflammation, and stress resilience. |
2021-07-30 |
2023-08-13 |
Not clear |
| Zuotian Wu, Ling Xiao, Huiling Wang, Gaohua Wan. Neurogenic hypothesis of positive psychology in stress-induced depression: Adult hippocampal neurogenesis, neuroinflammation, and stress resilience. International immunopharmacology. vol 97. 2021-07-30. PMID:33915495. |
the hippocampus is one of the most severely damaged brain regions in stress-induced depression. |
2021-07-30 |
2023-08-13 |
Not clear |
| Vlad Dionisie, Adela Magdalena Ciobanu, Vlad Alexandru Toma, Mihnea Costin Manea, Ioana Baldea, Diana Olteanu, Alexandra Sevastre-Berghian, Simona Clichici, Mirela Manea, Sorin Riga, Gabriela Adriana Fili. Escitalopram Targets Oxidative Stress, Caspase-3, BDNF and MeCP2 in the Hippocampus and Frontal Cortex of a Rat Model of Depression Induced by Chronic Unpredictable Mild Stress. International journal of molecular sciences. vol 22. issue 14. 2021-07-30. PMID:34299103. |
escitalopram targets oxidative stress, caspase-3, bdnf and mecp2 in the hippocampus and frontal cortex of a rat model of depression induced by chronic unpredictable mild stress. |
2021-07-30 |
2023-08-13 |
rat |