| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Haiyang Wang, Lanxiang Liu, Xuechen Rao, Benhua Zeng, Ying Yu, Chanjuan Zhou, Li Zeng, Peng Zheng, Juncai Pu, Shaohua Xu, Ke Cheng, Hanping Zhang, Ping Ji, Hong Wei, Peng Xi. Integrated phosphoproteomic and metabolomic profiling reveals perturbed pathways in the hippocampus of gut microbiota dysbiosis mice. Translational psychiatry. vol 10. issue 1. 2021-06-18. PMID:33051451. |
here we utilized mass spectrometry to identify the global phosphorylation dynamics in hippocampus tissue in germ-free mice and specific pathogen-free mice (gf vs spf), fecal microbiota transplantation (fmt) model ("depression microbiota" and the "healthy microbiota" recipient mice). |
2021-06-18 |
2023-08-13 |
mouse |
| Lin Li, Yuting Zou, Baoe Liu, Runan Yang, Jingjian Yang, Minghao Sun, Zijing Li, Xiumei Xu, Guilin Li, Shuangmei Liu, Wolfgang Greffrath, Rolf-Detlef Treede, Guodong Li, Shangdong Lian. Contribution of the P2X4 Receptor in Rat Hippocampus to the Comorbidity of Chronic Pain and Depression. ACS chemical neuroscience. vol 11. issue 24. 2021-06-18. PMID:33284579. |
contribution of the p2x4 receptor in rat hippocampus to the comorbidity of chronic pain and depression. |
2021-06-18 |
2023-08-13 |
rat |
| Lin Li, Yuting Zou, Baoe Liu, Runan Yang, Jingjian Yang, Minghao Sun, Zijing Li, Xiumei Xu, Guilin Li, Shuangmei Liu, Wolfgang Greffrath, Rolf-Detlef Treede, Guodong Li, Shangdong Lian. Contribution of the P2X4 Receptor in Rat Hippocampus to the Comorbidity of Chronic Pain and Depression. ACS chemical neuroscience. vol 11. issue 24. 2021-06-18. PMID:33284579. |
the hippocampus is an important region for the interaction between depression and pain. |
2021-06-18 |
2023-08-13 |
rat |
| Lin Li, Yuting Zou, Baoe Liu, Runan Yang, Jingjian Yang, Minghao Sun, Zijing Li, Xiumei Xu, Guilin Li, Shuangmei Liu, Wolfgang Greffrath, Rolf-Detlef Treede, Guodong Li, Shangdong Lian. Contribution of the P2X4 Receptor in Rat Hippocampus to the Comorbidity of Chronic Pain and Depression. ACS chemical neuroscience. vol 11. issue 24. 2021-06-18. PMID:33284579. |
this work investigated the potential implication of the p2x4 receptor in the hippocampus in comorbidity of chronic pain and depression. |
2021-06-18 |
2023-08-13 |
rat |
| Lin Li, Yuting Zou, Baoe Liu, Runan Yang, Jingjian Yang, Minghao Sun, Zijing Li, Xiumei Xu, Guilin Li, Shuangmei Liu, Wolfgang Greffrath, Rolf-Detlef Treede, Guodong Li, Shangdong Lian. Contribution of the P2X4 Receptor in Rat Hippocampus to the Comorbidity of Chronic Pain and Depression. ACS chemical neuroscience. vol 11. issue 24. 2021-06-18. PMID:33284579. |
these findings suggest that the p2x4 receptor in the hippocampus may mediate and significantly contribute to the pathological processes of comorbid pain and depression. |
2021-06-18 |
2023-08-13 |
rat |
| Aiping Li, Jing Tian, Jianwen Yang, Xiang Ren, Zhiwen Zhou, Wensheng Zho. Expression of fibroblast growth factor 9 and its receptors in the dentate gyrus of hippocampus in poststroke depression rats. Neuroreport. vol 32. issue 4. 2021-06-18. PMID:33470768. |
expression of fibroblast growth factor 9 and its receptors in the dentate gyrus of hippocampus in poststroke depression rats. |
2021-06-18 |
2023-08-13 |
rat |
| Yao Gao, Junfang Mu, Teng Xu, Ting Linghu, Huiliang Zhao, Junsheng Tian, Xuemei Qi. Metabolomic analysis of the hippocampus in a rat model of chronic mild unpredictable stress-induced depression based on a pathway crosstalk and network module approach. Journal of pharmaceutical and biomedical analysis. vol 193. 2021-06-17. PMID:33190083. |
metabolomic analysis of the hippocampus in a rat model of chronic mild unpredictable stress-induced depression based on a pathway crosstalk and network module approach. |
2021-06-17 |
2023-08-13 |
rat |
| Yao Gao, Junfang Mu, Teng Xu, Ting Linghu, Huiliang Zhao, Junsheng Tian, Xuemei Qi. Metabolomic analysis of the hippocampus in a rat model of chronic mild unpredictable stress-induced depression based on a pathway crosstalk and network module approach. Journal of pharmaceutical and biomedical analysis. vol 193. 2021-06-17. PMID:33190083. |
increasing evidence suggests that hippocampus metabolism is strongly involved in the pathogenesis of chronic mild unpredictable stress (cums)-induced depression. |
2021-06-17 |
2023-08-13 |
rat |
| Yao Gao, Junfang Mu, Teng Xu, Ting Linghu, Huiliang Zhao, Junsheng Tian, Xuemei Qi. Metabolomic analysis of the hippocampus in a rat model of chronic mild unpredictable stress-induced depression based on a pathway crosstalk and network module approach. Journal of pharmaceutical and biomedical analysis. vol 193. 2021-06-17. PMID:33190083. |
the principal objective of this study was to reveal important information concerning the pathogenesis of depression through a comprehensive analysis of metabolites in the hippocampus in a cums rat model. |
2021-06-17 |
2023-08-13 |
rat |
| Qi Zhang, Su Hong, Jun Cao, Yi Zhou, Xiaoming Xu, Ming Ai, Li Kuan. Hippocampal Subfield Volumes in Major Depressive Disorder Adolescents with a History of Suicide Attempt. BioMed research international. vol 2021. 2021-06-17. PMID:33954172. |
the hippocampus, which consists of multiple functionally specialized subfields, may contribute to the pathophysiology of depression and suicidal behavior. |
2021-06-17 |
2023-08-13 |
Not clear |
| Xiaoyan Zhai, Jing Liu, Aihua Ni, Jun Y. MiR-497 promotes microglia activation and proinflammatory cytokines production in chronic unpredictable stress-induced depression via targeting FGF2. Journal of chemical neuroanatomy. vol 110. 2021-06-16. PMID:33068702. |
these results showed that mir-497 aggravated hippocampal microglial activation in cus-induced depression in rat via targeting fgf2, providing a novel potential target for treatment of depression. |
2021-06-16 |
2023-08-13 |
rat |
| Alessandra Borsini, Anna Nicolaou, Dolores Camacho-Muñoz, Alexandra C Kendall, Maria Grazia Di Benedetto, Juliette Giacobbe, Kuan-Pin Su, Carmine M Pariant. Omega-3 polyunsaturated fatty acids protect against inflammation through production of LOX and CYP450 lipid mediators: relevance for major depression and for human hippocampal neurogenesis. Molecular psychiatry. 2021-06-16. PMID:34131267. |
omega-3 polyunsaturated fatty acids protect against inflammation through production of lox and cyp450 lipid mediators: relevance for major depression and for human hippocampal neurogenesis. |
2021-06-16 |
2023-08-13 |
human |
| Yusuke Sakai, Haiyan Li, Hiromichi Inaba, Yuki Funayama, Erina Ishimori, Ayako Kawatake-Kuno, Hirotaka Yamagata, Tomoe Seki, Teruyuki Hobara, Shin Nakagawa, Yoshifumi Watanabe, Susumu Tomita, Toshiya Murai, Shusaku Uchid. Gene-environment interactions mediate stress susceptibility and resilience through the CaMKIIβ/TARPγ-8/AMPAR pathway. iScience. vol 24. issue 5. 2021-06-12. PMID:34113835. |
the ventral hippocampus (vhpc) plays key roles in motivation, sociability, anhedonia, despair-like behaviors, anxiety, sleep, and feeding, pointing to the involvement of this brain region in depression. |
2021-06-12 |
2023-08-13 |
Not clear |
| Sayan Ghosh, Sreetama Choudhury, Olivia Chowdhury, Sudeshna Mukherjee, Ankur Das, Arindam Sain, Payal Gupta, Arghya Adhikary, Sreya Chattopadhya. Inflammation-induced behavioral changes is driven by alterations in Nrf2-dependent apoptosis and autophagy in mouse hippocampus: Role of fluoxetine. Cellular signalling. vol 68. 2021-06-09. PMID:31881324. |
taken together, the data suggests that systemic inflammation potentiates nrf2-dependent changes in cell death and autophagy pathway in the hippocampus, eventually leading to major pathologic sequelae associated with depression. |
2021-06-09 |
2023-08-13 |
mouse |
| Mahino Fatima, Mir Hilal Ahmad, Saurabh Srivastav, Moshahid Alam Rizvi, A C Monda. A selective D2 dopamine receptor agonist alleviates depression through up-regulation of tyrosine hydroxylase and increased neurogenesis in hippocampus of the prenatally stressed rats. Neurochemistry international. vol 136. 2021-06-07. PMID:32201282. |
a selective d2 dopamine receptor agonist alleviates depression through up-regulation of tyrosine hydroxylase and increased neurogenesis in hippocampus of the prenatally stressed rats. |
2021-06-07 |
2023-08-13 |
rat |
| Mahino Fatima, Mir Hilal Ahmad, Saurabh Srivastav, Moshahid Alam Rizvi, A C Monda. A selective D2 dopamine receptor agonist alleviates depression through up-regulation of tyrosine hydroxylase and increased neurogenesis in hippocampus of the prenatally stressed rats. Neurochemistry international. vol 136. 2021-06-07. PMID:32201282. |
prenatal stress (pns) has its negative impact on both the infant hippocampal neurogenesis and pregnancy outcomes in the neonates that serves as a risk factor for postnatal depression in adult offsprings. |
2021-06-07 |
2023-08-13 |
rat |
| Mahino Fatima, Mir Hilal Ahmad, Saurabh Srivastav, Moshahid Alam Rizvi, A C Monda. A selective D2 dopamine receptor agonist alleviates depression through up-regulation of tyrosine hydroxylase and increased neurogenesis in hippocampus of the prenatally stressed rats. Neurochemistry international. vol 136. 2021-06-07. PMID:32201282. |
pns induced changes resulted in depression validated by the depression-like behaviours, increased oxidative stress, decreased th expression, altered expression of selective developmental genes, along with the reduced hippocampal neurogenesis and bdnf expression in the brain of adult offsprings. |
2021-06-07 |
2023-08-13 |
rat |
| Zixuan Cai, Ting Ye, Xing Xu, Minhui Gao, Yaru Zhang, Dan Wang, Yiming Gu, Haojie Zhu, Lijuan Tong, Jiashu Lu, Zhuo Chen, Chao Huan. Antidepressive properties of microglial stimulation in a mouse model of depression induced by chronic unpredictable stress. Progress in neuro-psychopharmacology & biological psychiatry. vol 101. 2021-06-04. PMID:32201112. |
the decrease of microglia in the hippocampus is a novel mechanism for depression onset. |
2021-06-04 |
2023-08-13 |
mouse |
| Peili Hu, Dan Wang, Yaru Zhang, Zixuan Cai, Ting Ye, Lijuan Tong, Xing Xu, Jiashu Lu, Fengguo Liu, Xu Lu, Chao Huan. Apoptosis-triggered decline in hippocampal microglia mediates adolescent intermittent alcohol exposure-induced depression-like behaviors in mice. Neuropharmacology. vol 170. 2021-06-03. PMID:32217088. |
these results reveal a possible mechanism for aie-induced depression and demonstrate that the restoration of hippocampal microglial homeostasis may be a therapeutic strategy for depression induced by alcohol intake and withdrawal. |
2021-06-03 |
2023-08-13 |
mouse |
| Milenna T van Dijk, Jiook Cha, David Semanek, Natalie Aw, Marc J Gameroff, Eyal Abraham, Priya J Wickramaratne, Myrna M Weissman, Jonathan Posner, Ardesheer Talat. Altered Dentate Gyrus Microstructure in Individuals at High Familial Risk for Depression Predicts Future Symptoms. Biological psychiatry. Cognitive neuroscience and neuroimaging. vol 6. issue 1. 2021-06-03. PMID:32855106. |
altered hippocampal, and specifically dentate gyrus (dg), structure and function may be involved in depression development. |
2021-06-03 |
2023-08-13 |
Not clear |